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https://read.qxmd.com/read/30779109/the-identification-of-new-biomarkers-for-bladder-cancer-a-study-based-on-tcga-and-geo-datasets
#1
Junyi Hu, Lijie Zhou, Zhengshuai Song, Ming Xiong, Youpeng Zhang, Yu Yang, Ke Chen, Zhaohui Chen
Bladder cancer (BC) is one of the most common neoplastic diseases worldwide. With the highest recurrence rate among all cancers, treatment of BC only improved a little in the last 30 years. Available biomarkers are not sensitive enough for the diagnosis of BC, whereas the standard diagnostic method, cystoscopy, is an invasive test and expensive. Hence, seeking new biomarkers of BC is urgent and challenging. With that order, we screened the overlapped differentially expressed genes (DEGs) of GSE13507 and TCGA BLCA datasets...
February 18, 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30765874/tyro3-as-a-molecular-target-for-growth-inhibition-and-apoptosis-induction-in-bladder-cancer
#2
Florent Dufour, Linda Silina, Hélène Neyret-Kahn, Aura Moreno-Vega, Clémentine Krucker, Narjesse Karboul, Marion Dorland-Galliot, Pascale Maillé, Elodie Chapeaublanc, Yves Allory, Nicolas Stransky, Hélène Haegel, Thierry Menguy, Vanessa Duong, François Radvanyi, Isabelle Bernard-Pierrot
BACKGROUND: Muscle-invasive bladder cancer (MIBC) is an aggressive neoplasm with poor prognosis, lacking effective therapeutic targets. Oncogenic dependency on members of the TAM tyrosine kinase receptor family (TYRO3, AXL, MERTK) has been reported in several cancer types, but their role in bladder cancer has never been explored. METHODS: TAM receptor expression was evaluated in two series of human bladder tumours by gene expression (TCGA and CIT series), immunohistochemistry and western blotting analyses (CIT series)...
February 15, 2019: British Journal of Cancer
https://read.qxmd.com/read/30765842/inhibition-of-g9a-by-a-small-molecule-inhibitor-unc0642-induces-apoptosis-of-human-bladder-cancer-cells
#3
Yue-Peng Cao, Jing-Ya Sun, Mei-Qian Li, Yu Dong, Yuan-Heng Zhang, Jun Yan, Rui-Min Huang, Xiang Yan
Urinary bladder cancer (UBC) is characterized by frequent recurrence and metastasis despite the standard chemotherapy with gemcitabine and cisplatin combination. Histone modifiers are often dysregulated in cancer development, thus they can serve as an excellent drug targets for cancer therapy. Here, we investigated whether G9a, one of the histone H3 methyltransferases, was associated with UBC development. We first analyzed clinical data from public databases and found that G9a was significantly overexpressed in UBC patients...
February 14, 2019: Acta Pharmacologica Sinica
https://read.qxmd.com/read/30744595/cancer-associated-fibroblasts-induce-epithelial-mesenchymal-transition-of-bladder-cancer-cells-through-paracrine-il-6-signalling
#4
Cassandra Ringuette Goulet, Audrey Champagne, Geneviève Bernard, Dominique Vandal, Stéphane Chabaud, Frédéric Pouliot, Stéphane Bolduc
BACKGROUND: Cancer-associated fibroblasts (CAFs), activated by tumour cells, are the predominant type of stromal cells in cancer tissue and play an important role in interacting with neoplastic cells to promote cancer progression. Epithelial-mesenchymal transition (EMT) is a key feature of metastatic cells. However, the mechanism by which CAFs induce EMT program in bladder cancer cells remains unclear. METHODS: To investigate the role of CAFs in bladder cancer progression, healthy primary bladder fibroblasts (HFs) were induced into CAFs (iCAFs) by bladder cancer-derived exosomes...
February 11, 2019: BMC Cancer
https://read.qxmd.com/read/30736840/spag5-upregulation-contributes-to-enhanced-c-myc-transcriptional-activity-via-interaction-with-c-myc-binding-protein-in-triple-negative-breast-cancer
#5
Ming Li, Anqi Li, Shuling Zhou, Hong Lv, Wentao Yang
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that lacks effective therapeutic targets. Sperm-associated antigen 5 (SPAG5) is a mitotic spindle-associated protein that is involved in various biological processes in cervical cancer and bladder urothelial carcinoma. However, the role of SPAG5 in TNBC remains undefined. METHODS: The expression of SPAG5 was examined in TNBC patients via quantitative real-time polymerase chain reaction (qRT-PCR), western blotting, and immunohistochemistry (IHC)...
