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Diabetes mirna

S-Z Zhang, X-J Qiu, S-S Dong, L-N Zhou, Y Zhu, M-D Wang, L-W Jin
OBJECTIVE: Diabetic nephropathy (DN) is a major diabetic micro-vascular complication, and podocyte apoptosis induced by high glucose (HG) is a typical early feature of DN. Studies have shown that microRNAs (miRNAs) play a crucial role in the pathogenesis of DN. The purpose of the current study was to explore the role and molecular mechanism of miR-770-5p in podocyte apoptosis in DN. PATIENTS AND MATERIALS AND METHODS: In vitro podocyte model of DN was conducted by treatment conditionally immortalized mouse podocytes with HG (30 mM D-glucose)...
February 2019: European Review for Medical and Pharmacological Sciences
Elena V Dolmatova, Kathy K Griendling
Vascular smooth muscle cell (VSMC) phenotype switching from a contractile state to a synthetic phenotype has been implicated in intimal remodeling during vascular injury. While multiple studies have focused on dedifferentiation of VSMCs, prevention of VSMC-mediated excessive repair remains poorly understood. In this issue of the JCI, Zeng et al. identified a mechanism by which platelet-derived microRNA-223 (miRNA-223) reverses VSMC dedifferentiation. The authors show that suppression of proliferation occurs after platelet internalization by VSMCs...
February 18, 2019: Journal of Clinical Investigation
Tao Li, Yu Ma, Min Wang, Tao Wang, Jing Wei, Rui Ren, Min He, Guixue Wang, Johnson Boey, David G Armstrong, Wuquan Deng, Bing Chen
Aim: This study was designed to examine the potential mechanism underlying these roles of platelet-rich plasma in treating diabetic foot ulcers (DFUs). Methods: Staphylococcus aureus and HaCaT were co-cultured under high glucose conditions to serve as an in vitro model for infected cells in DFUs. Platelet-rich gel (PRG) or extract liquid of platelet-rich gel (EPG) were used to interfere with the model to observe the growth of HaCaT cells and S. aureus , and the effect of miR-21 changes in HaCaT cells on PDCD4, NF-κB activity and related inflammatory factors...
2019: Infection and Drug Resistance
Parvaneh Seiri, Abbas Abi, Mohammad Soukhtanloo
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily. PPARs are categorized into three subtypes, PPARα, β/δ, and γ, encoded by different genes, expressed in diverse tissues and participate in various biological functions and can be activated by their metabolic derivatives in the body or dietary fatty acids. The PPAR-γ also takes parts in the regulation of energy balance, lipoprotein metabolism, insulin sensitivity, oxidative stress, and inflammatory signaling. It has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis, and cancers...
February 15, 2019: Journal of Cellular Biochemistry
Marah C Runtsch, Morgan C Nelson, Soh-Hyun Lee, Warren Voth, Margaret Alexander, Ruozhen Hu, Jared Wallace, Charisse Petersen, Vanja Panic, Claudio J Villanueva, Kimberley J Evason, Kaylyn M Bauer, Timothy Mosbruger, Sihem Boudina, Mary Bronner, June L Round, Micah J Drummond, Ryan M O'Connell
Identifying regulatory mechanisms that influence inflammation in metabolic tissues is critical for developing novel metabolic disease treatments. Here, we investigated the role of microRNA-146a (miR-146a) during diet-induced obesity in mice. miR-146a is reduced in obese and type 2 diabetic patients and our results reveal that miR-146a-/- mice fed a high-fat diet (HFD) have exaggerated weight gain, increased adiposity, hepatosteatosis, and dysregulated blood glucose levels compared to wild-type controls. Pro-inflammatory genes and NF-κB activation increase in miR-146a-/- mice, indicating a role for this miRNA in regulating inflammatory pathways...
February 15, 2019: PLoS Genetics
Yang Xu, Yan Huang, Yibing Guo, Yicheng Xiong, Shajun Zhu, Liancheng Xu, Jingjing Lu, Xiaohong Li, Jian Wan, Yuhua Lu, Zhiwei Wang
BACKGROUND: The regulatory mechanism of insulin-producing cells (IPCs) differentiation from induced pluripotent stem cells (iPSCs) in vitro is very important in the phylogenetics of pancreatic islets, the molecular pathogenesis of diabetes, and the acquisition of high-quality pancreatic β-cells derived from stem cells for cell therapy. METHODS: miPSCs were induced for IPCs differentiation. miRNA microarray assays were performed by using total RNA from our iPCs-derived IPCs containing undifferentiated iPSCs and iPSCs-derived IPCSs at day 4, day 14, and day 21 during step 3 to screen the differentially expressed miRNAs (DEmiRNAs) related to IPCs differentiation, and putative target genes of DEmiRNAs were predicted by bioinformatics analysis...
