Mónica Fumero-Velázquez, Michael Hagstrom, Soneet Dhillon, Shantel Olivares, Lawrence J Jennings, David Dittman, Madina Sukhanova, Nicoleta C Arva, Seth D Goldstein, Amy Theos, Peter Pavlidakey, Zachary Carr, Pedram Gerami
BACKGROUND: The conventionally understood pathogenesis of agminated Spitz nevi includes a mosaic HRAS mutation followed by copy number gains in 11p. However, we have recently observed agminated presentations of fusion-driven melanocytic neoplasms. METHODS: We retrieved cases from our database of benign fusion-induced melanocytic neoplasms with an agminated presentation. Both the primary lesion and the secondary lesion were sequenced. TERT-promoter mutational testing and the melanoma fluorescence in situ hybridization assay were also performed...
July 5, 2023: Journal of Cutaneous Pathology