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JOURNAL ARTICLE
Misha Singh, Jennifer Crosthwait, Alexander Sorisky, Ella Atlas
BACKGROUND/OBJECTIVES: Obesity and its associated metabolic diseases are increasing globally. Sedentary lifestyle, high caloric diet, and genetic predisposition are known to contribute to the onset of obesity. It is increasingly recognized that exposure to environmental chemicals such as Bisphenol A (BPA) may also play a significant role. BPA has been correlated with an array of adverse health effects, including obesity and metabolic disorders. Due to public concern, manufacturers are replacing BPA with structural analogues for which there is limited toxicological data...
February 22, 2024: International Journal of Obesity
#42
JOURNAL ARTICLE
Soumyadeep Sarkar, Cailin Deiter, Jennifer E Kyle, Michelle A Guney, Dylan Sarbaugh, Ruichuan Yin, Xiangtang Li, Yi Cui, Mireia Ramos-Rodriguez, Carrie D Nicora, Farooq Syed, Jonas Juan-Mateu, Charanya Muralidharan, Lorenzo Pasquali, Carmella Evans-Molina, Decio L Eizirik, Bobbie-Jo M Webb-Robertson, Kristin Burnum-Johnson, Galya Orr, Julia Laskin, Thomas O Metz, Raghavendra G Mirmira, Lori Sussel, Charles Ansong, Ernesto S Nakayasu
BACKGROUND: Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream signaling regulate β-cell death. METHODS: We performed lipidomics using three models of insulitis: human islets and EndoC-βH1 β cells treated with the pro-inflammatory cytokines interlukine-1β and interferon-γ, and islets from pre-diabetic non-obese mice...
February 21, 2024: Cell Communication and Signaling: CCS
#43
JOURNAL ARTICLE
Ming-Hao Liu, Ning-Ning Zhao, Wan-Tong Yu, Jian-Ge Qiu, Bing-Hua Jiang, Yan Zhang, Chun-Yang Zhang
Fat mass and obesity-associated protein (FTO) is a crucial eraser of RNA N6 - methyladenosine (m6 A) modification, and abnormal FTO expression level is implicated in pathogenesis of numerous cancers. Herein, we demonstrate the construction of a label-free fluorescent biosensor for homogeneous detection of m6 A eraser FTO in breast cancer tissues. When FTO is present, it specifically erases the methyl group in m6 A, inducing the cleavage of demethylated DNA by endonuclease DpnII and the generation of a single-stranded DNA (ssDNA) with a 3'-hydroxyl group...
February 15, 2024: Talanta
#44
JOURNAL ARTICLE
Amanda J Croft, Conagh Kelly, Dongqing Chen, Tatt Jhong Haw, Lucy A Murtha, Lohis Balachandran, Andrew J Boyle, Aaron L Sverdlov, Doan T M Ngo
Sex-based differences in the development of obesity-induced cardio-metabolic dysfunction are well documented, however the specific mechanisms are not completely understood. Obesity has been linked to dysregulation of the epitranscriptome, but the role of N6-methyladenosine (m6A) RNA methylation has not been investigated in relation to the sex differences during obesity-induced cardiac dysfunction. In the current study, male and female C57BL/6J mice were subjected to short- and long-term high-fat/high-sucrose (HFHS) diet to induce obesogenic stress...
February 16, 2024: American Journal of Physiology. Heart and Circulatory Physiology
#45
JOURNAL ARTICLE
Nikos Papadimitriou, Conghui Qu, Tabitha A Harrison, Alaina M Bever, Richard M Martin, Konstantinos K Tsilidis, Polly A Newcomb, Stephen N Thibodeau, Christina C Newton, Caroline Y Um, Mireia Obón-Santacana, Victor Moreno, Hermann Brenner, Marko Mandic, Jenny Chang-Claude, Michael Hoffmeister, Andrew J Pellatt, Robert E Schoen, Sophia Harlid, Shuji Ogino, Tomotaka Ugai, Daniel D Buchanan, Brigid M Lynch, Stephen B Gruber, Yin Cao, Li Hsu, Jeroen R Huyghe, Yi Lin, Robert S Steinfelder, Wei Sun, Bethany Van Guelpen, Syed H Zaidi, Amanda E Toland, Sonja I Berndt, Wen-Yi Huang, Elom K Aglago, David A Drew, Amy J French, Peter Georgeson, Marios Giannakis, Meredith Hullar, Johnathan A Nowak, Claire E Thomas, Loic Le Marchand, Iona Cheng, Steven Gallinger, Mark A Jenkins, Marc J Gunter, Peter T Campbell, Ulrike Peters, Mingyang Song, Amanda I Phipps, Neil Murphy
BACKGROUND: Obesity has been positively associated with most molecular subtypes of colorectal cancer (CRC); however, the magnitude and the causality of these associations is uncertain. METHODS: We used Mendelian randomization (MR) to examine potential causal relationships between body size traits (body mass index [BMI], waist circumference, and body fat percentage) with risks of Jass classification types and individual subtypes of CRC (microsatellite instability [MSI] status, CpG island methylator phenotype [CIMP] status, BRAF and KRAS mutations)...
