keyword
https://read.qxmd.com/read/38393023/identification-of-mortalin-as-the-main-interactor-of-mycalin-a-a-poly-brominated-c-15-acetogenin-sponge-metabolite-by-ms-based-proteomics
#1
JOURNAL ARTICLE
Elva Morretta, Alessandra Capuano, Gilda D'Urso, Antonia Voli, Matteo Mozzicafreddo, Sonia Di Gaetano, Domenica Capasso, Marina Sala, Maria Carmina Scala, Pietro Campiglia, Vincenzo Piccialli, Agostino Casapullo
Mycalin A (MA) is a polybrominated C-15 acetogenin isolated from the marine sponge Mycale rotalis . Since this substance displays a strong antiproliferative bioactivity towards some tumour cells, we have now directed our studies towards the elucidation of the MA interactome through functional proteomic approaches, (DARTS and t-LIP-MS). DARTS experiments were performed on Hela cell lysates with the purpose of identifying MA main target protein(s); t-LiP-MS was then applied for an in-depth investigation of the MA-target protein interaction...
January 23, 2024: Marine Drugs
https://read.qxmd.com/read/38339324/laherradurin-inhibits-tumor-growth-in-an-azoxymethane-dextran-sulfate-sodium-colorectal-cancer-model-in-vivo
#2
JOURNAL ARTICLE
Michael Joshue Rendón-Barrón, Eduardo Pérez-Arteaga, Izamary Delgado-Waldo, Jossimar Coronel-Hernández, Carlos Pérez-Plasencia, Frida Rodríguez-Izquierdo, Rosa Linares, Alma Rosa González-Esquinca, Isela Álvarez-González, Eduardo Madrigal-Bujaidar, Nadia Judith Jacobo-Herrera
Colorectal cancer (CRC) is the third most common neoplasia in the world. Its mortality rate is high due to the lack of specific and effective treatments, metastasis, and resistance to chemotherapy, among other factors. The natural products in cancer are a primary source of bioactive molecules. In this research, we evaluated the antitumor activity of an acetogenin (ACG), laherradurin (LH), isolated from the Mexican medicinal plant Annona macroprophyllata Donn.Sm. in a CRC murine model. The CRC was induced by azoxymethane-dextran sulfate sodium (AOM/DSS) in Balb/c mice and treated for 21 days with LH or cisplatin...
January 29, 2024: Cancers
https://read.qxmd.com/read/38322972/silica-annona-muricata-nano-hybrid-synthesis-and-anticancer-activity-against-breast-cancer
#3
JOURNAL ARTICLE
Gopi Krishna Perinbarajan, Bruce Joshua Sinclair, Abdel-Tawab Mossa, Nupur Ohja, Peerzada Gh Jeelani
Biogenically derived silica nanoparticles may serve as a well-defined target vehicle for drug delivery and have a wide range of applications in biomedicine. Silica nanoparticles are an excellent candidate as drug carriers due to their mesoporous structure, high drug loading capacity, low toxicity, environmental friendliness and low economic synthesis procedures. In this study, nano structured silica was extracted from sugarcane bagasse through an alkali leaching extraction and conjugated with A. muricata extract overcoming its poor solubility and improving its bioavailability within the host system...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38237151/acetogenins-from-the-stem-of-uvaria-rufa-and-their-cytotoxic-activity
#4
JOURNAL ARTICLE
Aleksandra Gurgul, Manead Khin, Onevilay Souliya, Kongmany Sydara, Joanna E Burdette, Jeremy J Johnson, Chun-Tao Che
Four new adjacent bis-tetrahydrofuran acetogenins, bullacin C ( 7 ), uvarirufin ( 9 ), and uvariasolins III ( 12 ) and IV ( 13 ), along with 11 known acetogenins, were isolated from the stem of Uvaria rufa . Their structures were elucidated based on spectroscopic data analysis, including 1D and 2D NMR, HRESIMS, and MALDI-MS/MS of the lithium adducts. Absolute configurations were assigned using Mosher ester analysis and ECD measurements. Uvarirufin ( 9 ) possesses a unique C-39 skeleton among acetogenins. Most tested acetogenins exhibited cytotoxicity against human cancer cell lines (HCT 116, 22Rv1, MDA-MB-435, OVCAR3)...
