keyword
https://read.qxmd.com/read/38392943/how-intuitive-is-the-administration-of-pediatric-emergency-medication-devices-for-parents-objective-observation-and-subjective-self-assessment
#21
JOURNAL ARTICLE
Ruth Melinda Müller, Birthe Herziger, Sarah Jeschke, Martina Patrizia Neininger, Thilo Bertsche, Astrid Bertsche
BACKGROUND: to assess the intuitiveness of parents' administration of pediatric emergency devices (inhalation, rectal, buccal, nasal, and auto-injector). METHODS: We invited parents without prior experience to administer the five devices to dummy dolls. We observed whether the parents chose the correct administration route and subsequently performed the correct administration procedures without clinically relevant errors. We interviewed parents for their self-assessment of their own administration performance and willingness to administer devices in actual emergencies...
February 18, 2024: Pharmacy (Basel, Switzerland)
https://read.qxmd.com/read/38359155/real-time-quantification-of-nanoplastics-induced-oxidative-stress-in-stretching-alveolar-cells
#22
JOURNAL ARTICLE
Yi Zhao, Wen-Ting Fan, Kai-Qi Jin, Jing Yan, Yu-Ting Qi, Wei-Hua Huang, Yan-Ling Liu
Nanoplastics from air pollutants can be directly inhaled into the alveoli in the lungs and further enter blood circulation, and numerous studies have revealed the close relation between internalized nanoplastics with many physiological disorders via intracellular oxidative stress. However, the dynamic process of nanoplastics-induced oxidative stress in lung cells under breath-mimicked conditions is still unclear, due to the lack of methods that can reproduce the mechanical stretching of the alveolar and simultaneously monitor the oxidative stress response...
February 15, 2024: ACS Nano
https://read.qxmd.com/read/38359086/evaluation-of-the-quality-and-content-of-youtube-videos-as-an-educational-resource-in-developing-patients-inhaler-use-skills
#23
JOURNAL ARTICLE
Ozlem Canbolat, Ayse Buket DoganAktas, Gulhayat Sipal, Kokturk Nurdan
Background: YouTube has educational videos on inhalers. However, their content and quality are not adequately known. Objectives: This study investigated the quality and content of educational YouTube videos on inhalers. Methods: This descriptive study analyzed 178 YouTube videos on inhalers between May and July 2022. Two researchers independently evaluated the videos. The Global Quality Score, Journal of American Medical Association Benchmark Criteria, and Inhaler Application Checklist were used to assess the quality and content of the videos...
February 15, 2024: Journal of Asthma
https://read.qxmd.com/read/38356031/excipients-for-novel-inhaled-dosage-forms-an-overview
#24
REVIEW
Carol Yousry, Mimansa Goyal, Vivek Gupta
Pulmonary drug delivery is a form of local targeting to the lungs in patients with respiratory disorders like cystic fibrosis, pulmonary arterial hypertension (PAH), asthma, chronic pulmonary infections, and lung cancer. In addition, noninvasive pulmonary delivery also presents an attractive alternative to systemically administered therapeutics, not only for localized respiratory disorders but also for systemic absorption. Pulmonary delivery offers the advantages of a relatively low dose, low incidence of systemic side effects, and rapid onset of action for some drugs compared to other systemic administration routes...
February 14, 2024: AAPS PharmSciTech
https://read.qxmd.com/read/38337804/mycological-methods-for-routine-air-sampling-and-interpretation-of-results-in-operating-theaters
#25
REVIEW
Rok Tomazin, Tadeja Matos
Many infectious diseases are transmitted via the air and are, therefore, particularly difficult to combat. These infections include various invasive mycoses caused by molds. The usual route of infection is the inhalation of conidia. In hospitals, infection can also occur through the deposition of conidia in otherwise sterile anatomical sites during surgical and other invasive procedures. Therefore, knowledge of airborne mold concentrations can lead to measures to protect patients from fungal infections. The literature on this topic contains insufficient and sometimes ambiguous information...
