keyword
https://read.qxmd.com/read/38524068/antifungal-susceptibility-profile-of-clinical-and-environmental-isolates-of-aspergillus-species-from-a-tertiary-care-center-in-north-india
#21
JOURNAL ARTICLE
Manharpreet Kaur, Nidhi Singla, Deepak Aggarwal, Reetu Kundu, Neelam Gulati, Mani Bhushan Kumar, Satinder Gombar, Jagdish Chander
INTRODUCTION: Aspergillus species are ubiquitously found in the environment worldwide and are important causative agents for infection. Drug resistance among Aspergillus species is emerging, hence the present study was undertaken to look for antifungal susceptibility profiles of clinical and environmental isolates of Aspergillus species. MATERIALS AND METHODS: During the period from January 2018 to June 2019, a total of 102 Aspergillus isolates (40 clinical, 40 hospital, and 22 community environment) were tested for antifungal susceptibility testing for determination of minimum inhibitory concentration (MIC)/minimum effective concentration (MEC) as per Clinical and Laboratory Standards Institute (CLSI) M38-A3 method for itraconazole, voriconazole, amphotericin B, and caspofungin...
February 2024: Curēus
https://read.qxmd.com/read/38523928/clinical-course-and-outcomes-of-covid-19-patients-admitted-to-the-icu-of-a-tertiary-care-hospital-in-central-india-a-cross-sectional-study
#22
JOURNAL ARTICLE
Alka Modi Asati, Rakesh Patel, Kritika Singhal, Chakresh Jain, Sonali Tripathi
BACKGROUND: Coronavirus disease 2019 (COVID-19) rapidly spread globally, leading to a pandemic significantly impacting individuals, communities, and economies worldwide. Public health measures such as social distancing, mask-wearing, and hand hygiene have been implemented globally to mitigate the spread of the virus. Many people recovered from COVID-19, but some cases needed intensive care unit (ICU) care, among whom most required mechanical ventilation (MV). MATERIALS AND METHODS: This hospital-based cross-sectional study was done among 75 clinical or reverse transcriptase-polymerase chain reaction (RT-PCR) test-confirmed cases of COVID-19 infection admitted to the ICU of a tertiary care unit in India...
February 2024: Curēus
https://read.qxmd.com/read/38523527/structural-and-sequence-analysis-of-the-rpo30-gene-of-sheeppox-and-goatpox-viruses-from-india
#23
JOURNAL ARTICLE
Gundallahalli Bayyappa Manjunatha Reddy, Krishnappa Sumana, Revanaiah Yogisharadhya, Hosakote Venkatappa Mohan, Vijaykumar Kolar Lavanya, Basavarajappa Harlipura Chethankumar, Nayakwadi Shivasharanappa, Mani Saminathan, Sajjanar Basavaraj, Kuldeep Dhama, Shivachandra Bhadravati Sathish
Sheeppox and goatpox are transboundary viral diseases of sheep and goats that cause significant economic losses to small and marginal farmers worldwide, including India. Members of the genus Capripoxvirus (CaPV), namely Sheeppox virus (SPPV), Goatpox virus (GTPV), and Lumpy skin disease virus (LSDV), are antigenically similar, and species differentiation can only be accomplished using molecular approaches. The present study aimed to understand the molecular epidemiology and host specificity of SPPV and GTPV circulating in India through sequencing and structural analysis of the RNA polymerase subunit-30 kDa ( RPO30 ) gene...