January 18, 2024: Journal of Natural Products
https://read.qxmd.com/read/38149859/annonaceous-acetogenins-as-promising-dna-methylation-inhibitors-to-prevent-and-treat-leukemogenesis-an-in-silico-approach
#5
JOURNAL ARTICLE
Udayadharshini Subaramaniyam, Divya Ramalingam, Ranjini Balan, Biswaranjan Paital, Pranati Sar, Nirmaladevi Ramalingam
Leukemia is a haematological malignancy affecting blood and bone marrow, ranking 10th among the other common cancers. DNA methylation is an epigenetic dysregulation that plays a critical role in leukemogenesis. DNA methyltransferases (DNMTs) such as DNMT1, DNMT3A and DNMT3B are the key enzymes catalysing DNA methylation. Inhibition of DNMT1 with secondary metabolites from medicinal plants helps reverse DNA methylation. The present study focuses on inhibiting DNMT1 protein (PDB ID: 3PTA) with annonaceous acetogenins through in-silico studies...
December 27, 2023: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38113989/overcoming-multi-drug-resistance-mediated-by-abc-transporters-by-a-novel-acetogenin-annonacin-from-annona-muricata-l
#6
JOURNAL ARTICLE
Jeevitha Priya Manoharan, Hema Palanisamy, Subramanian Vidyalakshmi
ETHNOPHARMACOLOGICAL RELEVANCE: Multi-Drug Resistance (MDR), mediated by P-glycoprotein (P-gp) is one of the barriers to successful chemotherapy in colon cancer patients. Annona muricata L. (A.muricata), commonly known as soursop/Graviola, is a medicinal plant that has been traditionally used in treating diverse diseases including cancer. Phytochemicals of A.muricata (Annonaceous Acetogenins-AGEs) have been well-reported for their anti-cancer effects on various cancers. AIM OF THE STUDY: The study aimed to examine the effect of AGEs in reversing MDR in colorectal cancer cells...
December 17, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/38093819/in-silico-studies-on-cytotoxicity-and-antitumoral-activity-of-acetogenins-from-annona-muricata-l
#7
JOURNAL ARTICLE
Houéfa Egidia Fallon Adido, Cristian Kallahan Silva Chagas, Gleison Gonçalves Ferreira, Mírian Letícia Carmo Bastos, Maria Fâni Dolabela
As life expectancy increases, the number of people affected by cancer is increasing. The available drugs still cause several adverse reactions, and it is important to look for less toxic drugs that act on resistant cancers. The present study evaluated the antitumor potential of acetogenins. Through a literature review, 44 acetogenins isolated from Annona muricata were selected and subjected to in silico studies to predict the physicochemical properties, pharmacokinetics (Preadmet and Admet lab), toxicity (Preadmet and Protox II) and molecular docking in caspase 3 (DockThor)...
2023: Frontiers in Chemistry
https://read.qxmd.com/read/37836749/-annona-cherimola-seed-extracts-trigger-an-early-apoptosis-response-and-selective-anticlonogenic-activity-against-the-human-gastric-carcinoma-cell-line-snu-1
#8
JOURNAL ARTICLE
Johan Macuer-Guzmán, Claudia Giovagnoli-Vicuña, Giuliano Bernal, Lorena Lobos-González, Erwin de la Fuente-Ortega, Michael Araya-Castillo, Cristian Ibáñez
The aim of this study was to evaluate, for the first time, the antiproliferative, apoptotic and diminishing effects of the anchored growth-independent capacity of an ethanol macerate extract from the Annona cherimola seed (EMCHS) in the human gastric cancer cell line SNU-1. The cells treated with EMCHS (20 μg/mL) significantly reduced the capacity to form clones of the tumor cell. Moreover, 50 μg/mL of EMCHS extract induced apoptosis, as was shown by the Annexin-V assay. UHPLC-MS/MS analysis detected two acetogenins ( Annonacinone and Annonacin ) in the EMCHS, which could be largely responsible for its selective antiproliferative effect...