February 15, 2019: Stem Cell Research & Therapy
S Sucharita, V Ashwini, J S Prabhu, S T Avadhany, V Ayyar, G Bantwal
Background: Circulating microRNA (miRNA/miR) levels are emerging out as markers of tissue level changes; however, their role in type 2 diabetes (T2D) needs to be explored. The study aimed to compare the circulating levels of the miRNA (miR9, miR30d, miR1, miR133a, miR29a, miR143) between T2D and gender matched controls and also to evaluate the strength of association between circulating miRNAs and beta cell function/insulin resistance among Indians with T2D. Subjects and Methods: Thirty T2D (25-60 years) and their gender matched controls ( n = 30) were recruited...
November 2018: Indian Journal of Endocrinology and Metabolism
Sandeep Kumar, Reinier A Boon, Lars Maegdefessel, Stefanie Dimmeler, Hanjoong Jo
Abdominal aortic aneurysm (AAA) is a local dilatation of the abdominal aortic vessel wall and is among the most challenging cardiovascular diseases as without urgent surgical intervention, ruptured AAA has a mortality rate of >80%. Most patients present acutely after aneurysm rupture or dissection from a previously asymptomatic condition and are managed by either surgery or endovascular repair. Patients usually are old and have other concurrent diseases and conditions, such as diabetes mellitus, obesity, and hypercholesterolemia making surgical intervention more difficult...
February 15, 2019: Circulation Research
Hassan Dehaini, Hussein Awada, Ahmed El-Yazbi, Fouad A Zouein, Khodr Issa, Assaad A Eid, Maryam Ibrahim, Adnan Badran, Elias Baydoun, Gianfranco Pintus, Ali H Eid
BACKGROUND: Ischemia-Reperfusion (I/R) injury is the tissue damage that results from re-oxygenation of ischemic tissues. There are many players that contribute to I/R injury. One of these factors is the family of microRNAs (miRNAs), which are currently being heavily studied. This review aims to critically summarize the latest papers that attributed roles of certain miRNAs in I/R injury, particularly in diabetic conditions and dissect their potential as novel pharmacologic targets in the treatment and management of diabetes...
February 12, 2019: Cells
L Bertoccini, F Sentinelli, M Incani, D Bailetti, F A Cimini, I Barchetta, A Lenzi, M G Cavallo, E Cossu, M G Baroni
No abstract text is available yet for this article.
February 13, 2019: Acta Diabetologica
Zhen He, Jian Jun Yang, Rong Zhang, Hua Ting Li, Liang Wu, Feng Jiang, Wei Ping Jia, Cheng Hu
AIM: The early screening of non-alcoholic fatty liver disease (NAFLD) is of great significance for early detection and intervention in NAFLD. MicroRNAs (miRNAs) are important regulators of metabolic disease, including NAFLD. The aim of this study was to examine the association of serum miR-29a-c with NAFLD in a Chinese population. METHODS: 276 individuals were enrolled in this study and divided into non-diabetic and diabetic groups. Real-time PCR was performed to quantify the serum miR-29a-c expression levels...
February 12, 2019: Journal of Digestive Diseases
Hui-Wen Tseng, Sung-Chou Li, Kuo-Wang Tsai
Melanoma is a highly aggressive cancer with high mortality in advanced stages.Metformin is an oral biguanide drug used for diabetes and has demonstrated positive effects oncancer prevention and treatment. Herein, we found that metformin significantly suppressedmelanoma cancer cell motility and growth through inducing cell cycle arrest at the G2/M phase andpromoting cell apoptosis. Using the next-generation sequencing approach, we identified threeupregulated microRNAs (miRNA; miR-192-5p, miR-584-3p, and miR-1246) in melanoma cellstreated with metformin...
February 11, 2019: Cancers
Vikas Ghai, David Baxter, Xiaogang Wu, Taek-Kyun Kim, Johanna Kuusisto, Markku Laakso, Tom Connolly, Yong Li, Patricia Andrade-Gordon, Kai Wang
Type 2 Diabetes Mellitus (T2DM) is the most prevalent form of diabetes in the USA, thus, the identification of biomarkers that could be used to predict the progression from prediabetes to T2DM would be greatly beneficial. Recently, circulating RNA including microRNAs (miRNAs) present in various body fluids have emerged as potential biomarkers for various health conditions, including T2DM. Whereas studies that examine the changes of miRNA spectra between healthy controls and T2DM individuals have been reported, the goal of this study is to conduct a baseline comparison of prediabetic individuals who either progress to T2DM, or remain prediabetic...