December 2024: Veterinary Quarterly
https://read.qxmd.com/read/38523275/wiskott-aldrich-syndrome-protein-expression-in-female-was-carriers-a-flow-cytometry-study-from-north-india
#24
JOURNAL ARTICLE
Suprit Basu, Rashmi Rikhi, Kanika Arora, Vibhu Joshi, Saniya Sharma, Amit Rawat, Surjit Singh, Deepti Suri
INTRODUCTION: Wiskott-Aldrich syndrome (WAS) is a rare X-linked inborn error of immunity characterized by microthrombocytopenia, infections, eczema, and increased predisposition to develop autoimmunity and malignancy. Flow cytometric assay for determining WAS protein (WASp) is a rapid and cost-effective tool for detecting patients. However, very few studies described WASp expression in female carriers. Most WAS carriers are clinically asymptomatic. Active screening of female family members helps identify female carriers, distinguish de novo mutations, and to select appropriate donor prior to curative stem cell transplantation...
March 24, 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/38517556/new-duck-papillomavirus-type-identified-in-a-mallard-in-missouri-usa
#25
JOURNAL ARTICLE
Diego Olivo, Simona Kraberger, Arvind Varsani
Papillomaviruses are small circular DNA viruses that infect epithelial and mucosal cells and have co-evolved with their hosts. Some papillomaviruses in mammals are well studied (especially those associated with disease). However, there is limited information on papillomaviruses associated with avian hosts. From a cloacal swab sample of a mallard (Anas platyrhynchos) sampled in Missouri, USA (6 Jan 2023), we identified a papillomavirus (7839 nt) that shares ~68% genome-wide nucleotide sequence identity with Anas platyrhynchos papillomavirus 1 (AplaPV1) from a mallard sampled in Newfoundland (Canada) and ~40% with AplaPV2 from a mallard sampled in Minnesota (USA) with mesenchymal dermal tumors...
March 22, 2024: Archives of Virology
https://read.qxmd.com/read/38517215/neutralizing-antibody-responses-to-sars-cov-2-omicron-variants-post-six-months-following-two-dose-three-dose-vaccination-of-chadox1-ncov-19-or-bbv152
#26
JOURNAL ARTICLE
Pragya D Yadav, Viren Sardana, Gururaj Rao Deshpande, Pradnya V Shinde, Jeromie Wesley Vivian Thangaraj, Leyanna S George, Gajanan N Sapkal, Deepak Y Patil, Rima R Sahay, Anita M Shete, Madhavi Joshi, Manoj Murhekar, Sheela Godbole, Nivedita Gupta, Satyartha Prakash, Mamta Rathore, Rajat Ujjainiya, Ajay Pratap Singh, Aastha Mishra, Debasis Dash, Kumardeep Chaudhary, Shantanu Sengupta
BACKGROUND OBJECTIVES: The Omicron sub-lineages are known to have higher infectivity, immune escape and lower virulence. During December 2022 - January 2023 and March - April 2023, India witnessed increased SARS-CoV-2 infections, mostly due to newer Omicron sub-lineages. With this unprecedented rise in cases, we assessed the neutralization potential of individuals vaccinated with ChAdOx1 nCoV (Covishield) and BBV152 (Covaxin) against emerging Omicron sub-lineages. METHODS: Neutralizing antibody responses were measured in the sera collected from individuals six months post-two doses (n=88) of Covishield (n=44) or Covaxin (n=44) and post-three doses (n=102) of Covishield (n=46) or Covaxin (n=56) booster dose against prototype B...
March 21, 2024: Indian Journal of Medical Research
https://read.qxmd.com/read/38517089/expanded-spectrum-of-varicella-disease-and-the-need-for-vaccination-in-india
#27
JOURNAL ARTICLE
Padma Srikanth, Ilakkiya Arumugam, Seetha N Jeganathan, Rithvik Ramesh, Lakshmi Narasimhan Ranganathan, Shanthi Vijayaraghavan
Varicella vaccine was first licensed in Japan and South Korea in 1989 for use in healthy children and was introduced in US in 1995. So far, 29 countries have adopted varicella vaccine in their universal immunization program (UIP). No Asian country, India included, has adopted the varicella vaccine as part of their UIP. The extra-cutaneous sites for VZV diseases are central nervous system and gastrointestinal tract, the expanded disease spectrum includes vasculopathy, myelitis, inflammatory bowel disease, perforated ulcers, and gastritis...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38513824/current-challenges-of-blood-transfusions-in-patients-with-thalassemia-in-india-and-future-perspectives
#28
JOURNAL ARTICLE
Suvro Sankha Datta, Ayesha Sinha
The introduction of regular red blood cell transfusions transformed thalassemia major from a fatal childhood disease into a chronic disorder. Thalassemia is highly prevalent in South Asia, including the Indian subcontinent, and blood transfusion remains the cornerstone of management for these patients. But safe blood transfusions still remain a major problem in India. Difficulties in maintaining adequate blood inventory, a lack of a national blood act, and fragmented blood transfusion services are some of the major contributing factors for the delay in blood supply...