February 12, 2024: EBioMedicine
#46
JOURNAL ARTICLE
Duo Yang, Juan Shen, Chao Tang, Zhaoxin Lu, Fengxia Lu, Xiaomei Bie, Fanqiang Meng, Haizhen Zhao
Obesity-related diabetes, cardiovascular disease, and hypertension pose many risks to human health. Thus, mice on a high-fat diet were gavaged with millet bran (unfermented/fermented) soluble dietary fiber (RSDF/FSDF, 500 mg·kg-1 ) for 10 weeks in current research, and then evaluated the various biological indicators. These findings revealed that RSDF and FSDF supplements could prevent fat synthesis by inhibiting sterol regulatory element-binding protein-1c gene expression. The RSDF supplements can also accelerate fat catabolism through enhanced the mRNA expression levels of adipose triglyceride lipase and peroxisome proliferator-activated receptor α...
March 2024: Food Research International
#47
JOURNAL ARTICLE
Qiang Li, Yaju Wang, Xiangshu Meng, Wenjing Wang, Feifan Duan, Shuya Chen, Yukun Zhang, Zhiyong Sheng, Yu Gao, Lei Zhou
Papillary thyroid carcinoma (PTC) stands as the leading cancer type among endocrine malignancies, and there exists a strong correlation between thyroid cancer and obesity. However, the clinical significance and molecular mechanism of lipid metabolism in the development of PTC remain unclear. In this study, it was demonstrated that the downregulation of METTL16 enhanced lipid metabolism and promoted the malignant progression of PTC. METTL16 was expressed at lower levels in PTC tissues because of DNMT1-mediated hypermethylation of its promoter...
February 9, 2024: Cellular and Molecular Life Sciences: CMLS
#48
Bethany C Taylor, Loic H Steinthal, Michelle Dias, Hari K Yalamanchili, Scott A Ochsner, Gladys E Zapata, Nitesh R Mehta, Neil J McKenna, Nicolas L Young, Alli M Nuotio-Antar
Regulation of the thermogenic response by brown adipose tissue (BAT) is an important component of energy homeostasis with implications for the treatment of obesity and diabetes. Our preliminary analyses uncovered many nodes representing epigenetic modifiers that are altered in BAT in response to chronic thermogenic activation. Thus, we hypothesized that chronic thermogenic activation broadly alters epigenetic modifications of DNA and histones in BAT. Motivated to understand how BAT function is regulated epigenetically, we developed a novel method for the first-ever unbiased top- down proteomic quantitation of histone modifications in BAT and validated our results with a multi-omic approach...
January 22, 2024: bioRxiv
#49
JOURNAL ARTICLE
Anying Xiong, Xiang He, Shengbin Liu, Qin Ran, Lei Zhang, Junyi Wang, Manling Jiang, Bin Niu, Ying Xiong, Guoping Li
In order to comprehend the underlying mechanisms contributing to the development and exacerbation of asthma resulting from exposure to fine particulate matter (PM2.5), we established an asthmatic model in fat mass and obesity-associated gene knockdown mice subjected to PM2.5 exposure. Histological analyses using hematoxylin-eosin (HE) and Periodic Acid-Schiff (PAS) staining revealed that the down-regulation of the fat mass and obesity-associated gene (Fto) expression significantly ameliorated the pathophysiological alterations observed in asthmatic mice exposed to PM2...
