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https://read.qxmd.com/read/30782732/study-protocol-for-an-open-label-single-arm-multicentre-phase-ii-trial-to-evaluate-the-efficacy-and-safety-of-combined-triplet-therapy-and-olanzapine-for-prevention-of-carboplatin-induced-nausea-and-vomiting-in-gynaecological-cancer-patients
#1
Hirotoshi Iihara, Mototsugu Shimokawa, Masakazu Abe, Yoh Hayasaki, Yukiyoshi Fujita, Yuki Nagasawa, Michiru Sakurai, Rie Matsuoka, Akio Suzuki, Kenichiro Morishige
INTRODUCTION: Carboplatin (CBDCA) administered at a dosage of 4 mg/mL/min or more area under the blood concentration-time curve (AUC) is considered to be ranked as the highest chemotherapy-induced nausea and vomiting (CINV) risk of the moderately emetogenic chemotherapy agents. The complete response (CR) rate for preventing overall CINV, defined as no emetic episodes and no use of rescue medication, for standard triplet antiemetic therapy (5-HT3 RA, 5-hydroxytryptamine-3 receptor antagonist; NK1 RA, neurokinin-1 receptor antagonist; DEX, dexamethasone) was approximately 60% in gynaecological cancer patients receiving CBDCA-based therapy...
January 17, 2019: BMJ Open
https://read.qxmd.com/read/30778742/two-year-follow-up-of-a-multi-centre-randomized-controlled-trial-to-study-effectiveness-of-a-hospital-based-work-support-intervention-for-cancer-patients
#2
S J Tamminga, J H A M Verbeek, M M E M Bos, G Fons, J J E M Kitzen, P W Plaisier, M H W Frings-Dresen, A G E M de Boer
Purpose Purpose is to: (1) study effectiveness of the hospital-based work support intervention for cancer patients at two years of follow-up compared to usual care and (2) identify which early factors predict time to return-to-work (RTW). Methods In this multi-center randomised controlled trial (RCT), 106 (self-)employed cancer patients were randomized to an intervention group or control group and provided 2 years of follow-up data. The intervention group received patient education and work-related support at the hospital...
February 16, 2019: Journal of Occupational Rehabilitation
https://read.qxmd.com/read/30773599/vulvar-basal-cell-carcinoma-clinical-features-and-treatment-outcomes-from-a-tertiary-care-centre
#3
Rama P Namuduri, Timothy Yk Lim, Philip Kl Yam, Rene Gatsinga, Soo Kim Lim-Tan, Sung Hock Chew, Mark Ja Koh, Sorsiah Mansor
We retrospectively reviewed the clinical features, management and outcomes of patients diagnosed with basal cell carcinoma (BCC) of the vulva at the Gynaecological Cancer Centre, KK Women's and Children's Hospital, Singapore, between 1 January 2000 and 28 February 2014. Patients with vulvar BCC were identified from the cancer registry, and their medical records reviewed and analysed. A total of 11 patients with vulvar BCC were identified. Mean age at diagnosis was 63 (range 30¬-85) years. Ethnically, ten patients were Chinese and one was Malay...
February 18, 2019: Singapore Medical Journal
https://read.qxmd.com/read/30772826/impact-of-gene-specific-germline-pathogenic-variants-on-presentation-of-endometrial-cancer-in-lynch-syndrome
#4
Giorgio Bogani, Maria Teresa Ricci, Marco Vitellaro, Antonino Ditto, Valentina Chiappa, Francesco Raspagliesi
OBJECTIVE: Lynch syndrome is a risk factor for developing endometrial carcinoma. Our aim was to evaluate the impact of gene-specific germline pathogenic variants on clinical features of patients affected by endometrial cancer. METHODS: Patients with a diagnosis of endometrial cancer and with a germline pathogenic variant in mismatch repair genes were reviewed. Patients were classified on the basis of classes of risk according to the ESGO-ESGO-ESTRO (European Society of Medical Oncology/European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology) guidelines...
February 16, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30771995/frequency-and-risk-factors-of-thoracic-metastases-and-optimisation-of-the-use-of-cross-sectional-chest-imaging-in-follow-up-patients-with-cervical-cancer
#5
K K Nakao, A Kido, T Imai, K Abiko, K Fujimoto, A Horie, S Minamiguchi, S Tanaka, M Mandai, K Togashi
AIM: To optimise cross-sectional chest imaging usage by identifying frequency and risk factors associated with thoracic metastases in cervical cancer patients after initial definitive treatment. MATERIALS AND METHODS: This study, conducted during 2004-2015, examined 361 consecutive patients with histopathologically proven cervical carcinoma with at least 1 year of follow-up. Electronic medical records and all available imaging modes were used to record and assess patient and tumour characteristics and timing of thoracic metastases...
