keyword
https://read.qxmd.com/read/38546455/pelvic-lymph-node-involvement-and-risk-of-recurrence-in-hpv-associated-endocervical-adenocarcinoma-stage-ia2-ib1-according-to-silva-s-system-in-two-colombian-cancer-centers
#1
JOURNAL ARTICLE
Jairo Alonso Hernández, Juliana Rodríguez, Gabriel Rendón, Lina Maria Trujillo, María Islena Beltrán, Carolina Mantilla, Carolina Echeverry, María Angélica Mendoza, Mónica Gil, Marcela Núñez, Marcela Hernández, Jonathan Peralta, René Pareja
OBJECTIVE: To compare the pelvic lymph node involvement and risk of recurrence in patients with human papillomavirus (HPV)-associated endocervical adenocarcinoma stage IA2-IB1 undergoing hysterectomy and/or trachelectomy plus lymphadenectomy, according to Silva's classification system. METHODS: A retrospective cohort study was performed in two Colombian cancer centers. The cases were classified according to the Silva classification system. Clinical, surgical, and histopathological variables were evaluated...
March 28, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38542164/tissue-inhibitor-of-metalloproteinase-3-unravelling-its-biological-function-and-significance-in-oncology
#2
REVIEW
Wei-Ting Lee, Pei-Ying Wu, Ya-Min Cheng, Yu-Fang Huang
Tissue inhibitor of metalloproteinases-3 (TIMP3) is vital in regulating several biological processes. TIMP3 exerts antitumour effects via matrix metalloproteinase (MMP)-dependent and MMP-independent pathways. Due to promoter methylation and miRNA binding, TIMP3 expression has been observed to decrease in various cancers. Consequently, the migration and invasion of cancer cells increases. Conflicting results have reported that expression levels of TIMP3 in primary and advanced cancers are higher than those in healthy tissues...
March 10, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38539490/management-of-patients-with-hypersensitivity-to-platinum-salts-and-taxane-in-gynecological-cancers-a-cross-sectional-study-by-the-european-network-of-young-gynaecologic-oncologists-enygo
#3
JOURNAL ARTICLE
Tibor A Zwimpfer, Esra Bilir, Khayal Gasimli, Andrej Cokan, Nicolò Bizzarri, Zoia Razumova, Joanna Kacperczyk-Bartnik, Tanja Nikolova, Andrei Pletnev, Ilker Kahramanoglu, Alexander Shushkevich, Aleksandra Strojna, Charalampos Theofanakis, Tereza Cicakova, Marcus Vetter, Céline Montavon, Gilberto Morgan, Viola Heinzelmann-Schwarz
Platinum and taxane chemotherapy is associated with the risk of hypersensitivity reactions (HSRs), which may require switching to less effective treatments. Desensitization to platinum and taxane HSRs can be used to complete chemotherapy according to the standard regimen. Therefore, we aimed to investigate the current management of HSRs to platinum and/or taxane chemotherapy in patients with gynecologic cancers. We conducted an online cross-sectional survey among gynecological and medical oncologists consisting of 33 questions...
March 14, 2024: Cancers
https://read.qxmd.com/read/38539419/characteristics-of-cancer-stem-cells-and-their-potential-role-in-endometrial-cancer
#4
REVIEW
Karolina Frąszczak, Bartłomiej Barczyński
Endometrial cancer is one of most common types of gynaecological tumours in developing countries. It has been suggested that cancer stem cells play an important role in the development of endometrial cancer. These are a subset of highly tumorigenic cells with similar features to normal stem cells (unlimited proliferation, multi-potential differentiation, self-renewal, aggressiveness, invasion, recurrence, and chemo- and endocrine therapy resistance). Wnt/β-catenin, Hedghog, and Notch1 are the most frequently activated pathways in endometrial cancer stem cells...
March 7, 2024: Cancers
https://read.qxmd.com/read/38537385/transcriptomes-of-cervical-cancer-provide-novel-insights-into-dysregulated-pathways-potential-therapeutic-targets-and-repurposed-drugs
#5
JOURNAL ARTICLE
Md Tamzid Hossain Tanim, Sudipta Deb Nath, Sumaiya Farah Khan, Abira Khan, Abu Ashfaqur Sajib
Cervical cancer ranks as the fourth most prevalent gynaecological malignancy and is a significant contributor to mortality among women globally. With the exception of HPV-mediated oncogenesis, the molecular etiology of the disease is poorly understood, and there is a critical dearth of knowledge concerning cancer that is not caused by HPV. Moreover, none of the options presently accessible for the treatment of cancers specifically target cervical cancer. In context with this, this research aims to identify the critical genes, regulators, and pathways that contribute to the pathogenesis of cervical cancer, in addition to prospective pharmacological targets and repurposed therapeutic agents that can be directed against the targets...
