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computed tomography perfusion

Whady Hueb
No abstract text is available yet for this article.
February 2019: Arquivos Brasileiros de Cardiologia
Sundas Khan, Safiya Richardson, Andrew Liu, Vinodh Mechery, Lauren McCullagh, Andy Schachter, Salvatore Pardo, Thomas McGinn
BACKGROUND: Successful clinical decision support (CDS) tools can help use evidence-based medicine to effectively improve patient outcomes. However, the impact of these tools has been limited by low provider adoption due to overtriggering, leading to alert fatigue. We developed a tracking mechanism for monitoring trigger (percent of total visits for which the tool triggers) and adoption (percent of completed tools) rates of a complex CDS tool based on the Wells criteria for pulmonary embolism (PE)...
February 20, 2019: JMIR Human Factors
Jacob O Connelly, Mark A Tait, John W Bracey, Jasen H Gilley, Tarun Pandey, Roopa Ram, Shahryar Ahmadi
The posterior approach is a commonly employed exposure of the elbow that provides excellent visualization and efficacy for various orthopedic procedures, including total elbow arthroplasty (TEA) and fracture care. The posterior approach to the elbow has been associated with an increased rate of wound complications, including infection, skin necrosis, and wound dehiscence. Despite an association between these complications and decreased elbow perfusion, data regarding the intrinsic anatomic etiology for preferential complications in this area has been scarcely reported in the literature...
February 19, 2019: Clinical Anatomy
Yasuyoshi Shimada, Masakazu Kobayashi, Kenji Yoshida, Kazunori Terasaki, Shunrou Fujiwara, Yoshitaka Kubo, Takaaki Beppu, Kuniaki Ogasawara
BACKGROUND: Hypoxic but viable neural tissue is seen on 1-(2-18F-fluoro-1-[hydroxymethyl]ethoxy) methyl-2-nitroimidazole (18F-FRP170) positron emission tomography (PET) in patients with chronic cerebral ischemia with a combination of misery perfusion and moderately reduced oxygen metabolism. Cognitive function sometimes improves after revascularization surgery in patients with chronic cerebral ischemia. OBJECTIVES: We used brain perfusion single-photon emission computed tomography (SPECT) and 18F-FRP170 PET to determine whether hypoxic tissue was reduced following the restoration of cerebral perfusion after carotid endarterectomy (CEA) in patients with severe stenosis of the cervical internal carotid artery (ICA) and whether the reduction in hypoxic tissue was associated with cognitive improvement...
February 15, 2019: Cerebrovascular Diseases
Munehiro Otsuka, Yuichiro Kikkawa, Tomoya Kamide, Kaima Suzuki, Aoto Shibata, Toshiki Ikeda, Hiroki Kurita
BACKGROUND: This study aimed to investigate factors related to improvement of hemodynamics and evaluated the usefulness of intraoperative Doppler for predicting postoperative hemodynamics in patients with cerebrovascular atherosclerotic steno-occlusive disease (CASD) of the internal carotid artery (ICA) or middle cerebral artery (MCA) who were treated with extracranial-intracranial (EC-IC) bypass surgery. METHOD: Forty-eight patients with CASD of the ICA or MCA who were treated by superficial temporal artery to middle cerebral artery bypass with a follow-up longer than 12 months were enrolled...
February 18, 2019: Acta Neurochirurgica
B Aklan, B Zilles, P Paprottka, K Manz, M Pfirrmann, M Santl, S Abdel-Rahman, L H Lindner
BACKGROUND: Temperature distributions resulting from hyperthermia treatment of patients with high-risk soft-tissue sarcoma (STS) were quantitatively evaluated and globally compared with thermal simulations performed by a treatment planning system. The aim was to test whether the treatment planning system was able to predict correct temperature distributions. METHODS: Five patients underwent computed tomography (CT) fluoroscopy-guided placement of tumor catheters used for the interstitial temperature measurements...
February 19, 2019: International Journal of Hyperthermia
Isabel Fragata, Marta Alves, Ana Luísa Papoila, Ana Paiva Nunes, Patrícia Ferreira, Mariana Diogo, Nuno Canto-Moreira, Patrícia Canhão
BACKGROUND: Computed tomography (CT) perfusion has been studied as a tool to predict delayed cerebral ischemia (DCI) and clinical outcome in spontaneous subarachnoid hemorrhage (SAH). The purpose of the study was to determine whether quantitative CT perfusion performed within 72 hours after admission can predict the occurrence of DCI and clinical outcome as measured with a modified Rankin scale (mRS) at 3 months after ictus. METHODS: Cerebral perfusion was assessed in a prospective cohort of patients with acute SAH...
