keyword
https://read.qxmd.com/read/38531890/highlighting-the-effects-of-high-intensity-interval-training-on-the-changes-associated-with-hypertrophy-apoptosis-and-histological-proteins-of-the-heart-of-old-rats-with-type-2-diabetes
#1
JOURNAL ARTICLE
Mohammad Rami, Amirhossein Ahmadi Hekmatikar, Samaneh Rahdar, Sayed Shafa Marashi, D Maryama Awang Daud
T2DM is known to cause disturbances in glucose homeostasis and negative changes in the heart muscle, while aging and diabetes are recognized risk factors for CVD. Given this, our study aims to investigate a method for controlling and managing CVDs induced by T2DM in elderly populations. To achieve this, we categorized 40 rats into 5 groups, including HAD (n = 8), HA (n = 8), AD (n = 8), AHT (n = 8), and ADT (n = 8). The exercise protocol consisted of eight weeks of HIIT (three sessions per week) performed at 90-95% of maximal speed...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38449449/frailty-of-prostate-cancer-patients-receiving-androgen-deprivation-therapy-a-scoping-review
#2
JOURNAL ARTICLE
Jeongok Park, Gi Wook Ryu, Hyojin Lee, Young Deuk Choi, Youngkyung Kim
PURPOSE: This study aimed to explore the existing literature on frailty experienced by patients with prostate cancer (PC) receiving androgen deprivation therapy (ADT). MATERIALS AND METHODS: Database and manual searches were conducted to identify relevant studies published in English, with no limitation on the year of publication, according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews guidelines. Four databases-PubMed, Cochrane Library, EMBASE, and CINAHL-were used for database searches and reference lists, related journals, and Google Scholar were used for manual searches...
November 7, 2023: World Journal of Men's Health
https://read.qxmd.com/read/38432212/comparing-efficacies-of-different-exercises-on-androgen-deprivation-therapy-adverse-effects-in-prostate-cancer-patients-a-network-meta-analysis
#3
Siping Hu, Xingyu Xiong, Shi Qiu, Jiakun Li, Hang Xu, Xianghong Zhou, Sheng Wang, Qiang Wei, Lu Yang
INTRODUCTION: Previous studies showed exercise have efficacies for androgen deprivation therapy (ADT) adverse effects. To compare the efficacies of different exercises on ADT adverse effects, we conducted the network meta-analysis (NMA). METHODS: Literature retrieval was performed in PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL). 19 studies (1184 participants) were included. All analyses were performed in R 4.1.2 or RevMan 5.4.1. RESULTS: NMA results showed that compared with the control group, both aerobic + resistance training (ART) (MD = 5...
March 2, 2024: Urologia Internationalis
https://read.qxmd.com/read/38300697/effectiveness-of-a-nurse-led-mobile-based-health-coaching-program-for-patients-with-prostate-cancer-at-high-risk-of-metabolic-syndrome-randomized-waitlist-controlled-trial
#4
JOURNAL ARTICLE
Kyoungjin Lee, Jeongok Park, Eui Geum Oh, JuHee Lee, Chang Park, Young Deuk Choi
BACKGROUND: Androgen deprivation therapy (ADT), a standard treatment for prostate cancer (PC), causes many physical side effects. In particular, it causes metabolic changes such as fasting glucose abnormalities or accumulation of body fat, and its continuation can lead to metabolic syndrome (MetS), which is closely related to diabetes and cardiovascular disease. Therefore, it is important to maintain and practice a healthy lifestyle in patients with PC. OBJECTIVE: This study aims to evaluate the effectiveness of a nurse-led mobile-based program that aims to promote a healthy lifestyle in patients with PC undergoing ADT with MetS risk factors...