January 29, 2024: Diagnostics
https://read.qxmd.com/read/38337592/tele-monitoring-applications-in-respiratory-allergy
#26
REVIEW
Xenofon Aggelidis, Maria Kritikou, Michael Makris, Michael Miligkos, Niki Papapostolou, Nikolaos G Papadopoulos, Paraskevi Xepapadaki
Respiratory allergic diseases affect over 500 million people globally and pose a substantial burden in terms of morbidity, mortality, and healthcare costs. Restrictive factors such as geographical disparities, infectious pandemics, limitations in resources, and shortages of allergy specialists in underserved areas impede effective management. Telemedicine encompasses real-time visits, store-and-forward option triage, and computer-based technologies for establishing efficient doctor-patient communication. Recent advances in digital technology, including designated applications, informative materials, digital examination devices, wearables, digital inhalers, and integrated platforms, facilitate personalized and evidence-based care delivery...
February 4, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38334050/the-use-of-triple-therapy-in-asthma-the-gema-forum-v-task-force
#27
JOURNAL ARTICLE
V Plaza, J A Trigueros, J A Carretero, I Ojanguren Arranz, J M Vega Chicote, C Almonacid Sánchez, J Bartra Tomás, C Cisneros Serrano, L Domínguez Juncal, J Domínguez-Ortega, J Figueroa Rivero, J G Soto Campos, E Macías Fernández, S Martínez, J Montoro Lacomba, S Quirce
No abstract text is available yet for this article.
February 9, 2024: Journal of Investigational Allergology & Clinical Immunology
https://read.qxmd.com/read/38333983/a-cell-based-nasal-model-for-screening-the-deposition-biocompatibility-and-transport-of-aerosolized-plga-nanoparticles
#28
JOURNAL ARTICLE
Aida Maaz, Ian S Blagbrough, Paul A De Bank
The olfactory region of the nasal cavity directly links the brain to the external environment, presenting a potential direct route to the central nervous system (CNS). However, targeting drugs to the olfactory region is challenging and relies on a combination of drug formulation, delivery device, and administration technique to navigate human nasal anatomy. In addition, in vitro and in vivo models utilized to evaluate the performance of nasal formulations do not accurately reflect deposition and uptake in the human nasal cavity...
February 9, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38333644/adjustments-to-maintenance-therapy-and-the-reasoning-behind-them-among-copd-outpatients-in-austria-the-step-study
#29
JOURNAL ARTICLE
Florian Vafai-Tabrizi, Ulrich Schwab, Stephan Brecht, Georg-Christian Funk
BACKGROUND: Adjustments to COPD maintenance treatment are based on different guidelines. In Austria, there is a lack of real-world data on treatment adjustments of COPD outpatients and their underlying rationale. The STEP study characterised change patterns of pharmacological maintenance therapy in COPD outpatients in predefined categories of step-up, step-down and switch, the underlying reasons, and predictors in clinical routine in Austria. METHODS: STEP was a single-visit non-interventional study in Austria...
January 2024: ERJ Open Research
https://read.qxmd.com/read/38326272/treatment-pathways-economic-burden-and-clinical-outcomes-in-new-users-of-inhaled-corticosteroid-long-acting-b-2-agonist-dual-therapy-with-chronic-obstructive-pulmonary-disease-in-a-primary-care-setting-in-england-a-retrospective-cohort-study
#30
JOURNAL ARTICLE
Alexandrosz Czira, Victoria Banks, Gema Requena, Robert Wood, Theo Tritton, Rosie Wild, Chris Compton, Afisi Ismaila
OBJECTIVE: Management of chronic obstructive pulmonary disease (COPD) with inhaled corticosteroid/long-acting β2 -agonist (ICS/LABA) improves lung function and health status and reduces COPD exacerbation risk versus monotherapy. This study described treatment use, healthcare resource utilisation (HCRU), healthcare costs and outcomes following initiation of single-device ICS/LABA as initial maintenance therapy (IMT). DESIGN: Retrospective cohort study. SETTING: Primary care, England...