February 8, 2019: Journal of Hematology & Oncology
https://read.qxmd.com/read/30688659/mapk4-overexpression-promotes-tumor-progression-via-noncanonical-activation-of-akt-mtor-signaling
#6
Wei Wang, Tao Shen, Bingning Dong, Chad J Creighton, Yanling Meng, Wolong Zhou, Qing Shi, Hao Zhou, Yinjie Zhang, David D Moore, Feng Yang
MAPK4 is an atypical MAPK. Currently, little is known about its physiological function and involvement in diseases, including cancer. A comprehensive analysis of 8887 gene expression profiles in The Cancer Genome Atlas (TCGA) revealed that MAPK4 overexpression correlates with decreased overall survival, with particularly marked survival effects in patients with lung adenocarcinoma, bladder cancer, low-grade glioma, and thyroid carcinoma. Interestingly, human tumor MAPK4 overexpression also correlated with phosphorylation of AKT, 4E-BP1, and p70S6K, independent of the loss of PTEN or mutation of PIK3CA...
January 28, 2019: Journal of Clinical Investigation
https://read.qxmd.com/read/30675249/overexpression-of-the-aspm-gene-is-associated-with-aggressiveness-and-poor-outcome-in-bladder-cancer
#7
Zhenglin Xu, Qi Zhang, Frank Luh, Baiye Jin, Xiyong Liu
Abnormal spindle-like microcephaly-associated ( ASPM ) protein is essential for mitotic spindle function during cell replication. The present study aimed to evaluate the hypothesis that ASPM serves a critical role in cancer invasiveness and may act as a prognostic biomarker in bladder cancer. In total, 6 independent worldwide bladder cancer microarray mRNA expression datasets (n=1,355) with clinical and follow-up annotations were collected from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases...
February 2019: Oncology Letters
https://read.qxmd.com/read/30652029/predicting-responses-to-platin-chemotherapy-agents-with-biochemically-inspired-machine-learning
#8
Eliseos J Mucaki, Jonathan Z L Zhao, Daniel J Lizotte, Peter K Rogan
The selection of effective genes that accurately predict chemotherapy responses might improve cancer outcomes. We compare optimized gene signatures for cisplatin, carboplatin, and oxaliplatin responses in the same cell lines and validate each signature using data from patients with cancer. Supervised support vector machine learning is used to derive gene sets whose expression is related to the cell line GI50 values by backwards feature selection with cross-validation. Specific genes and functional pathways distinguishing sensitive from resistant cell lines are identified by contrasting signatures obtained at extreme and median GI50 thresholds...
2019: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/30642841/serum-metabolic-profiling-identified-a-distinct-metabolic-signature-in-bladder-cancer-smokers-a-key-metabolic-enzymes-associated-with-patient-survival
#9
Chandra Sekhar Amara, Chandrashekar R Ambati, Venkatrao Vantaku, Danthasinghe Waduge Badrajee Piyarathna, Sri Ramya Donepudi, Shiva Shankar Ravi, James M Arnold, Vasanta Putluri, Gurkamal Chatta, Khurshid A Guru, Hoda Badr, Martha K Terris, Roni J Bollag, Arun Sreekumar, Andrea B Apolo, Nagireddy Putluri
BACKGROUND: The current system to predict the outcome of smokers with Bladder cancer (BLCA) is insufficient due to complex genomic and transcriptomic heterogeneities. This study aims to identify serum metabolite associated genes related to survival in this population. METHODS: We performed liquid chromatography-mass spectrometry (LC-MS) based targeted metabolomic analysis for >300 metabolites in serum obtained from two independent cohorts of BLCA never smokers, smokers, healthy smokers, and healthy never smokers...
January 14, 2019: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/30588263/glucocorticoid-inducible-kinase-2-promotes-bladder-cancer-cell-proliferation-migration-and-invasion-by-enhancing-%C3%AE-catenin-c-myc-signaling-pathway
#10
Jin-Bo Chen, Meng Zhang, Xiao-Long Zhang, Yu Cui, Pei-Hua Liu, Jiao Hu, Hui-Huang Li, Hang Jin, Long-Fei Liu, Min-Feng Chen, He-Qun Chen, Chao-Zhao Liang, Xiong-Bing Zu
Background: Bladder cancer is one of the most common malignancies in urologic system. The glucocorticoid-inducible kinase 2 (SGK2) expression and function were largely unknown in cancers. Current study was aimed to investigate the role of SGK2 in bladder cancer and its potential mechanisms. Methods: SGK2 expression was quantified by western blot (WB) in multiple bladder cancer cell lines (T24, 5637, J82 and UMUC3) compared with normal urothelial cell line (SVHUC). SGK2 knocking down and overexpression model were established by lentivirus transfection...
