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(Skin metastasis) melanoma

Chi-Che Hsieh, Che-Hung Shen
Melanoma is the deadliest form of skin cancer worldwide. The rising melanoma incidence and mortality, along with its high propensity for metastasis highlights the urgency to identify more effective therapeutic targets. Approximately, one half of advanced melanoma bears a mutation in the BRAF gene that makes BRAF as an important therapeutic target. Significant clinical benefit is associated with BRAF and MEK inhibitors (MAPKi) on targeting patients with BRAF V600 mutations. However, the frequent and rapid development of acquired resistance still is the major challenge facing the melanoma...
February 18, 2019: Current Treatment Options in Oncology
Yanqian Wang, Gang Liu, Lin Ren, Kun Wang, Aimin Liu
Melanoma is an aggressive type of skin cancer, characterized by high mortality rates worldwide. Therefore, the identification of new diagnostic markers and therapeutic targets for melanoma is imperative. Accumulating evidence has demonstrated that long non-coding RNAs (lncRNAs) play important roles in tumor initiation and progression. It was recently reported that the expression of lncRNA taurine upregulated 1 (TUG1) was relatively higher in cancer compared with that in normal cells, and that TUG1 promoted the progression of various cancers...
January 28, 2019: International Journal of Oncology
Lukasz Kuryk, Anne-Sophie W Møller, Magnus Jaderberg
Malignant melanoma is an aggressive type of skin cancer whose incidence is increasing globally. Although surgery is effective in early stage melanoma, patients with advanced melanoma only have a 20% 5-year survival rate. Hence, combinations of existing and new immunotherapy technologies and immunotherapeutic agents are being evaluated. ONCOS-102 is an oncolytic adenovirus armed with human GM-CSF and an Ad5/3 chimeric capsid. It has shown to be well tolerated in phase I study (NCT01598129) wherein it induced antitumor immunity, infiltration of CD8 + T cells to tumors, and up-regulation of PD-L1...
2019: Oncoimmunology
Priyanka Prasad, Andrea Vasas, Judit Hohmann, Anupam Bishayee, Dona Sinha
Malignant melanoma is a highly aggressive form of skin cancer which has a propensity for metastasis. Epithelial mesenchymal transition (EMT) plays a primordial role in the progression of metastatic disease. Metastatic melanoma is resistant to conventional therapies. Hence, researchers have been exploring alternative approaches, including the utility of bioactive phytochemicals to manage metastatic disease. In the present study, we investigated the potential of cirsiliol, a flavonoid isolated from Centaurea jacea L...
January 31, 2019: International Journal of Molecular Sciences
Han Byul Lee, So Eun Han, Lan Sook Chang, Soo Hyang Lee
Chronic burn scars often cause various skin malignancies at rates of up to 2%. These lesions are usually squamous cell carcinomas, but rarely, malignant melanoma is reported. We report a 67-year-old male with a malignant melanoma on a burn scar with regional metastasis. This patient presented an ulcerative lesion only in 2 weeks. After histopathological diagnosis, we performed only palliative surgery on patient's demand, and followed up the subsequent deterioration course. Our case reemphasizes the need for rapid diagnosis and treatment when suspect lesions are present on chronic burn scar...
February 1, 2019: Archives of Craniofacial Surgery
Pei-Pei Wang, Xi Zhou, Xi Chen, Li-Wen Wang, Yong Liu
RATIONALE: Malignant melanoma with indiscoverable skin manifestations is unusual and refractory hypercalcemia with high metabolic signal of the rectum as initial manifestation is very rare. PATIENT CONCERNS: We present a case that presented with paresis, nausea, and vomiting. DIAGNOSES: Malignant melanoma with spinal metastasis. INTERVENTIONS AND OUTCOMES: The patient underwent posterior decompression, partial tumor resection, bone cement reconstruction, and internal fixation...
February 2019: Medicine (Baltimore)
Nima Milani-Nejad, Chase Scarbrough, Shakuntala H Mauzo, Sara B Peters, Mark A Bechtel, David Carr
Melanoma is a highly aggressive cutaneous malignancy with considerable risk for metastasis. These malignant tumors are typically pigmented given that they arise from melanocytes capable of producing melanin. Amelanotic melanomas are a rare variant and there is often a delay in diagnosis owing to lack of pigmentation. Although there are various presentations of amelanotic melanoma, a solitary polypoid nodule is unusual and warrants further reporting. Herein, we present a patient with a 3-year history of a tender firm, skin-to-pink colored polypoid nodule...