February 19, 2019: Neuroradiology Journal
Francis T Delaney, Emma L Gray, Joseph C Lee
We present a case of lung cancer incidentally detected as a pulmonary nodule on computed tomography attenuation correction (CTAC) images during myocardial perfusion scintigraphy (MPS). Unfortunately, the incidental lesion was not fully investigated following MPS report and had developed into metastatic lung carcinoma when diagnosed over 1 year later, with failure of subsequent emergent chemotherapy. The disease appeared to be localized when initially detected during MPS. This case highlights the importance and potential clinical value of routine review of CTAC images in MPS with appropriate reporting and further investigation of suspicious incidental findings...
January 2019: World Journal of Nuclear Medicine
Rajlaxmi Jagtap, Ramesh V Asopa, Sandip Basu
The aim of this prospective study was to explore the feasibility of 18 F-fluoromisonidazole (18 F-FMISO) cardiac positron emission tomography/computed tomography (PET/CT) in the detection of cardiac hypoxia in patients of ischemic heart disease (IHD) and to compare the uptake pattern with that of 99m Tc-MIBI and 18 F-fluorodeoxyglucose (18 F-FDG). Twenty-six patients suffering from IHD were evaluated in this study. The patients initially underwent 99m Tc-MIBI rest/stress myocardial perfusion imaging and 18 F-FDG cardiac PET/CT as a part of their routine cardiac imaging...
January 2019: World Journal of Nuclear Medicine
Todd A Miano, Grigor Abelian, Mark J Seamon, Kristen Chreiman, Patrick M Reilly, Niels D Martin
BACKGROUND: Venous thromboembolism (VTE) events are tracked in trauma registries and by administrative datasets. Both databases are used to assess outcomes despite having varying processes for data capture. STUDY DESIGN: This study was performed at an urban, university-based, level-one trauma center from 2004-2014. Retrospective review of the trauma registry and the hospital's administrative database was performed querying for all VTEs. Each VTE was then validated through manual chart review...
February 14, 2019: Journal of the American College of Surgeons
Cristian Palmiere, Silke Grabherr
Postmortem biochemical investigations in vitreous humor samples collected before and after performing multiphase postmortem computed tomography angiography were performed in the past and demonstrated that specific contrast material injection allowed perfusion and radiological identification of the main vessels of the eye to be obtained without any changes in vitreous humor composition. In the study presented herein, we aimed to test whether the injection of the same contrast material using the same postmortem angiography protocol might influence pericardial fluid composition...
February 2, 2019: Forensic Science International
Daniel M Halperin, J Jack Lee, Chaan S Ng, Jonathan R Strosberg, Jeannelyn S Estrella, Cecile G Dagohoy, Arvind Dasari, James C Yao
OBJECTIVES: Therapies for patients with advanced well-differentiated pancreatic neuroendocrine tumors (pNETs) are insufficient, with patients succumbing to disease despite recent treatment advances. Ziv-aflibercept is a fusion protein of portions of the vascular endothelial growth factor (VEGF) receptors 1 and 2, fused to the Fc portion of immunoglobulin G1, forming a VEGF trap. Perfusion computed tomography (CT) has previously defined hyperperfused neuroendocrine tumors, potentially predicting antiangiogenic benefit...
February 14, 2019: Pancreas
Valeria Gaudieri, Wanda Acampa, Francesco Rozza, Carmela Nappi, Emilia Zampella, Roberta Assante, Teresa Mannarino, Ciro Mainolfi, Mario Petretta, Hein J Verberne, Parthiban Arumugam, Alberto Cuocolo
AIMS: Impaired myocardial perfusion reserve (MPR) may occur earlier than coronary atherosclerosis and it may be an early manifestation of developing coronary artery disease (CAD) in patients with resistant hypertension (RH). We evaluated the relationship between RH and MPR in patients with systemic arterial hypertension after balancing for coronary risk factors. METHODS AND RESULTS: We studied 360 subjects without overt CAD and normal myocardial perfusion at stress-rest 82Rb positron emission tomography/computed tomography...
February 14, 2019: European Heart Journal Cardiovascular Imaging
Young Bin Song, Armin Arbab-Zadeh, Matthew B Matheson, Mohammad R Ostovaneh, Andrea L Vavere, Marc Dewey, Carlos Rochitte, Hiroyuki Niinuma, Roger Laham, Joanne D Schuijf, Christopher Cox, Jeffrey Brinker, Marcelo di Carli, João A C Lima, Julie M Miller
Background Ongoing advancements of coronary computed tomographic angiography (CTA) continue to challenge the role of invasive coronary angiography (ICA) as the gold standard for the evaluation of coronary artery disease (CAD). We sought to investigate the diagnostic accuracy of 320-slice CTA for detecting obstructive CAD in reference to ICA and nuclear myocardial perfusion imaging using single-photon emission computed tomography. Methods For the CORE320 study (Coronary Artery Evaluation Using 320-Row Multidetector Computed Tomography Angiography and Myocardial Perfusion), 381 patients at 16 centers underwent CTA, nuclear myocardial perfusion imaging by single-photon emission computed tomography, and ICA for the evaluation of CAD...