February 6, 2024: Ecotoxicology and Environmental Safety
#50
REVIEW
Cham Jazieh, Tarek Ziad Arabi, Zohaib Asim, Belal Nedal Sabbah, Aljohara Waleed Alsaud, Khaled Alkattan, Ahmed Yaqinuddin
Type 2 diabetes mellitus (T2DM) is a rapidly escalating global health concern, with its prevalence projected to increase significantly in the near future. This review delves into the intricate role of epigenetic modifications - including DNA methylation, histone acetylation, and micro-ribonucleic acid (miRNA) expression - in the pathogenesis and progression of T2DM. We critically examine how these epigenetic changes contribute to the onset and exacerbation of T2DM by influencing key pathogenic processes such as obesity, insulin resistance, β-cell dysfunction, cellular senescence, and mitochondrial dysfunction...
2024: Frontiers in Endocrinology
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JOURNAL ARTICLE
Yunfan Yang, Jiajun Ren, Jifeng Zhang, Henghe Shi, Junnan Wang, Youyou Yan
Doxorubicin (DOX)-induced cardiotoxicity seriously limits its clinical applicability, and no therapeutic interventions are available. Ferroptosis, an iron-dependent regulated cell death characterised by lipid peroxidation, plays a pivotal role in DOX-induced cardiotoxicity. N6-methyladenosine (m6A) methylation is the most frequent type of RNA modification and involved in DOX-induced ferroptosis, however, its underlying mechanism remains unclear. P21 was recently found to inhibit ferroptosis by interacting with Nrf2 and is regulated in a P53-dependent or independent manner, such as through m6A modification...
February 2, 2024: Redox Biology
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REVIEW
Courtney B Lagarde, Joachim Kavalakatt, Megan C Benz, Mackenzie L Hawes, Carter A Arbogast, Nicole M Cullen, Emily C McConnell, Caroline Rinderle, Katherine L Hebert, Maninder Khosla, Jorge A Belgodere, Van T Hoang, Bridgette M Collins-Burow, Bruce A Bunnell, Matthew E Burow, Suresh K Alahari
Both breast cancer and obesity can regulate epigenetic changes or be regulated by epigenetic changes. Due to the well-established link between obesity and an increased risk of developing breast cancer, understanding how obesity-mediated epigenetic changes affect breast cancer pathogenesis is critical. Researchers have described how obesity and breast cancer modulate the epigenome individually and synergistically. In this review, the epigenetic alterations that occur in obesity, including DNA methylation, histone, and chromatin modification, accelerated epigenetic age, carcinogenesis, metastasis, and tumor microenvironment modulation, are discussed...
February 3, 2024: Oncogene
#53
JOURNAL ARTICLE
Evi De Ryck, Manosij Ghosh, Tim S Nawrot, Brigitte Reimann, Gudrun Koppen, Els Verachtert, Roland Devlieger, Lode Godderis, Sara Pauwels
The prevalence of childhood obesity is rapidly increasing. Therefore, gaining more information on the role of environmental parameters is key. With overexpression of leptin (encoded by LEP) in obesity, LEP methylation might be altered by environmental exposures. This study aims to assess effects of ambient air pollution and nearby greenness on obesity-related growth and LEP methylation in early childhood. We monitored 120 mother-child pairs from conception until the age of five. Buccal swabs and anthropometric measurements of the children were taken at six months, one year, and five years old...
February 1, 2024: Environmental Pollution
#54
JOURNAL ARTICLE
Oluwasefunmi Akeju, Michelle M J Mens, Robert Warmerdam, Marjolein Dijkema, Anita H J van den Biggelaar, Lude Franke, Jaap Goudsmit, Julia W Wu
Longevity and disease-free survival are influenced by a combination of genetics and lifestyle. Biological age (BioAge), a measure of aging based on composite biomarkers, may outperform chronological age in predicting health and longevity. This study investigated the relationship between genetic risks, lifestyle factors and delta age (Δage), estimated as the difference between biological and chronological age. BioAge and Δage were calculated for 52,418 participants from the population-based Lifelines cohort...