August 15, 2018: Dermatology Online Journal
Indranil Banerjee, Manjarika De, Goutam Dey, Rashmi Bharti, Sankha Chattopadhyay, Nahid Ali, Partha Chakrabarti, Rui L Reis, Subhas C Kundu, Mahitosh Mandal
Melanoma is a highly aggressive skin cancer. A paclitaxel formulation of solid lipid nanoparticles modified with Tyr-3-octreotide (PSM) is employed to treat melanoma that highly expresses somatostatin receptors (SSTRs). PSM exerts more apoptotic and anti-invasive effects in B16F10 mice melanoma cells as compared to dacarbazine (DTIC), an approved chemotherapeutic drug for treating aggressive melanoma. Besides, PSM induces one of the biomarkers of immunogenic cell death in vitro and in vivo as confirmed by calreticulin exposure on the B16F10 cell surface...
January 17, 2019: Biomaterials Science
Cristian Navarrete-Dechent, Miguel Cordova, Michael A Postow, Melissa Pulitzer, Cecilia Lezcano, Allan C Halpern, Anthony M Rossi
Importance: Melanoma incidence and the use of systemic treatments for it are rising. Current treatment monitoring uses clinical examination and radiologic examinations; however, cutaneous involvement and cutaneous metastasis may not be well visualized. Reflectance confocal microscopy (RCM) is a US Food and Drug Administration-approved, noninvasive technology that enables visualization of the skin with quasihistological resolution. Objective: To evaluate the feasibility of using RCM to monitor advanced melanomas treated with immunotherapy...
January 9, 2019: JAMA Dermatology
Renata-Lucena Markman, Giuliano-Augusto-Belizario Rosa, Leonardo Cardili, Luciana-Estevam Simonato, Thais-Bianca Brandão, Ana-Carolina-Prado Ribeiro
Introduction: Malignant metastases to the oral cavity are rare and metastatic melanomas of the tongue are considered exceptionally uncommon, with less than 10 cases published in the English literature so far. Case reports: Two female patients in the 7th decade of life presented to our dental service with nodules in the tongue. Both patients had multiple metastases at the time of oral diagnosis and primary melanoma originated on the skin. An intra-oral incisional biopsy was performed under local anesthesia and the histopathologic analysis was characterized by the proliferation of atypical epithelioid cells displaying a poorly delimited cytoplasm and hyperchromatic nucleus which contained eosinophilic macronucleoli...
November 2018: Journal of Clinical and Experimental Dentistry
Amal Makhlouf, Istvan Hajdu, Siddesh V Hartimath, Elahe Alizadeh, Kayla Wharton, Kishor M Wasan, Ildiko Badea, Humphrey Fonge
Melanoma is a devastating form of skin cancer with high tendency to metastasis. This work addresses the development of new targeted nanoparticles that can be used for SPECT imaging of melanoma. Melanoma-specific glycoprotein non-metastatic b (GPNMB) antigen targeted and non-targeted gemini nanoparticles were prepared, characterized and radiolabeled with 111In. 111In-labeled nanoparticles comprised of gemini surfactant grafted with monoclonal antibody Fab fragment that targets GPNMB. Specific uptake of GPNMB-Fab was studied in six melanoma cell lines using flow cytometry...
January 3, 2019: Molecular Pharmaceutics
Shelian Lu, Qunyuan Xu
Melanoma is the main cause of death associated with skin cancer. Surgical resection and adjuvant therapy are currently effective treatments, but the recurrence rate is very high. The understanding of microRNA (miR) dynamics after surgical resection of melanoma is essential to accurately explain the changes in the recurrence of melanoma. In this study, we hypothesized that microRNA-23a (miR-23a) affects the cell proliferation, migration, and invasion of melanoma with a mechanism related to SDCBP and the MAPK/ERK signaling pathway...
December 27, 2018: IUBMB Life
Hsin-Yu Chen, Yi-Wen Jiang, Chao-Lin Kuo, Tzong-Der Way, Yu-Cheng Chou, Yuan-Shiun Chang, Jing-Gung Chung
Numerous evidences have shown that chrysin induced cytotoxic effects via induced cell cycle arrest and induction of cell apoptosis in human cancer cell lines, however, no information showed that chrysin inhibited skin cancer cell migration and invasion. In this study, we investigated anti-metastasis mechanisms of chrysin in human melanoma cancer A375.S2 cells in vitro. Under sub-lethal concentrations of chrysin (0, 5, 10, and 15 μM) which inhibits cell mobility, migration and invasion of A375.S2 cells that were assayed by wound healing and Transwell filter...
December 22, 2018: Environmental Toxicology
V Kaplan, C Morales, F Bobadilla, J Fernández, L Segovia, V Vera, I Sanhueza
BACKGROUND AND OBJECTIVE: Cutaneous metastases (CMs) account for 2% of skin tumors and their incidence varies between 0.7% and 9% in patients with cancer. The objective of this study was to describe and analyze the demographic, clinical, and histopathologic characteristics of CM in patients who visited 2 hospitals in the Santiago de Chile metropolitan region. MATERIAL AND METHOD: We performed a retrospective, descriptive, analytical, observational, cross-sectional study...