February 2019: Circulation. Cardiovascular Imaging
Yahui Zhao, Shaochen Yu, Jiaxi Li, Junlin Lu, Qian Zhang, Dong Zhang, Rong Wang, Yuanli Zhao
OBJECTIVES: Anterior cerebral artery (ACA) territory, a crucial area of intellectual development in children, is frequently involved in the progress of moyamoya disease (MMD). However, revascularization surgeries for this area are not as established as surgeries for middle cerebral artery (MCA) territory. This study aimed to describe our experience and study the effect of revascularizing ACA territory with periocranium and dural leaflets, which is referred to as 'encephalo-duro-periosteal-synangiosis (EDPS)'...
February 4, 2019: Clinical Neurology and Neurosurgery
Aida Vehabovic-Delic, Marija Balic, Christopher Rossmann, Thomas Bauernhofer, Hannes A Deutschmann, Helmut Schoellnast
INTRODUCTION: The aim of this study was to assess the significance of volume computed tomography perfusion imaging of metastasizing renal cell carcinoma (mRCC) in the early period after the initiation of targeted therapy. METHODS: Blood flow (BF), blood volume, and clearance (CL) were calculated in 10 patients with histologically verified mRCC before and 1 month after initiation of targeted therapy using compartmental analysis algorithms. In addition, the longest diameter of tumor was measured for both time points and compared...
February 11, 2019: Journal of Computer Assisted Tomography
Lu Yin, Hongwei Jiang, Weiwei Zhao, Hui Li
Therapeutic hypothermia is a treatment method to reduce brain injuries after stroke, especially for cerebral ischemia. This study investigates in the temperature distribution of the head within selective brain cooling (SBC). Anatomically accurate geometries based on CT images of head and neck regions are used to develop the 3D geometry and physical model for the finite element modeling. Two cooling methods, the direct head surface cooling strategy and the combination cooling strategy of both head and neck, are evaluated to analyze the inducing hypothermia...
February 12, 2019: Medical & Biological Engineering & Computing
David Lagier, David Tonon, Philippe Garrigue, Benjamin Guillet, Laura Giacomino, Jean-Charles Martin, Marie-Christine Alessi, Nicolas Bruder, Lionel J Velly
BACKGROUND: Several lipid metabolites in cerebrospinal fluid are correlated with poor outcomes in aneurysmal subarachnoid haemorrhage. Most of these metabolites bind to ubiquitous thromboxane-prostaglandin (TP) receptors, causing vasoconstriction and inflammation. Here, we evaluated terutroban (TBN), a specific TP receptor antagonist, for the prevention of post-haemorrhage blood-brain barrier disruption, neuronal apoptosis and delayed cerebral hypoperfusion. METHODS: The rat double subarachnoid haemorrhage model was produced by twice injecting (days 1 and 2) autologous blood into the cisterna magna...
February 11, 2019: Critical Care: the Official Journal of the Critical Care Forum
Blandine Truffault, Philippe Robin, Cecile Tromeur, Alexandra Le Duc Pennec, Ronan Abgral, David Bourhis, Francis Couturaud, Gregoire Le Gal, Pierre-Yves Salaun, Pierre-Yves Le Roux
OBJECTIVE: Following the implementation of single-photon emission computed tomography ventilation/perfusion (SPECT V/Q) in our department, we previously carried out an observational study over the period 2011-2013 that showed the safety of SPECT V/Q to rule out pulmonary embolism (PE). However, PE prevalence (28%) was high compared with some studies. Our hypothesis was that the use of SPECT V/Q may be responsible for an overdiagnosis of PE, especially at the implementation phase of the test...
February 7, 2019: Nuclear Medicine Communications
Michael J Zellweger
Patient tailored diagnosis and risk stratification in patients with suspected or known coronary artery disease (CAD) are pivotal. At present, cardiac imaging modalities provide the possibility to evaluate the whole ischaemic cascade noninvasively. In asymptomatic patients, the evaluation of the calcium score may be beneficial and also guide the individual preventive strategy. Furthermore, the calcium score provides complimentary information to the information as assessed by functional testing. Coronary computed tomographic angiography (CCTA) is an excellent tool to exclude CAD, having a negative predictive value of 97–99%...
February 11, 2019: Swiss Medical Weekly
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