February 1, 2024: JMIR MHealth and UHealth
https://read.qxmd.com/read/38057016/efficacy-of-multidisciplinary-interventions-in-preventing-metabolic-syndrome-and-improving-body-composition-in-prostate-cancer-patients-treated-with-androgen-deprivation-therapy-a-systematic-review-and-meta-analysis
#5
JOURNAL ARTICLE
Uhjin Yang, Athulya Harikrishna, Veronica Preda, Juliana Chen
BACKGROUND: Exercise is known to reduce adverse side effects of androgen-deprivation therapy (ADT) on quality of life, bone health and fatigue for prostate cancer (PCa) patients. We conducted a systematic review with meta-analysis to evaluate the effect of multidisciplinary interventions on body composition and metabolic syndrome (MetS) in ADT-treated PCa patients. METHODS: A systematic review and meta-analysis were conducted based on searches of EMBASE, MEDLINE, CENTRAL and Scopus databases from inception to March 2023...
December 2023: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38048764/resistance-exercise-training-a-simple-intervention-to-preserve-muscle-mass-and-strength-in-prostate-cancer-patients-on-androgen-deprivation-therapy
#6
JOURNAL ARTICLE
Lisanne H P Houben, Milou Beelen, Luc J C van Loon, Sandra Beijer
Androgen deprivation therapy (ADT) forms the cornerstone in the treatment of advanced prostate cancer. However, by suppressing testosterone ADT results in a decrease of skeletal muscle mass. In this narrative review, we explore the magnitude and mechanisms of ADT-induced muscle mass loss and the consequences for muscle strength and physical performance. Subsequently, we elucidate the effectiveness of supervised resistance exercise training as a means to mitigate these adverse effects. Literature shows that resistance exercise training can effectively counteract ADT-induced loss of appendicular lean body mass and decline in muscle strength, while the effect on physical performances is inconclusive...
December 4, 2023: International Journal of Sport Nutrition and Exercise Metabolism
https://read.qxmd.com/read/37976654/home-based-versus-supervised-group-exercise-in-men-with-prostate-cancer-on-androgen-deprivation-therapy-a-randomized-controlled-trial-and-economic-analysis
#7
RANDOMIZED CONTROLLED TRIAL
Shabbir M H Alibhai, Efthymios Papadopoulos, Daniel Santa Mina, Paul Ritvo, George Tomlinson, Catherine M Sabiston, Sara Durbano, Karen E Bremner, James Chiarotto, Andrew Matthew, Padraig Warde, Meagan O'Neill, S Nicole Culos-Reed
INTRODUCTION: Differences between health outcomes, participation/adoption, and cost-effectiveness of home-based (HOME) interventions and supervised group-based training (GROUP) in men with prostate cancer (PC) on androgen deprivation therapy (ADT) are currently unknown. The objective of this study was to assess the clinical efficacy, adherence, and cost-effectiveness of HOME versus GROUP in men on ADT for PC. MATERIALS AND METHODS: This was a multicentre, 2-arm non-inferiority randomized controlled trial and companion cost-effectiveness analysis...
January 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/37972755/a-comparison-of-aerobic-and-resistance-emphasised-exercise-on-cardiometabolic-health-and-quality-of-life-in-men-receiving-androgen-deprivation-therapy-for-prostate-cancer-protocol-for-a-feasibility-trial
#8
JOURNAL ARTICLE
Kira Murphy, Bróna Kehoe, Suzanne Denieffe, Dayle Hacking, Ciaran M Fairman, Michael Harrison
BACKGROUND: Those with intermediate and high-risk prostate cancer typically receive Androgen Deprivation Therapy (ADT) as part of their treatment. ADT often results in extensive side effects including increased risk of cardiometabolic disease. Many ADT side effects can be influenced by exercise, both resistance and aerobic training. Exercise regimes typically combine aerobic and resistance exercise but the appropriate emphasis for achieving the broadest range of therapeutic benefits has yet to be determined...