December 18, 2018: Actas Dermo-sifiliográficas
Pan Zhang, Mengli Zhang, Di Yu, Wenming Liu, Lin Hu, Bin Zhang, Quansheng Zhou, Zhifei Cao
Metastatic melanoma accounts for 60% of death for skin cancer. Although great efforts have been made to treat the disease, effective drugs against metastatic melanoma still lack at the clinical setting. In the current study, we found that lycorine, a small molecule of isoquinoline alkaloid, significantly suppressed melanoma cell migration and invasion in vitro, and decreased the metastasis of melanoma cells to lung tissues in tumor-bearing mice, resulting in significant prolongation of the survival of the mice without obvious toxicity...
November 22, 2018: Journal of Cellular Physiology
Ayoung Pyo, Hyeon-Sik Kim, Gyeongmin Kim, Hyung-Seok Kim, Misun Yun, Dong-Yeon Kim, Jung-Joon Min
Malignant melanoma is a very aggressive and serious form of skin cancer, with prognosis and treatment outcome depending heavily on the clinical stage of the disease at the time of diagnosis. Here, we synthesized a novel 18 F-labeled benzamide derivative to target melanoma, and then evaluated its biological characteristics in small animal models. Methods : N -(2-(dimethylamino)ethyl)-4-18 F-fluorobenzamide (18 F-DMFB) was synthesized by reaction of N -succinimidyl 4-18 F-fluorobenzoate with N , N -dimethylethylenediamine...
December 14, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Serafinella Patrizia Cannavò, Alessandro Tonacci, Lucrezia Bertino, Marco Casciaro, Francesco Borgia, Sebastiano Gangemi
Melanoma is the most aggressive skin tumour, which incidence is rising fast over the year. The metastatic stage of disease is extremely difficult to treat and the mortality rate is still high. Emerging evidence suggested that oxidative stress (OS) is involved in the pathophysiological pathways of several chronic diseases and in the transformation and progression of many common cancers, including melanoma. In particular, it has emerged that OS interacts with inflammatory and immune response, all taking part in the melanomagenic process...
November 24, 2018: Pathology, Research and Practice
Martin J Bullock, Jonathan J Beitler, Diane L Carlson, Isabel Fonseca, Jennifer L Hunt, Nora Katabi, Philip Sloan, S Mark Taylor, Michelle D Williams, Lester D R Thompson
Standardized, synoptic pathologic reporting for tumors greatly improves communication among clinicians, patients, and researchers, supporting prognostication and comparison about patient outcomes across institutions and countries. The International Collaboration on Cancer Reporting is a nonprofit organization whose mission is to develop evidence-based, universally available surgical pathology reporting data sets. Within the head and neck region, lymph node excisions and neck dissections are frequently performed as part of the management of head and neck cancers arising from the mucosal sites (sinonasal tract, nasopharynx, oropharynx, hypopharynx, oral cavity, and larynx), along with bone tumors, skin cancers, melanomas, and other tumor categories...
November 30, 2018: Archives of Pathology & Laboratory Medicine
Bing Wang, Xing-Long Qu, Yong Chen
The melanoma is one of the most dangerous forms of skin diseases. It may spread to other parts of the body and cause serious illness and death. Early detection and diagnosis are crucial. However, the systemic expression analysis for the different staging of melanoma is still lacking to date. In this study, we analyzed the gene expression profiles of the different staging of melanoma by the differential expression analysis and random forest analysis. First, the results of the principal component analysis showed that the clustering of primary tumor samples, normal samples, and pigment nevus samples got closer, while the clustering of tumor metastatic samples and normal samples was far away...
November 30, 2018: Journal of Cellular Physiology
Chang Liu, Depeng Wang, Ye Zhan, Lingyue Yan, Qian Lu, Michael Yz Chang, Jingwen Luo, Lidai Wang, Dan Du, Yuehe Lin, Jun Xia, Yun Wu
Glutathione is overexpressed in tumor cells and regulates cancer growth, metastasis and drug resistance. Therefore, detecting glutathione levels may greatly facilitate cancer diagnosis and treatment response monitoring. Photoacoustic (PA) imaging is a noninvasive modality for high-sensitivity, high-resolution, deep-tissue optical imaging. Switchable PA probes that offer signal on/off responses to tumor targets would further improve the detection sensitivity and signal-to-noise ratio of PA imaging. Here we explore the use of MnO2 nanotubes as a switchable and biodegradable PA probe for dynamic imaging of glutathione in cancer...
November 30, 2018: ACS Applied Materials & Interfaces
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