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JOURNAL ARTICLE
María Ángeles Bernal-Jiménez, German Calle, Alejandro Gutiérrez Barrios, Livia Luciana Gheorghe, Celia Cruz-Cobo, Nuria Trujillo-Garrido, Amelia Rodríguez-Martín, Josep A Tur, Rafael Vázquez-García, María José Santi-Cano
BACKGROUND: Coronary heart disease is one of the leading causes of mortality worldwide. Secondary prevention is essential, as it reduces the risk of further coronary events. Mobile health (mHealth) technology could become a useful tool to improve lifestyles. OBJECTIVE: This study aimed to evaluate the effect of an mHealth intervention on people with coronary heart disease who received percutaneous coronary intervention. Improvements in lifestyle regarding diet, physical activity, and smoking; level of knowledge of a healthy lifestyle and the control of cardiovascular risk factors (CVRFs); and therapeutic adherence and quality of life were analyzed...
April 22, 2024: JMIR MHealth and UHealth
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JOURNAL ARTICLE
Sara Torres-Esquius, Alba Llop-Guevara, Sara Gutiérrez-Enríquez, Marcel Romey, Àlex Teulé, Gemma Llort, Ana Herrero, Pilar Sánchez-Henarejos, Anna Vallmajó, Santiago González-Santiago, Isabel Chirivella, Juana Maria Cano, Begoña Graña, Sara Simonetti, Isabela Díaz de Corcuera, Teresa Ramon Y Cajal, Judit Sanz, Sara Serrano, Andrea Otero, Cristina Churruca, Ana Beatriz Sánchez-Heras, Sonia Servitja, Carmen Guillén-Ponce, Joan Brunet, Carsten Denkert, Violeta Serra, Judith Balmaña
IMPORTANCE: RAD51C and RAD51D are involved in DNA repair by homologous recombination. Germline pathogenic variants (PVs) in these genes are associated with an increased risk of ovarian and breast cancer. Understanding the homologous recombination deficiency (HRD) status of tumors from patients with germline PVs in RAD51C/D could guide therapeutic decision-making and improve survival. OBJECTIVE: To characterize the clinical and tumor characteristics of germline RAD51C/D PV carriers, including the evaluation of HRD status...
April 1, 2024: JAMA Network Open
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JOURNAL ARTICLE
Sergio D Ezquerra Riega, Matías E Gutierrez Suburu, Hernán B Rodríguez, Beatriz Lantaño, Martin Kleinschmidt, Christel M Marian, Cristian A Strassert
Singlet dioxygen has been widely applied in different disciplines such as medicine (photodynamic therapy or blood sterilization), remediation (wastewater treatment) or industrial processes (fine chemicals synthesis). Particularly, it can be conveniently generated by energy transfer between a photosensitizer's triplet state and triplet dioxygen upon irradiation with visible light. Among the best photosensitizers, substituted zinc(II) phthalocyanines are prominent due to their excellent photophysical properties, which can be tuned by structural modifications, such as halogen- and chalcogen-atom substitution...
April 22, 2024: Chemistry: a European Journal
#4
JOURNAL ARTICLE
Alfredo Echarri Sucunza, Patricia Fernández Del Valle, Jose Antonio Iglesias Vázquez, Youcef Azeli, Jose María Navalpotro Pascual, Juan Valenciano Rodriguez, Cristian Fernández Barreras, Sonia Royo Embid, Carmen Gutiérrez-García, María Isabel Ceniceros Rozalén, Cesar Manuel Guerra García, Carmen Del Pozo Pérez, María José Luque-Hernández, Silvia Sola Muñoz, Ana Belén Forner Canos, María Isabel Herrera Maíllo, Marcos Juanes García, Natividad Ramos García, Belén Muñoz Isabel, Junior Jose García Mendoza, José Antonio Cortés Ramas, Faustino Redondo Revilla, Inmaculada Mateo-Rodríguez, Félix Rivera Sanz, Emily Knox, Antonio Daponte Codina, José Ignacio Ruiz Azpiazu, Fernando Rosell Ortiz
INTRODUCTION: Recent data are not available on ongoing CPR for emergency services with an onboard physician. The aim of the present study was to identify factors associated with the decision to transport patients to hospital with ongoing CPR and examine their survival to hospital discharge with good neurological status. METHODS: An observational study based on a registry of out-of-hospital cardiac arrests attended to by emergency services with an onboard physician...
June 2024: Resuscitation plus
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JOURNAL ARTICLE
Héctor Gutiérrez-Espinoza, María Cassola-Cajiao, Emilia Garzón-Ulloa, Daniela Celi-Lalama, Carlos Bastidas-Caldes, Felipe Araya-Quintanilla, Carlos Cristi-Montero, José Francisco López-Gil
INTRODUCTION: Admission to university has been identified as a period involving the adoption of unhealthy lifestyle behaviors. However, few studies have addressed the extent of this experience among Latin American university students. The aim of this study was twofold: first, to describe anthropometric variables, body composition, physical activity, sedentary behavior, sleep duration and quality, diet, and alcohol consumption in first-year students entering physiotherapy school at the Universidad de las Americas in Quito, Ecuador; second, to test differences in these variables between sexes...