February 13, 2019: Clinical Radiology
https://read.qxmd.com/read/30765097/-circulating-tumor-dna-assessment-for-gynaecological-cancers-management
#6
REVIEW
Roxane Mari, Éric Lambaudie, Magali Provansal, Renaud Sabatier
Gynaecological cancers are frequent, with more than 16,000 cases per year in France for 6500 deaths. Few improvements in diagnostic methods, prognostic tools, and therapeutic strategies have occurred in the last two decades. Tumour genomic analyses from, at least in part, the Cancer Genome Atlas have identified some of the molecular alterations involved in gynaecological tumours growth and spreading. However, these data remain incomplete and have not led to dramatic changes in the clinical management of our patients...
February 11, 2019: Bulletin du Cancer
https://read.qxmd.com/read/30755567/molecular-diagnosis-of-human-papilloma-virus-by-pcr
#7
F Nahar, M A Hossain, S K Paul, M U Ahmed, S Khatun, G R Bhuiyan, S A Nasreen, N Haque, S Ahmed, N Kobayashi, S N Akter, H Begum
Cervical cancer is a major world health problem and the fourth most leading cause of death in women around the world. High risk HPV DNA has been shown to be present in 99.7% of cervical cancers worldwide. So detection of HPV DNA by PCR may help in early detection and management of cervical cancer. This cross sectional observational study was done to detect L1 antigen gene of HPV from cervical swab by nested PCR. Following universal safety precautions a total of 141 endocervical swabs were collected from Colposcopy clinic of Obstetrics and Gynaecology department of MMCH from January 2015 to December 2015...
January 2019: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/30755547/distribution-of-hpv-16-and-hpv-18-from-the-patients-attending-at-mymensingh-medical-college-hospital-by-newly-developed-oncoprotein-detection-assay
#8
S Abedin, S K Paul, N Haque, S Ahmed, S A Nasreen, N Akhter, N Haque, S R Sarkar, S Roy, F Nahar, M U Ahmed, J Switzer, N Kobayashi, M A Hossain, U W Chowdhury
Cervical cancer is one of cause of death in women in many developing countries. Persistent infection with Human Papilloma Virus (HPV), primarily high risk types 16 and 18, is recognized as a causal and essential factor for the development of cervical cancer. The objective of this cross sectional observational study is to detect the distribution of HPV-16 and HPV-18 among Onco E6 positive cases. Following universal safety precautions a total of 180 endocervical swabs were collected from Colposcopy clinic of Obstetrics and Gynaecology Department of Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh from January 2016 to December 2016...
January 2019: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/30753458/reduced-%C3%AE-2-6-sialylation-regulates-cell-migration-in-endometriosis
#9
Chloé Maignien, Pietro Santulli, Sandrine Chouzenoux, Iñaki Gonzalez-Foruria, Louis Marcellin, Ludivine Doridot, Mohammed Jeljeli, Philippe Grange, Fernando M Reis, Charles Chapron, Frédéric Batteux
STUDY QUESTION: Is endometriosis associated with aberrant sialylation patterns and what is the potential impact of such anomalies on cell migratory properties? SUMMARY ANSWER: The reduced α-2,6 sialylation patterns in the peritoneal fluid of endometriosis-affected women and in stromal and epithelial cells from endometriotic lesions could be associated with enhanced cell migration. WHAT IS KNOWN ALREADY: Endometriosis is considered to be a benign disease although, like cancer, it has the characteristic of being an invasive disease with cells that have an enhanced capacity to migrate...
February 12, 2019: Human Reproduction
https://read.qxmd.com/read/30735593/risk-reducing-early-salpingectomy-and-delayed-oophorectomy-as-a-two-staged-alternative-for-primary-prevention-of-ovarian-cancer-in-increased-risk-women-a-commentary
#10
Faiza Gaba, Jurgen Piek, Usha Menon, Ranjit Manchanda
Ovarian cancer (OC) is the leading cause of death from gynaecological malignancies in the UK. Despite considerable funding to develop new treatments, 10-year survival remains poor at ~30%. This translates into 4,271 deaths annually in the UK, 42,700 in Europe and 152,000 deaths annually worldwide. High (e.g.-BRCA1/BRCA2) and moderate (e.g.-RAD51C/RAD51D/BRIP1) penetrance gene-mutations account for most of the known hereditary-risk of OC. At least 10% of women with epithelial-OC carry these germline mutations...
