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Inhalation device

Matthias Budde, Simon Leiner, Marcel Köpke, Johannes Riesterer, Till Riedel, Michael Beigl
Precise, location-specific fine dust measurement is central for the assessment of urban air quality. Classic measurement approaches require dedicated hardware, of which professional equipment is still prohibitively expensive (>10k$) for dense measurements, and inexpensive sensors do not meet accuracy demands. As a step towards filling this gap, we propose FeinPhone , a phone-based fine dust measurement system that uses camera and flashlight functions that are readily available on today's off-the-shelf smart phones...
February 12, 2019: Sensors
Rui He, Li Han, Ping Liu, Hai Hu, Jia Yang, Hong Cai, Chang Huang, Lei Wang, Juntian Liu, Jian Huang, Lue Ha, Yaomeng Liu, Jihong Wu, Maoxiang Zhu, Baixiao Zhao
Objective: Moxibustion is a complementary therapy that has been used for thousands of years. Burning moxa produces smoke and inhalable particulates. Recent research has indicated that smoke inhalation is associated with negative lung effects. This study aimed to evaluate the lung function of rats after moxa smoke exposure at different concentrations. Methods: Using a randomised block experiment design, 28 male Wistar rats were randomly divided into three moxa smoke groups (opacity) (n=7): low concentration (27...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Michael Roitzsch, Anja Schäferhenrich, Anja Baumgärtel, Katrin Ludwig-Fischer, Ralph Hebisch, Thomas Göen
Background: The caterpillars of the oak processionary moth (OPM) form stinging hairs, which release an irritant poison. They cause skin and eye irritation and sometimes even breathing difficulties and allergic reactions. OPM is mainly controlled by spraying insecticides. Insecticides applied for protection of human health must be authorized under the Biocidal Products Regulation (BPR) (EU) No 528/2012. In order to assess safety of professional use, which is a key requirement for the authorization, a risk assessment based on exposure estimation has to be performed...
February 9, 2019: Annals of Work Exposures and Health
Catherine E Johnson
Nursing programs are stressful learning environments, and students are expected to maintain high academic performance to successfully graduate. Cognitive test anxiety has been minimally studied among nursing students, including how to successfully manage. The Cognitive Test Anxiety Scale (CTAS) was administered to 31 students before and after a high-stakes nursing examination. The intervention was inhaled lemon essential oil delivered via a personal nasal device. Neither the control nor the experimental group demonstrated a statistically significant change in the CTAS score from pretest to posttest (P = ...
March 2019: Holistic Nursing Practice
Francesco Puma, Mattia Meattelli, Miroslawa Kolodziejek, Marina Giuliana Properzi, Rosanna Capozzi, Alberto Matricardi, Lucio Cagini, Jacopo Vannucci
An innovative technique for airway management, utilizing a small diameter, short-cuffed, orotracheal tube for assisting rigid bronchoscopy in critical airway obstruction is reported. The device, part of Translaryngeal Tracheostomy KIT, was placed beyond the stenosis and used in combination with the rigid bronchoscope. This procedure improves safety during the management of critical tracheal stenoses, because the airway is constantly under the anesthesiologist's control. Consequently, inhalation anesthesia is feasible, use of neuromuscular blockage is possible, end-tidal CO2 monitoring is reliable and the distal airway is protected by blood and debris soilage during the tumor debulking...
February 7, 2019: Annals of Thoracic Surgery
Worth Longest, Dale Farkas
Computational fluid dynamics (CFD) modeling offers a powerful tool for the development of drug delivery devices using a first principles approach but has been underutilized in the development of pharmaceutical inhalers. The objective of this study was to develop quantitative correlations for predicting the aerosolization behavior of a newly proposed dry powder inhaler (DPI). The dose aerosolization and containment (DAC) unit DPI utilizes inlet and outlet air orifices designed to maximize the dispersion of spray-dried powders, typically with low air volumes (~ 10 mL) and relatively low airflow rates (~ 3 L/min)...
February 7, 2019: AAPS Journal
Louise Selby, Sejal Saglani
PURPOSE OF REVIEW: Children with poor asthma control despite maximal maintenance therapy have problematic severe asthma (PSA). A step-wise approach including objective adherence monitoring and a detailed multidisciplinary team assessment to identify modifiable factors contributing to poor control is needed prior to considering therapy escalation. Pathophysiological phenotyping in those with true severe therapy-resistant asthma (STRA) and the current array of add-on therapies will be discussed...