2024: Frontiers in sports and active living
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M Trincado Cobos, B Tapia Salinas, A Gutiérrez Venturini, I Aragón Niño, J L Del Castillo Pardo de Vera, J L Cebrián Carretero, R Uña Orejón
We describe the use of three-dimensional printing to create precise airway models for a patient with Treacher Collins syndrome who presented for bimaxillary temporomandibular joint prostheses, and for whom airway management was predicted to be difficult. The model was based on pre-operative cone beam computed tomography images and printed in the 3D Lab of Hospital Universitario La Paz. Transparent models allowed clear visualisation for simulation and iterative refinement of airway management techniques and aided in risk assessment and instrument sizing...
2024: Anaesthesia reports
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JOURNAL ARTICLE
Judith Ndongo Embola Torimiro, Kerina Duri, Nadège M Goumkwa, Solange M Atah, Juliette-Laure Ndzie Ondigui, Cindy Lobe, Marielle Bouyou, Bénédicte Ndeboko, Ali Mahamat Moussa, Camengo Police, Patrick Awoumou, Puinta Peyonga, Prisca V Djivida, Assah Felix, Godwin W Nchinda, Brigitte Wandji, Rachel K Simo, Sylvie Agnès Moudourou, Ana Gutierrez, Rosi Garcia, Isabelle Fernandez, Evelyn Mah, Sarah Rowland-Jones, Robinson Mbu
The WHO African Region had 81 million people with chronic hepatitis B in 2019, which remains a silent killer. Hepatitis B virus (HBV), hepatitis delta virus (HDV), and HIV can be transmitted from the mother to child. If the HBV infection is acquired at infancy, it may lead to chronic hepatitis B in 90% of the cases. WHO reports that 6.4 million children under 5 years live with chronic hepatitis B infection worldwide. The prevention of mother-to-child transmission (PMTCT) of HBV is therefore critical in the global elimination strategy of viral hepatitis as we take lessons from PMTCT of HIV programs in Africa...
2024: Frontiers in Public Health
#8
Patrick M Laughlin, Kimberly Young, Giovanni Gonzalez-Gutierrez, Joseph C Y Wang, Adam Zlotnick
SARS-CoV-2 Nucleocapsid protein ( N ) is a viral structural protein that packages the 30kb genomic RNA inside virions and forms condensates within infected cells through liquid-liquid phase separation ( LLPS ). N, in both soluble and condensed forms, has accessory roles in the viral life cycle including genome replication and immunosuppression. The ability to perform these tasks depends on phase separation and its reversibility. The conditions that stabilize and destabilize N condensates and the role of N-N interactions are poorly understood...
April 11, 2024: bioRxiv
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Binoy Yohannan, Juan Carlos Martinez Gutierrez, Peng Roc Chen, Adan Rios
Intracerebral hemorrhage is a potentially fatal complication in patients with acute leukemia and contributing factors include thrombocytopenia and coagulopathy. Patients with acute leukemia may develop subdural hematoma (SDH) spontaneously or secondary to trauma. In patients with acute leukemia and SDH, the surgical evacuation of the hematoma causes significant morbidity and mortality. New approaches and strategies to reduce the need for surgical evacuation are needed to improve outcomes in patients with acute leukemia and intracerebral hemorrhage...
April 2024: Journal of Hematology (Brossard, Quebec)
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JOURNAL ARTICLE
Tomas Nakazato, Pablo Quezada, César Gutiérrez, Franco Romaní
OBJECTIVE: To estimate the prevalence of chronic neck pain (CNP) among the adult population in Peru during the post-coronavirus disease 2019 (COVID-19) restriction period compared with that during the pre-pandemic period and evaluate its association with prolonged digital devices connected to the internet (DDCI) screen viewing. METHODS: We conducted a cross-sectional study using a representative sample of adults living in Peru in November 2022. A structured survey was employed to identify CNP, and the exposure variable was set as the duration of DDCI screen viewing...
April 22, 2024: Annals of Rehabilitation Medicine
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REVIEW
Patricia Villar, Sofía Carreño, Sara Moro, Inés Díez Galindo, Ángel Bernardo, Laura Gutiérrez
While there are various aspects of platelet biology that can be studied in the lab (i.e. adhesion, degranulation, integrin activation), the master test for platelet function is that which gives a measure of the platelet aggregation capacity upon stimulation with an agonist. Platelet function testing is necessary for the diagnosis of platelet disorders and the monitoring of patients receiving anti-platelet treatments. Furthermore, it becomes relevant in the quality control of platelet concentrates for transfusion purposes, especially considering the global concern about long term storage, other forms of storage (i...
