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Biomarker preterm infants

Wataru Miura, Nobuhiko Nagano, Ryota Kato, Aya Okahashi, Kayo Yoshikawa, Kensuke Ohashi, Tsugumichi Koshinaga, Ichiro Morioka
Intestinal failure-associated liver disease (IFALD) is a fatal complication of short bowel syndrome managed with parenteral nutrition. A clinical cohort study reported the usefulness of parenteral administration of fish-derived omega-3 fatty acids in improving IFALD; however, no biomarker has been developed as yet. The authors report the case of a preterm infant with IFALD complicated by extensive short bowel syndrome. Intravenous administration of omega-3 fatty acids were introduced using Omegaven®at the age of 4 mo for IFALD...
February 13, 2019: Indian Journal of Pediatrics
Yonghui Wu, Xinyi Lin, Ives Yubin Lim, Li Chen, Ai Ling Teh, Julia L MacIsaac, Kok Hian Tan, Michael S Kobor, Yap Seng Chong, Peter D Gluckman, Neerja Karnani
BACKGROUND: Preterm birth (PTB), defined as child birth before completion of 37 weeks of gestation, is a major challenge in perinatal health care and can bear long-term medical and financial burden. Over a million children die each year due to PTB complications, and those who survive can face developmental delays. Unfortunately, our understanding of the molecular pathways associated with PTB remains limited. There is a growing body of evidence suggesting the role of DNA methylation (DNAm) in mediating the effects of PTB on future health outcomes...
February 11, 2019: Clinical Epigenetics
Phyllis A Dennery, Juliann M Di Fiore, Namasivayam Ambalavanan, Eduardo Bancalari, John L Carroll, Nelson Claure, Aaron Hamvas, Anna Maria Hibbs, Premananda Indic, James Kemp, Katy N Krahn, Douglas Lake, Aaron Laposky, Richard J Martin, Aruna Natarajan, Casey Rand, Molly Schau, Debra E Weese-Mayer, Amanda M Zimmet, J Randall Moorman
BACKGROUND: The increasing incidence of bronchopulmonary dysplasia in premature babies may be due in part to immature ventilatory control, contributing to hypoxemia. The latter responds to ventilation and/or oxygen therapy, treatments associated with adverse sequelae. This is an overview of the Prematurity-Related Ventilatory Control Study which aims to analyze the under-utilized cardiorespiratory continuous waveform monitoring data to delineate mechanisms of immature ventilatory control in preterm infants and identify predictive markers...
February 1, 2019: Pediatric Research
Morgan R Firestein, Michael M Myers, Judy Austin, Raymond I Stark, Joseph L Barone, Robert J Ludwig, Martha G Welch
Early exposure to antibiotics has been shown to increase risk for poor neurobehavioral development, particularly with regard to attention deficit disorders. Clinically, electroencephalography (EEG) is increasingly used as a biomarker of these deficits. Less is known about the effects of antibiotics on neurobehavioral and neurophysiological outcomes in preterm infants, a population at particularly high risk for attention deficits and perinatal antibiotic exposure. This study examines the effects of perinatal antibiotic exposure on neonatal EEG and attention deficits as measured by the Child Behavior Checklist in 4- to 5-year-old children who were enrolled in an NICU-based randomized controlled trial comparing Family Nurture Intervention (FNI) to standard care...
January 22, 2019: Developmental Psychobiology
Zhenya Yuan, Junmei Yan, Hongyu Wen, Xiaoyi Deng, Xianbin Li, Siting Su
Feeding intolerance (FI) is a common disease in preterm infants, often causing a delay in individual development. Gut microbiota play an important role in nutrient absorption and metabolism of preterm infants. To date, few studies have focused on the community composition of gut microbiota of preterm infants with feeding intolerance. In this study, we collected fecal samples from 41 preterm infants diagnosed with feeding intolerance and 29 preterm infants without feeding intolerance, at three specific times during the development and prevalence of feeding intolerance (after birth, when feeding intolerance was diagnosed, after feeding intolerance was gone), from different hospitals for 16S rRNA gene sequencing...
2019: PloS One
Sharon G Casavant, Xiaomei Cong, Roslyn H Fitch, James Moore, Ted Rosenkrantz, Angela Starkweather
BACKGROUND: Every year, an estimated 15 million babies are born preterm (<37 weeks' gestational age) globally. These preterm infants are exposed to repeated stressful and often painful procedures as part of routine life-saving care within the neonatal intensive care unit (NICU). Low thresholds for tactile and nociceptive input make it more difficult for neonates to discriminate between noxious and nonnoxious stimuli, which can result in continuous activation of stress responses in an attempt to achieve stability through adaptation, or allostasis...