November 14, 2023: Contemporary Clinical Trials
https://read.qxmd.com/read/37917926/exergaming-improves-cardiac-risk-factors-in-prostate-cancer-patients-a-single-blinded-randomized-controlled-trial
#9
JOURNAL ARTICLE
Brigitta R Villumsen, Jan Frystk, Martin Grønbech Jørgensen, Britta Hørdam, Michael Borre
Purpose: Androgen deprivation therapy (ADT) may induce unfavorable changes in metabolic outcomes, insulin sensitivity, insulin-like growth factors (IGFs), and in serum levels of adipocyte-derived hormones. In this preplanned randomized ancillary study, we aimed to investigate the ability of exercise to counteract alterations in triglyceride, cholesterol, waist circumference, and insulin caused by ADT in men with locally advanced and metastatic prostate cancer (PCa). Materials and Methods: Forty-six PCa patients undergoing treatment were randomized to 12 weeks of 180 minutes of weekly unsupervised home-based exergaming or usual care...
November 2, 2023: Games for Health
https://read.qxmd.com/read/37705024/cardiometabolic-healthcare-for-men-with-prostate-cancer-an-md-anderson-cancer-center-experience
#10
JOURNAL ARTICLE
Andrew W Hahn, Whittney Thoman, Efstratios Koutroumpakis, Amer Abdulla, Sumit K Subudhi, Ana Aparicio, Karen Basen-Enngquist, Christopher J Logothetis, Susan C Gilchrist
BACKGROUND: Men diagnosed with prostate cancer are at risk for competing morbidity and mortality due to cardiometabolic disease given their advanced age at diagnosis, high prevalence of pre-existing risk factors, and receipt of systemic therapy that targets the androgen receptor (AR). Expert panels have stressed the importance of cardiometabolic risk assessment in the clinic and proposed evaluating key risks using consensus paradigms. Yet, there is a gap in real-world evidence for implementation of comprehensive cardiometabolic care for men with prostate cancer...
September 13, 2023: Cardio-Oncology
https://read.qxmd.com/read/37680229/a-systematic-review-evaluating-the-effectiveness-of-exercise-training-on-physical-condition-in-prostate-cancer-patients-undergoing-androgen-deprivation-therapy
#11
REVIEW
Fan Yuan, Yang Wang, Xiwei Xiao, Xufan Zhang, Mingyi Jing, Hubert Kamecki, Yu Guang Tan, Silvia García Barreras, Jeanny B Aragon-Ching, Ziyang Ma, Peihai Zhang, Degui Chang, Yaodong You
BACKGROUND: Androgen deprivation therapy (ADT) is an effective prostate cancer (PCa) treatment strategy that can curb the development or progression of the disease. This review aimed to examine and summarize available systematic reviews/meta-analyses (SRs/MAs) of exercise training on physical condition of PCa patients undergoing ADT. METHODS: A comprehensive search of 8 databases was conducted for relevant literature published before April 25, 2022 with the language restrictions of Chinese and English...
August 31, 2023: Translational Andrology and Urology
https://read.qxmd.com/read/37402060/feasibility-of-home-based-exercise-training-during-adjuvant-treatment-for-metastatic-castrate-resistant-prostate-cancer-patients-treated-with-an-androgen-receptor-pathway-inhibitor-exact
#12
JOURNAL ARTICLE
Malcolm Brown, Marie H Murphy, Helen McAneney, Ken McBride, Ffiona Crawford, Aidan Cole, Joe M O'Sullivan, Suneil Jain, Gillian Prue
BACKGROUND: Exercise is an effective adjuvant therapy that can alleviate treatment-related toxicities for men with prostate cancer (PC). However, the feasibility of delivering exercise training to men with advanced disease and the wider impact on clinical outcomes remain unknown. The purpose of the EXACT trial was to determine the feasibility and effects of home-based exercise training in men with metastatic castrate-resistant prostate cancer (mCRPC). METHODS: Patients with mCRPC receiving ADT + an androgen receptor pathway inhibitor (ARPI) were prescribed 12 weeks of home-based, remotely monitored, moderate intensity, aerobic and resistance exercise...
