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Cancer AND FDG

Anwin Joseph Kavanal, Joyita Bharati, Shelvin Kumar Vadi, Krishan Lal Gupta, Rajender Kumar, Bhagwant Rai Mittal
We present a case of a 22-year-old man with history of allogenic renal transplantation on immunosuppression, who underwent F-FDG-PET/CT to characterize a lesion in the transplanted kidney on ultrasonogram and contrast-enhanced computed tomography imaging. PET/CT revealed FDG avid lesion in the transplanted kidney and mural thickening involving the distal ileum, ileocecal junction, and ileocolic lymph nodes. Subsequent histopathological examination from the renal lesion revealed renal cell carcinoma in the transplanted kidney...
February 8, 2019: Clinical Nuclear Medicine
Mischa de Ridder, Zeno A R Gouw, Arash Navran, Olga Hamming-Vrieze, Bas Jasperse, Michiel W M van den Brekel, Wouter V Vogel, A Al-Mamgani
PURPOSE: Early detection of residual disease (RD) after (chemo)radiation for oropharyngeal (OPC) is crucial. Surveillance of neck nodes with FDG-PET/CT has been studied extensively, whereas its value for local RD remains less clear. We aim to evaluate the diagnostic value of post-treatment FDG-PET/CT in detecting local RD and the outcome of patients with local RD. METHODS: A cohort (n = 352) of consecutively treated OPC patients at our institute between 2010 and 2017 was evaluated...
February 13, 2019: European Archives of Oto-rhino-laryngology
Hye Lim Park, Ie Ryung Yoo, Sun Ha Boo, Sonya Youngju Park, Jae Kil Park, Sook Whan Sung, Seok Whan Moon
PURPOSE: To evaluate the prognostic value of FDG PET/CT metabolic parameter compared to clinico-pathological risk factors in surgical margin-negative stage IA non-small cell lung cancer (NSCLC) patients. METHODS: 167 patients with consecutive FDG PET/CT scans from 2009 to 2015 performed for staging of NSCLC stage IA with plans for curative surgery were retrospectively reviewed. Maximum standardized uptake value (SUVmax) of primary tumor and mean SUV of liver were acquired from PET/CT...
February 13, 2019: Journal of Cancer Research and Clinical Oncology
Liza Lindenberg, Esther Mena, Peter L Choyke, Kirsten Bouchelouche
PURPOSE OF REVIEW: Worldwide, over 400 000 new cases of kidney cancer were diagnosed and over 175 000 deaths anticipated in 2018. It is ranked as the 14th most common cancer in women and 9th most common in men. Imaging is important for initial detection, staging, and monitoring to assist treatment planning, but conventional anatomic imaging is limited. Although functional PET/CT has proven helpful in the diagnosis and management of many cancers, its value in renal cell carcinoma (RCC) is still in evolution...
February 11, 2019: Current Opinion in Oncology
Hitoshi Dejima, Hiroaki Kuroda, Yuko Oya, Noriaki Sakakura, Yoshitaka Inaba, Tsuneo Tamaki, Yasushi Yatabe, Yukinori Sakao
Background: Volumetric parameters based on 3-dimensional reconstruction have recently been introduced for cancer staging. We aimed to improve the ability to diagnose hilar lymph node metastasis in patients with non-small cell lung cancer. Methods: We evaluated 142 patients with non-small cell lung cancer who underwent right upper lobectomy and radical lymph node dissection. Metastatic involvement of right upper lobar lymph nodes was assessed using high-resolution computed tomography (HRCT) and 18F-2-floro-2-deoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT)...
December 2018: Journal of Thoracic Disease
Pierpaolo Trimboli, Arnoldo Piccardo, Maria Alevizaki, Camilla Virili, Mehrdad Naseri, Simona Sola, Gaetano Paone, Gilles Russ, Luca Giovanella
BACKGROUND: Several ultrasound (US) risk stratification systems have been proposed for the assessment of thyroid nodules, and their performance was shown as good. However, the rate of nodules assessed at intermediate risk is not negligible and whether they should be submitted or not to further examination is still under debate. The present study aimed to evaluate the reliability of 18 F-FDG PET/CT in stratifying the risk of malignancy in these lesions. METHODS: Two institutions participated to this retrospective study in which a dedicated 18 F-FDG PET/CT was proposed to patients having a thyroid nodule with US assessment of EU-TIRADS 4 or 5...
February 11, 2019: Clinical Endocrinology
Alexander Lin, Sirui Ma, Farrokh Dehdashti, Stephanie Markovina, Julie Schwarz, Barry Siegel, Matthew Powell, Perry Grigsby
OBJECTIVE: The detection of distant metastatic disease in cervical cancer patients at diagnosis is critical in accurate prognostication and directing treatment strategies. This study describes the frequency and sites of distant metastatic disease at diagnosis in patients with cervical cancer as detected by positron emission tomography with 18 F-fluorodeoxyglucose (FDG-PET). METHODS: Patients with newly diagnosed cervical cancer underwent pre-treatment whole-body FDG-PET starting in 1997 at an academic institution...
