Cyrielle Holuka, Chloé Morel, Sarah Roth, Yordenca Lamartinière, Sophie B Mériaux, Justine Paoli, Pauline Guébels, Radu C Duca, Lode Godderis, An van Nieuwenhuyse, Pascaline Kremarik-Bouillaud, Ronan Cariou, Claude Emond, Henri Schroeder, Jonathan D Turner, Nathalie Grova
There is a growing evidence that methylation at the N6 position of adenine (6-mA), whose modulation occurs primarily during development, would be a reliable epigenetic marker in eukaryotic organisms. The present study raises the question as to whether early-life exposure to α-hexabromocyclododecane (α-HBCDD), a brominated flame retardant, may trigger modifications in 6-mA epigenetic hallmarks in the brain during the development which, in turn could affect the offspring behaviour in adulthood. Pregnant Wistar rats were split into two groups: control and α-HBCDD (66 ng/kg/per os, G0-PND14)...
July 20, 2023: Environment International