March 19, 2024: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://read.qxmd.com/read/38513558/hiv-associated-disseminated-cryptococcosis-an-unusual-clinical-and-diagnostic-picture-with-successful-cure-by-single-dose-liposomal-amphotericin-b-treatment
#29
Chhavi Gupta, Prerna Dogra, Varun Jain, Ravneet Kaur, Jyoti Bala Sharma
BACKGROUND: Cryptococcosis is an invasive, opportunistic fungal infection seen especially in human immunodeficiency virus (HIV) infected patients. Cryptococcal meningitis (CM) is the second leading cause of mortality in HIV patients. We report a case of disseminated cryptococcosis presenting with altered mental status in a newly diagnosed HIV infection. METHODS AND RESULTS: A 50-year-old with a short history of altered mental sensorium and a history of low-grade fever and weight loss for few months presented at a tertiary care hospital in North India...
February 25, 2024: Diagnostic Microbiology and Infectious Disease
https://read.qxmd.com/read/38510907/effectiveness-of-ceftazidime-avibactam-in-gram-negative-nosocomial-pneumonia-a-real-world-study-in-india
#30
JOURNAL ARTICLE
Neha Gupta, Sanjith Saseedharan, Yashesh Paliwal
BACKGROUND AND OBJECTIVE: The incidences of nosocomial pneumonia in intensive care units (ICUs) in India have been reported to range from 9% to 58% and are associated with a mortality rate of 30-70%. Ceftazidime-avibactam has activity against OXA-48-like carbapenem-resistant Enterobacterales (CRE) and has a safer adverse effect profile as compared to the nephrotoxic colistin. The current study aimed to assess the effectiveness and usage pattern of ceftazidime-avibactam in gram-negative hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) in real-world settings in India...
February 2024: Curēus
https://read.qxmd.com/read/38510774/audit-on-practices-of-endotracheal-suctioning-in-intensive-care-unit-patients-among-health-care-workers-hcws
#31
JOURNAL ARTICLE
Rahil Singh, Anju Romina Bhalotra, Shubhangi Sharma
BACKGROUND: Endotracheal suctioning (ETS) is one of the most frequently performed invasive procedures in intensive care units (ICUs). This audit was aimed at studying current practices and knowledge regarding ETS in the Indian critical care setup, with the background aim of raising awareness regarding correct practices as per current recommendations in critically ill patients. MATERIALS AND METHODS: After registering the trial with the clinical trial registry, India, a structured audit questionnaire containing 20 questions pertaining to ETS was distributed through electronic media among resident doctors working in the ICUs across India...
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38510760/transient-locked-in-syndrome-after-aneurysmal-subarachnoid-bleeding-due-to-spasm-hypoxemia
#32
JOURNAL ARTICLE
Josef Finsterer
How to cite this article: Finsterer J. Transient Locked-in Syndrome after Aneurysmal Subarachnoid Bleeding due to Spasm Hypoxemia? Indian J Crit Care Med 2024;28(1):86.