October 2, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37440207/an-evaluation-of-the-quality-of-annona-muricata-leaf-products
#9
JOURNAL ARTICLE
Wai-Jo Jocelin Chan, Joanna E Harnett, Alexandra Meroni, Andrew J McLachlan, Jane R Hanrahan
OBJECTIVES: Annona muricata, also known as graviola, is traditionally used for the treatment of a range of disorders including cancer. Interest in A. muricata use has increased in recent years. This study investigated the quality and safety of a selection of commercially available A. muricata leaf products. METHODS: Seven commercially available products were purchased via online shopping sites. Each product was assessed for quality indicators including weight variation, quantification of the bioactive constituent annonacin, presence of annonaceous acetogenins and contaminants...
July 13, 2023: Journal of Pharmacy and Pharmacology
https://read.qxmd.com/read/37367643/in-vitro-and-in-silico-evaluation-of-red-algae-laurencia-obtusa-anticancer-activity
#10
JOURNAL ARTICLE
Jéssica Raquel Borges Monteiro, Ricardo Pereira Rodrigues, Ana Carolina Mazzuco, Rita de Cassia Ribeiro Gonçalves, Angelo Fraga Bernardino, Ricardo Machado Kuster, Rodrigo Rezende Kitagawa
Studies estimate that nearly 2 million new cases of gastric cancer will occur worldwide during the next two decades, which will increase mortality associated with cancer and the demand for new treatments. Marine algae of the Laurencia genus have secondary metabolites known for their cytotoxic action, such as terpenes and acetogenins. The species Laurencia obtusa has demonstrated cytotoxicity against many types of tumors in previous analyses. In this study, we determined the structure of terpenes, acetogenins, and one fatty acid of Laurencia using mass spectrometry (ESI-FT-ICR/MS)...
May 24, 2023: Marine Drugs
https://read.qxmd.com/read/37263318/antibiofilm-potential-of-annona-muricata-l-ethanolic-extract-against-multi-drug-resistant-candida-albicans
#11
JOURNAL ARTICLE
Lara Melo Campos, Thiago P Silva, Ari Sérgio de Oliveira Lemos, Irley Olívia Mendonça Diniz, Cinthia Palazzi, Vinícius Novaes da Rocha, Marcelo Gonzaga de Freitas Araújo, Rossana C N Melo, Rodrigo Luiz Fabri
ETNOPHARMACOLOGICAL RELEVANCE: Traditional uses of Annona muricata L. (soursop) include treatment for cancer, fungal infections, and inflammatory diseases. Its phytoconstituents, mainly acetogenins and alkaloids, are associated with therapeutic activity and clinical application is currently under investigation. However, the application of phytotherapy to treat diseases caused by fungal biofilms, such as vulvovaginal candidiasis (VVC), is still limited. AIM OF THE STUDY: To investigate the activity of the ethanolic extract of A...
May 30, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37049648/targeting-carbohydrate-mimetics-of-tetrahydrofuran-containing-acetogenins-to-prostate-cancer
#12
JOURNAL ARTICLE
Patricia Gonzalez Periche, Jacky Lin, Naga V S D K Bhupathiraju, Teja Kalidindi, Delissa S Johnson, Nagavarakishore Pillarsetty, David R Mootoo
The high potency of the tetrahydrofuran-containing acetogenins (THF-ACGs) against a broad range of human cancer cell lines has stimulated interest in structurally simpler mimetics. In this context, we have previously reported THF-ACG mimetics in which the THF and butenolide moieties of a mono-THF-ACG were replaced with carbohydrate and thiophene residues, respectively. In the present study, towards the targeting of these carbohydrate analogues to prostate cancer (PCa), we synthesized prodrugs in which a parent thiophene or butenolide congener was conjugated through a self-immolative linker to 2-[3-(1,3-dicarboxypropyl)ureido] pentanedioic acid (DUPA), a highly specific ligand for prostate-specific membrane antigen (PSMA), which is overexpressed on prostate tumors...