February 7, 2024: BMJ Open
https://read.qxmd.com/read/38326156/inhaled-medications-and-inhalation-chambers-for-childhood-asthma-spanish-network-of-working-groups-on-asthma-in-pediatrics-regap
#31
JOURNAL ARTICLE
Juan Carlos Juliá Benito, Laura Moreno-Galarraga, Esther Bragado Alcaraz, María Teresa Asensi Monzó, Cristina Ortega Casanueva, Luis Moral, Carmen Rosa Rodríguez Fernández-Oliva, José Sanz Ortega, Laura Valdesoiro Navarrete
Asthma, the most prevalent chronic disease in pediatric age, continues to pose challenges in its management and treatment. National and international guidelines emphasize the importance of therapeutic education (TE) to achieve disease control. TE involves imparting knowledge and skills to the patient and their family, enhancing medication adherence, rectifying errors in inhalation technique, and tailoring treatment based on individual patient characteristics. It is essential for TE to be progressive, gradual, and personalized, spanning all levels of care...
February 6, 2024: Anales de pediatría
https://read.qxmd.com/read/38323583/digitally-monitored-inhaled-therapy-a-smart-way-to-manage-severe-asthma
#32
JOURNAL ARTICLE
Dominic L Sykes, Yee Yong See, Evon C Y Chow, Michael G Crooks, Helena Cummings, Mandy Robinson, Karen Watkins, Joanne Thompson, Kylie Overton, Charlotte Riches, Shoaib Faruqi
One of the fundamental challenges of managing patients with severe asthma is treatment adherence, particularly with inhaled corticosteroids. Adherence is difficult to measure objectively and poor adherence is associated with worse outcomes. In this study, assess the ability of a 'smart' inhaler to record adherence in severe asthma patients and measure the impact of this on asthma control.Consecutive consenting patients meeting criteria for biologics had their existing high-dose ICS/LABA//LAMA combination inhaler/s switched to mometasone/indacaterol/glycopyrronium (114/46/136)...
February 7, 2024: Journal of Asthma
https://read.qxmd.com/read/38318475/pulmonary-inhalation-for-disease-treatment-basic-research-and-clinical-translations
#33
REVIEW
Bin Wang, Lin Wang, Qian Yang, Yuming Zhang, Tang Qinglai, Xinming Yang, Zian Xiao, Lanjie Lei, Shisheng Li
Pulmonary drug delivery has the advantages of being rapid, efficient, and well-targeted, with few systemic side effects. In addition, it is non-invasive and has good patient compliance, making it a highly promising drug delivery mode. However, there have been limited studies on drug delivery via pulmonary inhalation compared with oral and intravenous modes. This paper summarizes the basic research and clinical translation of pulmonary inhalation drug delivery for the treatment of diseases and provides insights into the latest advances in pulmonary drug delivery...
April 2024: Materials today. Bio
https://read.qxmd.com/read/38312057/dentists-perspective-and-experiences-relative-to-accidental-dropping-of-implant-drivers-and-components-intra-orally-a-survey-of-practicing-clinicians
#34
JOURNAL ARTICLE
Chandur Pk Wadhwani, Timothy A Hess, Todd R Schoenbaum, Yasmin H Wadhwani, Kwok-Hung Chung
STATEMENT OF THE PROBLEM: Ingestion or aspiration of dental implant screwdrivers or implant components is potentially life-threatening. There are no reports on the frequency at which dentists drop these devices within the mouth or which components are most problematic. There are few reports on what protective measures clinicians take, where risks exist, and how this problem is managed. MATERIALS AND METHODS: A nine-part questionnaire was provided to dentists. Data collected included Clinicians' roles, implant surgeons, restorative clinicians, or both-frequency of dropping implant screwdrivers or components, items considered most problematic...
February 5, 2024: Journal of Oral Implantology
https://read.qxmd.com/read/38309959/-standard-technical-specifications-for-methacholine-chloride-methacholine-bronchial-challenge-test-2023
#35
JOURNAL ARTICLE
(no author information available yet)
The methacholine challenge test (MCT) is a standard evaluation method of assessing airway hyperresponsiveness (AHR) and its severity, and has significant clinical value in the diagnosis and treatment of bronchial asthma. A consensus working group consisting of experts from the Pulmonary Function and Clinical Respiratory Physiology Committee of the Chinese Association of Chest Physicians, the Task Force for Pulmonary Function of the Chinese Thoracic Society, and the Pulmonary Function Group of Respiratory Branch of the Chinese Geriatric Society jointly developed this consensus...
