Matthias Christen, Anna Oevermann, Stefan Rupp, Frédéric M Vaz, Eric J M Wever, Barbara K Braus, Vidhya Jagannathan, Alexandra Kehl, Marjo K Hytönen, Hannes Lohi, Tosso Leeb
We investigated a syndromic disease comprising blindness and neurodegeneration in 11 Saarlooswolfdogs. Clinical signs involved early adult onset retinal degeneration and adult-onset neurological deficits including gait abnormalities, hind limb weakness, tremors, ataxia, cognitive decline and behavioral changes such as aggression towards the owner. Histopathology in one affected dog demonstrated cataract, retinal degeneration, central and peripheral axonal degeneration, and severe astroglial hypertrophy and hyperplasia in the central nervous system...
January 21, 2024: Molecular Genetics and Metabolism