March 2019: Biological Research for Nursing
Amy L D'Agata, Mary B Roberts, Terri Ashmeade, Samia Valeria Ozorio Dutra, Bradley Kane, Maureen W Groer
BACKGROUND AND OBJECTIVES: Infants who begin life in the medicalized environment of the neonatal intensive care unit (NICU) do so under stressful conditions. Environmental exposures are often abrasive to vulnerable infants, while invasive and noninvasive lifesaving interventions provide additional pain and/or stress. The most commonly selected biomarker to measure stress is cortisol. The skin is the barrier between the external environment and communicates with our neurological, endocrine and immune regulatory networks...
December 18, 2018: Psychoneuroendocrinology
Samantha L Simpson, Stephanie Grayson, Jennifer H Peterson, John J Moore, Maroun J Mhanna, Miriam K Perez, Fariba Rezaee, Giovanni Piedimonte
OBJECTIVE: Preterm birth is a significant cause of infant morbidity and mortality, which are primarily the result of respiratory and neurodevelopmental complications. However, no objective biomarker is currently available to predict at birth the risk and severity of such complications. Thus, we sought to determine whether serum neurotrophins concentrations measured at birth correlate with risk for later development of bronchopulmonary dysplasia (BPD) and long-term neurodevelopmental outcomes...
December 21, 2018: Pediatric Pulmonology
Angie M S Tosson, Kirsten Glaser, Toni Weinhage, Dirk Foell, Mohamed S Aboualam, Amira A Edris, Mervat El Ansary, Sohilla Lotfy, Christian P Speer
INTRODUCTION: Sepsis has a grave impact on neonatal morbidity and mortality. Proper timely diagnosis and a subsequently tailored management are crucial to improve neonatal outcome and survival. New diagnostic methods are needed and much effort is directed to this objective. In this work, we aimed to evaluate S100A12 protein as a biomarker of neonatal sepsis. MATERIALS AND METHODS: In this prospective single-center study, 118 preterm and term neonates were enrolled and assigned to four groups: controls, infants with no infection, infants with probable infection and infants with proven infection...
December 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
Isabella Panfoli, Giovanni Candiano, Mariya Malova, Laura De Angelis, Valentina Cardiello, Giuseppe Buonocore, Luca A Ramenghi
The risk of oxidative stress is high in preterm newborns. Room air exposure of an organism primed to develop in a hypoxic environment, lacking antioxidant defenses, and subjected to hyperoxia, hypoxia, and ischemia challenges the newborn with oxidative stress production. Free radicals can be generated by a multitude of other mechanisms, such as glutamate excitotoxicity, excess free iron, inflammation, and immune reactions. Free radical-induced damage caused by oxidative stress appears to be the major candidate for the pathogenesis of most of the complications of prematurity, brain being especially at risk, with short to long-term consequences...
2018: Frontiers in Pediatrics
K Sarafidis, O Begou, O Deda, H Gika, C Agakidis, N Efstathiou, G Theodoridis
Intraventricular hemorrhage (IVH) is a major cause of morbidity and mortality in preterm neonates. Elucidation of the mechanisms underlying IVH and/or development of disease biomarkers is essential. The aim of the study was to investigate the urine metabolic profile of preterm neonates (gestational age < 32 weeks) IVH and explore the role of metabolomics in understanding pathophysiological mechanisms of the disease from which novel biomarkers could be derived. In this single-center, prospective, case-control study, urine samples were collected from seven preterm infants with early IVH (IVH group) and from 11 preterm ones without IVH (control group) on days 1, 3 and 9 of life...
November 22, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Antoinette Depoorter, Roland P Neumann, Christian Barro, Urs Fisch, Peter Weber, Jens Kuhle, Sven Wellmann
Background: Neurofilament light chain (NfL) is a highly promising biomarker of neuroaxonal injury that has mainly been studied in adult neurodegenerative disease. Its involvement in neonatal disease remains largely unknown. Our aim was to establish NfL plasma concentrations in preterm and term infants in the first week of life. Methods: Plasma NfL was measured by single molecule array immunoassay in two neonatal cohorts: cohort 1 contained 203 term and preterm infants, median gestational age (GA) 37.9 weeks (interquartile range [IQR] 31...
2018: Frontiers in Neurology
Unzila Ali Nayeri, Catalin S Buhimschi, Guomao Zhao, Irina A Buhimschi, Vineet Bhandari
We aimed to test the hypothesis that determinants of the perinatal clinical exposome related to the underlying etiology of premature birth (PTB) impact differently on select neonatal outcomes. We conducted a prospective longitudinal study of 377 singleton preterm neonates [gestational age (GA) at birth: 23-34 weeks] separated into three distinct contemporaneous newborn cohorts: i) spontaneous PTB in the setting of intra-amniotic infection/inflammation (yes-IAI, n = 116); ii) spontaneous PTB in the absence of IAI (no-IAI, n = 130), and iii) iatrogenic PTB for preeclampsia (iPTB-PE, n = 131)...