January 31, 2019: Current Opinion in Allergy and Clinical Immunology
Nina D'Vaz, Toluwalose A Okitika, Claire Shackleton, Sunalene G Devadason, Graham L Hall
INTRODUCTION: Spacer devices optimize delivery of aerosol therapies and maximize therapeutic efficacy. We assessed the impact of spacer device on the prevalence and magnitude of bronchodilator response (BDR) in children with asthma. METHODS: Children with physician confirmed asthma and parentally reported symptoms in the last 12 months were recruited for this study. Each participant completed two separate visits (5-10 days apart) with spirometry performed at baseline and following cumulative doses of salbutamol (200, 400, 800, and 200 μg) delivered by either a small volume disposable spacer or a large volume multi-use spacer...
February 4, 2019: Pediatric Pulmonology
Anna-Maria Ciciliani, Peter Langguth, Herbert Wachtel
Age and comorbidities can impact on the success of handling an inhaler. In this pilot study, we assessed finger strength in 62 participants (aged 5-17 years [n = 20], 18-65 years [n = 22] and > 65 years [n = 20]) by using different types of inhalers with integrated sensors (Respimat®, Breezhaler®, Aerolizer®, Genuair®, Diskus®, Ellipta®, HandiHaler®, Turbohaler® and a pressurized metered-dose inhaler [Atrovent®]). Parameters under investigation included the spontaneous and maximum achievable force and torque required to operate devices...
January 31, 2019: International Journal of Pharmaceutics
Paola Rogliani, Luigino Calzetta, Maria Gabriella Matera, Nicola di Daniele, Andrea Girolami, Mario Cazzola, Josuel Ora
Chronic obstructive pulmonary disease (COPD) therapy includes a multi-dimensional approach, taking into account both symptoms of the patient and the number of acute exacerbations of COPD (AECOPDs). There are three main pharmaceutical classes currently available including long-acting muscarinic antagonists (LAMA), long-acting β2 -agonists (LABA) and inhaled corticosteroids (ICS). COPD is a major risk factor for most cardiovascular diseases, and cardiac comorbidities are very common in COPD patients. Both LAMA and LABA have a considerable impact on cardiac function by stimulating cardiac β2-adrenergic receptors or inhibiting the heart M2 muscarinic receptors...
February 1, 2019: Expert Opinion on Pharmacotherapy
John Z Chen, Ira M Katz, Marine Pichelin, Kaixian Zhu, Georges Caillibotte, Warren H Finlay, Andrew R Martin
BACKGROUND: Portable oxygen concentrators (POCs) deliver oxygen in intermittent pulses. The challenge of establishing equivalence between continuous flow oxygen and nominal pulse flow settings on different POCs is well known. In vitro bench measurements and in silico mathematical modeling were used to compare the performance of 4 POCs versus continuous flow oxygen by predicting the F IO2 at the trachea and entering the acini. METHODS: Each of the 4 POCs was connected to a 3-dimensional printed replica of a human adult nasal airway via nasal cannula...
January 29, 2019: Respiratory Care
Tiago Maricoto, Jaime Correia-de-Sousa, Luís Taborda-Barata
INTRODUCTION: Chronic Obstructive Pulmonary Disease (COPD)and asthma affect more than 10% of the population. Most patients use their inhaler incorrectly, mainly the elderly, thereby becoming more susceptible to poor clinical control and exacerbations. Placebo device training is regarded as one of the best teaching methods, but there is scarce evidence to support it as the most effective one to improve major clinical outcomes. Our objective is to perform a single-blinded RCT to assess the impact of this education tool in these patients...
January 28, 2019: BMJ Open
Stewart Yeung, Daniela Traini, Alan Tweedie, David Lewis, Tanya Church, Paul M Young
This study aims to investigate the implications of loaded formulation mass on aerosol performance using a reservoir novel dry powder inhaler containing a custom dosing cup to deliver carrier-based formulation to the lungs. A 3D printed dosing cup with volume size of 133.04 mm3 was manufactured to allow for the progressive loading of different carrier formulation masses of 1% beclomethasone dipropionate BDP (w/w) formulation (10 to 60 mg, with increments of 10 mg), in a novel customizable DPI device. Scanning electron micrographs were used to investigate BDP detachment from carrier particles post-aerosolisation and particle deposition on the USP induction port...