February 8, 2019: BJOG: An International Journal of Obstetrics and Gynaecology
https://read.qxmd.com/read/30732650/an-unusual-cause-of-postmenopausal-vaginal-haemorrhage-a-case-report
#11
Junyan Sun, Ying Guo, Li Ma, Zhaoxia Qian, Dongmei Lai
BACKGROUND: Post-menopause vaginal haemorrhage is typically related to gynaecological malignancies. Bleeding from vaginal varices rarely occurs, especially in nonpregnant women. Moreover, nonpregnancy-related causes of vaginal varicosities include portal hypertension, especially that caused by liver cirrhosis, pelvic congestion syndrome and Klippel-Trenaunay syndrome or Parkes-Weber syndrome. Here, we report an unusual cause of nonpregnancy-associated vaginal variceal bleeding. CASE PRESENTATION: A 55-year-old postmenopausal woman presented in our outpatient department with complaints of recurrent bloody vaginal discharge...
February 7, 2019: BMC Women's Health
https://read.qxmd.com/read/30720156/knockdown-of-long-non-coding-rna-linc00518-inhibits-cervical-cancer-proliferation-and-metastasis-by-modulating-jak-stat3-signaling
#12
D-W Wang, D You, J Dong, T-F Liu
OBJECTIVE: Long intergenic non-protein coding RNA 518 (LINC00518) was reported to be implicated and aberrantly expressed in multiple cancers. However, the pathogenic implications of LINC00518 in cervical cancer (CC) are still unclear. In this study, we focused on LINC00518 and investigated its expression pattern, clinical significance, and biological function in CC. PATIENTS AND METHODS: The expression levels of LINC00518 in CC tissues and cell lines were determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR), and its clinical significance was assessed by statistical analysis...
January 2019: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/30720106/prostaglandin-d2-expression-is-prognostic-in-high%C3%A2-grade-serous-ovarian-cancer
#13
Mariana Rezende Alves, Nayra Soares Do Amaral, Fabio Albuquerque Marchi, Felipe Ilelis De Barros Silva, Alexandre André Balieiro Anastácio Da Costa, Kátia Cândido Carvalho, Glauco Baiocchi, Fernando Augusto Soares, Louise De Brot, Rafael Malagoli Rocha
To identify biomarkers that could predict response or lack of response to conventional chemotherapy at the time of diagnosis of high‑grade serous ovarian carcinoma (HGSOC), the present study compared large‑scale gene expression from patients with short or long disease‑free survival times, according to the last cycle of chemotherapy, and validated these findings using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and conventional immunohistochemical (IHC) analysis. Samples were selected for microarray evaluation, at the time of diagnosis, using the following criteria: Identical debulking primary surgery, International Federation of Gynaecology and Obstetrics staging, histological subtype and grade...
January 28, 2019: Oncology Reports
https://read.qxmd.com/read/30719165/long-noncoding-rna-gihcg-functions-as-an-oncogene-and-serves-as-a-serum-diagnostic-biomarker-for-cervical-cancer
#14
Xiaolian Zhang, Lihua Mao, Lihua Li, Zhihong He, Naiqun Wang, Yanfeng Song
Cervical cancer is the most common and lethal gynaecological tumor. Long noncoding RNAs (lncRNAs) have critical roles in various cancers, including cervical cancer. However, few studies investigated the diagnostic value of lncRNAs for cervical cancer. In this study, we investigated the expression pattern of a recently identified lncRNA GIHCG in cervical cancer tissues, cell lines, and serums by qRT-PCR. Furthermore, we explored the roles of GIHCG in cervical cancer using gain-of-function and loss-of-function assays...