July 4, 2023: Supportive Care in Cancer
https://read.qxmd.com/read/37325799/acute-exercise-induces-distinct-quantitative-and-phenotypical-t-cell-profiles-in-men-with-prostate-cancer
#13
JOURNAL ARTICLE
Erik D Hanson, Samy Sakkal, Lauren C Bates-Fraser, Shadney Que, Eunhan Cho, Guillaume Spielmann, Elif Kadife, John A Violet, Claudio L Battaglini, Lee Stoner, David B Bartlett, Glenn K McConell, Alan Hayes
BACKGROUND: Reduced testosterone levels can influence immune system function, particularly T cells. Exercise during cancer reduces treatment-related side effects and provide a stimulus to mobilize and redistribute immune cells. However, it is unclear how conventional and unconventional T cells (UTC) respond to acute exercise in prostate cancer survivors compared to healthy controls. METHODS: Age-matched prostate cancer survivors on androgen deprivation therapy (ADT) and those without ADT (PCa) along with non-cancer controls (CON) completed ∼45 min of intermittent cycling with 3 min at 60% of peak power interspersed by 1...
2023: Frontiers in sports and active living
https://read.qxmd.com/read/37229882/moderators-of-resistance-based-exercise-programs-effect-on-sarcopenia-related-measures-in-men-with-prostate-cancer-previously-or-currently-undergoing-androgen-deprivation-therapy-an-individual-patient-data-meta-analysis
#14
JOURNAL ARTICLE
Pedro Lopez, Robert U Newton, Dennis R Taaffe, Kerri Winters-Stone, Daniel A Galvão, Laurien M Buffart
INTRODUCTION: Older men with prostate cancer are commonly affected by reductions in lean mass and physical function following androgen deprivation therapy (ADT). Resistance-based exercise programs are critical to counteract the musculoskeletal toxicities derived from prostate cancer treatment and aging. However, there is significant variability in the effects of exercise interventions. Examining demographic and clinical moderators of exercise effects in this patient group can assist in identifying which subgroups of patients benefit most...
May 23, 2023: Journal of Geriatric Oncology
https://read.qxmd.com/read/37166341/effects-of-exercise-on-physical-function-and-quality-of-life-in-prostate-cancer-patients-receiving-androgen-deprivation-therapy-high-intensity-interval-training-versus-moderate-intensity-continuous-training
#15
JOURNAL ARTICLE
Sangjun Yoo, Kyung Hee Lee, Parivash Jamrasi, Min Chul Cho, Wook Song, Hyeon Jeong
INTRODUCTION: We assessed the effects of exercise on the physical function and health quality of life (hQoL) in prostate cancer patients underwent androgen deprivation therapy (ADT). Additionally, the effects of high-intensity interval training (HIIT) on the physical function and hQoL in these patients were compared with those of moderate-intensity continuous training (MICT). METHODS: Seventeen prostate cancer patients who underwent ADT were prospectively allocated to either HIIT (n = 9) or MICT (n = 8)...
April 25, 2023: Urologia Internationalis
https://read.qxmd.com/read/37161470/resistance-exercise-counteracts-the-impact-of-androgen-deprivation-therapy-on-muscle-characteristics-in-cancer-patients
#16
JOURNAL ARTICLE
Maarten Overkamp, Lisanne H P Houben, Thorben Aussieker, Janneau M X van Kranenburg, Philippe J M Pinckaers, Ulla R Mikkelsen, Milou Beelen, Sandra Beijer, Luc J C van Loon, Tim Snijders
CONTEXT: Androgen deprivation therapy (ADT) forms the cornerstone in prostate cancer (PCa) treatment. However, ADT also lowers skeletal muscle mass. OBJECTIVE: To identify the impact of ADT with and without resistance exercise training on muscle fiber characteristics in PCa patients. METHODS: Twenty-one PCa patients (72 ± 6 years) starting ADT were included. Tissue samples from the vastus lateralis muscle were assessed at baseline and after 20 weeks of usual care (n = 11) or resistance exercise training (n = 10)...
