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complications of respiratory distress syndrome

Uwe Schmidt, Claudia Capek, Cahit Birdir, Christine Erfurt, Katharina Nitzsche
INTRODUCTION: It can be observed that there is an increase in the methamphetamine (MA) consumption in Saxony (Federal Republic of Germany). There is so far no data available in German speaking countries about the risk of MA consumption in pregnancy or delivery. METHODS: The data from all pregnant women who were examined or delivered at the Clinic for Obstetrics and Gynaecology between 2010-2015 were retrospectively searched for MA consumption. 119 pregnancies with 113 deliveries of 115 women consuming MA could be evaluated...
February 20, 2019: Zeitschrift Für Geburtshilfe und Neonatologie
Hazem Abdelhamid Mohamed, Yasser M Elbastawisy, Wael M Elsaed
Introduction: Lipopolysaccharide is a bacterial endotoxin that induces acute lung injury in experimental animals, which is similar to acute respiratory distress syndrome in humans. The induced tissue trauma ends in fibrosis. Understanding the pathogenesis is important in the prevention and treatment of the complications. This study was assigned to investigate the long-term lipopolysaccharide-induced lung injury and the postulated protective effect of ascorbic acid on these changes. Materials and methods: Twenty-four adult male albino rats were divided into three groups...
2019: SAGE Open Medicine
Hiroshi Yokomichi, Mie Mochizuki, Joseph Jonathan Lee, Reiji Kojima, Tetsuji Yokoyama, Zentaro Yamagata
OBJECTIVE: To calculate the incidence of hospitalisation due to acute respiratory failure, pneumonia, acute respiratory distress syndrome (ARDS), febrile seizures and encephalitis/encephalopathy among influenza-positive patients in Japan, where point-of-care tests are routinely used to diagnose influenza. DESIGN: A cross-sectional study using routinely collected data. SETTING: Japanese clinics and hospitals between 2012 and 2016. PARTICIPANTS: Japanese patients aged 0-74 years diagnosed with influenza by a rapid test in employment-related health insurance records...
January 17, 2019: BMJ Open
Thea Tagliaferro, Deepak Jain, Silvia Vanbuskirk, Eduardo Bancalari, Nelson Claure
BACKGROUND: Preeclampsia (PE) is a pregnancy complication characterized by an anti-angiogenic environment. This can affect fetal pulmonary vascular and alveolar development but data of the impact of PE on respiratory outcome in extremely premature infants are inconclusive. OBJECTIVE: To determine if PE is associated with an increased risk for severe respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in extremely premature infants. METHODS: Prospectively collected single center data from a cohort of infants born at 23-28 w gestational age between January 2005 and December 2015 were analyzed...
February 15, 2019: Pediatric Research
Radek Vrba, David Vrána, Čestmír Neoral, Bohuslav Melichar, René Aujeský, Jana Tesarikova, Jan Cincibuch, Jana Zapletalová, Tomáš Jínek, Martin Stašek
Introduction: Respiratory complications (RC) including respiratory failure and adult respiratory distress syndrome (ARDS) affect the outcomes of esophagectomy substantially. In order to decrease their incidence, identification of important features of RC is necessary. Aim: To evaluate the incidence and risk factors of postoperative RC following hybrid esophagectomy. Material and methods: The retrospective analysis of consecutive hybrid esophagectomies for malignancies (transhiatal laparoscopic or thoracoscopic resection and limited open reconstruction phase) assessed the incidence and outcomes of RC in relation to the patients' age, ASA score, neoadjuvant therapy, type of surgical procedure, TNM stage, the incidence of anastomotic leak and Clavien-Dindo classification...