March 21, 2024: Cancer Treatment and Research Communications
https://read.qxmd.com/read/38536861/predictors-for-participation-in-mass-treatment-and-female-genital-schistosomiasis-re-investigation-and-the-effect-of-praziquantel-treatment-in-south-african-adolescents
#6
JOURNAL ARTICLE
Takalani Girly Nemungadi, Elisabeth Kleppa, Hashini Nilushika Galappaththi-Arachchige, Pavitra Pillay, Svein Gunnar Gundersen, Birgitte Jyding Vennervald, Patricia Doris Ndhlovu, Myra Taylor, Saloshni Naidoo, Eyrun Floerecke Kjetland
OBJECTIVE: Female Genital Schistosomiasis (FGS) causes intravaginal lesions and symptoms that could be mistaken for sexually transmitted diseases or cancer. In adults, FGS lesions [grainy sandy patches (GSP), homogenous yellow patches (HYP), abnormal blood vessels and rubbery papules] are refractory to treatment. The effect of treatment has never been explored in young women; it is unclear if gynaecological investigation will be possible in this young age group (16-23 years). We explored the predictors for accepting anti-schistosomal treatment and/or gynaecological reinvestigation in young women, and the effects of anti-schistosomal mass-treatment (praziquantel) on the clinical manifestations of FGS at an adolescent age...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536512/potential-role-of-immune-cell-therapy-in-gynecological-cancer-and-future-promises-a-comprehensive-review
#7
REVIEW
Sandipan Dasgupta, Sakuntala Gayen, Tania Chakraborty, Naureen Afrose, Ranita Pal, Sutapa Mahata, Vilas Nasare, Souvik Roy
Gynecological malignancies are most leading causes of death among women worldwide. The high prevalence of gynecologic malignancies remains significant, necessitating to turn the novel treatment approach like immunotherapy, wherein cancer cells are killed by the invasion of immune system. In recent year, immunotherapy has mostly an advanced treatment approach to repressing the tumor cells survival, proliferation, and invasion via the activation of immune systems. Moreover, various types of immune cells including T-cells, B-cells, and dendritic cells are associated with the immunotherapeutic strategy in cancer treatment...
March 27, 2024: Medical Oncology
https://read.qxmd.com/read/38531551/treating-anaplastic-lymphoma-kinase-alk-fusion-driven-metastatic-non-small-cell-lung-cancer-nsclc-with-alectinib-through-pregnancy
#8
JOURNAL ARTICLE
Florence Wu, Rebekah Rittberg, Kenneth Lim, Cheryl Ho
Management of cancer during pregnancy requires careful consideration of risks and benefits from maternal and fetal perspectives. For advanced lung adenocarcinomas, with no targetable driver mutations, there is evidence-based guidance on the use of carboplatin-paclitaxel chemotherapy after first trimester. In contrast, for epidermal growth factor receptor (EGFR)-mutated or anaplastic lymphoma kinase (ALK)-rearranged metastatic lung adenocarcinomas, there is a paucity of clinical data on the safety of EGFR and ALK tyrosine kinase inhibitors to mother and fetus for official guidelines to recommend the use of these otherwise-first-line therapies in pregnancy...
March 25, 2024: BMJ Case Reports
https://read.qxmd.com/read/38528763/ovarian-surveillance-including-endometrial-cytology-for-patients-with-hereditary-breast-and-ovarian-cancer-before-risk-reducing-salpingo-oophorectomy-a-retrospective-analysis
#9
JOURNAL ARTICLE
Atsushi Fusegi, Hidetaka Nomura, Arisa Ueki, Akiko Abe, Mayumi Kamata, Satoki Misaka, Yoichi Aoki, Terumi Tanigawa, Mayu Yunokawa, Hiroyuki Kanao
AIM: Ovarian surveillance in women with hereditary breast and ovarian cancer who do not undergo risk-reducing salpingo-oophorectomy has been controversial. Therefore, this study aimed to demonstrate the clinical features of ovarian surveillance at our institution using a technique that combines serum cancer antigen 125 measurements, transvaginal ultrasonography, and uterine endometrial cytology. METHODS: We retrospectively examined 65 women, who had not undergone risk-reducing salpingo-oophorectomy diagnosed with hereditary breast and ovarian cancer between 2000 and 2021 at our hospital...
