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JOURNAL ARTICLE
Adriana Souza Dos Santos, Meirylanne Gomes da Costa, Aline Martins Faustino, Wellington de Almeida, Chris Krebs Danilevicz, Ariadni Mesquita Peres, Bruna Carolina de Castro Saturnino, Ana Paula Muterle Varela, Thais Fumaco Teixeira, Paulo Michel Roehe, Rachel Krolow, Carla Dalmaz, Lenir Orlandi Pereira
The congenital Zika syndrome (CZS) has been characterized as a set of several brain changes, such as reduced brain volume and subcortical calcifications, in addition to cognitive deficits. Microcephaly is one of the possible complications found in newborns exposed to Zika virus (ZIKV) during pregnancy, although it is an impacting clinical sign. This study aimed to investigate the consequences of a model of congenital ZIKV infection by evaluating the histopathology, blood-brain barrier, and neuroinflammation in pup rats 24 h after birth, and neurodevelopment of the offspring...
January 30, 2024: Experimental Neurology
#42
Kathryn M Moore, Adam-Nicolas Pelletier, Stacey Lapp, Amanda Metz, Gregory K Tharp, Michelle Lee, Swati Sharma Bhasin, Manoj Bhasin, Rafick-Pierre Sékaly, Steven E Bosinger, Mehul S Suthar
Zika virus (ZIKV) is a mosquito-borne flavivirus that caused an epidemic in the Americas in 2016 and is linked to severe neonatal birth defects, including microcephaly and spontaneous abortion. To better understand the host response to ZIKV infection, we adapted the 10x Genomics Chromium single cell RNA sequencing (scRNA-seq) assay to simultaneously capture viral RNA and host mRNA. Using this assay, we profiled the antiviral landscape in a population of human moDCs infected with ZIKV at the single cell level...
January 21, 2024: bioRxiv
#43
JOURNAL ARTICLE
Guan-Gen Huang, Hao-Yu Wang, Xiao-Han Wang, Tao Yang, Xiao-Meng Zhang, Chun-Lan Feng, Wei-Min Zhao, Wei Tang
BACKGROUND: Zika virus (ZIKV) is a single-stranded RNA flavivirus transmitted by mosquitoes. Its infection is associated with neurological complications such as neonatal microcephaly and adult Guillain-Barré syndrome, posing a serious threat to the health of people worldwide. Therefore, there is an urgent need to develop effective anti-ZIKV drugs. Atranorin is a lichen secondary metabolite with a wide range of biological activities, including anti-inflammatory, antibacterial and antioxidant, etc...
January 8, 2024: Phytomedicine
#44
JOURNAL ARTICLE
Xiang Chen, Rui-Ting Li, Ru-Yi Chen, Pan-Deng Shi, Zi-Xin Liu, Ya-Nan Lou, Mei Wu, Rong-Rong Zhang, Wei Tang, Xiao-Feng Li, Cheng-Feng Qin
During the life cycle of mosquito-borne flaviviruses, substantial subgenomic flaviviral RNA (sfRNA) is produced via incomplete degradation of viral genomic RNA by host XRN1. Zika virus (ZIKV) sfRNA has been detected in mosquito and mammalian somatic cells. Human neural progenitor cells (hNPCs) in the developing brain are the major target cells of ZIKV, and antiviral RNA interference (RNAi) plays a critical role in hNPCs. However, whether ZIKV sfRNA was produced in ZIKV-infected hNPCs as well as its function remains not known...
February 20, 2024: Journal of Virology
#45
REVIEW
Gaetano Scotto, Salvatore Massa, Francesca Spirito, Vincenzina Fazio
The progressive reappearance of Zika virus (ZIKV) infections since October 2013 and its circulation in >70 countries and territories (from French Polynesia to Brazil and other countries in the Americas, with sporadic spread in Europe and the East) has long been reported as a global public health emergency. ZIKV is a virus transmitted by arthropods (arboviruses), mainly by Aedes mosquitoes. ZIKV can also be transmitted to humans through mechanisms other than vector infection such as sexual intercourse, blood transfusions, and mother-to-child transmission...