February 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/38293192/microfluidic-platform-enables-shear-less-aerosolization-of-lipid-nanoparticles-for-messenger-rna-inhalation
#36
Jeonghwan Kim, Antony Jozic, Elissa Bloom, Brian Jones, Michael Marra, Namratha Turuvekere Vittala Murthy, Yulia Eygeris, Gaurav Sahay
Leveraging the extensive surface area of the lungs for gene therapy, inhalation route offers distinct advantages for delivery. Clinical nebulizers that employ vibrating mesh technology are the standard choice for converting liquid medicines into aerosols. However, they have limitations when it comes to delivering mRNA through inhalation, including severe damage to nanoparticles due to shearing forces. Here, we introduce a novel microfluidic aerosolization platform (MAP) that preserves the structural and physicochemical integrity of lipid nanoparticles, enabling safe and efficient mRNA delivery to the respiratory system...
January 20, 2024: bioRxiv
https://read.qxmd.com/read/38285231/effects-on-mechanical-power-of-different-devices-used-for-inhaled-sedation-in-a-bench-model-of-protective-ventilation-in-icu
#37
JOURNAL ARTICLE
Pierre-Louis Pellet, Neven Stevic, Florian Degivry, Bruno Louis, Laurent Argaud, Claude Guérin, Martin Cour
BACKGROUND: Inhaled sedation during invasive mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) has received increasing attention. However, inhaled sedation devices increase dead-space ventilation and an undesirable effect is the increase in minute ventilation needed to maintain CO2 removal. A consequence of raising minute ventilation is an increase in mechanical power (MP) that can promote lung injury. However, the effect of inhaled sedation devices on MP remains unknown...
January 29, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38283629/effects-of-a-valved-infant-bottle-with-ergonomic-teat-on-the-coordination-of-sucking-swallowing-and-respiration-in-late-preterm-infants-the-safe-oral-feeding-randomized-trial
#38
JOURNAL ARTICLE
Francesco Cresi, Elena Maggiora, Martina Capitanio, Cecilia Bovio, Federica Borla, Sara Cosimi, Desirèe Enrietti, Francesca Faggiano, Sara Loro, Serena Maria Rovei, Federica Runfola, Mariangela Scrufari, Michela Vigna Taglianti, Federica Vignali, Chiara Peila, Alessandra Coscia
INTRODUCTION: Breastfeeding naturally enables the coordination of sucking, swallowing, and respiration patterns for safe feeding. When breastfeeding is not possible a feeding device that releases milk in response to intra-oral vacuum could potentially offer improved coordination of sucking, swallowing, and breathing patterns compared to conventional devices. The aim of the study is to evaluate the effect of a valved infant-bottle with an ergonomic teat compared to a standard infant-bottle...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38276480/improved-olfactory-deposition-of-theophylline-using-a-nanotech-soft-mist-nozzle-chip
#39
JOURNAL ARTICLE
Madeline X Zhang, Frank Verhoeven, Pieter Ravensbergen, Stefan Kooij, Rick Geoffrion, Daniel Bonn, Cees J M van Rijn
Currently, nasal administration of active pharmaceutical ingredients is most commonly performed using swirl-nozzle-based pump devices or pressurized syringes. However, they lead to limited deposition in the more active regions of the nasal cavity, especially the olfactory region, which is crucial for nose-to-brain drug delivery. This research proposes to improve deposition in the olfactory region by replacing the swirl nozzle with a nanoengineered nozzle chip containing micrometer-sized holes, which generates smaller droplets of 10-50 μm travelling at a lower plume velocity...
December 19, 2023: Pharmaceutics
https://read.qxmd.com/read/38276056/topical-anaesthesia-using-a-soft-mist-spray-device-allows-comfortable-awake-visualisation-of-the-airway-via-self-videolaryngoscopy-in-volunteers
#40
JOURNAL ARTICLE
Hielke Markerink, Geert-Jan van Geffen, Jörgen Bruhn
Background : During endotracheal intubation, there is a 10% incidence of difficult laryngoscopy, which may result in serious complications. It is important to obtain as much information about the visibility of laryngeal structures before the patient is anaesthetised. Performing awake (video-) laryngoscopy on a patient is uncomfortable and can trigger gagging and coughing reflexes, making visualisation nearly impossible. The objective of this study is to evaluate the effectiveness of a soft mist spray device for airway anaesthesia during awake (video-) laryngoscopy...
January 19, 2024: Medicina
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