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Toxic stress syndrome

Giuseppina Camiolo, Daniele Tibullo, Cesarina Giallongo, Alessandra Romano, Nunziatina L Parrinello, Giuseppe Musumeci, Michelino Di Rosa, Nunzio Vicario, Maria V Brundo, Francesco Amenta, Margherita Ferrante, Chiara Copat, Roberto Avola, Giovanni Li Volti, Antonio Salvaggio, Francesco Di Raimondo, Giuseppe A Palumbo
Iron toxicity is associated with organ injury and has been reported in various clinical conditions, such as hemochromatosis, thalassemia major, and myelodysplastic syndromes. Therefore, iron chelation therapy represents a pivotal therapy for these patients during their lifetime. The aim of the present study was to assess the iron chelating properties of α-lipoic acid (ALA) and how such an effect impacts on iron overload mediated toxicity. Human mesenchymal stem cells (HS-5) and animals (zebrafish, n = 10 for each group) were treated for 24 h with ferric ammonium citrate (FAC, 120 µg/mL) in the presence or absence of ALA (20 µg/mL)...
January 31, 2019: International Journal of Molecular Sciences
Bernhard N Bohnert, Thomas Dörffel, Sophie Daiminger, Carsten Calaminus, Sandro Aidone, Almuth Falkenau, Antje Semrau, Mai J Le, Franz Iglauer, Ferruh Artunc
Doxorubicin-induced nephropathy in mice is a model for studying experimental nephrotic syndrome. It corresponds to puromycin aminonucleoside nephrosis in rats. In this model, susceptible 129 S1/SvImJ mice are administered a rapid intravenous injection that can be accomplished via either the lateral tail vein or the retrobulbar sinus. Because doxorubicin is a highly toxic substance, extravasation must be avoided during the administration of the intravenous injection to prevent the development of large necrotizing lesions and exacerbation of the animals' stress...
January 24, 2019: Laboratory Animals
Yves Jr Menezo, Brian Dale, Kay Elder
Life expectancy has increased since World War II and this may be attributed to several aspects of modern lifestyles. However, now we are faced with a downturn, which seems to be the result of environmental issues. This paradigm is paralleled with a reduction in human fertility: decreased sperm quality and increased premature ovarian failure and diminished ovarian reserve syndromes. Endocrine Disruptor Compounds (EDCs) and other toxic chemicals: herbicides, pesticides, plasticizers, to mention a few, are a rising concern in today environment...
January 17, 2019: Molecular Reproduction and Development
Teresa Janas, Karolina Sapoń, Michael H B Stowell, Tadeusz Janas
The distribution of amyloid beta peptide 42 (Aβ42) between model exosomal membranes and a buffer solution was measured. The model membranes contained liquid-ordered regions or phosphatidylserine. Results demonstrated that up to ca. 20% of amyloid peptide, generated in the plasma (or intracellular) membrane as a result of proteolytic cleavage of amyloid precursor proteins by β- and γ-secretases, can stay within the membrane milieu. The selection of RNA aptamers that bind to Aβ42 incorporated into phosphatidylserine-containing liposomal membranes was performed using the selection-amplification (SELEX) method...
January 13, 2019: International Journal of Molecular Sciences
Amy E Ford, Catherine Denicourt, Kevin A Morano
The eukaryotic cytosolic proteome is vulnerable to changes in proteostatic and redox balance caused by temperature, pH, oxidants and xenobiotics. Cysteine-containing proteins are especially at risk as the thiol side chain is subject to oxidation, adduction and chelation by thiol-reactive compounds. The thiol-chelating heavy metal cadmium is a highly toxic environmental pollutant demonstrated to induce the heat shock response and recruit protein chaperones to sites of presumed protein aggregation in the budding yeast Saccharomyces cerevisiae...
January 2, 2019: Molecular Biology of the Cell
Xian-Zhe Dong, Yu-Ning Wang, Xiao Tan, Ping Liu, Dai-Hong Guo, Can Yan
This study aims at investigating the radioprotective effect of ethanol extract from Ji-Xue-Teng (JXT, Spatholobus suberectus ) on radiation-induced hematopoietic alteration and oxidative stress in the liver. Mice were exposed to a single acute γ -radiation for the whole body at the dose of 6.0 Gy, then subjected to administration of amifostine (45 mg/kg) or JXT (40 g crude drug/kg) once a day for 28 consecutive days, respectively. Bone marrow cells and hemogram including white cells, red cells, platelet counts, and hemoglobin level were examined...
2018: Oxidative Medicine and Cellular Longevity
David Lalaouna, Emma Desgranges, Isabelle Caldelari, Stefano Marzi
Staphylococcus aureus is a Gram-positive major human pathogen involved in a wide range of human infectious diseases (from minor skin infections to septicemia, endocarditis or toxic shock syndrome). The treatment of S. aureus infections is very challenging due to the emergence of multiple antibiotic-resistant isolates. The high diversity of clinical symptoms caused by S. aureus depends on the precise expression of numerous virulence factors and stress response pathways, which are tightly regulated at every level (transcriptional, posttranscriptional, translational, and posttranslational)...
