Sacha Rozencwajg, Silver Heinsar, Karin Wildi, Jae-Seung Jung, Sebastiano Maria Colombo, Chiara Palmieri, Kei Sato, Carmen Ainola, Xiaomeng Wang, Gabriella Abbate, Noriko Sato, Wayne B Dyer, Samantha Livingstone, Leticia Helms, Nicole Bartnikowski, Mahe Bouquet, Margaret R Passmore, Kieran Hyslop, Bruno Vidal, Janice D Reid, Daniel McGuire, Emily S Wilson, Indrek Rätsep, Roberto Lorusso, Matthieu Schmidt, Jacky Y Suen, Gianluigi Li Bassi, John F Fraser
Differential hypoxaemia (DH) is common in patients supported by femoral veno-arterial extracorporeal membrane oxygenation (V-A ECMO) and can cause cerebral hypoxaemia. To date, no models have studied the direct impact of flow on cerebral damage. We investigated the impact of V-A ECMO flow on brain injury in an ovine model of DH. After inducing severe cardiorespiratory failure and providing ECMO support, we randomised six sheep into two groups: low flow (LF) in which ECMO was set at 2.5 L min-1 ensuring that the brain was entirely perfused by the native heart and lungs, and high flow (HF) in which ECMO was set at 4...
March 10, 2023: Scientific Reports