2019: Journal of Cancer
https://read.qxmd.com/read/30712414/the-mtor-downstream-regulator-p-4ebp1-is-a-novel-independent-prognostic-marker-in-ovarian-cancer
#15
M L Alabdullah, D A Ahmad, P Moseley, S Madhusudan, S Chan, E Rakha
Ovarian cancer is associated with the highest mortality rate among gynaecologic malignancies. There is a need to refine the classification of ovarian cancer and identify novel targets. The mammalian target of rapamycin (mTOR) pathway has a crucial role in the pathogenesis and progression of ovarian cancer. This study aims to investigate the prognostic role of p-mTOR and its major downstream effectors p-4EBP1 (eukaryotic initiation factor 4E-binding protein 1) and p-P70S6K (ribosomal protein S6 kinase) in ovarian cancer...
February 4, 2019: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://read.qxmd.com/read/30712025/potential-of-osteopontin-in-the-management-of-epithelial-ovarian-cancer
#16
Katarina Cerne, Benjamin Hadzialjevic, Erik Skof, Ivan Verdenik, Borut Kobal
Background Osteopontin (sOPN) is a promising blood tumour marker for detecting epithelial ovarian cancer (EOC). However, other clinical uses of sOPN as a tumour marker in EOC are still lacking. Since sOPN concentrations in serum are not associated with those in ascites, we compared clinical value of sOPN concentrations in the two body fluids. Patients and methods The study included 31 women with advanced EOC and 34 women with benign gynaecological pathology. In the EOC group, serum for sOPN analysis was obtained preoperatively, after primary debulking surgery and after chemotherapy...
January 31, 2019: Radiology and Oncology
https://read.qxmd.com/read/30711374/uterus-transplantation-and-fertility-preservation
#17
REVIEW
Mats Brännström, Pernilla Dahm-Kähler
Absolute uterine factor infertility (AUFI), with uterine absence or presence of a non-functional uterus, was considered untreatable until 2014, when the first child was born after transplantation of a uterus from a postmenopausal woman to a woman of fertile age who was born with no uterus, as a part of the Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. Concerning gynaecological cancer, AUFI may occur after hysterectomy for malignancy or after surgery/radiation that will preserve the uterus but causing non-functionality in terms of future implantation and pregnancy...
February 2019: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://read.qxmd.com/read/30706448/is-peritonectomy-and-hyperthermic-intraperitoneal-chemotherapy-a-new-standard-of-treatment-for-advanced-epithelial-ovarian-cancer
#18
REVIEW
Rhonda Farrell
Ovarian cancer is the leading cause of death due to gynaecological malignancy with a five-year relative survival of only 20-30% for Australian women with stage 3 and 4 disease. Most cases present with spread of cancer cells outside the pelvis to the peritoneal surfaces of the abdomen and associated viscera. Efforts to improve survival from advanced disease have therefore led to more extensive cytoreductive surgery, including the use of peritonectomy surgery, which is usually combined with hyperthermic intraperitoneal chemotherapy (HIPEC)...
February 1, 2019: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://read.qxmd.com/read/30705906/clinical-impact-of-18-f-fdg-pet-ct-on-the-management-of-gynecologic-cancers-one-center-experience
#19
Akram Al-Ibraheem, Abedallatif AlSharif, Ramiz Abu-Hijlih, Imad Jaradat, Asem Mansour
Objectives: We aim to investigate the clinical impact of 18 F-FDG PET/CT in managing patients with gynecological malignancies and pelvic or extrapelvic lymph nodes that are of equivocal significance on conventional imaging. Methods: We retrospectively evaluated 18 F-FDG PET/CT scans of patients with gynecologic tumors who were referred to King Hussein Cancer Center from January 2010 to August 2014. PET/CT results were compared with MRI and CT findings. We evaluated sensitivity and specificity of 18 F-FDG PET/CT, its role in changing treatment plan and its positive predictive value (PPV) and negative predictive value (NPV)...
2019: Asia Oceania Journal of Nuclear Medicine & Biology
https://read.qxmd.com/read/30686608/occult-vaginal-evisceration-case-report
#20
Fady Shehata, Olga Bougie, Kevin Baker, Hisham Khalil
BACKGROUND: Vaginal evisceration is a rare gynaecologic emergency that necessitates surgical intervention. It may manifest with obvious vaginal rupture, or it may be occult, specifically in patients with chronic pelvic organ prolapse. CASE: A 66-year-old woman with a history of bowel cancer and irradiation presented with occult vaginal evisceration. This was discovered during a routine follow-up appointment. It was repaired in two layers with xenograft derived from porcine intestinal mucosa (Surgisis, Cook Medical, Bloomington, IN) interposition and a concomitant colpocleisis...
January 24, 2019: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
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