2018: PloS One
Jing-Jing Pan, Zhong-Yi Sun, Xiao-Yu Zhou, Yu-Hua Hu, Rui Cheng, Xiao-Qing Chen, Yang Yang
Background: The objective of this study is to evaluate the value of neutrophil gelatinase-associated lipocalin (NGAL) for becoming a good endogenous marker of renal function in asphyxial preterm babies. Materials and Methods: This is a two-center retrospective study. Between October 2016 and October 2017, 71 asphyxial preterm infants were included in asphyxia group. Seventy babies were randomly included in control group. Samples were tested at 24, 48, and 96 h after birth...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Bing Ma, Elias McComb, Pawel Gajer, Hongqiu Yang, Mike Humphrys, Adora C Okogbule-Wonodi, Alessio Fasano, Jacques Ravel, Rose M Viscardi
Intestinal barrier immaturity, or "leaky gut," is the proximate cause of susceptibility to necrotizing enterocolitis in preterm neonates. However, the impact of intestinal microbiota development on intestinal mucosal barrier maturation has not been evaluated in this population. In this study, we investigated a longitudinally sampled cohort of 38 preterm infants < 33 weeks gestation monitored for intestinal permeability (IP) and fecal microbiota during the first 2 weeks of life. Rapid decrease in IP indicating intestinal barrier function maturation correlated with significant increase in community diversity...
2018: Frontiers in Microbiology
María Álvarez-Fuente, Laura Moreno, Jane A Mitchell, Irwin K Reiss, Paloma Lopez, Dolores Elorza, Liesbeth Duijts, Alejandro Avila-Alvarez, Luis Arruza, Manuel Ramirez Orellana, Eugenio Baraldi, Patrizia Zaramella, Santiago Rueda, Álvaro Gimeno-Díaz de Atauri, Hercília Guimarães, Gustavo Rocha, Elisa Proença, Bernard Thébaud, Maria Jesús Del Cerro
Bronchopulmonary dysplasia (BPD) is the most prevalent chronic lung disease in infants and presents as a consequence of preterm birth. Due to the lack of effective preventive and treatment strategies, BPD currently represents a major therapeutic challenge that requires continued research efforts at the basic, translational, and clinical levels. However, not all very low birth weight premature babies develop BPD, which suggests that in addition to known gestational age and intrauterine and extrauterine risk factors, other unknown factors must be involved in this disease's development...
November 21, 2018: Pediatric Research
Charalampos Dokos, Christos Tsakalidis, Kyriakoula Manaridou, George Koliakos
Background Almost 30% of the premature infants have low body weight and bone mineral density due to prematurity. There is no consensus of screening premature neonates for metabolic bone disease; therefore, it is important to investigate the use of bone biochemical parameters. Latest studies involved the activity of acetylcholinesterase as a mediator in bone remodeling. It is hypothesized that there is a possible correlation of bone biochemical biomarkers and acetylcholinesterase (AChE) activity in premature infants...
November 14, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Sagori Mukhopadhyay, Shaon Sengupta, Karen M Puopolo
Antibiotic stewardship programmes aim to optimise antimicrobial use to prevent the emergence of resistance species and protect patients from the side effects of unnecessary medication. The high incidence of systemic infection and associated mortality from these infections leads neonatal providers to frequently initiate antibiotic therapy and make empiric antibiotic courses one of the main contributors of antibiotic use in the neonatal units. Yet, premature infants are also at risk for acute life-threatening complications associated with antibiotic use such as necrotising enterocolitis and for long-term morbidities such as asthma...
November 13, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
Amira M Aker, Kelly K Ferguson, Zaira Y Rosario, Bhramar Mukherjee, Akram N Alshawabkeh, José F Cordero, John D Meeker
BACKGROUND: Prenatal exposure to certain xenobiotics has been associated with adverse birth outcomes. We examined the associations of triclocarban, phenols and parabens in a cohort of 922 pregnant women in Puerto Rico, the Puerto Rico Testsite for Exploring Contamination Threats Program (PROTECT). METHODS: Urinary triclocarban, phenols and parabens were measured at three time points in pregnancy (visit 1: 16-20 weeks, visit 2: 20-24 weeks, visit 3: 24-28 weeks gestation)...
October 31, 2018: Environmental Research
Chuen-Bin Jiang, Yu-Mei Hsueh, Guang-Lin Kuo, Chyong-Hsin Hsu, Jui-Hsing Chang, Ling-Chu Chien
The neurological prognoses of very low birth weight preterm (VLBWP) children during the first 2 years of life will influence their neurodevelopment during subsequent childhood years and adolescence. The objective of this study was to systemic investigate relationships of urinary arsenic (As) concentrations, the As methylation capability, and toenail As concentrations on cognitive, language, and motor development in VLBWP children under 24 months of corrected age.Participants (n = 60) in our study were recruited from October 2010 to April 2013...
October 2018: Medicine (Baltimore)
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