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38510759/assessment-of-nursing-staff-s-knowledge-attitude-and-practice-regarding-oral-hygiene-care-in-intensive-care-unit-patients-a-multicenter-cross-sectional-study
#33
JOURNAL ARTICLE
Surender Kumar, Bishnupati Singh, Amit Vasant Mahuli, Sanjay Kumar, Ankita Singh, Awanindra Kumar Jha
BACKGROUND: Oral care is one of the fundamental nursing care procedures used to decrease oral colonization, dental plaque, respiratory infections, patient stay, and cost. The importance of good oral hygiene for patients in intensive care units (ICUs) is well recognized, however, the most effective way to achieve good oral care in the ICU is unclear. Therefore, the aim of this study was to assess the knowledge, attitude, and practice of nursing professionals regarding oral healthcare in ICUs among various medical institutes across India...
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38508984/can-locking-plate-fixation-and-free-vascularised-fibular-transfer-with-skin-island-achieve-good-functional-outcome-in-the-treatment-of-large-bone-defects-of-tibia-a-study-of-26-cases
#34
JOURNAL ARTICLE
Jayaramaraju Dheenadhayalan, Asif Imran, Agraharam Devendra, Hari Venkatramani, Purnaganapathi Sundaram Velmurugesan, Shanmuganathan Rajasekaran, Shanmuganathan Raja Sabapathy
BACKGROUND: Despite the availability of multiple treatment options, management of tibial bone loss continues to be a challenge. Free vascularized fibula graft (FVFG) with a skin paddle offers better advantages over the other methods. We aimed to study the functional outcomes and QALY of patients with large tibial bone defects following FVFG with a locking plate in 26 patients. MATERIALS AND METHODS: We analyzed 26 consecutive patients with large tibial bone defects treated by free vascularized fibular graft (FVFG) and stabilization using a long locking plate between 2009 and 2018...
February 28, 2024: Injury
https://read.qxmd.com/read/38508584/building-citizen-science-intelligence-for-outbreak-preparedness-and-response-a-mixed-method-study-in-nine-countries-to-assess-knowledge-readiness-and-feasibility
#35
JOURNAL ARTICLE
Yi-Roe Tan, Manh Duc Nguyen, Caroline Antonia Mubaira, Dan Kajungu, Dinesh Kumar, Felipe C Canlas, Firli Yogiteten Sunaryoko, Gyanu Raja Maharjan, Harjyot Khosa, Ingo Hauter, Joan Thiga, Md Mazharul Anowar, Patrick Okwen, Tariro Kutadza, Walter Chikanya, Marc Choisy, Peiling Yap
INTRODUCTION: Citizen science (CS) is an emerging approach in public health to harness the collective intelligence of individuals to augment traditional scientific efforts. However, citizens' viewpoint, especially the hard-to-reach population, is lacking in current outbreak-related literature. We aim to understand the awareness, readiness and feasibility of outbreak-related CS, including digitally enabled CS, in low-income and middle-income countries. METHODS: This mixed-method study was conducted in nine countries between October 2022 and June 2023...
March 19, 2024: BMJ Global Health
https://read.qxmd.com/read/38506550/genomic-analysis-of-inter-hospital-transmission-of-vancomycin-resistant-enterococcus-faecium-sequence-type-80-isolated-during-an-outbreak-in-hiroshima-japan
#36
JOURNAL ARTICLE
Takaya Segawa, Kanako Masuda, Junzo Hisatsune, Kasumi Ishida-Kuroki, Yo Sugawara, Masao Kuwabara, Hideki Nishikawa, Takahiro Hiratsuka, Tatsuaki Aota, Yasuo Tao, Yoshimi Iwahashi, Kuniko Ueda, Kaori Mae, Ken Masumoto, Hiroki Kitagawa, Hitoshi Komatsuzawa, Hiroki Ohge, Motoyuki Sugai
Outbreaks caused by vancomycin-resistant enterococci that transcend jurisdictional boundaries are occurring worldwide. This study focused on a vancomycin-resistant enterococcus outbreak that occurred between 2018 and 2021 across two cities in Hiroshima, Japan. The study involved genetic and phylogenetic analyses using whole-genome sequencing of 103 isolates of vancomycin-resistant enterococci to identify the source and transmission routes of the outbreak. Phylogenetic analysis was performed using core genome multilocus sequence typing and core single-nucleotide polymorphisms; infection routes between hospitals were inferred using BadTrIP...
