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Gastric conditioning

Takashi Takenoya, Nobushige Yabe, Shiho Morishige, Eri Tamura, Yuri Sakimoto, Yuki Tajima, Ippei Oto, Takahisa Yoshikawa, Koji Osumi, Shinji Murai
A man in the 60s visited our hospital with the complaints of epigastralgia and weight loss. Following an investigation, he was diagnosed with human epidermal growth factor receptor 2(HER2)-positive gastric cancer with invasion to the pancreas (T4b[pancreas], N2, M0, Stage ⅣA[Union for International Cancer Control 8th edition]). Preoperatively, he was administered a chemotherapeutic regimen of S-1 and cisplatin plus trastuzumab. After 2 courses of chemotherapy, computed tomography revealed invasion to the abdominal wall and pyloric stenosis; however, invasion to the pancreas was obscured, and the lymph node metastases had shrunk...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Jong-Il Shin, Yong-Joon Jeon, Sol Lee, Yoon Gyeong Lee, Ji Beom Kim, Kyungho Lee
The omega-3 fatty acid docosahexaenoic acid (DHA) is known to induce apoptosis and cell cycle arrest via the induction of reactive oxygen species (ROS) production and endoplasmic reticulum (ER) stress in many types of cancers. However, the roles of DHA in drug-resistant cancer cells have not been elucidated. In this study, we investigated the effects of DHA in cisplatin-resistant gastric cancer SNU-601/cis2 cells. DHA was found to induce ROS-dependent apoptosis in these cells. The inositol 1,4,5-triphosphate receptor (IP3R) blocker 2-aminoethyl diphenylboninate (2-APB) reduced DHA-induced ROS production, consequently reducing apoptosis...
November 27, 2019: Molecules and Cells
M Mauro, R A De Grandis, M L De Campos, A Bauermeister, R G Peccinini, F R Pavan, N P Lopes, N V De Moraes
ETHNOPHARMACOLOGICAL RELEVANCE: Copaiba oleoresin has been used in folk medicine in the treatment of bronchitis, syphilis, skin diseases and ulcers due to its anti-inflammatory and antiseptic activities, but there is no information about major compounds oral absorption to support the traditional use. AIM OF STUDY: Considering the potential of copalic (CA) and kaurenoic acid (KA) - major biological activity (in vitro) diterpenes found in the oleoresin, this study aimed to evaluate the intestinal permeability of CA and KA using Caco-2 cells model as predictive test for oral drug absorption...
February 11, 2019: Journal of Ethnopharmacology
Grace Lai-Hung Wong, Andy Jinhua Ma, Huiqi Deng, Jessica Yuet-Ling Ching, Vincent Wai-Sun Wong, Yee-Kit Tse, Terry Cheuk-Fung Yip, Louis Ho-Shing Lau, Henry Hin-Wai Liu, Chi-Man Leung, Steven Woon-Choy Tsang, Chun-Wing Chan, James Yun-Wong Lau, Pong-Chi Yuen, Francis Ka-Leung Chan
BACKGROUND: Patients with a history of Helicobacter pylori-negative idiopathic bleeding ulcers have an increased risk of recurring ulcer complications. AIM: To build a machine learning model to identify patients at high risk for recurrent ulcer bleeding. METHODS: Data from a retrospective cohort of 22 854 patients (training cohort) diagnosed with peptic ulcer disease in 2007-2016 were analysed to build a model (IPU-ML) to predict recurrent ulcer bleeding...
February 13, 2019: Alimentary Pharmacology & Therapeutics
Chiau Ming Long, Kin Tang, Hitesh Chokshi, Nikoletta Fotaki
The aim of this study is to investigate the dissolution properties of poorly soluble drugs from their pure form and their amorphous formulation under physiological relevant conditions for oral administration based on surface dissolution ultraviolet (UV) imaging. Dissolution of two poorly soluble drugs (cefuroxime axetil and itraconazole) and their amorphous formulations (Zinnat® and Sporanox® ) was studied with the Sirius Surface Dissolution Imager (SDI). Media simulating the fasted state conditions (compendial and biorelevant) with sequential media/flow rate change were used...
February 13, 2019: AAPS PharmSciTech
Zlatan Zvizdic, Asmir Jonuzi, Aleksandra Djuran, Semir Vranic
Gastric necrosis with perforation is a rare and potentially life-threatening condition in childhood beyond the neonatal period. We report a case of gastric necrosis and perforation of a portion of the great curvature due to a massive gastric dilatation caused by pathological aerophagia in a 13-years-old, mentally impaired adolescent girl. Despite the successful surgical treatment, the patient's condition rapidly deteriorated post-operatively and she died due to the multisystem organ failure and multiple infections...
