keyword
https://read.qxmd.com/read/35033487/2021-clinical-practice-guidelines-for-the-diagnosis-treatment-and-follow-up-of-patients-with-peripheral-spondyloarthritis-colombian-association-of-rheumatology
#21
JOURNAL ARTICLE
Lina M Saldarriaga-Rivera, Wilson Bautista-Molano, Alejandro Junca-Ramírez, Andrés R Fernández-Aldana, Daniel G Fernández-Ávila, Diego A Jaimes, Edwin A Jáuregui, Juan S Segura-Charry, Consuelo Romero-Sánchez, Oscar J Felipe-Diaz
BACKGROUND: Peripheral spondyloarthritis is a chronic inflammatory disease in which clinical presentation is related to the presence of arthritis, enthesitis and/or dactylitis. This term is used interchangeably with some of its subtypes such as psoriatic arthritis, reactive arthritis, and undifferentiated spondyloarthritis. OBJECTIVE: To develop and formulate a set of specific recommendations based on the best available evidence for the diagnosis, treatment and monitoring of adult patients with peripheral spondyloarthritis...
January 2022: Reumatología clinica
https://read.qxmd.com/read/34918133/rheumatologic-manifestations-in-a-cohort-of-patients-with-vogt-koyanagi-harada-disease
#22
JOURNAL ARTICLE
Sinem Burcu Kocaer, Mahmut Kaya, Suzan Guven Yilmaz, Ziya Ayhan, Ali Osman Saatci, Fatos Onen, Ismail Sari
OBJECTIVES: Vogt-Koyanagi-Harada Disease (VKHD) is a systemic autoimmune disorder characterized by granulomatous panuveitis. Inflammatory rheumatic diseases (IRDs) are among the differential diagnosis of VKHD. However, current knowledge on the rheumatological aspects of VKHD is still limited. We aimed to investigate the prevalence of rheumatic conditions in VKHD patients. METHODS: VKHD patients were included in the study and they were reviewed in terms of the presence of any rheumatological manifestations...
August 20, 2022: Modern Rheumatology
https://read.qxmd.com/read/34647979/comment-on-incidence-of-extra-articular-manifestations-in-ankylosing-spondylitis-psoriatic-arthritis-and-undifferentiated-spondyloarthritis-results-from-a-national-register-based-cohort-study
#23
JOURNAL ARTICLE
https://read.qxmd.com/read/34394873/ankylosing-spondylitis
#24
REVIEW
Nazanin Ebrahimiadib, Sahar Berijani, Mohammadreza Ghahari, Fatemeh Golsoorat Pahlaviani
The seronegative spondyloarthropathies are a group of autoimmune inflammatory diseases lacking rheumatoid factor or antinuclear antibody in their serum. They include ankylosing spondylitis (AS), reactive arthritis, psoriatic arthritis, spondylitis associated with Crohn's disease and ulcerative colitis, and undifferentiated spondyloarthropathies. Inflammation mostly affects the axial joints, entheses, and extra-articular structures such as uveal tract, gastrointestinal tract, mucocutaneous tissue, and heart...
2021: Journal of Ophthalmic & Vision Research
https://read.qxmd.com/read/34300172/hla-allele-prevalence-in-disease-modifying-antirheumatic-drugs-responsive-enthesitis-and-or-arthritis-not-fulfilling-asas-criteria-comparison-with-psoriatic-and-undifferentiated-spondyloarthritis
#25
JOURNAL ARTICLE
Elvira Favoino, Livio Urso, Alessandra Serafino, Francesca Misceo, Giacomo Catacchio, Marcella Prete, Federico Perosa
Spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases characterized by common clinical features, such as inflammatory enthesitis, arthritis and/or back pain. SpA is strongly associated with human leukocyte antigen (HLA) class I allotype B27. Ankylosing spondylitis has historically been the SpA subgroup with one of the strongest, best-proven associations with HLA-B27. The remaining SpA subgroups, namely psoriatic arthritis (PsA), inflammatory bowel diseases-associated arthritis/spondylitis, reactive arthritis, and undifferentiated SpA (uSpA), have also been associated with HLA allotypes other than HLA-B27...