December 28, 2023: Life
#46
JOURNAL ARTICLE
Anna Pires Terra, Ricardo Rohweder, Silvani Herber, Luciana Friedrich, Maria Teresa Vieira Sanseverino, Catia Favreto, Fernanda Santa Maria, Emilly de Jesus Athayde, Laércio Moreira Cardoso-Júnior, Andrea Cristina Pereira Marinho, Allanamara Pereira Marinho, Tailine Zarpelon, Lavínia Schuler-Faccini
Northeast Brazil was the first region to detect a significant increase in babies born with microcephaly associated with prenatal zika virus infection in 2015. Rio Grande do Sul (RS) state was less impacted due to the temperate climate preventing the spread of the vector. This study investigated the prevalence and etiology of congenital microcephaly in RS in two different periods. This cross-sectional descriptive study included all live births with congenital microcephaly in RS from 2015 to 2022. Cases were divided into two groups: P1 "outbreak" (2015-16); and P2 "endemic" (2017-22)...
2024: Genetics and Molecular Biology
#47
JOURNAL ARTICLE
Nichole Link, J Michael Harnish, Brooke Hull, Shelley Gibson, Miranda Dietze, Uchechukwu E Mgbike, Silvia Medina-Balcazar, Priya S Shah, Shinya Yamamoto
In the past decade, Zika virus (ZIKV) emerged as a global public health concern. While adult infections are typically mild, maternal infection can lead to adverse fetal outcomes. Understanding how ZIKV proteins disrupt development can provide insights into the molecular mechanisms of disease caused by this virus including microcephaly. In this study, we generated a toolkit to ectopically express ZIKV proteins in vivo in Drosophila melanogaster in a tissue-specific manner using the GAL4/UAS system. We use this toolkit to identify phenotypes and potential host pathways targeted by the virus...
January 12, 2024: Disease Models & Mechanisms
#48
JOURNAL ARTICLE
Zhe-Yu Peng, Song Yang, Hong-Zhen Lu, Lin-Min Wang, Ni Li, Hai-Ting Zhang, Si-Yu Xing, Yi-Nan Du, Sheng-Qun Deng
Zika virus (ZIKV), which belongs to the Flavivirus family, is mainly transmitted via the bite of Aedes mosquitoes. In newborns, ZIKV infection can cause severe symptoms such as microcephaly, while in adults, it can lead to Guillain‒Barré syndrome (GBS). Due to the lack of specific therapeutic methods against ZIKV, the development of a safe and effective vaccine is extremely important. Several potential ZIKV vaccines, such as live attenuated, inactivated, nucleic acid, viral vector, and recombinant subunit vaccines, have demonstrated promising outcomes in clinical trials involving human participants...
January 8, 2024: Pathogens and Disease
#49
JOURNAL ARTICLE
Thaíse Yasmine Vasconcelos de Lima Cavalcanti, Morganna Costa Lima, Paula Bargi-Souza, Rafael Freitas Oliveira Franca, Rodrigo Antonio Peliciari-Garcia
Rhythmic regulations are virtually described in all physiological processes, including central nervous system development and immunologic responses. Zika virus (ZIKV), a neurotropic arbovirus, has been recently linked to a series of birth defects and neurodevelopmental disorders. Given the well-characterized role of the intrinsic cellular circadian clock within neurogenesis, cellular metabolism, migration, and differentiation among other processes, this study aimed to characterize the influence of ZIKV infection in the circadian clock expression in human neuronal cells...
December 23, 2023: Cellular and Molecular Neurobiology
#50
JOURNAL ARTICLE
Cristina de Souza Rodrigues, Raillon Keven Santos Souza, Cosmo Vieira Rocha Neto, Rodrigo Haruo Otani, Daniel de Medeiros Batista, Ana Karla Nelson de Oliveira Maia, Kleber Pinheiro de Oliveira Filho, Thais Dourado de Andrade, Emmilyn de Andrade Almeida, Luiz Henrique Gonçalves Maciel, Lucíola de Fátima Albuquerque Almeida Peixoto Castro, Marília Rosa Abtibol-Bernardino, Djane Clarys Baia-da-Silva, Silvana Gomes Benzecry, Marcia da Costa Castilho, Flor Ernestina Martínez-Espinosa, Maria das Graças Costa Alecrim, Rosane Sampaio Santos, Camila Botto-Menezes
Oropharyngeal dysphagia (OD) is a swallowing disorder that involves difficulty in safely passing the food bolus from the oral cavity to the stomach. OD is a common problem in children with congenital Zika virus syndrome (CZS). In this case series, we describe the clinical and acoustic alterations of swallowing in children exposed to the Zika virus during pregnancy in a cohort from Amazonas, Brazil. From July 2019 to January 2020, 22 children were evaluated, 6 with microcephaly and 16 without microcephaly. The mean age among the participants was 35 months (±4...