March 23, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36999935/retraction-notice-to-sq-2-a-biotinylated-annonaceous-acetogenin-induces-apoptosis-autophagy-and-s-phase-arrest-by-activating-the-mapk-pathway-in-breast-cancer-cells
#13
JOURNAL ARTICLE
Peiyan He, Ziyu Li, Junzhen Zhou, Jie Yang, Xiaoyi Wei, Ping Wu, Wendan Chen, Jinxia Cheng, Li Yang, Jie Tang, Qiang Li, Qing Zhang, Jianwei Jiang
No abstract text is available yet for this article.
January 25, 2023: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/36836708/-annona-muricata-comprehensive-review-on-the-ethnomedicinal-phytochemistry-and-pharmacological-aspects-focusing-on-antidiabetic-properties
#14
REVIEW
Siti Norliyana Zubaidi, Hidayah Mohd Nani, Mohd Saleh Ahmad Kamal, Taha Abdul Qayyum, Syahida Maarof, Adlin Afzan, Norazlan Mohmad Misnan, Hamizah Shahirah Hamezah, Syarul Nataqain Baharum, Ahmed Mediani
Plants have played an important role over the centuries in providing products that have been used to help combat ailments and diseases. Many products originating from fresh, dried-plant materials, or extracts are utilized as community remedies in traditional practices or even in modern medicine. The Annonaceae family contains different types of bioactive chemical properties, such as alkaloids, acetogenins, flavonoids, terpenes, and essential oil, meaning the plants in this family are potential therapeutic agents...
January 28, 2023: Life
https://read.qxmd.com/read/36762500/sq-2-a-biotinylated-annonaceous-acetogenin-induces-apoptosis-autophagy-and-s-phase-arrest-by-activating-the-mapk-pathway-in-breast-cancer-cells
#15
JOURNAL ARTICLE
Peiyan He, Ziyu Li, Junzhen Zhou, Jie Yang, Xiaoyi Wei, Ping Wu, Wendan Chen, Jinxia Cheng, Li Yang, Jie Tang, Qiang Li, Qing Zhang, Jianwei Jiang
<p indent="0mm">Squamocin, an annonaceous acetogenin isolated from plants in the <italic>Annonaceae</italic> family, has antitumour activity. In this study, we report that Sq-2, a biotinylated squamocin monomer, has a favorable antitumour effect on MDA-MB-231 and SKBR3 breast cancer cells <italic>in vitro</italic>. MTT assays show that Sq-2 has a better antitumour effect on MDA-MB-231 cells than Sq-5 and Sq-6. Furthermore, RNA-Seq and KEGG enrichment analyses reveal that Sq-2 activates the MAPK signaling pathway, and results of western blot analysis demonstrate that Sq-2 activates the JNK and p38 pathways in MDA-MB-231 and SKBR3 cells...
February 10, 2023: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/36615425/evaluation-of-genotoxicity-and-toxicity-of-annona-muricata-l-seeds-and-in-silico-studies
#16
JOURNAL ARTICLE
Gleison Gonçalves Ferreira, Ana Carolina Sousa Quaresma, Dayse Lúcia do Nascimento Brandão, Andrey Moacir do Rosario Marinho, José Edson de Sousa Siqueira, Kamila Leal Correa, José Otávio Carréra Silva-Júnior, Sandro Percario, Maria Fâni Dolabela
Cancer is a multifactorial organic dysfunction for which great efforts are being devoted in searching for new treatments and therapeutic adjuvants. Annona muricata is a fruit that has promising activity against several types of cancer, as it contains acetogenins, the metabolite group associated with this action. Thus, the objective of this study was to evaluate, in experimental models, the toxic behavior of an extract and fraction rich in acetogenins from A. muricata seeds and study the acetogenin, Annonacin, in silico...