February 7, 2019: Journal of Cellular and Molecular Medicine
Qiong Luo, Yonghao Feng, Yangmei Xie, Yiye Shao, Men Wu, Xiaolin Deng, Weien Yuan, Yinghui Chen, Xiaohong Shi
Nontoxic and nonimmunogenic nanoparticles play an increasingly important role in the application of pharmaceutical nanocarriers. The pathogenesis of diabetic peripheral neuropathy (DPN) has been extensively studied. However, the role of microRNAs in DPN remains to be clarified. We verified in vitro that miR-146a-5p mimics inhibited the expression of proinflammatory cytokines and apoptosis. Then, we explored the protective effect of nanoparticle-miRNA-146a-5p polyplexes (nano-miR-146a-5p) on DPN rats. We demonstrated that nano-miR-146a-5p improved nerve conduction velocity and alleviated the morphological damage and demyelination of the sciatic nerve of DPN rats...
February 2, 2019: Nanomedicine: Nanotechnology, Biology, and Medicine
Tian Su, Yuzhong Xiao, Ye Xiao, Qi Guo, Changjun Li, Yan Huang, Qiufang Deng, Jingxiang Wen, Fangliang Zhou, Xiang-Hang Luo
Insulin resistance is the major pathological characteristic of type 2 diabetes and the elderly often develop insulin resistance. However, the deep-seated mechanisms for aging-related insulin resistance remain unclear. Here, we showed that nano-sized exosomes released by bone marrow mesenchymal stem cells (BM-MSCs) of aged mice could be taken up by adipocytes, myocytes, and hepatocytes, resulting in insulin resistance both in vivo and in vitro. Using microRNA (miRNA) array assays, we found that the amount of miR-29b-3p was dramatically increased in exosomes released by BM-MSCs of aged mice...
February 4, 2019: ACS Nano
Hadeel A Al-Rawaf, Sami A Gabr, Ahmad H Alghadir
Green tea ( Camellia sinensis ) has many biological activities and may promote diabetic wound healing by regulation of circulating hypoxia responsive microRNAs (HRMs) which triggers the wound repairing process in diabetic and nondiabetic wounds. Thus, in this study, the potential effects of green tea extract (GTE) on the expression of miRNAs; miR-424, miR-199a, miR-210, miR-21, and fibrogenitic markers; hydroxyproline (HPX), fibronectin (FN), and nitric oxide (NO) were evaluated in wounds of diabetic and nondiabetic rats...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Rodolphe Dusaulcy, Sandra Handgraaf, Florian Visentin, Christian Vesin, Jacques Philippe, Yvan Gosmain
OBJECTIVE: Diabetes is a complex disease implicating several organs and cell types. Within the islets, dysregulation occurs in both alpha- and beta-cells, leading to defects of insulin secretion and increased glucagon secretion. Dysregulation of alpha-cells is associated with transcriptome changes. We hypothesized that microRNAs (miRNAs) which are negative regulators of mRNA stability and translation could be involved in alpha-cell alterations or adaptations during type 2 diabetes. METHODS: miRNA microarray analyses were performed on pure alpha- and beta-cells from high-fat diet fed obese hyperglycemic mice and low-fat diet fed controls...
January 18, 2019: Molecular Metabolism
Himanshu Sankrityayan, Yogesh A Kulkarni, Anil Bhanudas Gaikwad
Diabetic nephropathy (DN) is still one of the leading causes of end-stage renal disease despite the emergence of different therapies to counter the metabolic, hemodynamic and fibrotic pathways, implicating a prominent role of genetic and epigenetic factors in its progression. Epigenetics is the study of changes in the expression of genes which may be inheritable and does not involve a change in the genome sequence. Thrust areas of epigenetic research are DNA methylation and histone modifications. Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) control the expression of genes via post-transcriptional mechanisms...
January 26, 2019: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Cheng-Yong Yu, Chun-Yun Yang, Zhi-Lian Rui
Type 2 diabetes mellitus (T2DM) is a progressive disease, accompanied by increased insulin resistance and deteriorating β-cell function. Previous studies have revealed that microRNA (miRNA) plays a crucial role in the treatment of T2DM. Hence, we aim to investigate the role of microRNA-125b-5p (miR-125b-5p) in pancreatic β-cell function and insulin sensitivity of mice with T2DM with the involvement of Dishevelled antagonist Dapper1 (DACT1) and the c-Jun NH2-terminal kinases (JNK) signaling pathway. Firstly, a mouse model of T2DM was established by administering a high-fat diet plus low dosage of streptozotocin, and function of pancreatic β-cell and insulin sensitivity in the normal and T2DM mice were detected...
January 23, 2019: Life Sciences
Boris Novakovic, Toby Mansell, Richard Saffery
Healthy development in utero relies on the appropriate exchange of nutrients and other signalling between the maternal and fetal circulations. Disruption to this fine balance is associated with several pregnancy and adverse birth outcomes, including gestational diabetes mellitus (GDM). This is a complex condition influenced by genetic, environment and potentially epigenetic factors in association with a range of altered developmental outcomes. A recent study, published in Clinical Science, explores miRNAs as a molecular mechanism underpinning the altered function of placental endothelial cells in GDM pregnancies...
January 31, 2019: Clinical Science (1979-)
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