2018: Methods in Enzymology
Betre Legesse, Amandeep Kaur, Doreswamy Kenchegowda, Bernadette Hritzo, William E Culp, Maria Moroni
PURPOSE: Understanding the physiopathology underlying the Acute Radiation Syndrome (ARS) and the mechanism of action of drugs known to ameliorate ARS is expected to help identify novel countermeasure candidates and improve the outcome for victims exposed to radiation. G-CSF has been approved by the FDA for treatment of hematopoietic ARS (H-ARS) based on its ability to alleviate myelosuppression. Besides its role in hematopoiesis, G-CSF is known to protect the cardiovascular and neurological systems, to attenuate vascular injury and cardiac toxicity, to preserve gap junction function, and to modulate inflammation and oxidative stress...
November 26, 2018: International Journal of Radiation Oncology, Biology, Physics
Zhi Dong Zhou, Ji Chao Tristan Lee, Eng King Tan
Mutations of F-box only protein 7 (FBXO7) gene are associated with a severe form of autosomal recessive juvenile Parkinson's disease (PD) (PARK15) with clinical features of Parkinsonian-Pyramidal syndrome (PPS). FBXO7 is an adaptor protein in SCFFBXO7 ubiquitin E3 ligase complex that recognizes and mediates degradative or non-degradative ubiquitination of substrates. The FBXO7 protein can regulate cell cycle, proliferation, mitochondrial and proteasome functions via interactions with multiple target proteins...
October 2018: Mutation Research
Yanhua Shi, Xiang Kong, Hongmei Yin, Wentong Zhang, Wei Wang
OBJECTIVE: To evaluate the potential beneficial effects of hawthorn leaf flavonoids (HLF) against polycystic ovary syndrome (PCOS) in a rat model of disease and elucidate the underlying molecular mechanism. METHODS: The PCOS model was established by subcutaneous injection of dehydroepiandrosterone (DHEA, 60 mg/kg/day) for 21 consecutive days. HLF (200 mg/kg/day) were orally administered simultaneously or after the injection. The body weight was regularly monitored and recorded...
November 7, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
Catherine M Bulka, Victoria W Persky, Martha L Daviglus, Ramon A Durazo-Arvizu, Maria Argos
BACKGROUND: Epidemiologic studies suggest toxic metals are linked with diabetes and cardiovascular disease, while experimental studies indicate nutritionally essential metals are involved in the metabolism of macronutrients and defense against oxidative stress. OBJECTIVES: We sought to evaluate how essential and toxic metals are cross-sectionally related to metabolic syndrome, a clustering of cardiometabolic conditions. METHODS: Using data from the 2011-2014 National Health and Nutrition Examination Survey (n = 1088), we characterized metal concentrations as measured in spot urine (arsenic, cadmium, and inorganic/elemental mercury), whole blood (manganese, lead, methylmercury, and selenium), and serum (copper and zinc) samples...
January 2019: Environmental Research
Sanaz Nasoohi, Kehkashan Parveen, Tauheed Ishrat
Empirical evidence indicates a strong association between insulin resistance and pathological alterations related to Alzheimer's disease (AD) in different cerebral regions. While cerebral insulin resistance is not essentially parallel with systemic metabolic derangements, type 2 diabetes mellitus (T2DM) has been established as a risk factor for AD. The circulating "toxic metabolites" emerging in metabolic syndrome may engage several biochemical pathways to promote oxidative stress and neuroinflammation leading to impair insulin function in the brain or "type 3 diabetes"...
2018: Journal of Alzheimer's Disease: JAD
Fernando Bessone, María Valeria Razori, Marcelo G Roma
Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic syndrome. It represents a wide spectrum of histopathological abnormalities ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) with or without fibrosis and, eventually, cirrhosis and hepatocellular carcinoma. While hepatic simple steatosis seems to be a rather benign manifestation of hepatic triglyceride accumulation, the buildup of highly toxic free fatty acids associated with insulin resistance-induced massive free fatty acid mobilization from adipose tissue and the increased de novo hepatic fatty acid synthesis from glucose acts as the "first hit" for NAFLD development...
October 20, 2018: Cellular and Molecular Life Sciences: CMLS
L Hefez, K Zaghbib, E Sbidian, L Valeyrie-Allanore, M Allain, T A Duong, A Colin, F Bellivier, H Romano, N de Prost, K Chazelas, O Chosidow, P Wolkenstein, S Ingen-Housz-Oro
BACKGROUND: Epidermal necrolysis is a rare and severe cutaneous adverse reaction to drugs with long-term somatic consequences and potentially underrecognized psychological complications. OBJECTIVES: To assess the prevalence and risk factors of post-traumatic stress disorder (PTSD) in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in a population of adults undergoing psychiatric evaluation. METHODS: In this prospective study, we included adult patients admitted at the acute phase of SJS/TEN to our dermatology department from June 2009 to February 2013...