July 6, 2021: Journal of Clinical Medicine
https://read.qxmd.com/read/34199710/ultrasound-verified-peripheral-arthritis-in-patients-with-hla-b-35-positive-spondyloarthritis
#26
JOURNAL ARTICLE
Daniela Šošo, Jure Aljinović, Sanja Lovrić Kojundžić, Ivanka Marinović, Esma Čečuk Jeličić, Daniela Marasović Krstulović
BACKGROUND: We aimed to investigate possible association between the HLA-B*35 allele and peripheral arthritis, tenosynovitis and enthesitis. METHODS: Ultrasound of peripheral joints and tendons was performed in 72 HLA-B*35 positive patients with preliminary diagnosis of undifferentiated axial form of spondyloarthitis and joint and tendon pain. Patients with other known types of axial and peripheral spondyloarthritis were excluded as well as patients with other known types of arthritis...
June 4, 2021: Life
https://read.qxmd.com/read/34144605/reactive-arthritis-and-undifferentiated-peripheral-spondyloarthritis-share-human-leucocyte-antigen-b27-subtypes-and-serum-and-synovial-fluid-cytokine-profiles
#27
COMPARATIVE STUDY
Jyoti Ranjan Parida, Sandeep Kumar, Sakir Ahmed, Smriti Chaurasia, Ratnadeep Mukherjee, Rajeev Singh, Balachandran Ravindran, Amita Aggarwal, Ramnath Misra
OBJECTIVES: Peripheral SpA (pSpA) is comprised of ReA, PsA, enteritis-associated arthritis and undifferentiated pSpA (upSpA). ReA and upSpA share T cell oligotypes and metabolomics in serum and SF. We investigated HLA-B27 subtypes and cytokines in serum and SF that were compared between ReA and upSpA. METHODS: ReA and upSpA were compared in two cohorts. In cohort I (44 ReA and 56 upSpA), HLA-B27 subtyping was carried out. In cohort II (17 ReA and 21 upSpA), serum and SF cytokines were compared using a multiplex cytokine bead assay (27 cytokines)...
June 18, 2021: Rheumatology
https://read.qxmd.com/read/33948552/undifferentiated-connective-tissue-disease-presenting-with-optic-neuritis-and-concomitant-axial-spondyloarthritis-a-rare-case-report
#28
Başak Mansız-Kaplan, Barış Nacır, Cevriye Mülkoğlu, Seçil Pervane-Vural, Hakan Genç
Undifferentiated connective tissue disease (UCTD) represents a group of diseases which do not fulfill the criteria of rheumatologic diseases or may be considered as an early stage of any of these diseases. Axial spondyloarthritis (axSpA) is a disease accompanied by symptoms of inflammatory low back pain and peripheral symptoms, with more spine and sacroiliac joint involvement. In this report, we, for the first time, present a case of UCTD presenting with axSpA in whom the initial finding was optic neuritis, which is rarely seen in UCTD...
March 2021: Turkish journal of physical medicine and rehabilitation
https://read.qxmd.com/read/33763437/the-increased-levels-of-fecal-calprotectin-in-children-with-active-enthesitis-related-arthritis-and-mri-signs-of-sacroiliitis-the-results-of-a-single-center-cross-sectional-exploratory-study-in-juvenile-idiopathic-arthritis-patients
#29
JOURNAL ARTICLE
Lovro Lamot, Marijana Miler, Rudolf Vukojević, Mandica Vidović, Mirta Lamot, Ivana Trutin, Nora Nikolac Gabaj, Miroslav Harjaček
Enthesitis related arthritis (ERA) is a specific subtype of juvenile idiopathic arthritis (JIA), often regarded as an undifferentiated form of juvenile spondyloarthritis (jSpA). While gut is increasingly recognized as origin and/or target of inflammation in adult onset spondyloarthritis (SpA), the incidence of gut involvement in ERA patients is largely unknown. The aim of this study was to measure the concentration of fecal calprotectin (fCAL), a surrogate marker of gut inflammation, in patients with different subtypes of JIA, as well as to correlate the results with various demographic, clinical, laboratory, imaging, and treatment characteristics...