March 25, 2024: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/38528468/accuracy-of-endometrial-sampling-in-the-diagnosis-of-endometrial-cancer-a-multicenter-retrospective-analysis-of-the-jago-noggo
#10
MULTICENTER STUDY
Zaher Alwafai, Maximilian Heinz Beck, Sepideh Fazeli, Kathleen Gürtler, Christine KunzYoung Academy Of Gynecologic Oncology, Juliane Singhartinger, Dominika Trojnarska, Dario Zocholl, David Johannes Krankenberg, Jens-Uwe Blohmer, Jalid Sehouli, Klaus Pietzner
BACKGROUND: Accurate preoperative molecular and histological risk stratification is essential for effective treatment planning in endometrial cancer. However, inconsistencies between pre- and postoperative tumor histology have been reported in previous studies. To address this issue and identify risk factors related to inaccurate histologic diagnosis after preoperative endometrial evaluation, we conducted this retrospective analysis. METHODS: We conducted a retrospective analysis involving 375 patients treated for primary endometrial cancer in five different gynaecological departments in Germany...
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38523872/late-stage-ovarian-cancer-with-systemic-multiple-metastases-shows-marked-shrinkage-using-a-combination-of-wilms-tumor-antigen-1-wt1-dendritic-cell-vaccine-natural-killer-nk-cell-therapy-and-nivolumab
#11
Hisashi Nagai, Ryusuke Karube
A patient with bilateral ovarian cancer, peritoneal dissemination, and multiple liver and lung metastases was found with a sudden accumulation of ascites six months after delivery. Chemotherapy was started, but the prognosis was judged to be poor, so immuno-cell therapy was combined with chemotherapy. After multiple cycles of Wilms' tumor antigen 1 (WT1) dendritic cell vaccine therapy and highly activated natural killer (NK) cell therapy, the patient showed a disappearance of ascites and a remarkable reduction of multiple cancers in the whole body...
March 2024: Curēus
https://read.qxmd.com/read/38519383/how-long-does-contouring-really-take-results-of-the-royal-college-of-radiologists-contouring-surveys
#12
JOURNAL ARTICLE
E Montague, T Roques, K Spencer, A Burnett, J Lourenco, N Thorp
AIMS: The success and safety of modern radiotherapy relies on accurate contouring. Understanding the time taken to complete radiotherapy contours is critical to informing workforce planning and, in the context of a workforce shortfall, advocating for investment in technology and multi-professional skills mix. We aimed to quantify the time taken to delineate target volumes for radical radiotherapy. MATERIALS AND METHODS: The Royal College of Radiologists circulated two electronic surveys via email to all clinical oncology consultants in the UK...
March 15, 2024: Clinical Oncology: a Journal of the Royal College of Radiologists
https://read.qxmd.com/read/38517850/the-effect-of-a-mobile-application-for-patients-living-with-gynaecological-cancer-on-their-physical-and-psychosocial-adaptation
#13
JOURNAL ARTICLE
Okan Vardar, Pınar Serçekuş
BACKGROUND: Education of patients with cancer and patient self-management allow better clinical outcomes using e-health or mobile health applications. AIMS: To develop a mobile application to increase the physical and psychosocial adaptation for patients with gynecological cancer who are receiving chemotherapy and to investigate the effectiveness of the mobile application. METHODS: This study was planned as a parallel, single-blind, pre-post test randomised controlled experimental study in which two groups (intervention-control) will be compared...
March 2, 2024: International Journal of Palliative Nursing
https://read.qxmd.com/read/38514153/ewing-sarcoma-of-the-cervix-an-unusual-site-of-presentation
#14
JOURNAL ARTICLE
Jesús Guillermo Hernández-García, Luis José Pinto García, Osvaldo Alexis Marché Fernández, Juan Daniel Diaz-Garcia
Ewing sarcoma is an exceedingly rare form of cancer that affects the cervix. It falls within the spectrum of neoplastic diseases known as Ewing's family of tumours, typically observed in osseous tissues. A woman in her 40s, experiencing symptoms of leucorrhoea and transvaginal bleeding that commenced 3 months before her consultation, was referred to our gynaecological oncology clinic with a preliminary diagnosis of ovarian teratoma. A colposcopy procedure was conducted unveiling a complete loss of cervical anatomy with friable and malodorous tissue...
March 21, 2024: BMJ Case Reports
https://read.qxmd.com/read/38512538/the-effectiveness-of-digital-psychosocial-interventions-on-psychological-distress-depression-anxiety-and-health-related-quality-of-life-in-patients-with-gynaecological-cancer-a-systematic-review-and-meta-analysis
#15
REVIEW
Kai Yoong Yen, Jing Ying Cheng, Jin-Qiu Li, Zheng An Toh, Hong-Gu He
PURPOSE: Patients with gynaecological cancer often experience psychological issues due to multiple stressors. Psychological disturbances have debilitating effects on patients with gynaecological cancer. In recent decades, digital psychosocial interventions have rapidly advanced and been incorporated into mental health interventions. Digital psychosocial interventions could provide patients with several benefits over traditional in-person interventions, including convenience, anonymity, flexible scheduling, and geographic mobility...
