A R Almeida-Oliveira, Jcj Aquino-Junior, A Abbasi, A Santos-Dias, M C Oliveira-Junior, R W Alberca-Custodio, N C Rigonato-Oliveira, L P Salles-Dias, N R Damaceno-Rodrigues, E G Caldini, F M Arantes-Costa, A P Ligeiro-Oliveira, M G Belvisi, R P Vieira
BACKGROUND: Aerobic training (AT) decreases airway inflammation in asthma, but the underlying cellular and molecular mechanisms are not completely understood. Thus, this study evaluated the participation of SOCS-JAK-STAT signaling in the effects of AT on airway inflammation, remodeling and hyperresponsiveness in a model of allergic airway inflammation. METHODS: C57Bl/6 mice were divided into Control (Co), Exercise (Ex), HDM (HDM), and HDM+Exercise (HDM+ Ex). Dermatophagoides pteronyssinus (100ug/mouse) were administered oro-tracheally on days 0, 7, 14, 21, 28, 35, 42 and 49...
2019: Exercise Immunology Review