September 18, 2023: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/37080399/effects-and-moderators-of-exercise-medicine-on-cardiometabolic-outcomes-in-men-with-prostate-cancer-previously-or-currently-undergoing-androgen-deprivation-therapy-an-individual-patient-data-meta-analysis
#17
REVIEW
Pedro Lopez, Robert U Newton, Dennis R Taaffe, Kerri Winters-Stone, Laurien M Buffart, Daniel A Galvão
PURPOSE: To examine the effects and moderators of exercise effects on cardiometabolic outcomes in men with prostate cancer previously or currently undergoing androgen deprivation therapy (ADT). RESULTS: Seven trials including 560 patients were examined. Exercise resulted in significant effects on whole-body and regional fat mass (P≤0.001). For whole-body fat mass, significant exercise effects were observed in patients who were unmarried (-1.4kg, P<0.05) and who presented with higher fat mass levels (-1...
April 18, 2023: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/36658635/does-inflammation-markers-or-treatment-type-moderate-exercise-intensity-effects-on-changes-in-muscle-strength-in-cancer-survivors-participating-in-a-6-month-combined-resistance-and-endurance-exercise-program-results-from-the-phys-can-trial
#18
JOURNAL ARTICLE
Anna Henriksson, Emelie Strandberg, Andreas Stenling, Anne-Sophie Mazzoni, Katarina Sjövall, Sussanne Börjeson, Truls Raastad, Ingrid Demmelmaier, Sveinung Berntsen, Karin Nordin
BACKGROUND: Resistance exercise has a beneficial impact on physical function for patients receiving oncological treatment. However, there is an inter-individual variation in the response to exercise and the tolerability to high-intensity exercise. Identifying potential moderating factors, such as inflammation and treatment type, for changes in muscle strength is important to improve the effectiveness of exercise programs. Therefore, we aimed to investigate if inflammation and type of oncological treatment moderate the effects of exercise intensity (high vs...
January 19, 2023: BMC Sports Science, Medicine and Rehabilitation
https://read.qxmd.com/read/36578945/preference-based-versus-randomized-controlled-trial-in-prostate-cancer-survivors-comparison-of-recruitment-adherence-attrition-and-clinical-outcomes
#19
JOURNAL ARTICLE
Shabbir M H Alibhai, Efthymios Papadopoulos, Sara Durbano, George Tomlinson, Daniel Santa Mina, Paul Ritvo, Catherine M Sabiston, Andrew G Matthew, James Chiarotto, Souraya Sidani, S Nicole Culos-Reed
INTRODUCTION: Patients' unwillingness to be randomized to a mode of exercise may partly explain their poor recruitment, adherence, and attrition in randomized controlled trials (RCTs) of exercise in oncology. It is unknown whether a preference-based trial can improve recruitment, adherence, retention, and clinical outcomes compared to a RCT of the same exercise interventions. OBJECTIVE: We assessed the effects of a 2-arm exercise preference trial on adherence and clinical outcomes compared to a similar 2-arm RCT in men with prostate cancer (PC)...
2022: Frontiers in Oncology
https://read.qxmd.com/read/36534950/resistance-exercise-training-increases-muscle-mass-and-strength-in-prostate-cancer-patients-on-androgen-deprivation-therapy
#20
RANDOMIZED CONTROLLED TRIAL
Lisanne H P Houben, Maarten Overkamp, Puck VAN Kraaij, Jorn Trommelen, Joep G H VAN Roermund, Peter DE Vries, Kevin DE Laet, Saskia VAN DER Meer, Ulla R Mikkelsen, Lex B Verdijk, Luc J C VAN Loon, Sandra Beijer, Milou Beelen
PURPOSE: This study aimed to assess the effects of 20 wk resistance exercise training with or without protein supplementation on body composition, muscle mass, muscle strength, physical performance, and aerobic capacity in prostate cancer patients receiving androgen deprivation therapy (ADT). METHODS: Sixty prostate cancer patients receiving ADT were randomly assigned to perform 20 wk of resistance exercise training with supplementation of 31 g whey protein (EX + PRO, n = 30) or placebo (EX + PLA, n = 30), consumed immediately after exercise and every night before sleep...
April 1, 2023: Medicine and Science in Sports and Exercise
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