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https://read.qxmd.com/read/30760332/study-of-negative-pressure-wound-therapy-as-an-adjunct-treatment-for-acute-burns-in-children-sonata-in-c-protocol-for-a-randomised-controlled-trial
#1
Cody C Frear, Bronwyn Griffin, Leila Cuttle, Steven M McPhail, Roy Kimble
BACKGROUND: Although negative pressure wound therapy (NPWT) is widely used in the management of several wound types, its efficacy as a primary therapy for acute burns has not yet been adequately investigated, with research in the paediatric population particularly lacking. There is limited evidence, however, that NPWT might benefit children with burns, amongst whom scar formation, wound progression and pain continue to present major management challenges. The purpose of this trial is to determine whether NPWT in conjunction with standard therapy accelerates healing, reduces wound progression and decreases pain more effectively than standard treatment alone...
February 13, 2019: Trials
https://read.qxmd.com/read/30759046/dtmp-gh-fusion-protein-therapy-improves-survival-after-radiation-injury-combined-with-skin-burn-trauma-in-mice
#2
Shuang Long, Guojian Wang, Mingqiang Shen, Na Zhao, Huimin Wan, Yang Xu, Song Wang, Cheng Wang, Jining Gao, Yuhui Hao, Aiping Wang, Rong Li, Xinze Ran, Yongping Su, Junping Wang, Tao Wang
Exposure to ionizing radiation combined with traumatic tissue injury is an important life-threatening condition found in the civilian populations after nuclear and radiological events. The significance feature of radiation combined injury (RCI) is the severe combined effect, which makes the injury more complicated. At present, there are limited measures available to treat RCI. Here we show that a chimeric protein dTMP-GH, fusing human growth hormone (hGH) with a tandem dimer of thrombopoietin mimetic peptide (dTMP), could be an effective therapy agent for RCI in a mice model...
February 13, 2019: Radiation Research
https://read.qxmd.com/read/30755777/lung-function-decline-after-24-weeks-of-moxa-smoke-exposure-in-rats
#3
Rui He, Li Han, Ping Liu, Hai Hu, Jia Yang, Hong Cai, Chang Huang, Lei Wang, Juntian Liu, Jian Huang, Lue Ha, Yaomeng Liu, Jihong Wu, Maoxiang Zhu, Baixiao Zhao
Objective: Moxibustion is a complementary therapy that has been used for thousands of years. Burning moxa produces smoke and inhalable particulates. Recent research has indicated that smoke inhalation is associated with negative lung effects. This study aimed to evaluate the lung function of rats after moxa smoke exposure at different concentrations. Methods: Using a randomised block experiment design, 28 male Wistar rats were randomly divided into three moxa smoke groups (opacity) (n=7): low concentration (27...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/30753425/targeting-malaria-parasite-invasion-of-red-blood-cells-as-an-antimalarial-strategy
#4
Amy L Burns, Madeline G Dans, Juan M Balbin, Tania deKoning-Ward, Paul R Gilson, James G Beeson, Michelle J Boyle, Danny W Wilson
Plasmodium spp. parasites that cause malaria disease remain a significant global-health burden. With the spread of parasites resistant to artemisinin combination therapies in Southeast Asia, there is a growing need to develop new antimalarials with novel targets. Invasion of the red blood cell by Plasmodium merozoites is essential for parasite survival and proliferation, thus representing an attractive target for therapeutic development. Red blood cell invasion requires a co-ordinated series of protein/protein interactions, protease cleavage events, intracellular signals, organelle release and engagement of an actin-myosin motor, which provide many potential targets for drug development...