January 2019: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
Catia Cillóniz, Cristina Dominedò, Antonello Nicolini, Antoni Torres
Worldwide, there is growing concern about the burden of pneumonia. Severe community-acquired pneumonia (CAP) is frequently complicated by pulmonary and extra-pulmonary complications, including sepsis, septic shock, acute respiratory distress syndrome, and acute cardiac events, resulting in significantly increased intensive care admission rates and mortality rates. Streptococcus pneumoniae (Pneumococcus) remains the most common causative pathogen in CAP. However, several bacteria and respiratory viruses are responsible, and approximately 6% of cases are due to the so-called PES ( Pseudomonas aeruginosa , extended-spectrum β-lactamase Enterobacteriaceae , and methicillin-resistant Staphylococcus aureus ) pathogens...
February 12, 2019: Microorganisms
Samuel M Galvagno, Nirav G Shah, Christopher R Cornachione, Kristopher B Deatrick, Michael A Mazzeffi, Jay Menaker
INTRODUCTION: Diffuse alveolar damage is the histologic hallmark for the acute phase of acute respiratory distress syndrome and can occasionally present as diffuse alveolar hemorrhage. CASE REPORT: We report a patient with diffuse alveolar hemorrhage and acute respiratory distress syndrome requiring veno-venous extracorporeal life support for 210 days, who was successfully treated for a period of 130 consecutive days without intravenous anticoagulation. DISCUSSION: Although there are a few brief reports detailing long extracorporeal life support runs, the literature is largely devoid of data regarding long-term extracorporeal life support without full systemic anticoagulation...
February 11, 2019: Perfusion
Jessica Selter, Timothy Wen, Katherine L Palmerola, Alexander M Friedman, Zev Williams, Eric J Forman
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) is a potentially life-threatening clinical condition. OBJECTIVE: The objective of this study was to evaluate risk factors for life-threatening complications for patients with severe OHSS in a United States nationwide sample. MATERIALS AND METHODS: OHSS admissions from 2002-2011 from the Nationwide Inpatient Sample (NIS) were included in this study. The association between patient and hospital factors and life-threatening complications (deep vein thrombosis/pulmonary embolism [DVT/PE], acute respiratory distress syndrome [ARDS], acute renal failure [ARF], intubation), non-routine discharge (discharge to skilled nursing facility, transfer hospital), prolonged length of stay (LOS), and total hospital charges were analyzed...
February 8, 2019: American Journal of Obstetrics and Gynecology
William Bain, Tolani Olonisakin, Minting Yu, Yanyan Qu, Mei Hulver, Zeyu Xiong, Huihua Li, Joseph Pilewski, Rama K Mallampalli, Mehdi Nouraie, Anuradha Ray, Prabir Ray, Zhenyu Cheng, Robert M Q Shanks, Claudette St Croix, Roy L Silverstein, Janet S Lee
Thrombocytopenia is associated with worse outcomes in patients with acute respiratory distress syndrome, which is most commonly caused by infection and marked by alveolar-capillary barrier disruption. However, the mechanisms by which platelets protect the lung alveolar-capillary barrier during infectious injury remain unclear. We found that natively thrombocytopenic Mpl -/- mice deficient in the thrombopoietin receptor sustain severe lung injury marked by alveolar barrier disruption and hemorrhagic pneumonia with early mortality following acute intrapulmonary Pseudomonas aeruginosa (PA) infection; barrier disruption was attenuated by platelet reconstitution...
February 12, 2019: Blood Advances
Danqiong Wang, Guozheng Zhang, Weiwen Zhang, Jian Luo, Lihua Zhu, Jianhua Hu
RATIONALE: Because of the lack of an antidote or effective treatment, patients with severe acute diquat and glyphosate poisoning always died within a few hours. Extracorporeal membrane pulmonary oxygenation (ECMO), as an artificial heart-lung supporting system, can be applied to support lung that is expected to recover from reversible pathological damage. However, to our knowledge, the application of ECMO for patients with diquat and glyphosate poisoning has not been reported. PATIENT CONCERNS: A 40-year-old man ingested in 100 ml of diquat (20 g/100 ml) and 400 ml glyphosate (41 g/100 ml) was admitted to the intensive care unit (ICU), immediately complicated by the development of ventricular fibrillation, respiratory failure, renal failure, and multi-organ failure...