2019: Frontiers in Surgery
Esra Acar Soykut, Emine Kübra Tayyarcan, Şefika Evran, İsmail Hakkı Boyacı, İbrahim Çakır, Maha Khaaladi, Sami Fattouch
Nowadays, phage therapy emerges as one of the alternative solutions to the problems arising from antibiotic resistance in pathogenic bacteria. Although phage therapy has been successfully applied both in vitro and in vivo, one of the biggest concerns in this regard is the stability of phages in body environment. Within the scope of this study, microencapsulation technology was used to increase the resistance of phages to physiological conditions, and the resulting microcapsules were tested in environments simulating body conditions...
February 12, 2019: Folia Microbiologica
Minah Kim, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Background: Compared to the general population, patients with end-stage renal disease have more gastrointestinal symptoms and a higher prevalence of peptic ulcer. Risk factors for peptic ulcer disease in patients with end-stage renal disease, however, remain poorly defined. This study aims to better identify those risk factors. Methods: We analyzed 577 patients with end-stage renal disease from 2004 to 2016. We excluded patients with life-threatening conditions...
February 12, 2019: Kidney Research and Clinical Practice
Asahi Hishida, Tomotaka Ugai, Ryosuke Fujii, Masahiro Nakatochi, Michael C Wu, Hidemi Ito, Isao Oze, Tajika Masahiro, Niwa Yasumasa, Takeshi Nishiyama, Hiroko Nakagawa-Senda, Sadao Suzuki, Teruhide Koyama, Daisuke Matsui, Yoshiyuki Watanabe, Takahisa Kawaguchi, Fumihiko Matsuda, Yukihide Momozawa, Michiaki Kubo, Mariko Naito, Keitaro Matsuo, Kenji Wakai
Although recent genome-wide association studies (GWASs) have identified genetic variants associated with Helicobacter pylori (HP)-induced gastric cancer, few studies have examined the genetic traits associated with the risk of HP-induced gastric precancerous conditions. This study aimed to elucidate genetic variants associated with these conditions using a genome-wide approach. Data from four sites of the J-MICC Study were used in the discovery phase (Stage I); two datasets from the HERPACC2 Study were used in the replication phases (Stages II and III), and SKAT (SNP-set Kernel Association Test) and single variant-based GWASs were conducted for the risks of gastric atrophy (GA) and severe GA defined by serum pepsinogen (PG) levels, and PG1 and PG1/2 ratios...
February 8, 2019: Carcinogenesis
Sampsa Pikkarainen, Timi Martelius, Ari Ristimäki, Sanna Siitonen, Mikko R J Seppänen, Martti Färkkilä
OBJECTIVES: Common variable immunodeficiency (CVID) is associated with a spectrum of autoimmune complications. We studied the prevalence of gastrointestinal (GI) manifestations and infections in patients with CVID. METHODS: Complete clinical data of 132 Finnish patients with CVID (106 probable and 26 possible CVID) followed up between 2007 and 2016 were collected to a structured database. Data on endoscopies, histology, and laboratory studies were retrieved from patient files...
February 8, 2019: American Journal of Gastroenterology
Luís Eduardo S Fontes, Ana Luiza C Martimbianco, Carolina Zanin, Rachel Riera
BACKGROUND: Helicobacter pylori (H pylori) is one of the most common pathogens to establish and cause infection in human beings, affecting about 50% of the world's population. Prevalence may be as high as 83% in Latin American countries and as low as 17% in North America. Approximately 20% of infected people will manifest disease; people at high risk include those who live in low- and middle-income countries with poor sanitary conditions, since the mechanism of transmission seems to be oral-oral or faecal-oral (mostly during infancy)...
February 12, 2019: Cochrane Database of Systematic Reviews
Paul Sayad, Audrey Zhen Tan
INTRODUCTION: An inguinoscrotal hernia is defined as giant if descending below the midpoint of the inner thigh of a patient in upright position. It is an uncommon condition and rarely encountered in clinical practice that can lead to severe complications such as gastric perforation. PRESENTATION OF CASE: We present a case of a 50-year old male suffering from a gastric perforation in a giant inguinoscrotal hernia that was managed in a two-step approach. DISCUSSION: In our patient, we opted for a two-step approach...
February 1, 2019: International Journal of Surgery Case Reports
Umair Ahmad, Muhammad Sohail, Mahmood Ahmad, Muhammad Usman Minhas, Shahzeb Khan, Zahid Hussain, Mubeen Kousar, Sabeeh Mohsin, Mudassir Abbasi, Syed Ahmed Shah, Haroon Rashid
Oral drug delivery is natural, most acceptable and desirable route for nearly all drugs, but many drugs like NSAIDs when delivered by this route cause gastrointestinal irritation, gastric bleeding, ulcers, and many undesirable effects which limits their usage by oral delivery. Moreover, it is almost impossible to control the release of a drug in a targeted location in body. We developed thermo-responsive chitosan-co-poly(N-isopropyl-acrylamide) injectable hydrogel as an alternative for the gastro-protective and controlled delivery of loxoprofen sodium as a model drug...