February 11, 2019: FEMS Microbiology Reviews
https://read.qxmd.com/read/30745984/microneedling-therapy-for-atrophic-acne-scar-effectiveness-and-safety-in-vietnamese-patients
#5
Phuong Pham Thi Minh, Diep Dang Bich, Van Nguyen Thi Hai, Thuong Nguyen Van, Van Tran Cam, Tran Hau Khang, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
AIM: To evaluate the effectiveness and safety of micro-needling therapy in atrophic acne scar treatment. METHOD: A prospective, single centred study was implemented in a total of 31 patients suffering from atrophic acne scar grade 2 to 4 of Goodman and Baron scaring grading system was recruited. They were treated by microneedle derma roller every week in 3 months. The scars were evaluated by a magic system camera and by dermatologists clinically using Goodman and Baron scaring grading system, and Lipper and Perez score at baseline, at final treatment, 1 month and 2 months after the final treatment...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745977/efficacy-of-10-potassium-hydroxide-solution-versus-10-salicylic-acid-ointment-in-treatment-of-molluscum-contagiosum-the-low-cost-dermatologic-therapy-in-vietnam
#6
Sau Nguyen Huu, Minh Nguyen Quang, Thuong Nguyen Van, Kiem Pham Cao, Hien Do Thi Thu, Lan Pham Thi, Van Tran Cam, My Le Huyen, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Molluscum contagiosum is a common viral disease primarily affecting children. AIM: The objective is to compare the efficacy of 10% potassium hydroxide (KOH) solution versus 10% salicylic pomade in the treatment of molluscum contagiosum. METHODS: Clinical trials on 70 patients were randomised into 2 groups: 39 patients treated with 10% KOH solution and 31 patients treated with 10% salicylic pomade. The evaluation was based on the complete clearance of lesions, side effects and complications of the drug...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745974/the-decline-of-puva-therapy-in-vietnam-effective-treatment-of-narrow-band-uvb-in-vietnamese-vitiligo-patients
#7
Hien Do Thi Thu, Nhung Do Thi Hong, Thuong Nguyen Van, Phuong Pham Thi Minh, Tam Hoang Van, Nghi Dinh Huu, Hao Nguyen Trong, Tro Chau Van, Trai Nguyen Ngoc, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
AIM: To examine the efficacy and safety of Narrowband ultraviolet B (NB-UVB) in Vietnamese vitiligo patients. METHODS: We recruited thirty-one patients (14 males, 17 females), aged from 7 to 67 years, with both segmental vitiligo (SV) and non-segmental vitiligo (NSV), treated three times weekly with NB-UVB. The starting dose for adults from 15 years old and children less than 15 years old was 200 mJ/cm2 and 150 mJ/cm2 , respectively, with 50 mJ/cm2 and 20 mJ/cm2 dose increments at each subsequent visit, respectively, until mild erythema lasting less than 24 hrs reported by patient, given for a period of 6 months...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745280/efficacy-of-curcumin-for-management-of-oral-submucous-fibrosis-a-systematic-review-of-randomized-clinical-trials
#8
REVIEW
Sadeq Ali Al-Maweri
OBJECTIVES: Oral submucous fibrosis (OSF) is a chronic debilitating disease that has a high risk of malignant transformation. Management of OSF is quite challenging, with no definitive cure being available. This systematic review assessed the available evidence for using curcumin for pain alleviation and clinical improvement in patients with OSF. STUDY DESIGN: A comprehensive search of PubMed/Medline, Scopus, and ISI Web of Science databases was conducted to identify all relevant clinical trials comparing patients receiving curcumin treatment to active and/or nonactive controls for the treatment of OSF...
January 16, 2019: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://read.qxmd.com/read/30740151/association-of-her-2-expression-and-clinicopathological-parameters-in-colorectal-carcinoma-in-indian-population
#9
Rameez Hasan, Deepti Bhatt, Shahbaz Khan, Vasiuddin Khan, Amit Kumar Verma, Afzal Anees, Kapil Dev
BACKGROUND: Human epidermal growth factor receptor 2 (HER-2) is an oncogenic gene and a well-established therapeutic target in several cancers including breast and ovary. AIM: The present study aimed to compare HER-2 expression status with histological grades as well as Clinicopathological parameters including age, bleeding per rectum, pain/burning sensation in defecation and exercise. METHODS: Her-2 status was assessed by immunohistochemistry (IHC)...
January 15, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30733824/current-management-strategies-for-the-pain-of-elderly-patients-with-burning-mouth-syndrome-a-critical-review
#10
REVIEW
Trang T H Tu, Miho Takenoshita, Hirofumi Matsuoka, Takeshi Watanabe, Takayuki Suga, Yuma Aota, Yoshihiro Abiko, Akira Toyofuku
Burning Mouth Syndrome (BMS), a chronic intraoral burning sensation or dysesthesia without clinically evident causes, is one of the most common medically unexplained oral symptoms/syndromes. Even though the clinical features of BMS have been astonishingly common and consistent throughout the world for hundreds of years, BMS remains an enigma and has evolved to more intractable condition. In fact, there is a large and growing number of elderly BMS patients for whom the disease is accompanied by systemic diseases, in addition to aging physical change, which makes the diagnosis and treatment of BMS more difficult...