February 2, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
#55
JOURNAL ARTICLE
Jie Yao, Feng Ning, Weijing Wang, Dongfeng Zhang
Obesity is an established risk factor for hypertension, but the mechanisms are only partially understood. We examined whether body mass index (BMI)-related DNA methylation (DNAm) variation would mediate the association of BMI with blood pressure (BP). We first conducted a genomewide DNA methylation analysis in monozygotic twin pairs to detect BMI-related DNAm variation and then evaluated the mediating effect of DNAm on the relationship between BMI and BP levels using the causal inference test (CIT) method and mediation analysis...
January 31, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
#56
JOURNAL ARTICLE
Fadia Milhem, Leah M Hamilton, Emily Skates, Mickey Wilson, Suzanne D Johanningsmeier, Slavko Komarnytsky
Obesity-resistant (non-responder, NR) phenotypes that exhibit reduced susceptibility to developing obesity despite being exposed to high dietary fat are crucial in exploring the metabolic responses that protect against obesity. Although several efforts have been made to study them in mice and humans, the individual protective mechanisms are poorly understood. In this exploratory study, we used a polygenic C57BL/6J mouse model of diet-induced obesity to show that NR mice developed healthier fat/lean body mass ratios (0...
January 20, 2024: Metabolites
#57
JOURNAL ARTICLE
Amandeep Kaur, Ranjeet Kumar, Amit Sharma
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes that damages the retina, leading to blindness. People with type 1 diabetes are at greater risk of developing DR than people with type 2 diabetes. Diabetic retinopathy may be divided into two primary categories: proliferative diabetic retinopathy (PDR) and non-proliferative diabetic retinopathy (NPDR). There are multiple risk factors for the onset and progression of diabetic retinopathy, such as hypertension, obesity, smoking, duration of diabetes, and genetics...
January 24, 2024: Current Diabetes Reviews
#58
JOURNAL ARTICLE
Tiina Föhr, Arne Hendrix, Anna Kankaanpää, Eija K Laakkonen, Urho Kujala, Kirsi H Pietiläinen, Terho Lehtimäki, Mika Kähönen, Olli Raitakari, Xiaoling Wang, Jaakko Kaprio, Miina Ollikainen, Elina Sillanpää
BACKGROUND: Metabolic syndrome (MetS) is associated with premature aging, but whether this association is driven by genetic or lifestyle factors remains unclear. METHODS: Two independent discovery cohorts, consisting of twins and unrelated individuals, were examined (N = 268, aged 23-69 years). The findings were replicated in two cohorts from the same base population. One consisted of unrelated individuals (N = 1 564), and the other of twins (N = 293)...
January 25, 2024: International Journal of Obesity
#59
JOURNAL ARTICLE
Danmeng Lily Li, Allison M Hodge, Lachlan Cribb, Melissa C Southey, Graham G Giles, Roger L Milne, Pierre-Antoine Dugué
Epigenetic age is an emerging marker of health that is highly predictive of disease and mortality risk. There is a lack of evidence on whether lifestyle changes are associated with changes in epigenetic ageing. We used data from 1,041 participants in the Melbourne Collaborative Cohort Study with blood DNA methylation measures at baseline (1990-1994, mean age: 57.4 years) and follow-up (2003-2007, mean age: 68.8 years). The Alternative Healthy Eating Index-2010 (AHEI-2010), the Mediterranean Dietary Score and the Dietary Inflammatory Index were used as measures of diet quality, and weight, waist circumference and waist-to-hip ratio as measures of body size...
January 24, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
#60
JOURNAL ARTICLE
Yu-Chen Wang, Yen Chin Koay, Calvin Pan, Zhiqiang Zhou, W H Wilson Tang, Jennifer Wilcox, Xinmin S Li, Alexia Zagouras, Francine Marques, Hooman Allayee, Federico E Rey, David M Kaye, John F O'Sullivan, Stanley L Hazen, Yang Cao, Aldons J Lusis
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a common but poorly understood form of heart failure, characterized by impaired diastolic function. It is highly heterogeneous with multiple comorbidities, including obesity and diabetes, making human studies difficult. METHODS: Metabolomic analyses in a mouse model of HFpEF showed that levels of indole-3-propionic acid (IPA), a metabolite produced by gut bacteria from tryptophan, were reduced in the plasma and heart tissue of HFpEF mice as compared with controls...
January 24, 2024: Circulation Research
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