Naz Karadag, Espen Hagen, Alexey A Shadrin, Dennis Van Der Meer, Kevin S O'Connell, Zillur Rahman, Gleda Kutrolli, Nadine Parker, Shahram Bahrami, Vera Fominykh, Kjell Heuser, Erik Tauboll, Torill Ueland, Nils Eiel Steen, Srdjan Djurovic, Anders M Dale, Oleksandr Frei, Ole A Andreassen, Olav B Smeland
Objective: Cognitive impairment is prevalent among individuals with epilepsy, and it is possible that genetic factors can underlie this relationship. Here, we investigated the potential shared genetic basis of common epilepsies and general cognitive ability (COG). Methods: We applied linkage disequilibrium score (LDSC) regression, MiXeR and conjunctional false discovery rate (conjFDR) to analyze different aspects of genetic overlap between COG and epilepsies. We used the largest available genome-wide association study data on COG ( n = 269,867) and common epilepsies ( n = 27,559 cases, 42,436 controls), including the broad phenotypes 'all epilepsy ', focal epilepsies and genetic generalized epilepsies (GGE), and as well as specific subtypes...
March 26, 2024: medRxiv