February 2019: Medicine (Baltimore)
Xin Huang, Louis J Magnotti, Timothy C Fabian, Martin A Croce, John P Sharpe
PURPOSE: Patients with thoracic trauma are presumed to be at higher risk for pulmonary dysfunction, but adult respiratory distress syndrome (ARDS) may develop in any patient, regardless of associated chest injury. This study evaluated the impact of thoracic trauma and pulmonary failure on outcomes in trauma patients admitted to the intensive-care unit (ICU). METHODS: All trauma patients admitted to the ICU over an 8-year period were identified. Patients that died within 48 h of arrival were excluded...
February 2, 2019: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Christina L Costantino, Abraham D Geller, Cameron D Wright, Harald C Ott, Ashok Muniappan, Douglas J Mathisen, Michael Lanuti
OBJECTIVES: Complete resection of neoplasms involving the carina are technically challenging and have high operative morbidity and mortality. This study examines the last 2 decades of clinical experience at our institution. METHODS: Medical records were retrospectively reviewed between 1997 and 2017 to identify all patients who underwent carinal resection. Primary outcome measures include risk factors for complications and overall survival. RESULTS: In total, 45 carinal resections were performed with a median follow-up of 3...
December 15, 2018: Journal of Thoracic and Cardiovascular Surgery
Hayato Go, Hitoshi Ohto, Kenneth E Nollet, Nozomi Kashiwabara, Kei Ogasawara, Mina Chishiki, Kyohei Miyazaki, Kenichi Sato, Maki Sato, Yukihiko Kawasaki, Nobuo Momoi, Mitsuaki Hosoya
To date, few studies have investigated whether perinatal factors affect coagulation parameters at birth in preterm and term neonates. We retrospectively investigated coagulation factors on day 1 in 609 consecutive neonates admitted to our neonatal intensive care unit between January 2010 and December 2017. We measured coagulation factors on day 1 using peripheral blood samples. Multivariate analysis revealed that prothrombin time-international normalized ratio correlated with intraventricular hemorrhage ( p  = 0...
January 31, 2019: American Journal of Perinatology
Pascal L Langlois, Fréderick D'Aragon, Gil Hardy, William Manzanares
OBJECTIVE: Acute respiratory distress syndrome (ARDS) is characterized by an acute inflammatory response in the lung parenchyma leading to severe hypoxemia. Because of its anti-inflammatory and immunomodulatory properties, omega-3 polyunsaturated fatty acids (ω-3 PUFA) have been administered to ARDS patients, mostly by the enteral route, as immune-enhancing diets with eicosapentaenoic acid, γ-linolenic acid, and antioxidants. However, clinical benefits of ω-3 PUFAs in ARDS patients remain unclear because clinical trials have found conflicting results...
November 5, 2018: Nutrition
Antonia Koutsoukou, Matteo Pecchiari
Expiratory flow limitation (EFL), that is the inability of expiratory flow to increase in spite of an increase of the driving pressure, is a common and unrecognized occurrence during mechanical ventilation in a variety of intensive care unit conditions. Recent evidence suggests that the presence of EFL is associated with an increase in mortality, at least in acute respiratory distress syndrome (ARDS) patients, and in pulmonary complications in patients undergoing surgery. EFL is a major cause of intrinsic positive end-expiratory pressure (PEEPi), which in ARDS patients is heterogeneously distributed, with a consequent increase of ventilation/perfusion mismatch and reduction of arterial oxygenation...