November 30, 2023: Viruses
#51
JOURNAL ARTICLE
Raissa Rilo Christoff, Jefferson H Quintanilha, Raiane Oliveira Ferreira, Jessica C C G Ferreira, Daniel Menezes Guimarães, Bruna Valério-Gomes, Luiza M Higa, Átila D Rossi, Maria Bellio, Amilcar Tanuri, Roberto Lent, Patricia Pestana Garcez
Congenital Zika syndrome (CZS) is a set of birth defects caused by Zika virus (ZIKV) infection during pregnancy. Microcephaly is its main feature, but other brain abnormalities are found in CZS patients, such as ventriculomegaly, brain calcifications, and dysgenesis of the corpus callosum. Many studies have focused on microcephaly, but it remains unknown how ZIKV infection leads to callosal malformation. To tackle this issue, we infected mouse embryos in utero with a Brazilian ZIKV isolate and found that they were born with a reduction in callosal area and density of callosal neurons...
November 28, 2023: Viruses
#52
REVIEW
Nohemi Camacho-Concha, María E Santana-Román, Nilda C Sánchez, Iván Velasco, Victoria Pando-Robles, Gustavo Pedraza-Alva, Leonor Pérez-Martínez
Zika virus (ZIKV) has emerged as a significant public health threat, reaching pandemic levels in 2016. Human infection with ZIKV can manifest as either asymptomatic or as an acute illness characterized by symptoms such as fever and headache. Moreover, it has been associated with severe neurological complications in adults, including Guillain-Barre syndrome, and devastating fetal abnormalities, like microcephaly. The primary mode of transmission is through Aedes spp. mosquitoes, and with half of the world's population residing in regions where Aedes aegypti , the principal vector, thrives, the reemergence of ZIKV remains a concern...
December 15, 2023: Biomedicines
#53
JOURNAL ARTICLE
Adriana M Mattos, Valmir N Rastely-Junior, Matheus M Pires, Juan P Aguilar, Millani S A Lessa, Clarina Regis, Mariana Wanderley, Julio Leony, Joseane Bouzon, Verena Ballalai, Carina Vieira, Gustavo B S Carvalho, João R M Almeida, Nivison Nery, Rodrigo Leal, Federico Costa, Albert I Ko, Mitermayer G Reis, Jamary Oliveira-Filho
UNLABELLED: The municipality of Salvador, situated in Brazil, distinguished itself as the epicenter of the emergence of microcephaly related to congenital manifestations of Zika syndrome. Despite the anticipated significant developmental setbacks in these children, research has indicated a varied range of outcomes, with certain instances even reflecting minimal developmental delay. Our objective was to pinpoint determinants that could forecast developmental anomalies in children diagnosed with microcephaly associated with congenital Zika syndrome (CZS)...
November 21, 2023: Children
#54
REVIEW
José Marreiro de Sales-Neto, Deyse Cristina Madruga Carvalho, Daniel Wilson Arruda Magalhães, Anna Beatriz Araujo Medeiros, Mariana Mendonça Soares, Sandra Rodrigues-Mascarenhas
Zika virus (ZIKV) is a mosquito-borne virus first reported from humans in Nigeria in 1954. The first outbreak occurred in Micronesia followed by an outbreak in French Polynesia and another in Brazil when the virus was associated with numerous cases of severe neurological manifestations such as Guillain-Barre syndrome in adults and congenital zika syndrome in fetuses, particularly congenital microcephaly. Innate immunity is the first line of defense against ZIKV through triggering an antiviral immune response...
December 15, 2023: International Immunopharmacology
#55
JOURNAL ARTICLE
Juliana Marin Fontes, Emmanuel Machado Oliveira, Tereza Cristina Monteiro de Melo Prazeres, Glaura Nisya de Oliveira Cruz, Marta Rizzini, Saulo Duarte Passos, Lilian Lira Lisboa, Grace Ferreira de Araújo, Valéria Azevedo de Almeida, Jociele Malacarne, Maria Emília de Domenico Garcia, Lilian Cagliari Linhares Barreto, Adriano Almeida Calado, Luciana Fernandes da Nóbrega, Maria Júlia Moura Nascimento Santos, Rafael Pauletti Gonçalves, Luana Farache, Maurício Feliciano da Silva, Fábio Valente Rizzo, Luiz Dias da Silva, Nilgicy Maria de Jesus Amorim, Hannah Cavalcante Guedes Pinheiro, Adriana Suely de Oliveira Melo, Fabiana de Oliveira Melo, Rômulo Dias Moreira, Benito Junior Santos da Costa, Melissa de Almeida Melo Maciel Mangueira, Margareth Catoia Varela, Lucia Maria Costa Monteiro
INTRODUCTION: Neurogenic bladder was first confirmed as a urological sequela of Congenital Zika Syndrome (CZS) in 2018. Further clinical-epidemiological evidence also confirmed neurogenic bowel dysfunction and cryptorchidism. To strengthen the care for these children, the Congenital Zika Virus Bladder and Bowel Sequelae Network (RASZ in Brazilian) was created, including six integrated centers in Brazil. This article represents the initial outcome of the efforts by RASZ. OBJECTIVE: To evaluate the prevalence of bladder and bowel dysfunction, cryptorchidism and other urological sequelae related to CZS in cohorts attended in six Brazilian states...
