Kyle D Pires, Joshua Bloom, Stephanie Golob, Barbara E Sahagún, Allison A Greco, Esha Chebolu, Jenny Yang, Peter Ting, Radu Postelnicu, Vanessa Soetanto, Leian Joseph, Sripal Bangalore, Sylvie F Hall, Rana Biary, Robert S Hoffman, David S Park, Carlos L Alviar, Rafael Harari, Silas W Smith, Mark K Su
Bupropion is a substituted cathinone (β-keto amphetamine) norepinephrine/dopamine reuptake inhibitor andnoncompetitive nicotinic acetylcholine receptor antagonist that is frequently used to treat major depressive disorder. Bupropion overdose can cause neurotoxicity and cardiotoxicity, the latter of which is thought to be secondary to gap junction inhibition and ion channel blockade. We report a patient with a confirmed bupropion ingestion causing severe cardiotoxicity, for whom prophylactic veno-arterial extracorporeal membrane oxygenation (ECMO) was successfully implemented...
February 2024: Curēus