2019: BioPsychoSocial Medicine
https://read.qxmd.com/read/30732865/head-and-neck-burns-are-associated-with-long-term-patient-reported-dissatisfaction-with-appearance-a-burn-model-system-national-database-study
#11
I Sinha, M Nabi, L C Simko, A W Wolfe, S Wiechman, G Giatsidis, D Bharadia, K McMullen, N S Gibran, K Kowalske, W J Meyer, L E Kazis, C M Ryan, J C Schneider
INTRODUCTION: Burns affecting the head and neck (H&N) can lead to significant changes in appearance. It is postulated that such injuries have a negative impact on patients' social functioning, quality of life, physical health, and satisfaction with appearance, but there has been little investigation of these effects using patient reported outcome measures. This study evaluates the effect of H&N burns on long-term patient reported outcomes compared to patients who sustained burns to other areas...
February 4, 2019: Burns: Journal of the International Society for Burn Injuries
https://read.qxmd.com/read/30732187/surgical-treatment-of-postburn-heterotopic-ossification-around-the-elbow-three-case-reports
#12
Ji-Ying Chen, Chun-Wei Fu, Hsu-Yu Ho, Yung-Chang Lu
RATIONALE: Heterotopic ossification (HO), which is defined as the formation of new bone in tissues that do not normally ossify, is an infrequent yet debilitating complication of burns. Herein, we report three patients who suffered from elbow HO after burn injury due to a dust explosion event. This is a case report that includes the most cases involved in a single mass casualty incident in the presented literature. PATIENT CONCERNS: Case 1: A 28-year-old man presented with second-to-third degree 88% total body surface area (TBSA) burns after the explosion event...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30723753/advances-in-the-treatment-of-traumatic-scars-with-laser-intense-pulsed-light-radiofrequency-and-ultrasound
#13
REVIEW
Xiujun Fu, Jiying Dong, Shen Wang, Min Yan, Min Yao
Traumatic scarring is one of the most common complications after soft tissue injury caused by burns and trauma, which affects tens of millions of people worldwide every year. Traumatic scars diminish the quality of life due to disfigurement, symptoms of pain and itch, and restricted motion. The pathogenesis and pathophysiology of traumatic scar remain elusive. The management for traumatic scars is comprised of surgical and non-surgical interventions such as pressure therapy, silicone, corticosteroid, and radiotherapy, which are chosen by clinicians based on the physical examinations of scars...
2019: Burns and Trauma
https://read.qxmd.com/read/30707210/early-protocolized-versus-usual-care-rehabilitation-for-pediatric-neurocritical-care-patients-a-randomized-controlled-trial
#14
Ericka L Fink, Sue R Beers, Amy J Houtrow, Rudolph Richichi, Cheryl Burns, Lesley Doughty, Roberto Ortiz-Aguayo, Catherine A Madurski, Cynthia Valenta, Maddie Chrisman, Lynn Golightly, Michelle Kiger, Cheryl Patrick, Amery Treble-Barna, Dorothy Pollon, Craig M Smith, Patrick Kochanek
OBJECTIVES: Few feasibility, safety, and efficacy data exist regarding ICU-based rehabilitative services for children. We hypothesized that early protocolized assessment and therapy would be feasible and safe versus usual care in pediatric neurocritical care patients. DESIGN: Randomized controlled trial. SETTING: Three tertiary care PICUs in the United States. PATIENTS: Fifty-eight children between the ages of 3-17 years with new traumatic or nontraumatic brain insult and expected ICU admission greater than 48 hours...
January 30, 2019: Pediatric Critical Care Medicine
https://read.qxmd.com/read/30706303/mitochondrial-transplantation-as-a-potential-and-novel-master-key-for-treatment-of-various-incurable-diseases
#15
REVIEW
Amaneh Mohammadi Roushandeh, Yoshikazu Kuwahara, Mehryar Habibi Roudkenar
Mitochondria are attractive cellular organelles which are so interesting in both basic and clinical research, especially after it was found that they were arisen as a bacterial intruder in ancient cells. Interestingly, even now, they are the focus of many investigations and their function and relevance to health and disease have remained open questions. More recently, research on mitochondria have turned out their potential application in medicine as a novel therapeutic intervention. The importance of this issue is highlighted when we know that mitochondrial dysfunction can be observed in a variety of diseases such as cardiovascular diseases, neurodegenerative diseases, ischemia, diabetes, renal failure, skeletal muscles disorders, liver diseases, burns, aging, and cancer progression...