February 6, 2019: International Journal of Biological Macromolecules
Lisa Freerks, Eleni Papadatou Soulou, Hannah Batchelor, Sandra Klein
Accurate prediction of oral absorption of drugs relies on biorelevant methodology. Current methods are based on Western healthy adult populations. Malnourished children have many differences in their gastrointestinal anatomy and physiology compared to a healthy Western adult. These differences may affect the oral absorption of medicines and it is important to gather knowledge on these GI differences in order to develop biorelevant predictive methods for this vulnerable population. A literature search was conducted within PubMed and Scopus to identify papers that describe how gastrointestinal physiology and anatomy is altered in malnourished children...
February 5, 2019: European Journal of Pharmaceutics and Biopharmaceutics
Vanesa Andreu, Ane Larrea, Pablo Rodriguez-Fernandez, Salvador Alfaro, Begoña Gracia, Ainhoa Lucía, Laura Usón, Andromeda-Celeste Gomez, Gracia Mendoza, Alicia Lacoma, Jose Dominguez, Cristina Prat, Victor Sebastian, José Antonio Ainsa, Manuel Arruebo
AIM: Production of Matryoshka-type gastroresistant microparticles containing antibiotic-loaded poly lactic-co-glycolic acid (PLGA) nanoparticles (NP) against Mycobacterium tuberculosis. MATERIALS & METHODS: The emulsification and evaporation methods were followed for the synthesis of PLGA-NPs and methacrylic acid-ethyl acrylate-based coatings to protect rifampicin from degradation under simulated gastric conditions. RESULTS & CONCLUSION: The inner antibiotic-loaded NPs here reported can be released under simulated intestinal conditions whereas their coating protects them from degradation under simulated gastric conditions...
February 8, 2019: Nanomedicine
Matthew R Krafft, John Y Nasr
The advancement of pancreatic endotherapy has increased the availability of minimally invasive endoscopic pancreatic ductal drainage techniques. In this regard, familiarity with endoscopic ultrasound-guided pancreatic duct drainage (EUS-PDD) is critical for treatment of obstructed pancreatic ductal systems, especially in nonsurgical candidates and in patients desiring a minimally invasive approach. Two distinct forms of EUS-PDD exist, viz. rendezvous-assisted endoscopic retrograde pancreatography (rendezvous-assisted ERP) and anterograde EUS-PDD...
February 7, 2019: Digestive Diseases and Sciences
Vincent Varlet, S Iwersen-Bergmann, M Alexandre, O Cordes, C Wunder, F Holz, H Andresen-Streichert, F Bevalot, V Dumestre-Toulet, S Malbranque, T Fracasso, S Grabherr
An increasing number of suicidal asphyxiation with a plastic bag with inert gases, and in particular helium (He), have been reported from numerous countries over the last decade. These cases are differently managed and lead to different and variable interpretations. Based on the 12 last cases analysed in the laboratory and on the review of the most recent literature about this topic, updated autopsy guidelines for sampling have been proposed regarding to the samples choice and analytical challenges required by the gaseous state of this substance...
February 7, 2019: International Journal of Legal Medicine
Yu-Ju Lin, Jo Anne Shatkin, Fanbin Kong
The mucoadhesive properties of three types of nanocellulose (CNF, CNC, and Tempo-CNF) was investigated in the digestive condition with ex vivo and in vitro assays. In the ex vivo flow-through method, three nanocellulose materials showed different levels of retention on porcine gastric and intestinal mucosal surfaces. Fluorescence microscopy confirmed that retention of CNF could be due to entanglement with the mucosal layer, while retention of Tempo-CNF could be due to instantaneous gelling on the mucosal surface...
April 15, 2019: Carbohydrate Polymers
Mohit Bhandari, Winni Mathur, Mathias Fobi, Susmit Kosta
BACKGROUND: Obesity is an epidemic with an increasing incidence in geriatric individuals also. The aim of the present study is to determine the outcomes in geriatric patients ≥ 65 years, who underwent Bariatric Surgery. MATERIAL AND METHODS: A retrospective review was performed of prospectively collected data on geriatric patients (age 65 to 80 years) who had undergone bariatric surgery at a single institution from Jan. 2010 to Dec. 2013. A cohort of adult patients (age 17 to 64 years) were matched for comparative evaluation who also underwent bariatric surgery in the same period...
February 5, 2019: Obesity Surgery
Xuan-Zhang Huang, Yu-Chong Yang, You Chen, Cong-Cong Wu, Rui-Fang Lin, Zhen-Ning Wang, Xi Zhang
Background: The prognostic value of preoperative anemia in gastric cancer remains unclear. Therefore, the purpose of the present study is to evaluate the prognostic value of preoperative anemia in gastric cancer. Methods: We searched Embase and PubMed databases for relevant studies from inception to March 2018. The prognostic value of preoperative anemia in gastric cancer was determined by calculating the hazard ratio (HR) and the corresponding 95% confidence interval (CI) as effect measures...
2019: Disease Markers
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