December 27, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36500310/a-gc-ms-protocol-for-the-identification-of-polycyclic-aromatic-alkaloids-from-annonaceae
#17
JOURNAL ARTICLE
Ilya A P Jourjine, Carolin Bauernschmidt, Christoph Müller, Franz Bracher
The Annonaceae are an old family of flowering plants belonging to the order Magnoliales, distributed mainly in tropical regions. Numerous Annonaceae species find ethnobotanical use for curing a broad range of diseases, among them cancer and infections by diverse pathogens. Hence, bioactive natural products from Annonaceae have received considerable interest in drug development. Beyond cytotoxic acetogenins, unique aporphine-derived polycyclic aromatic alkaloids are characteristic constituents of Annonaceae...
November 25, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36387488/increasing-the-effect-of-annonacin-using-nanodiamonds-to-inhibit-breast-cancer-cells-growth-in-rats-rattus-norvegicus-induced-breast-cancer
#18
JOURNAL ARTICLE
Firli Rahmah Primula Dewi, Nadia Shoukat, Na'ilah Insani Alifiyah, Sri Puji Astuti Wahyuningsih, A'liyatur Rosyidah, Muhammad Darwin Prenggono, Hartono Hartono
Background: Annonaceous acetogenins have been reported to have anti-cancer properties but low viability. In this study, we aimed to investigate the potency of nanodiamonds to be employed as a carrier of annonacin to help increase its viability and inhibit the growth of breast cancer cells. Methods: The annonacin was coupled with nanodiamond and characterized using UV-Vis spectrophotometer, FTIR, SEM, and PSA, and determined their stability and drug release. A cell growth inhibition assay and cell migration assay was performed using the breast cancer MCF7 and T747D cell lines, and in vivo analysis was performed in rats ( Rattus norvegicus )...
November 2022: Heliyon
https://read.qxmd.com/read/36355526/green-biosynthesis-of-silver-nanoparticles-using-annona-glabra-and-annona-squamosa-extracts-with-antimicrobial-anticancer-apoptosis-potentials-assisted-by-in-silico-modeling-and-metabolic-profiling
#19
JOURNAL ARTICLE
Fatma A Mokhtar, Nabil M Selim, Seham S Elhawary, Soha R Abd El Hadi, Mona H Hetta, Marzough A Albalawi, Ali A Shati, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Lamiaa I Fahmy, Rana M Ibrahim
Annona glabra L. (AngTE) and Annona squamosa L. (AnsTE) fruits have been widely used in cancer treatment. Accordingly, their extracts were used to synthesize silver nanoparticles via a biogenic route (Ang-AgNPs) and (Ans-AgNPs), respectively. Chemical profiling was established using UPLC-QTOF-MS/MS. All species were tested for anticancer activity against human cervical cancer cells (HeLa), prostate adenocarcinoma metastatic (PC3), and ovary adenocarcinoma (SKOV3) using sulphorhodamine B assay. Apoptosis was determined using Annexin flow cytometry along with cell cycle analysis and supported by a molecular docking...
November 2, 2022: Pharmaceuticals
https://read.qxmd.com/read/36328525/synthesis-of-acetogenin-analogs-comprising-pyrimidine-moieties-linked-by-amine-bonds-and-their-inhibitory-activity-against-human-cancer-cell-lines
#20
JOURNAL ARTICLE
Hiroyuki Hosomi, Akinobu Akatsuka, Shingo Dan, Hiroki Iwasaki, Hisanori Nambu, Naoto Kojima
Here, we synthesized three acetogenin analogs containing pyrimidine moieties linked by amine bonds, which represent the skeleton structure of pyrimidifen, a mitochondrial complex I-inhibiting insecticide. Replacing the pyrimidine moiety linked by the amine bond remarkably enhanced growth-inhibitory activity of the analogs against several human cancer cell lines. Moreover, these analogs selectively and potently inhibited the growth of these human cancer cell lines regardless of the pyrimidine substituents. Furthermore, COMPARE analyses suggested that these analogs inhibited cancer growth by inhibiting mitochondrial complex I...
2022: Chemical & Pharmaceutical Bulletin
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