April 18, 2024: Transfusion and Apheresis Science
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JOURNAL ARTICLE
Sara Gutierrez-Patricio, Jorge R Osman, José Luis Gonzalez-Pimentel, Valme Jurado, Leonila Laiz, Alfredo Laínez Concepción, Cesareo Saiz-Jimenez, Ana Zélia Miller
Cueva del Viento, located in the Canary Islands, Spain, is the Earth's sixth-longest lava tube, spanning 18,500 m, and was formed approximately 27,000 years ago. This complex volcanic cave system is characterized by a unique geomorphology, featuring an intricate network of galleries. Despite its geological significance, the geomicrobiology of Cueva del Viento remains largely unexplored. This study employed a combination of culture-dependent techniques and metabarcoding data analysis to gain a comprehensive understanding of the cave's microbial diversity...
April 2024: Environmental Microbiology Reports
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JOURNAL ARTICLE
Manolo Ortega-Romero, Elodia Rojas-Lima, Juan Carlos Rubio-Gutiérrez, Octavio Gamaliel Aztatzi-Aguilar, Juana Narváez-Morales, Mariela Esparza-García, Ángel Barrera-Hernández, Miguel Ángel Mejia, Pablo Mendez-Hernández, Mara Medeiros, Olivier Christophe Barbier
BACKGROUND: In kidney damage, molecular changes can be used as early damage kidney biomarkers, such as Kidney Injury Molecule-1 and Neutrophil gelatinase-associated lipocalin. These biomarkers are associated with toxic metal exposure or disturbed homeostasis of trace elements, which might lead to serious health hazards. This study aimed to evaluate the relationship between exposure to trace elements and early damage kidney biomarkers in a pediatric population. METHODS: In Tlaxcala, a cross-sectional study was conducted on 914 healthy individuals...
April 20, 2024: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
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Carlos Calvo-Asín, Fátima Tous-Romero, Jose Puig-Buendia, Raquel Cavestany-Rodríguez, Julia Montero-Menárguez, Christian Gutiérrez-Collar, José Luis Alejo-Fernández, Javier Ortiz-de Frutos
No abstract text is available yet for this article.
April 19, 2024: Contact Dermatitis
#15
JOURNAL ARTICLE
Beatriz Fernández-Varas, Cristina Manguan-García, Javier Rodriguez-Centeno, Lucía Mendoza-Lupiáñez, Joaquin Calatayud, Rosario Perona, Mercedes Martín-Martínez, Marta Gutierrez-Rodriguez, Carlos Benítez-Buelga, Leandro Sastre
Telomeres are nucleoprotein structures at the end of chromosomes that maintain their integrity. Mutations in genes coding for proteins involved in telomere protection and elongation produce diseases such as dyskeratosis congenita or idiopathic pulmonary fibrosis known as telomeropathies. These diseases are characterized by premature telomere shortening, increased DNA damage and oxidative stress. Genetic diagnosis of telomeropathy patients has identified mutations in the genes TERT and TERC coding for telomerase components but the functional consequences of many of these mutations still have to be experimentally demonstrated...
April 18, 2024: Human Molecular Genetics
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JOURNAL ARTICLE
Claudia Dorado-Martínez, Enrique Montiel-Flores, Jose Luis Ordoñez-Librado, Ana Luisa Gutierrez-Valdez, Cesar Alfonso Garcia-Caballero, Javier Sanchez-Betancourt, Leonardo Reynoso-Erazo, Rocio Tron-Alvarez, Vianey Rodríguez-Lara, Maria Rosa Avila-Costa
BACKGROUND: Previous work from our group has shown that chronic exposure to Vanadium pentoxide (V2O5) causes cytoskeletal alterations suggesting that V2O5 can interact with cytoskeletal proteins through polymerization and tyrosine phosphatases inhibition, causing Alzheimer's disease (AD)-like hippocampal cell death. OBJECTIVE: This work aims to characterize an innovative AD experimental model through chronic V2O5 inhalation, analyzing the spatial memory alterations and the presence of neurofibrillary tangles (NFTs), amyloid-β (Aβ) senile plaques, cerebral amyloid angiopathy, and dendritic spine loss in AD-related brain structures...
April 12, 2024: Journal of Alzheimer's Disease: JAD
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JOURNAL ARTICLE
Chunyu Guo, Glenn Wagner, Carsten Putzke, Dong Chen, Kaize Wang, Ling Zhang, Martin Gutierrez-Amigo, Ion Errea, Maia G Vergniory, Claudia Felser, Mark H Fischer, Titus Neupert, Philip J W Moll
Spontaneously broken symmetries are at the heart of many phenomena of quantum matter and physics more generally. However, determining the exact symmetries that are broken can be challenging due to imperfections such as strain, in particular when multiple electronic orders are competing. This is exemplified by charge order in some kagome systems, where evidence of nematicity and flux order from orbital currents remains inconclusive due to contradictory measurements. Here we clarify this controversy by fabricating highly symmetric samples of a member of this family, CsV3 Sb5 , and measuring their transport properties...