2021: Frontiers in Medicine
https://read.qxmd.com/read/33755519/is-family-history-a-predictor-of-response-to-tumour-necrosis-factor-inhibitors-in-spondyloarthritis-a-swedish-nationwide-cohort-study
#30
JOURNAL ARTICLE
M Morin, K Hellgren, U Lindström, T Frisell
Objective : To determine whether a family history of spondyloarthritis (SpA) is associated with clinical presentation at the start of tumour necrosis factor inhibitor (TNFi) treatment, or predictive of TNFi drug survival and treatment response in patients with SpA. Method : Family history of SpA in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA), and undifferentiated SpA (uSpA) from the Swedish Rheumatology Quality register starting a TNFi as their first biologic in 2006-2018 was assessed through national registers...
January 2022: Scandinavian Journal of Rheumatology
https://read.qxmd.com/read/33589106/suspecting-and-diagnosing-the-patient-with-spondyloarthritis-and-what-to-expect-from-therapy
#31
REVIEW
Philip J Mease
Spondyloarthritis is a common rheumatologic disease, present in up to 2% of the population, characterized by inflammatory arthritis, often with enthesitis, dactylitis, spondylitis, and skin disease. It has historically been characterized as ankylosing spondylitis, psoriatic arthritis, arthritis associated with inflammatory bowel disease, reactive arthritis, and undifferentiated spondyloarthritis. These subsets are now classified as axial-predominant and peripheral-predominant spondyloarthritis. This article provides an updated understanding of disease classification and practical advice about diagnosis to aid in the determination of which patients should be referred to rheumatology...
March 2021: Medical Clinics of North America
https://read.qxmd.com/read/33563055/the-increased-risk-of-atrial-fibrillation-in-inflammatory-arthritis-a-systematic-review-and-meta-analysis-of-cohort-studies
#32
JOURNAL ARTICLE
Yubo Ma, Zhipeng Pan, Dazhi Fan, Shanshan Xu, Faming Pan
Background : Atrial fibrillation (AF) is the most common cardiac arrhythmia contributing to stroke and sudden cardiac death. Numbers of studies indicated that patients with inflammatory arthritis have an increased risk of AF. The present study aims to assess the risk of AF in inflammatory arthritis patients. Methods : We systematically searched cohort studies regarding the risk of AF in patients with rheumatoid arthritis, or spondyloarthritis through PubMed, Web of Science, Cochrane Library, Clinical Trials Registry, and China National Knowledge from inception to August 1, 2019...
February 10, 2021: Immunological Investigations
https://read.qxmd.com/read/33562025/il-17a-and-tnf-modulate-normal-human-spinal-entheseal-bone-and-soft-tissue-mesenchymal-stem-cell-osteogenesis-adipogenesis-and-stromal-function
#33
JOURNAL ARTICLE
Tobias Russell, Abdulla Watad, Charlie Bridgewood, Hannah Rowe, Almas Khan, Abhay Rao, Peter Loughenbury, Peter Millner, Robert Dunsmuir, Richard Cuthbert, Ala Altaie, Elena Jones, Dennis McGonagle
OBJECTIVE: The spondylarthritides (SpA) are intimately linked to new bone formation and IL-17A and TNF pathways. We investigated spinal soft tissue and bone mesenchymal stem cell (MSC) responses to IL-17A and TNF, including their osteogenesis, adipogenesis, and stromal supportive function and ability to support lymphocyte recruitment. METHODS: Normal spinal peri-entheseal bone (PEB) and entheseal soft tissue (EST) were characterized for MSCs by immunophenotypic, osteogenic, chondrogenic, and adipogenic differentiation criteria...