February 9, 2019: International Journal of Gynecological Cancer
Carlotta Dolci, Chiara Spadavecchia, Cinzia Crivellaro, Elena De Ponti, Sergio Todde, Sabrina Morzenti, Elia Anna Turolla, Andrea Crespi, Luca Guerra, Claudio Landoni
PURPOSE: To investigate influences of reconstruction algorithms and count statistics variation on quantification and treatment response assessment in cancer patients, by using a large field of view-FOV scanner. METHODS: 54 cancer patients underwent PET/CT scan: 1) at baseline: 1.5 min/FOV, reconstructed by ordered-subset expectation maximization + point-spread-function-OSEM-PSF and bayesian penalised-likelihood-BPL algorithm 2) at restaging: 2 min/FOV, reconstructed also at 1...
January 2019: Physica Medica: PM
David A Pattison, Lisa L MacFarlane, Jason Callahan, Emma L Kane, Timothy Akhurst, Rodney J Hicks
BACKGROUND: Hyperglycaemia can influence 18 F-fluorodeoxyglucose (FDG) uptake due to competition for glucose transport and phosphorylation by hexokinase. Major international nuclear medicine societies recommend blood glucose level (BGL) < 11.1 mmol/L (200 mg/dL) prior to performing FDG positron emission tomography/computed tomography (PET/CT). However, there is no consensus approach and complications of previously proposed insulin guidelines included significant hypoglycaemia, inconvenience and skeletal muscle uptake...
February 8, 2019: EJNMMI Research
Guilherme D Kolinger, David Vállez García, Gerbrand M Kramer, Virginie Frings, Egbert F Smit, Adrianus J de Langen, Rudi A J O Dierckx, Otto S Hoekstra, Ronald Boellaard
BACKGROUND: Total metabolic active tumour volume (TMATV) and total tumour burden (TTB) are increasingly studied as prognostic and predictive factors in non-small cell lung cancer (NSCLC) patients. In this study, we investigated the repeatability of TMATV and TTB as function of uptake interval, positron emission tomography/computed tomography (PET/CT) image reconstruction settings, and lesion delineation method. We used six lesion delineation methods, four direct PET image-derived delineations and two based on a majority vote approach, i...
February 7, 2019: EJNMMI Research
Tyler J Fraum, Kathryn J Fowler, John P Crandall, Richard A Laforest, Amber Salter, Hongyu An, Michael A Jacobs, Perry W Grigsby, Farrokh Dehdashti, Richard L Wahl
Background: Knowledge of the within-subject variability of 18 F-FDG-PET/MRI measurements is necessary for proper interpretation of quantitative PET or MRI metrics in the context of therapeutic efficacy assessments with integrated PET/MRI scanners. The goal of this study was to determine the test-retest repeatability of these metrics on PET/MRI, with comparison to similar metrics acquired by PET/CT. Methods: This prospective study enrolled patients with pathology-proven pelvic malignancies. Baseline imaging consisted of PET/CT immediately followed by PET/MRI, utilizing a single 370 MBq 18 F-FDG dose...
February 7, 2019: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Vivek Subbiah, Peter Meade Anderson, Kalevi Kairemo, Kenneth R Hess, Winston W Huh, Vinod Ravi, Najat C Daw, Neeta Somaiah, Joseph A Ludwig, Robert S Benjamin, Sant P Chawla, David S Hong, Funda Meric-Bernstam, Gregory Ravizzini, Eugenie S Kleinerman, Homer A Macapinlac, Eric M Rohren
PURPOSE: The prognosis of metastatic osteosarcoma continues to be poor. We hypothesized that alpha-emitting, bone-targeting radium 223 dichloride (223 RaCl2 ) can be safely administered to patients with osteosarcoma and that early signals of response or resistance can be assessed by quantitative and qualitative correlative imaging studies and biomarkers. EXPERIMENTAL DESIGN: A 3+3 phase I, dose-escalation trial of 223 RaCl2 (50, 75, and 100 kBq/kg) was designed in recurrent/metastatic osteosarcoma patients aged ≥15 years...
February 7, 2019: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Timothy H Witney, David Y Lewis
Positron emission tomography (PET) enables the noninvasive spatiotemporal analysis of cancer metabolism in vivo. Both natural and nonnatural PET tracers have been developed to assess metabolic pathways during tumorigenesis, cancer progression, and metastasis. Here we describe the dynamic in vivo PET/CT imaging of the glucose analogue [18 F]fluoro-2-deoxy-D-glucose (FDG), taking into consideration the methodology for alternative metabolic PET substrates.