November 23, 2023: Journal of Pediatric Urology
#56
JOURNAL ARTICLE
Michael Heide, Wieland B Huttner
No abstract text is available yet for this article.
2023: Frontiers in Neuroscience
#57
JOURNAL ARTICLE
Atiene S Sagay, Szu-Chia Hsieh, Yu-Ching Dai, Charlotte Ajeong Chang, Jerry Ogwuche, Olukemi O Ige, Makshwar L Kahansim, Beth Chaplin, Godwin Imade, Michael Elujoba, Michael Paul, Donald J Hamel, Hideki Furuya, Ricardo Khoury, Viviane Sampaio Boaventura, Laíse de Moraes, Phyllis J Kanki, Wei-Kung Wang
OBJECTIVE: Chikungunya virus (CHIKV), a reemerging global public health concern, causes acute febrile illness, rash, and arthralgia and during pregnancy may affect both mothers and infants. Mother-to-child transmission (MTCT) of CHIKV in Africa remains understudied. METHODS: Our cohort study screened 1006 pregnant women with a Zika/dengue/CHIKV rapid test at two clinics in Nigeria between 2019 and 2022. Women who were rapid test positive were followed through pregnancy and their infants observed for six months, with a subset tested by RT-PCR and neutralization, to investigate seropositivity rates and MTCT of CHIKV...
December 4, 2023: International Journal of Infectious Diseases: IJID
#58
REVIEW
Richard A Stein, Alexis Grayon, Adi Katz, Frank A Chervenak
First isolated in 1947, the Zika virus was initially connected only to limited or sporadic human infections. In late 2015, the temporal clustering of a Zika outbreak and microcephaly in newborn babies from northeastern Brazil, and the identification of a causal link between the two, led to the characterization of the congenital Zika syndrome. In the wake of the epidemic, several countries from Latin America advised women to postpone pregnancies for periods ranging from six months to two years. These recommendations initiated critical conversations about the challenges of implementing them in societies with limited access to contraception, widespread socioeconomic inequalities, and high rates of unplanned and adolescent pregnancies...
December 2022: Germs
#59
JOURNAL ARTICLE
Imara Correia de Queiroz Barbosa, Luizabel de Paula Gomes, Israel Nilton de Almeida Feitosa, Luís Fábio Barbosa Botelho, Bruno Robalinho Cavalcanti Barbosa, Alex Barbosa, André Telis de Vilela Araújo, Marcelo Dantas Tavares de Melo, Adriana Suely de Oliveira Melo, Vera Maria Cury Salemi
INTRODUCTION: Zika virus infection during pregnancy causes fetal microcephaly and brain damage. Congenital Zika syndrome (CZS) is characterized by systemic involvement with diffuse muscle impairment, a high frequency of arthrogryposis, and microphthalmia. Cardiac impairment in CZS has rarely been evaluated. Our study assessed morphology and biventricular cardiac function in children with CZS and advanced neurological dysfunction. METHODS: This cross-sectional study was conducted on 52 children with CZS (Zika group; ZG) and 25 healthy children (control group; CG) in Paraiba, Brazil...
November 29, 2023: PLoS Neglected Tropical Diseases
#60
JOURNAL ARTICLE
Grégorie Lebeau, Daed El Safadi, Mathilde Hoarau, Olivier Meilhac, Pascale Krejbich-Trotot, Wildriss Viranaicken
Zika virus (ZIKV), has gained global attention due to its association with severe disorders, including microcephaly and congenital Zika syndrome. We investigated the role of ZIKV nonstructural protein 1 (NS1) in altering the host's antioxidant response. Using a stable cell line expressing NS1, we found that NS1 significantly reduced the expression of antioxidant-related genes, including heme oxygenase 1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), and sequestosome-1 (SQSTM1), which are regulated NRF2. Interestingly, this effect was attributed to increased expression of BACH1, a factor that competes with NRF2 for binding to certain antioxidant responsive elements (ARE)...
November 23, 2023: Biochemical and Biophysical Research Communications
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