March 20, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38505450/observational-study-of-clinical-profiles-and-management-of-liver-abscess-in-hospitalized-patients-a-north-indian-tertiary-care-perspective
#37
JOURNAL ARTICLE
Shishirendu S Parihar, Aakash S Shah, Nitesh Bassi, Ishan Mittal, Dawesh Yadav, Vinod K Dixit, Anurag K Tiwari
Background Liver abscesses are a significant health concern, necessitating prompt diagnosis and appropriate management. Spontaneous liver abscesses are a frequent reason for hospitalizations in India, particularly in the northern part. By analyzing demographics, symptoms, radiological findings, laboratory parameters, and treatment outcomes, this study will contribute valuable insights to enhance the understanding and management of liver abscesses. Aims and objective To evaluate demographic, clinical, laboratory, and radiological parameters and management options in hospitalized patients with liver abscesses at a tertiary care center...
February 2024: Curēus
https://read.qxmd.com/read/38503367/multiplex-pcr-method-for-minion-sequencing-of-bagaza-virus-isolated-from-wild-caught-mosquitoes-in-south-africa
#38
JOURNAL ARTICLE
T R Sekee, R Bubuluma, D van Jaarsveldt, P A Bester, F J Burt
Bagaza virus (BAGV) is a mosquito-borne orthoflavivirus known to occur in regions of southern Europe, Africa, India and the Middle East. The virus has been associated with neurological disease and fatalities in various wild bird species. Association with human disease is not confirmed although limited serological evidence has suggested human infection. Surveillance programs for screening mosquitoes for evidence of arbovirus infection play an important role in providing information regarding the circulation and spread of viruses in specific regions...
March 17, 2024: Journal of Virological Methods
https://read.qxmd.com/read/38502427/canonical-notch-activation-in-patients-with-scrub-typhus-association-with-organ-dysfunction-and-poor-outcome
#39
JOURNAL ARTICLE
Jan K Damås, Kari Otterdal, Elisabeth Astrup, Tove Lekva, Jeshina Janardhanan, Annika Michelsen, Pål Aukrust, George M Varghese, Thor Ueland
PURPOSE: The mechanisms that control inflammation in scrub typhus are not fully elucidated. The Notch pathways are important regulators of inflammation and infection, but have not been investigated in scrub typhus. METHODS: Plasma levels of the canonical Notch ligand Delta-like protein 1 (DLL1) were measured by enzyme immunoassay and RNA expression of the Notch receptors (NOTCH1, NOTCH2 and NOTCH4) in whole blood was analyzed by real-time PCR in patients with scrub typhus (n = 129), in patients with similar febrile illness without O...
March 19, 2024: Infection
https://read.qxmd.com/read/38501627/paediatric-symptomatic-seizures-in-india-unravelling-varied-etiologies-and-neuroimaging-patterns-a-multicentric-study
#40
JOURNAL ARTICLE
J Baradwaj, R Balaji, A Kumar, L Kannan, D Nayak
Pediatric neuroimaging presents a unique set of challenges, primarily stemming from the intricacies of normal myelination processes occurring within the initial two years of life. This complexity is particularly pronounced in the context of pediatric epilepsy, where a substantial proportion of neuroimaging cases appears normal, especially in instances of idiopathic or provoked seizures. Nevertheless, abnormalities in neuroimaging tend to manifest in cases of acute or remote symptomatic seizures. Notably, the etiological landscape of seizures in children diverges significantly from that observed in adults, with neurodevelopmental, neurometabolic, and neuro-infectious factors emerging as predominant contributors...
January 2024: Georgian Medical News
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