October 3, 2018: British Journal of Dermatology
Sana Ullah, Zhongqiu Li, Muhammad Zain Ul Arifeen, Shahid Ullah Khan, Shah Fahad
Deltamethrin (DLM) is α-cyano (type II) synthetic pyrethroid. DLM exposure leads to strong neurotoxic effects and a number of complex toxicological syndromes. The current study assessed DLM mediated oxidative stress, behavioral, hematological, histopathological, and biochemical toxic effects on silver carp (Hypophthalmichthys molitrix). Exposure to an acute concentration (2 μg/L) of DLM resulted in different behavioral inconsistencies and a time-dependent significant (P < 0.05) change in the hematology and serum biochemistry of silver carp...
September 25, 2018: Chemosphere
Andrea Romano, Marta Moraschi, Riccardo Cornia, Alessandro Bozzao, Maria Camilla Rossi-Espagnet, Federico Giove, Giorgio Albertini, Alberto Pierallini
PURPOSE: Cognitive decline in Down syndrome generally shows neurodegenerative aspects similar to what is observed in Alzheimer's disease. Few studies reported information on white matter integrity. The aim of this study was to evaluate white matter alterations in a cohort of young Down subjects, without dementia, by means of DTI technique, compared to a normal control group. METHODS: The study group consisted of 17 right-handed subjects with DS and many control subjects...
December 2018: Neuroradiology
Paul H Kim, Jennings Luu, Patrick Heizer, Yiping Tu, Thomas A Weston, Natalie Chen, Christopher Lim, Robert L Li, Po-Yu Lin, James C Y Dunn, Didier Hodzic, Stephen G Young, Loren G Fong
Hutchinson-Gilford progeria syndrome is a disorder of premature aging in children caused by de novo mutations in LMNA that lead to the synthesis of an internally truncated form of prelamin A (commonly called progerin). The production of progerin causes multiple disease phenotypes, including an unusual vascular phenotype characterized by the loss of smooth muscle cells in the arterial media and fibrosis of the adventitia. We show that progerin expression, combined with mechanical stress, promotes smooth muscle cell death...
September 26, 2018: Science Translational Medicine
Min-Xuan Xu, Yu-Ting Qin, Chen-Xu Ge, Ting-Ting Gu, De-Shuai Lou, Qiang Li, Lin-Feng Hu, Yuan-Yuan Li, Wei-Wei Yang, Jun Tan
Research suggests that particulate matter (PM2.5 ) is a predisposing factor for metabolic syndrome-related systemic inflammation and oxidative stress injury. TNF-α as a major pro-inflammatory cytokine was confirmed to participate in various diseases. Inactive rhomboid protein 2 (iRhom2) was recently determined as a necessary regulator for shedding of TNF-α in immune cells. Importantly, kidney-resident macrophages are critical to inflammation-associated chronic renal injury. Podocyte injury can be induced by stimulants and give rise to nephritis, but how iRhom2 contributes to PM2...
September 26, 2018: Nanotoxicology
Carla Maiara Lopes Cardozo, Aline Carla Inada, Gabriela Marcelino, Priscila Silva Figueiredo, Daniela Granja Arakaki, Priscila Aiko Hiane, Claudia Andrea Lima Cardoso, Rita de Cássia Avellaneda Guimarães, Karine de Cássia Freitas
Obesity, in conjunction with other metabolic disorders such as insulin resistance and dyslipidemia, is a feature of metabolic syndrome which is characterized by a pro-inflammatory state and increased oxidative stress. Therefore, antioxidant foods are proposed to prevent and treat these disorders. Medicinal plants are one of the main strategies in this regard. Guavira, a Brazilian Cerrado plant, contains different bioactive compounds with a high antioxidant capacity and without clinical or reproductive toxicity effects...
September 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Vivek Venkataramani, Thorsten R Doeppner, Desiree Willkommen, Catherine M Cahill, Yongjuan Xin, Guilin Ye, Yanyan Liu, Adam Southon, Allegra Aron, Ho Yu Au-Yeung, Xudong Huang, Debomoy K Lahiri, Fudi Wang, Ashley I Bush, Gerald G Wulf, Philipp Ströbel, Bernhard Michalke, Jack T Rogers
For more than 150 years it is known that occupational overexposure of manganese (Mn) causes movement disorders resembling Parkinson's disease (PD) and PD-like syndromes. However, the mechanisms of Mn toxicity are still poorly understood. Here, we demonstrate that Mn dose- and time-dependently blocks the protein translation of amyloid precursor protein (APP) and heavy-chain Ferritin (H-Ferritin), both iron homeostatic proteins with neuroprotective features. APP and H-Ferritin are post-transcriptionally regulated by iron responsive proteins (IRPs), which bind to homologous iron responsive elements (IREs) located in the 5'-untranslated regions (5'-UTRs) within their mRNA transcripts...
August 27, 2018: Journal of Neurochemistry
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