January 23, 2019: World Journal of Critical Care Medicine
Venkatesh Pooladanda, Sowjanya Thatikonda, Swarna Bale, Bijay Pattnaik, Dilep Kumar Sigalapalli, Nagendra Babu Bathini, Shashi Bala Singh, Chandraiah Godugu
Acute respiratory distress syndrome (ARDS) is characterized by an excessive acute inflammatory response in lung parenchyma, which ultimately leads to refractory hypoxemia. One of the earliest abnormalities seen in lung injury is the elevated levels of inflammatory cytokines, among them, the soluble tumor necrosis factor (TNF-α) has a key role, which exerts cytotoxicity in epithelial and endothelial cells thus exacerbates edema. The bacterial lipopolysaccharide (LPS) was used both in vitro (RAW 264.7, THP-1, MLE-12, A549, and BEAS-2B) and in vivo (C57BL/6 mice), as it activates a plethora of overlapping inflammatory signaling pathways involved in ARDS...
January 28, 2019: Cell Death & Disease
Guanhua Li, Li Zhang, Yunxia Sun, Jimei Chen, Chengbin Zhou
RATIONALE: Extracorporeal membrane oxygenation (ECMO) is a well-known technique to provide cardio-pulmonary support. Although continuous renal replacement therapy (CRRT) is frequently indicated, the need for faster fluid removal as the primary indication for ECMO is uncommon. Experiences on concomitant applications of ECMO, peritoneal dialysis (PD) and CRRT in neonates are relatively limited. PATIENT CONCERNS: We report a 2-day-old male neonate with life-threatening hyaline membrane disease (HMD), accompained by severe systemic fluid retention, sepsis and abdominal compartment syndrome...
January 2019: Medicine (Baltimore)
Elizabeth G Wheatley, Brenda J Curtis, Holly J Hulsebus, Devin M Boe, Kevin Najarro, Diana Ir, Charles E Robertson, Mashkoor A Choudhry, Daniel N Frank, Elizabeth J Kovacs
Maintenance of the commensal bacteria that comprise the gut microbiome is essential to both gut and systemic health. Traumatic injury, such as burn, elicits a number of changes in the gut, including a shift in the composition of the microbiome (dysbiosis), increased gut leakiness, and bacterial translocation into the lymphatic system and bloodstream. These effects are believed to contribute to devastating secondary complications following burn, including pneumonia, acute respiratory distress syndrome, multi-organ failure, and septic shock...
January 18, 2019: Shock
MiHye Park, Hyun Joo Ahn, Jie Ae Kim, Mikyung Yang, Burn Young Heo, Ji Won Choi, Yung Ri Kim, Sang Hyun Lee, HeeJoon Jeong, Soo Joo Choi, In Sun Song
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: Driving pressure (plateau minus end-expiratory airway pressure) is a target in patients with acute respiratory distress syndrome, and is proposed as a target during general anesthesia for patients with normal lungs. It has not been reported for thoracic anesthesia where isolated, inflated lungs may be especially at risk. WHAT THIS ARTICLE TELLS US THAT IS NEW: In a double-blinded, randomized trial (292 patients), minimized driving pressure compared with standard protective ventilation was associated with less postoperative pneumonia or acute respiratory distress syndrome...
January 17, 2019: Anesthesiology
Edda Vesteinsdottir, Gunnar Myrdal, Kristinn O Sverrisson, Sigurbjorg J Skarphedinsdottir, Olafur Gudlaugsson, Sigurbergur Karason
Tuberculosis is a rare cause of acute respiratory distress syndrome (ARDS) and mortality rates are high in tuberculosis patients that need treatment with mechanical ventilation. Experience of the use of extracorporeal membrane oxygenation (ECMO) in such circumstances is scarce. We report the case of an 18 year old man where prolonged therapy (50 days) with extracorporeal membrane oxygenation (ECMO) allowed extensive lung damage from miliary tuberculosis to heal. The case reflects how challenging the diagnosis of tuberculosis may be and how difficult it is to reach adequate blood levels of anti-tuberculosis drugs while on ECMO...
2019: Respiratory Medicine Case Reports
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