February 6, 2021: Cells
https://read.qxmd.com/read/33547063/tenosynovitis-has-a-high-sensitivity-for-early-acpa-positive-and-acpa-negative-ra-a-large-cross-sectional-mri-study
#34
JOURNAL ARTICLE
Xanthe Marijn Edmée Matthijssen, Fenne Wouters, Navkiran Sidhu, Ellis Niemantsverdriet, Annette van der Helm-van Mil
OBJECTIVES: Clinically evident tenosynovitis can be seen in established rheumatoid arthritis (RA). Imaging research has recently shown that tenosynovitis at small joints occurs in early RA, contributes to typical RA symptoms (including joint swelling) and is infrequent in healthy controls. Imaging-detectable tenosynovitis is often not recognisable at joint examination, hence its prevalence can therefore be underestimated. We hypothesised that if MRI-detectable tenosynovitis is a true RA feature, the sensitivity for RA is high, in both anti-citrullinated protein antibodies (ACPA)-positive and ACPA-negative RA, and lower in other diseases that are associated with enthesitis (such as spondyloarthritis (SpA) and psoriatic arthritis (PsA))...
August 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/33253491/one-year-treatment-outcomes-of-secukinumab-versus-tumor-necrosis-factor-inhibitors-in-spondyloarthritis-results-from-five-nordic-biologic-registries-including-more-than-10-000-treatment-courses
#35
JOURNAL ARTICLE
Bente Glintborg, Ulf Lindström, Daniela Di Giuseppe, Sella Aarrestad Provan, Bjorn Gudbjornsson, Merete Lund Hetland, Brigitte Michelsen, Johan K Wallman, Kalle Aaltonen, Anna-Mari Hokkanen, Dan Nordström, Tanja Schjødt Jørgensen, Rebekka Lund Hansen, Arni Jon Geirsson, Kathrine Lederballe Grøn, Niels Steen Krogh, Johan Askling, Lars Erik Kristensen, Lennart T H Jacobsson
OBJECTIVE: To describe baseline characteristics and to compare treatment effectiveness of secukinumab versus tumor necrosis factor inhibitors (TNFi) in patients with spondyloarthritis (SpA) using adalimumab as the main comparator. METHODS: This was an observational, prospective cohort study. Patients with SpA (clinical ankylosing spondylitis, nonradiographic axial SpA, or undifferentiated SpA) starting secukinumab or a TNFi during 2015-2018 were identified from 5 Nordic clinical rheumatology registries...
May 2022: Arthritis Care & Research
https://read.qxmd.com/read/33234498/the-clinical-utility-of-faecal-calprotectin-in-patients-with-differentiated-and-undifferentiated-spondyloarthritis-relevance-and-clinical-implications
#36
JOURNAL ARTICLE
Yasser Emad, Yasser Ragab, Nevin Hammam, Nashwa El-Shaarawy, Magdy Fawzi, Arwa Amer, Hesham El-Makhzangy, Ahmed Ismail, Ossama Ibrahim, Yosra Hassan, Ahmed Kamal, Johannes J Rasker
OBJECTIVES: There is cumulative evidence in the literature supporting a potential role of faecal calprotectin (FCP) as a biomarker for gut inflammation in spondyloarthritis (SpA). However its relevance in undifferentiated SpA (USpA) is still uncertain. The aim of the current study is to assess the diagnostic significance of FCP levels in patients with differentiated and undifferentiated SpA. MATERIAL AND METHODS: A total of 52 differentiated SpA, 33 USpA and 50 controls could be included...
