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BACKGROUND: Post-stroke depression (PSD) is one of the most prevalent emotional disorders after stroke and often results in poor outcomes. However, the underlying physiopathologic mechanism and effective treatment of PSD remain poorly elucidated. OBJECTIVE: To investigate whether paeoniflorin has antidepressant-like activity in a rat model of PSD. METHODS: Rats were randomly divided into four groups: sham-operated control (Sham), PSD, paeoniflorin (with PSD) and fluoxetine group(with PSD)...

We report the thermoelectric performance of p-type nanocrystalline SnSe obtained from the liquid phase sintering of blends of SnSe nanocrystals and Te nanorods. A cycled hot press procedure at a temperature above the Te melting point promoted the formation of crystallographically textured SnSe nanomaterials with relative densities up to 93%. After consolidation, part of this Te was found within the SnSe lattice and part remained as elemental Te between the SnSe grains. The presence of Te during the SnSe consolidation resulted in SnSe nanomaterials with higher electrical conductivities and lower Seebeck coefficients and thermal conductivities...

NEW FINDINGS: What is the central question of this study? Clinical reports have described and suggested respiratory central and peripheral abnormalities in PD patients; however, these reports have never addressed the occurrences of such abnormalities in an animal model before. PD mice has reduced NK1r-ir in the preBötC and Phox2b-expressing neurons in the RTN. PD mice has respiratory frequency and HCVR impairments. Lung collagen deposition and ribcage stiffness appear in PD mice. ABSTRACT: Parkinson's disease (PD) is a neurodegenerative motor disorder characterized by dopaminergic deficits in the brain...

Doping heteroatoms into phosphorene has attracted considerable attention due to its effectiveness in enhancing the stability and tailoring the electronic properties as well as sensing capability. In this work, we performed a density functional theory (DFT) calculation to study the effect of nonmetallic heteroatom dopants (X, X = Be, B, C, N, O, S, Se, Te, F, Cl, Br and I) on the stability and sensibility of X-doped phosphorene. We found that phosphorene structures doped with the 2nd period and VIA group atoms possess relatively high internal stability due to the effective X-P bonding...

The intake of fruit and vegetables is associated with beneficial health outcomes, and studies aimed at increasing fruit and vegetable intake lack long-term follow-up. The primary objective of this study was to evaluate the long-term (14-year) effects of a multicomponent school-based educational intervention targeted to increase fruit and vegetable intake in children. The secondary objective was to evaluate the potential synergistic effect between free school fruit and the educational program. A cluster randomized school-based intervention was initiated in 2001 in Norway, known as the Fruit and Vegetable Make the Marks study...

Tellurium (Te) is an intrinsically p-type doped narrow bandgap semiconductor with excellent electrical conductivity and low thermal conductivity. Bulk trigonal Te has been theoretically predicted and experimentally demonstrated to be an outstanding thermoelectric material with high value of thermoelectric figure-of-merit ZT. In view of the recent progress in developing synthesis route of two-dimensional (2D) tellurium thin films as well as the growing trend of exploiting nanostructures as thermoelectric devices, here for the first time we report excellent thermoelectric performance of tellurium nanofilms, with room temperature power factor of 31...

During plant vascular development, xylem tracheary elements (TEs) form water-conducting, empty pipes through genetically regulated cell death. Cell death is prevented from spreading to non-TEs by unidentified intercellular mechanisms, downstream of METACASPASE9 (MC9)-mediated regulation of autophagy in TEs. Here, we identified differentially abundant extracellular peptides in vascular-differentiating wild type and MC9-downregulated Arabidopsis cell suspensions. The peptide Kratos rescued the abnormally high ectopic non-TE death resulting from either MC9 knockout or TE-specific overexpression of the ATG5 autophagy protein during experimentally induced vascular differentiation in Arabidopsis cotyledons...

Objectives: Accurate and fast identification of carbapenemase producers is essential for optimal patient management. Here, a new lateral flow immunochromatographic RESIST-4 K-SeT assay was assessed for the detection of carbapenemases in Enterobacteriaceae and non-fermenters. Methods: The RESIST-4 K-SeT assay targets OXA-48-like, KPC, VIM and NDM, but not IMP carbapenemases. The assay was first evaluated using a collection of isolates with well-characterized resistance mechanisms to β-lactams (n = 134) and against an international external quality assessment carbapenemase panel (n = 8)...

OBJECTIVE: To explore the experiences of patients at risk for cardiovascular disease in primary care with the Activate intervention in relation to their success in increasing their physical activity. METHODS: A convergent mixed methods study was conducted, parallel to a cluster-randomised controlled trial in primary care, using a questionnaire and semi-structured interviews. Questionnaires from 67 patients were analysed, and semi-structured interviews of 22 patients were thematically analysed...