March 21, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38508606/transgastric-drainage-for-subdiaphragmatic-abscess-secondary-to-perforation-of-the-sigmoid-colon-after-cytoreductive-surgery-for-advanced-ovarian-cancer
#16
JOURNAL ARTICLE
Takuya Yokoe, Hiroshi Shiraga, Tsukasa Ikeura, Masato Kita
Drainage of subdiaphragmatic abscesses is difficult due to its anatomical location and it can result in adverse events, including organ damage and the spread of infection. In recent years, endoscopic ultrasonography (EUS) guided drainage for upper abdominal abscesses has become available. We report a case of successful infection control using this procedure for a subdiaphragmatic cyst secondary to perforation of the sigmoid colon after cytoreductive surgery for advanced ovarian cancer. A Japanese woman in her 60s underwent laparotomy for ovarian cancer, and then developed sigmoid colon perforation 6 days after surgery...
March 19, 2024: BMJ Case Reports
https://read.qxmd.com/read/38504431/establishing-the-sensitivity-and-specificity-of-the-gynaecological-cancer-distress-screen
#17
JOURNAL ARTICLE
Charrlotte Seib, Emma Harbeck, Debra Anderson, Janine Porter-Steele, Caroline Nehill, Jasotha Sanmugarajah, Lewis Perrin, Catherine Shannon, Nimithri Cabraal, Bronwyn Jennings, Geoffrey Otton, Catherine Adams, Anne Mellon, Suzanne Chambers
OBJECTIVE: Nuanced distress screening tools can help cancer care services manage specific cancer groups' concerns more efficiently. This study examines the sensitivity and specificity of a tool specifically for women with gynaecological cancers (called the Gynaecological Cancer Distress Screen or DT-Gyn). METHODS: This paper presents cross-sectional data from individuals recently treated for gynaecological cancer recruited through Australian cancer care services, partner organisations, and support/advocacy services...
March 2024: Psycho-oncology
https://read.qxmd.com/read/38490881/familial-and-social-implications-of-breast-and-gynaecological-cancer-in-kerala-india
#18
JOURNAL ARTICLE
Lorane Scaria, Saju Madavanakadu Devassy, Lynette Joubert
BACKGROUND: Due to the paucity of reliable data to determine the components of family-based comprehensive care for cancer in India, we explored the familial implications of gynaecological and breast cancer diagnosis and treatment through a mixed-method study. METHODS: The mixed method study included 130 women aged above 18 with a confirmed diagnosis of gynaecological or breast cancer recruited from three selected tertiary hospitals in Kerala, India. Information on quality of life (36-Item Short Form Survey (SF-36)), psychological distress (distress thermometer), and the familial, interpersonal, social, and community impacts of cancer (semi-structured interview guide) were elicited...
March 14, 2024: Current Problems in Cancer
https://read.qxmd.com/read/38490713/imaging-findings-of-granulosa-cell-tumour-of-right-ovary-with-rupture-and-torsion-presenting-as-acute-abdomen
#19
JOURNAL ARTICLE
Deepthi Arun Kumar, Senthil Kumar Aiyappan
No abstract text is available yet for this article.
March 15, 2024: BMJ Case Reports
https://read.qxmd.com/read/38485235/lenvatinib-plus-pembrolizumab-in-the-patients-with-advanced-previously-treated-endometrial-cancer-a-cost-effectiveness-analysis-in-the-united-states-and-in-china
#20
JOURNAL ARTICLE
Xiaodong Liao, Yajing Wu, Dong Lin, Dian Gu, Shaohong Luo, Xiaoting Huang, Xiongwei Xu, Xiuhua Weng, Shen Lin
PURPOSE: To investigate the cost-effectiveness of lenvatinib plus pembrolizumab (LP) compared to chemotherapy as a second-line treatment for advanced endometrial cancer (EC) from the United States and Chinese payers' perspective. METHODS: In this economic evaluation, a partitioned survival model was constructed from the perspective of the United States and Chinese payers. The survival data were derived from the clinical trial (309-KEYNOTE-775), while costs and utility values were sourced from databases and published literature...
March 14, 2024: Journal of Obstetrics and Gynaecology Research
keyword
keyword
108776
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.