2019: Methods in Molecular Biology
Robert M Hoffman
The general cancer-specific metabolic defect of methionine (MET) dependence is due to MET overuse for aberrant transmethylation reactions. The excess use of MET for aberrant transmethylation reactions apparently diverts methyl groups from DNA. The resulting global DNA hypomethylation is also a general phenomenon in cancer and leads to unstable genomes and aneuploid karyotypes. The excessive and aberrant use of MET in cancer is readily observed in [11 C]-MET-PET imaging, where high uptake of [11 C]-MET results in a very strong and selective tumor signal compared to normal tissue background for brain cancer and possibly other cancers...
2019: Methods in Molecular Biology
Robert M Hoffman
Methionine (MET) dependence is a cancer-specific metabolic abnormality that is due to MET overuse for aberrant transmethylation reactions. [11 C]-MET is very useful for positron-emission tomography (PET) due to MET overuse in malignant tumors. Many benefits of MET-PET have been demonstrated. MET-PET can differentiate recurrent glioma and necrosis. [11 C]-MET-PET can also predict prognosis in gliomas better than [18 F]-FDG PET. [11 C]-MET-PET is better than MRI for predicting survival in low-grade glioma (LGG)...
2019: Methods in Molecular Biology
Ruchi Roy, Eun-Ryeong Hahm, Alexander G White, Carolyn J Anderson, Shivendra V Singh
The overall promise of breast cancer chemoprevention is exemplified by clinical success of selective estrogen receptor modulators and aromatase inhibitors. Despite clinical efficacy, these interventions have limitations, including rare but serious side effects and lack of activity against estrogen receptor-negative breast cancers. We have shown previously that dietary administration of benzyl isothiocyanate (BITC), which occurs naturally as a thioglucoside conjugate in edible cruciferous vegetables, inhibits development of estrogen receptor-negative breast cancer in mouse mammary tumor virus-neu (MMTV-neu) transgenic mice...
February 5, 2019: Molecular Carcinogenesis
Mi Jeong Kim, Chul-Hee Lee, Youngeun Lee, Hyewon Youn, Keon Wook Kang, JoonHo Kwon, Abass Alavi, Sean Carlin, Gi Jeong Cheon, June-Key Chung
PURPOSE: 2-Deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) accumulation in inflammatory lesions can confound the diagnosis of cancer. In this study, we investigated [18 F]FDG accumulation and efflux in relation to the genes and proteins involved in glucose metabolism in murine inflammation and cancer models. PROCEDURES: [18 F]FDG accumulation and [18 F]FDG efflux were measured in cancer cells (breast cancer, glioma, thyroid cancer, and hepatoma cells) and RAW 264.7 cells (macrophages) activated with lipopolysaccharide (LPS)...
February 4, 2019: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Jahae Kim, Sang-Geon Cho, Sae-Ryung Kang, Su Woong Yoo, Seong Young Kwon, Jung-Joon Min, Hee-Seung Bom, Ho-Chun Song
BACKGROUND: The aim of this study was to investigate changes in myocardial uptake evaluated by oncologic 18 F-fluorodeoxyglucose (FDG) PET/CT scans and to determine the relationship between myocardial FDG uptake and cancer therapy-induced cardiotoxicity in breast cancer patients who underwent anthracycline or trastuzumab. METHODS: We reviewed 121 consecutive patients who underwent oncologic FDG PET/CT and echocardiography at baseline and post-therapy with anthracyclines or trastuzumab for breast cancer...
February 4, 2019: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Sang Yoon Kim, Chang Mo Moon, Hai-Jeon Yoon, Bom Sahn Kim, Ji Young Lim, Tae Oh Kim, A Reum Choe, Chung Hyun Tae, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim, Sung-Ae Jung
This study aimed to investigate the correlations between diffuse splenic Fluorine-18-fluorodeoxyglucose (18 F-FDG) uptake on positron emission tomography/computed tomography (PET/CT) and inflammatory markers and to evaluate the prognostic significance of splenic FDG uptake in rectal cancer patients who underwent curative surgery. We retrospectively analyzed the data from 161 patients who underwent splenic FDG PET/CT staging and subsequent curative surgical resection of rectal cancer between July 2006 and September 2014...
February 4, 2019: Scientific Reports
Prasanna Santhanam, Paul W Ladenson
Serum thyroglobulin monitoring along with anatomic and functional imaging play key roles in the surveillance of patients with differentiated thyroid cancer after initial treatment. Among patients with a disease stage justifying thyroid remnant ablation or with suspected metastatic disease, radioiodine whole-body scans are essential in the months after surgery. For patients with low to moderate-risk cancers, ultrasonography of the neck (with measurement of serum thyroglobulin on thyroid hormone replacement) are the best initial diagnostic modalities, and are often the only tests required...
March 2019: Endocrinology and Metabolism Clinics of North America
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