2024: Nature Physics
#18
JOURNAL ARTICLE
Francisco Hernández-Bernal, Donner Estenoz-García, Juan H Gutiérrez-Ronquillo, Yenima Martín-Bauta, Karen Catasús-Álvarez, Mario Gutiérrez-Castillo, Marbelys Guevara-Rodríguez, Aliuska Castro-Jeréz, Yoandra Fuentes-González, Yulemis Pinto-Cruz, Carmen Valenzuela-Silva, Verena L Muzio-González, Héctor Pérez-Saad, Nelvys Subirós-Martínez, Gerardo E Guillén-Nieto, Diana Garcia-Del-Barco-Herrera
OBJECTIVE: This study tested the hypothesis that a neuroprotective combined therapy based on epidermal growth factor (EGF) and growth hormone-releasing hexapeptide (GHRP6) could be safe for acute ischemic stroke patients, admitting up to 30% of serious adverse events (SAE) with proven causality. METHODS: A multi-centric, randomized, open-label, controlled, phase I-II clinical trial with parallel groups was conducted (July 2017 to January 2018). Patients aged 18-80 years with a computed tomography-confirmed ischemic stroke and less than 12 h from the onset of symptoms were randomly assigned to the study groups I (75 μg rEGF + 3...
2024: Frontiers in Neurology
#19
JOURNAL ARTICLE
Julia Sabin, Elisa Salas, Jesús Martín-Martínez, Antonio Candeliere-Merlicco, Francisco Javier Barrero, Ana Alonso, José Luis Sánchez-Menoyo, Laura Borrega, María Rodríguez-Rodríguez, Montserrat Gómez-Gutiérrez, Sara Eichau, Miguel Ángel Hernández-Pérez, Carmen Calles, Eva Fernández-Díaz, Olga Carmona, Aida Orvíz, Ana López-Real, Pablo López-Muñoz, Amelia Mendoza, Eduardo Agüera, Jorge Maurino, Javier Ballesteros
A multicenter study involving 204 adults with relapsing-remitting multiple sclerosis (RRMS) assessed the dimensionality and item characteristics of the Mishel-Uncertainty of Illness Scale (MUIS), a generic self-assessment tool. Mokken analysis identified two dimensions in the MUIS with an appropriate item and overall scale scalability after excluding nonclassifiable items. A refined 12-item MUIS, employing a grade response model, effectively discriminated uncertainty levels among RRMS patients (likelihood ratio test p -value = ...
2024: Multiple Sclerosis Journal—Experimental, Translational and Clinical
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JOURNAL ARTICLE
Sara Monzón, Sarai Varona, Anabel Negredo, Santiago Vidal-Freire, Juan Angel Patiño-Galindo, Natalia Ferressini-Gerpe, Angel Zaballos, Eva Orviz, Oskar Ayerdi, Ana Muñoz-Gómez, Alberto Delgado-Iribarren, Vicente Estrada, Cristina García, Francisca Molero, Patricia Sánchez-Mora, Montserrat Torres, Ana Vázquez, Juan-Carlos Galán, Ignacio Torres, Manuel Causse Del Río, Laura Merino-Diaz, Marcos López, Alicia Galar, Laura Cardeñoso, Almudena Gutiérrez, Cristina Loras, Isabel Escribano, Marta E Alvarez-Argüelles, Leticia Del Río, María Simón, María Angeles Meléndez, Juan Camacho, Laura Herrero, Pilar Jiménez, María Luisa Navarro-Rico, Isabel Jado, Elaina Giannetti, Jens H Kuhn, Mariano Sanchez-Lockhart, Nicholas Di Paola, Jeffrey R Kugelman, Susana Guerra, Adolfo García-Sastre, Isabel Cuesta, Maripaz P Sánchez-Seco, Gustavo Palacios
The 2023 monkeypox (mpox) epidemic was caused by a subclade IIb descendant of a monkeypox virus (MPXV) lineage traced back to Nigeria in 1971. Person-to-person transmission appears higher than for clade I or subclade IIa MPXV, possibly caused by genomic changes in subclade IIb MPXV. Key genomic changes could occur in the genome's low-complexity regions (LCRs), which are challenging to sequence and are often dismissed as uninformative. Here, using a combination of highly sensitive techniques, we determine a high-quality MPXV genome sequence of a representative of the current epidemic with LCRs resolved at unprecedented accuracy...
April 18, 2024: Nature Communications
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