2018: Journal of Cancer
https://read.qxmd.com/read/30588253/oip5-promotes-growth-metastasis-and-chemoresistance-to-cisplatin-in-bladder-cancer-cells
#11
Dailian Wang, Zhicong Chen, Fan Lin, Ziqiang Wang, Qunjun Gao, Haibiao Xie, Huizhong Xiao, Yifan Zhou, Fuyou Zhang, Yingfei Ma, Hongbin Mei, Zhiming Cai, Yuchen Liu, Weiren Huang
Opa interacting protein 5 (OIP5) has previously been identified as a tumorigenesis gene. The purpose of this study is to explore the role of OIP5 in the progression of bladder cancer (BC). The OIP5 expression and clinical behaviors in bladder cancer were collected from lager database. Our study showed that OIP5 was highly expressed in bladder cancer tissues and cells. Overexpression of OIP5 in tumor patients predicted worse overall survival (OS) and higher histological grade. Vitro and vivo experiments demonstrated that knockdown of OIP5 significantly inhibited cell growth of BC...
2018: Journal of Cancer
https://read.qxmd.com/read/30588098/clinical-significance-and-effect-of-mtdh-aeg-1-in-bladder-urothelial-cancer-a-study-based-on-immunohistochemistry-rna-seq-and-in-vitro-verification
#12
Yu Zhang, Li-Jie Zhang, Yi-Wu Dang, Sheng-Hua Li, Hai-Biao Yan, Gang Chen
Background: Overexpression of metadherin/astrocyte elevated gene-1 (MTDH/AEG-1) has been implicated in various cancers. However, the clinical significance and the potential biological functions of MTDH/AEG-1 in bladder urothelial carcinoma (BUC) are not established. Methods: In this study, the expression of MTDH/AEG-1in BUC was measured using the Cancer Genome Atlas (TCGA) database and immunohistochemistry, together with a meta-analysis, to investigate the expression and diagnostic value of MTDH/AEG-1...
2018: Cancer Management and Research
https://read.qxmd.com/read/30583038/microrna-biomarkers-for-patients-with-muscle-invasive-bladder-cancer-undergoing-selective-bladder-sparing-trimodality-treatment
#13
Wei Meng, Jason Efstathiou, Rajbir Singh, Joseph McElroy, Stefano Volinia, Ri Cui, Ahmed Ibrahim, Benjamin Johnson, Nirmala Gupta, Satvam Mehta, Huabao Wang, Eric Miller, Phuong Nguyen, Jessica Fleming, Chin-Lee Wu, S Jaharul Haque, William Shipley, Arnab Chakravarti
PURPOSE: Trimodality therapy with maximal transurethral resection of bladder tumor and definitive chemoradiation reserving cystectomy for salvage of local recurrence is an accepted treatment alternative to upfront cystectomy for selected patients with muscle-invasive bladder cancer. There is a need for molecular biomarkers to predict which patients will respond to bladder preservation therapy. METHODS AND MATERIALS: We sought to identify biomarkers with the ability to predict response to chemoradiation and survival after selective bladder preservation therapy in a cohort of 40 patients using a microRNA profiling approach...
December 21, 2018: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/30515906/thyrotroph-embryonic-factor-is-downregulated-in-bladder-cancer-and-suppresses-proliferation-and-tumorigenesis-via-the-akt-foxos-signalling-pathway
#14
Jianan Yang, Bin Wang, Han Chen, Xuhong Chen, Jing Li, Yanfei Chen, Daozhang Yuan, Shunsheng Zheng
OBJECTIVES: Thyrotroph embryonic factor (TEF) plays an important role in several different processes in normal human cells; however, its function in malignant cells has not been fully elucidated. MATERIALS AND METHODS: The mRNA levels of TEF in 408 bladder cancer (BC) samples from the Cancer Genome Atlas (TCGA) database were analysed in depth. Next, the expression of TEF in 7 BC cell lines was compared to that in normal bladder epithelial cells. The cell count, colony formation and anchorage-independent growth assays as well as a nude mouse xenograft model were utilized to examine the effects of TEF on proliferation and tumorigenesis...
December 4, 2018: Cell Proliferation
https://read.qxmd.com/read/30461333/long-non-coding-rna-meg3-suppresses-the-development-of-bladder-urothelial-carcinoma-by-regulating-mir-96-and-tpm1
#15
Guanghua Liu, Xin Zhao, Jingmin Zhou, Xiangming Cheng, Zixing Ye, Zhigang Ji
We aimed at investigating effects of long non-coding RNA maternally expressed 3 (MEG3) on the proliferation, cell cycle and apoptosis of bladder urothelial carcinoma cells and regulatory relationships among lncRNA MEG3, miR-96 and α-tropomyosin 1 (TPM1). Human clinical data from The Cancer Genome Atlas (TCGA) which contains bladder urothelial carcinoma tissues and adjacent tissues were used for analysis. The expression profiles of MEG3, miR-96, TPM1, cell cycle-related genes and apoptosis-related genes were examined by real-time quantitative polymerase chain reaction (RT-qPCR) and western blot...