January 31, 2019: Cytotechnology
https://read.qxmd.com/read/30705791/the-use-of-v-a-c-veraflo-cleanse-choice-in-the-burn-population
#16
Marc R Matthews, Aaron Hechtman, Asia N Quan, Kevin N Foster, Luis G Fernandez
Negative pressure wound therapy (NPWT) is routinely used in the treatment of acute and chronic wounds. The technology continues to evolve with improved results NPWT is routinely used at the Arizona Burn Center and the addition of the V.A.C. VERAFLO CLEANSE CHOICETM with its reticulated open foam device has been used with promising results in a variety of complicated wounds. We present a case series involving the use of this negative pressure wound therapy device and irrigation in burn and necrotizing soft tissue patients treated at the Arizona Burn Center...
November 26, 2018: Curēus
https://read.qxmd.com/read/30702477/gap-analysis-to-identify-clinical-education-needs-of-aeromedical-evacuation-clinicians
#17
Marla J De Jong, Susan F Dukes, Tiffany Losekamp
BACKGROUND: The Air Force has unique challenges in ensuring clinical proficiency for en route care clinicians. These challenges pertain to existing care environments, training opportunities, and the spectrum of training needed to care for patients with polytrauma and complicated medical conditions while being transported between medical treatment facilities. OBJECTIVE: The purpose of this study was to identify the clinical education needs of students entering the United States Air Force School of Aerospace Medicine Flight Nurse (FN) or Aeromedical Evacuation Technician (AET) course and Air Force FNs and AETs assigned to active duty aeromedical evacuation units...
March 2019: Dimensions of Critical Care Nursing: DCCN
https://read.qxmd.com/read/30701543/phosphodiesterase-5-inhibitors-for-pulmonary-hypertension
#18
REVIEW
Hayley Barnes, Zoe Brown, Andrew Burns, Trevor Williams
BACKGROUND: Pulmonary hypertension (PH) comprises a group of complex and heterogenous conditions, characterised by elevated pulmonary artery pressure, and which left untreated leads to right-heart failure and death. PH includes World Health Organisation (WHO) Group 1 pulmonary arterial hypertension (PAH); Group 2 consists of PH due to left-heart disease (PH-LHD); Group 3 comprises PH as a result of lung diseases or hypoxia, or both; Group 4 includes PH due to chronic thromboembolic occlusion of pulmonary vasculature (CTEPH), and Group 5 consists of cases of PH due to unclear and/or multifactorial mechanisms including haematological, systemic, or metabolic disorders...
January 31, 2019: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/30701184/development-and-use-of-biomaterials-as-wound-healing-therapies
#19
REVIEW
Rachael Zoe Murray, Zoe Elizabeth West, Allison June Cowin, Brooke Louise Farrugia
There is a vast number of treatments on the market for the management of wounds and burns, representing a multi-billion dollar industry worldwide. These include conventional wound dressings, dressings that incorporate growth factors to stimulate and facilitate the wound healing process, and skin substitutes that incorporate patient-derived cells. This article will review the more established, and the recent advances in the use of biomaterials for wound healing therapies, and their future direction.
2019: Burns and Trauma
https://read.qxmd.com/read/30696002/the-cutaneous-inflammatory-response-to-thermal-burn-injury-in-a-murine-model
#20
Zabeen Lateef, Gabriella Stuart, Nicola Jones, Andrew Mercer, Stephen Fleming, Lyn Wise
Many burn interventions aim to target the inflammatory response as a means of enhancing healing or limiting hypertrophic scarring. Murine models of human burns have been developed, but the inflammatory response to injury in these models has not been well defined. The aim of this study was to profile inflammatory cell populations and gene expression relative to healing and scarring in a murine model of thermal burns. Cutaneous injuries were created on the dorsal region of C57Bl/6 mice using a heated metal rod...
January 28, 2019: International Journal of Molecular Sciences
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