Most of the current knowledge on the genetic basis of adaptive evolution is based on the analysis of single nucleotide polymorphisms (SNPs). Despite increasing evidence for their causal role, the contribution of structural variants to adaptive evolution remains largely unexplored. In this work, we analyzed the population frequencies of 1,615 Transposable Element (TE) insertions annotated in the reference genome of Drosophila melanogaster, in 91 samples from 60 worldwide natural populations. We identified a set of 300 polymorphic TEs that are present at high population frequencies, and located in genomic regions with high recombination rate, where the efficiency of natural selection is high...

Isotopes of an element have the same electron number but differ in neutron number and atomic mass. However, due to the thickness-dependent properties in MX2 (M=Mo, W; X=S, Se, Te) transition metal dichalcogenides (TMDs), the isotopic effect in atomically-thin TMDs still remains unclear especially for phonon-assisted indirect excitonic transitions. Here, we report the first observation of the isotope effect on the electronic and vibrational properties of a TMD material, using naturally abundant NA WNA Se2 and isotopically pure bilayer 186 W80 Se2 single crystals over a temperature range of 4...

Bonding mechanisms, potential energy curves, accurate structures, energetics, and electron affinities are obtained for all M(CX)1-3 species with M = Li, Na, and X = O, S, Se, Te, and Po, at the coupled-cluster level with triple-ζ quality basis sets. We discuss and rationalize the trends within different molecular groups. For example, we found larger binding energies for M = Li, for CX = CPo, and for the tri-coordinated (n = 3) complexes. All three facts are explained by the fact that the global minimum of the titled complexes originate from the first excited 2 P (2p1 for Li or 3p1 for Na) state of the metal, with each ligand forming a dative bond with the metal...

The present study quantifies the levels of five trace elements (TEs) Zn, Cu, Ni, Pb, and Cd in the leaves and rhizomes of Cymodocea nodosa as well as the surficial sediments from three semi-enclosed coastal areas in Tunisia, in the south Mediterranean Sea. Samples were taken from the Bizerte and Ghar El Melh lagoons and from marina Cap Monastir. The TE ranking was found to be Zn > Cu > Pb > Ni > Cd in sediments and Zn > Cu = Ni = Pb = Cd in C. nodosa leaves and rhizomes...

Context: The association between adipsin and glucose metabolism in human subjects remains unclear. Objective: We investigated the associations between adipsin and insulin resistance/ β -cell function in subjects with various degrees of glucose intolerance. Design: Fasting blood samples were collected for measurements of fasting plasma glucose (FPG), insulin, and adipsin. An oral glucose tolerance test was conducted in subjects with no history of diabetes...

Noble metal nanolayers on flat substrates are often deposited with the use of semiconductor interlayers, which may strongly interact with the noble metal overlayer. We investigated the crystallinity, atomic concentration profile and optical parameters of ≈35 nm-thick silver and gold layers deposited on glass substrates with 2 nm-thick tellurium or selenium interlayers. Our study, based on X-ray reflectometry (XRR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and ellipsometric measurements, showed that using either of these interlayers introduces strain in nanocrystals of both plasmonic films...

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The bifunctional drug delivery system combining magnetic nanoparticles and fluorophore possesses the characterization of magnetism and fluorescence. However, the accurate tracing of the drug release and diffusion pathway is affected by the separation of drug and fluorescent molecule. In this paper, we synthesized the fluorescent-labeling drug by covalently binding Aspirin with rare earth ions Terbium (Te) and Gadolinium (Gd), which was incorporated into chitosan microspheres with magnetic nanoparticles Fe₃O₄ to prepare magnetic and fluorescent drug delivery system...

PURPOSE: The purpose of this study was to retrospectively compare the technical success and reliability of the measurements made using two 2-dimensional (2D) shear wave elastography (SWE) systems using the comb-push technique from the same manufacturer and to assess the intersystem reproducibility of the resultant liver stiffness (LS) measurements. METHODS: Ninety-four patients with suspected chronic liver diseases were included in this retrospective study. LS measurements were obtained using two 2D-SWE systems (LOGIQ E9 and LOGIQ S8) from the same manufacturer, with transient elastography (TE) serving as the reference standard, on the same day...

The UV-filter benzophenone-3 (BP-3) is widely used and is environmentally stable, lipophilic, and bioaccumulative. Previous in vitro and in vivo studies have shown that BP-3 can cause endocrine disrupting effects. However, little information is available on its ecotoxicity on coral reef fish. Agonistic behavior, which is regulated by the endocrine system, is crucial to the social structure of some coral reef fish species. Endocrine disruptors may disturb fish agonistic behavior and social interactions. In this study, we tested whether chronic BP-3 exposure can affect social behaviors in coral reef fish...

The repeatability or predictability of evolution is a central question in evolutionary biology and most often addressed in experimental evolution studies. Here, we infer how genetically heterogeneous natural systems acquire the same molecular changes to address how genomic background affects adaptation in natural populations. In particular, we take advantage of independently formed neo-sex chromosomes in Drosophila species that have evolved dosage compensation by co-opting the dosage-compensation male-specific lethal (MSL) complex to study the mutational paths that have led to the acquisition of hundreds of novel binding sites for the MSL complex in different species...