Laura J A Hardwick, Benjamin P Davies, Sara Pensa, Maedee Burge-Rogers, Claire Davies, André Figueiredo Baptista, Robert Knott, Ian S McCrone, Eleonora Po, Benjamin W Strugnell, Katie Waine, Paul Wood, Walid T Khaled, Huw D Summers, Paul Rees, John W Wills, Katherine Hughes
Signal transducers and activators of transcription (STAT) proteins regulate mammary development. Here we investigate the expression of phosphorylated STAT3 (pSTAT3) in the mouse and cow around the day of birth. We present localised colocation analysis, applicable to other mammary studies requiring identification of spatially congregated events. We demonstrate that pSTAT3-positive events are multifocally clustered in a non-random and statistically significant fashion. Arginase-1 expressing cells, consistent with macrophages, exhibit distinct clustering within the periparturient mammary gland...
May 9, 2024: Journal of Mammary Gland Biology and Neoplasia