November 21, 2020: Reumatología clinica
https://read.qxmd.com/read/33216939/incidence-of-extra-articular-manifestations-in-ankylosing-spondylitis-psoriatic-arthritis-and-undifferentiated-spondyloarthritis-results-from-a-national-register-based-cohort-study
#37
JOURNAL ARTICLE
Karin Bengtsson, Helena Forsblad-d'Elia, Anna Deminger, Eva Klingberg, Mats Dehlin, Sofia Exarchou, Ulf Lindström, Johan Askling, Lennart T H Jacobsson
OBJECTIVES: To estimate the incidence and strength of association of extra-articular manifestations [EAMs, here: anterior uveitis (AU), IBD and psoriasis] in patients with AS, undifferentiated SpA (uSpA) and PsA, compared with controls. METHODS: Three mutually exclusive cohorts of patients aged 18-69 years with AS (n = 8517), uSpA (n = 10 245) and PsA (n = 22 667) were identified in the Swedish National Patient Register 2001-2015...
June 18, 2021: Rheumatology
https://read.qxmd.com/read/33097958/ankle-arthritis-an-important-signpost-in-rheumatologic-practice
#38
REVIEW
Patrick D W Kiely, Mark E Lloyd
Ankle arthritis is a useful clinical signpost to differential diagnosis in rheumatic disease. Biomechanical features and differences in cartilage physiology compared with the knee may confer protection of the ankle joint from factors predisposing to certain arthritides. The prevalence of ankle OA is low, and usually secondary to trauma. Primary OA of the ankle should be investigated for underlying causes, especially haemochromatosis. New presentations of inflammatory mono/oligo arthritis involving the ankle are more likely due to undifferentiated arthritis or spondyloarthritis than RA, and gout over CPPD...
January 5, 2021: Rheumatology
https://read.qxmd.com/read/33047726/-multicenter-performance-of-the-different-classification-criteria-for-rheumatoid-arthritis
#39
MULTICENTER STUDY
C N Luo, Z F Li, L J Wu, H J Chen, C M Yang, W H Xu, X L Liu, W Tang, P Qiao, B Rena
OBJECTIVE: To evaluate the classification criteria of early rheumatoid arthritis (ERA) and compare the sensitivity and specificity with the criteria of 1987 American College of Rheumatology (ACR) criteria and 2010 ACR/European League Against Rheumatism (EULAR). METHODS: Patients from 4 hospitals, aged more than 16 years, with arthritis, whose disease duration was ≤1 year, and with ≥1 joint pain and swelling were enrolled in the study. The indicators including clinical manifestations, laboratory tests and imaging examinations were observed...
October 18, 2020: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://read.qxmd.com/read/32985314/antibodies-to-malondialdehyde-acetaldehyde-modified-low-density-lipoprotein-in-patients-with-newly-diagnosed-inflammatory-joint-disease
#40
JOURNAL ARTICLE
A Kononoff, S Hörkkö, P Pussinen, H Kautiainen, P Elfving, E Savolainen, L Arstila, H Niinisalo, J Rutanen, O Marjoniemi, O Kaipiainen-Seppänen
Objective :To assess antibodies to malondialdehyde-acetaldehyde-modified low-density lipoprotein (MAA-LDL) in patients with newly diagnosed inflammatory joint disease. Method : Patients with rheumatoid arthritis (RA), spondyloarthritis (SpA), and undifferentiated arthritis (UA), participating in the Northern Savo 2010 Study, were evaluated for metabolic syndrome (MetS), metabolic and inflammatory markers, antibodies to MAA-LDL, Aggregatibacter actinomycetemcomitans , and Porphyromonas gingivalis . Results : Among 135 newly diagnosed untreated patients, of whom 53 (39%) were diagnosed to have RA, 44 (33%) SpA, and 38 (28%) UA, 49%, 30%, and 47%, respectively, had MetS...
September 28, 2020: Scandinavian Journal of Rheumatology
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