November 21, 2018: Cancer Biology & Therapy
https://read.qxmd.com/read/30458195/loss-of-dusp2-predicts-a-poor-prognosis-in-patients-with-bladder-cancer
#16
Hubin Yin, Weiyang He, Yunhai Li, Ning Xu, Xin Zhu, Yong Lin, Xin Gou
Dual-specificity phosphatase 2 (DUSP2), a member of nuclear type I DUSP family, abolishes the activation of mitogen-activated protein kinases (MAPKs) and plays critical roles in the immune processes, inflammatory responses and cancer progression. Currently, whether DUSP2 is involved in pathogenesis of bladder cancer remains unclear. In this study, we demonstrate that the expression level of DUSP2 was predominantly down-regulated in bladder cancer tissues and cell lines as compared with that of paired normal tissues and benign urothelial cells...
November 17, 2018: Human Pathology
https://read.qxmd.com/read/30453959/genomic-analyses-based-on-pulmonary-adenocarcinoma-in-situ-reveal-early-lung-cancer-signature
#17
Dan Li, William Yang, Yifan Zhang, Jack Y Yang, Renchu Guan, Dong Xu, Mary Qu Yang
BACKGROUND: Non-small cell lung cancer (NSCLC) represents more than about 80% of the lung cancer. The early stages of NSCLC can be treated with complete resection with a good prognosis. However, most cases are detected at late stage of the disease. The average survival rate of the patients with invasive lung cancer is only about 4%. Adenocarcinoma in situ (AIS) is an intermediate subtype of lung adenocarcinoma that exhibits early stage growth patterns but can develop into invasion. METHODS: In this study, we used RNA-seq data from normal, AIS, and invasive lung cancer tissues to identify a gene module that represents the distinguishing characteristics of AIS as AIS-specific genes...
November 20, 2018: BMC Medical Genomics
https://read.qxmd.com/read/30430389/integrative-analysis-of-cd133-mrna-in-human-cancers-based-on-data-mining
#18
REVIEW
Gui-Min Wen, Fei-Fei Mou, Wei Hou, Dan Wang, Pu Xia
CD133 is a wildly used cancer stem cell marker. The purpose of this study was to explore the significance of CD133 mRNA in human cancers mainly based on The Cancer Genome Atlas (TCGA) database. Bioinformatic analyses were done by using public repositories, including BioGPS, SAGE Genie tools, Oncomine analysis, Regulome Explorer, COSMIC analysis, and Kaplan-Meier Plotter. The main findings in this study were: 1) High CD133 mRNA was correlated with a benign survival rate of gastric cancer and lung cancer; 2) Transmembrane protein 125 (TMEM125) in bladder urothelial carcinoma and intercellular adhesion molecule 2 (ICAM2) in ovarian serous cystadenocarcinoma were closely related to CD133 expression; 3) The location and the topological structure of CD133 protein were not determined by its transcript variant in cancer cells; 4) CD38 and CD200 may be used as novel surface markers for solid cancers...
November 14, 2018: Stem Cell Reviews
https://read.qxmd.com/read/30428628/the-emerging-role-of-epitranscriptomics-in-cancer-focus-on-urological-tumors
#19
REVIEW
João Lobo, Daniela Barros-Silva, Rui Henrique, Carmen Jerónimo
Epitranscriptomics has gained ground in recent years, especially after the advent of techniques for accurately studying these mechanisms. Among all modifications occurring in RNA molecules, N6-methyladenosine (m⁶A) is the most frequent, especially among mRNAs. m⁶A has been demonstrated to play important roles in many physiological processes and several disease states, including various cancer models (from solid to liquid tumors). Tumor cells' epitranscriptome is indeed disrupted in a way to promote cancer-prone features, by means of up/downregulating m⁶A-related players: the so-called writers, readers and erasers...
November 13, 2018: Genes
https://read.qxmd.com/read/30407690/nedd8-promotes-the-tumor-progression-and-predicts-the-poor-prognosis-of-patients-with-bladder-cancer
#20
Da-Wei Tian, Zhou-Liang Wu, Li-Ming Jiang, Jie Gao, Chang-Li Wu, Hai-Long Hu
Neddylation has been researched in many different human carcinomas. However, the roles of neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) in bladder cancer were still unknown. Our study was the first study which systematically investigated the possible functions of NEDD8 in bladder cancer (BC) progression. We performed immunohistochemistry to explore the associations between the expression of NEDD8 in tumor tissues and clinical outcomes of patients. RT-qPCR and western blot were used to detect the expressional levels of genes...
November 8, 2018: Cancer Science
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