January 28, 2019: AAPS PharmSciTech
C Chouaid, N Germain, G De Pouvourville, S Aballéa, D Korchagina, M Baldwin, K Le Lay, L Luciani, M Toumi, P Devillier
OBJECTIVES: Understanding inhaler preferences may contribute to improving adherence in COPD patients and improve long-term outcomes. This study aims to identify and quantify preferences for convenience-related inhaler attributes in French moderate-to-severe COPD patients, with discrete choice experiment (DCE) methodology. METHODS: Attributes were defined from a literature search, clinician- and patient interviews: shape, dose insertion, dose preparation, dose release, dose confirmation, dose counter, and reusability...
January 25, 2019: Current Medical Research and Opinion
Erminia Ridolo, Irene Pellicelli, Bruna Gritti, Cristoforo Incorvaia
Dual bronchodilation with long-acting beta-2 agonists and muscarinic antagonists is recommended in patients with severe to very severe COPD. Among dual bronchodilator combinations, indacaterol/glycopyrronium combination (IGC) received evidence of higher efficacy and good safety compared with monotherapy with either drug as well as with tiotropium. In randomized controlled trials, the primary outcome is usually the change in mean FEV1 resulting from treatment. However, the functional aspects that influence the physician's choice of the type of management may not be considered important by the patient, based on his perception of the disease...
2019: Patient Preference and Adherence
Adam Em Eltorai, Thomas J Martin, Shyam A Patel, Megan Tran, Ashley S Eltorai, Alan H Daniels, Grayson L Baird
BACKGROUND: Incentive spirometers were developed to facilitate sustained maximum inspiration. In addition to a slow-rising float that indicates volume displacement, the incentive spirometers includes a sensitive, rapid-fluttering flow indicator. Achieving the target inspiratory volume is believed to be the most important factor in successful incentive spirometers use. This investigation hypothesized that patients focus on the rapid fluttering of the flow indicator rather than volume float during incentive spirometers use...
January 22, 2019: Respiratory Care
Junhua Hu, Rui Zhang, Huimin Beng, Liangjun Deng, Qinqjin Ke, Wen Tan
The evaluation of particle size recommended in the pharmacopeias requires a constant flow rate, and the method for pediatric inhaled drugs is the same as for adult drugs. In this study, the aerosol concentration and particle size distribution (PSD) were measured under a realistic breathing pattern and constant flow. Two types of nebulizer (i.e., breath-enhanced nebulizer and vibrating-mesh nebulizer) and two formulations (i.e., budesonide suspension and albuterol solution) were chosen for comparison. The aerosol concentration under the realistic pattern was not constant, which was different from the result at constant flow...
January 18, 2019: International Journal of Pharmaceutics
Chaicharn Pothirat, Warawut Chaiwong, Atikun Limsukon, Nittaya Phetsuk, Nonglak Chetsadaphan, Woranoot Choomuang, Chalerm Liwsrisakun
BACKGROUND: Inhaler devices are a keystone in the management of asthma during the maintenance phase of treatment. OBJECTIVE: To evaluate techniques for using inhaler devices in asthma patients. METHODS: A prospective cross-sectional study was conducted to assess patient compliance with correct techniques for using inhaler devices across three regimens: pressurized metered-dose inhaler (pMDI), Accuhaler®, and Turbuhaler®. The compliance of patients with essential steps for correct device usage in the case of each regimen was recorded...
January 13, 2019: Asian Pacific Journal of Allergy and Immunology
José R Fernández-Soto, Elsy M Navarrete-Rodríguez, Blanca E Del-Río-Navarro, Omar J Saucedo-Ramírez, Jaime M Del-Río-Chivardi, Néstor A Meneses-Sánchez, Laura Gochicoa-Rangel, Juan J Sienra-Monge
Inhaled therapy is considered the cornerstone of asthma treatment. However, despite being the ideal form of drug delivery, it is recognized that only 70% of patients have an adequate attachment to their treatment and only 39-67% of physicians can explain the optimal inhaler technique. Inhaled therapy has very specific characteristics. Pulmonary deposit of an inhaled medication through the respiratory tract is more complex than when administered orally and depends on several factors inherent to both the medication and the administration...
2019: Boletín Médico del Hospital Infantil de México
Melles Mebrahtom, Nebiyu Mesfin, Hailay Gebreyesus, Mebrahtu Teweldemedhin
OBJECTIVE: In Asthma management, poor handling of inhalation devices and wrong inhalation technique are associated with decreased medication delivery and poor disease control. The aim of this study was to assess the status of Metered dose inhaler technique, associated factors and its impact on Asthma control among adult patients with Asthma. RESULTS: The mean duration of Asthma was 15 ± 13 years. Asthma was uncontrolled in 70.4% of the participants and the poor technique of Asthma inhaler device was observed in 71...
January 14, 2019: BMC Research Notes
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