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Function pulmonary

Joseph Jacob, Michael Pienn, Christian Payer, Martin Urschler, Maria Kokosi, Anand Devaraj, Athol U Wells, Horst Olschewski
BACKGROUND AND OBJECTIVE: This study aimed to investigate whether quantitative lung vessel morphology determined by a new fully automated algorithm is associated with functional indices in idiopathic pulmonary fibrosis (IPF). METHODS: A total of 152 IPF patients had vessel volume, density, tortuosity and heterogeneity quantified from computed tomography (CT) images by a fully automated algorithm. Separate quantitation of vessel metrics in pulmonary arteries and veins was performed in 106 patients...
February 20, 2019: Respirology: Official Journal of the Asian Pacific Society of Respirology
Cherrie H T Kong, Simon M Bryant, Judy J Watson, David M Roth, Hemal H Patel, Mark B Cannell, Andrew F James, Clive H Orchard
NEW FINDINGS: What is the central question of this study? Overexpression of caveolin-3 (Cav-3 OE) appears to protect the heart against many of the features of heart failure (HF) normally observed in vivo. The present study investigates the cellular basis of this protection. What is the main finding and its importance? Cav-3 OE has little effect in normal ventricular myocytes but reduces cellular hypertrophy and preserves t-tubular ICa, but not local t-tubular Ca release, in HF induced by pressure-overload in mice...
February 20, 2019: Experimental Physiology
Stéphane Gaudry, Jean-Pierre Quenot, Alexandre Hertig, Saber Davide Barbar, David Hajage, Jean-Damien Ricard, Didier Dreyfuss
Acute kidney injury (AKI) affects many intensive care unit patients and is responsible for increased morbidity and mortality. Although life-saving in many situations, renal replacement therapy (RRT) may be associated with complications and the appropriate timing of its initiation is still the subject of intense debate. An early initiation strategy can prevent some metabolic complications whereas a delayed one may allow for renal function recovery in some patients without need for this costly and potentially dangerous technique...
February 20, 2019: American Journal of Respiratory and Critical Care Medicine
D Merrill Dane, Cuneyt Yilmaz, Dipendra Gyawali, Roshni Iyer, Jyothi U Menon, Kytai T Nguyen, Priya Ravikumar, Aaron S Estrera, Connie C W Hsia
Paracrine erythropoietin (EPO) signaling in the lung recruits endothelial progenitor cells, promotes cell maturation and angiogenesis , and is upregulated during canine post-pneumonectomy (PNX) compensatory lung growth. To determine whether inhalational delivery of exogenous EPO augments endogenous post-PNX lung growth, adult canines underwent right PNX and received, via a permanent tracheal stoma, weekly nebulization of recombinant human EPO-containing nanoparticles or empty nanoparticles (control) for 16 weeks...
February 20, 2019: American Journal of Physiology. Lung Cellular and Molecular Physiology
András Salamon, Péter Faragó, Viola Luca Németh, Noémi Szépfalusi, Emese Horváth, Andrea Vass, Zsuzsanna Bereczky, János Tajti, László Vécsei, Péter Klivényi, Dénes Zádori
Hereditary hemorrhagic teleangiectasia (HHT, Osler-Rendu-Weber disease) is an autosomal dominantly inherited disorder caused by the mutation of several possible genes and characterized by malformations of the arteriovenous system in multiple organs. The clinical diagnosis is based on the Curaçao criteria ((1) spontaneous, recurrent epistaxis; (2) teleangiectasias in characteristic sites (lips, oral cavity, nose, fingers); (3) visceral lesions (gastrointestinal, pulmonary, cerebral, spinal); (4) affected first degree relative)...
January 30, 2019: Ideggyógyászati Szemle
Tania Deis, Louise Balling, Søren Boesgaard, Kasper Rossing, Morten Schou, Peter Oturai, Emil Wolsk, Finn Gustafsson
The interaction between hemodynamics and kidney function in heart failure (HF) is incompletely understood. We investigated the association between invasive hemodynamic parameters and measured glomerular filtration rate (mGFR) by plasma clearance of 51-chromium-labeled ethylenediamine tetra-acetic acid (51 Cr-EDTA) in patients with advanced HF and tested the hypothesis that patients with reduced mGFR have lower cardiac index (CI) and mean arterial pressure (MAP) as well as higher central venous pressure (CVP) and pulmonary capillary wedge pressure (PCWP)...
February 20, 2019: Scandinavian Journal of Clinical and Laboratory Investigation
Marta García-Clemente, Ana Isabel Enríquez-Rodríguez, Marta Iscar-Urrutia, Beatriz Escobar-Mallada, Miguel Arias-Guillén, Francisco Julián López-González, Claudia Madrid-Carbajal, Liliana Pérez-Martínez, Teresa Gonzalez-Budiño
OBJECTIVE: The aim of our study was to determine the tomographic findings and prevalence of bronchiectasis in our population of patients with severe asthma, and to identify factors associated with the presence of bronchiectasis in these patients. MATERIALS AND METHODS: We retrospectively collected data from the medical histories of patients referred to the asthma unit of our hospital, with a diagnosis of severe asthma between 2015 and 2017. Patients with ABPA, cystic fibrosis, immunodeficiency or systemic disease were excluded...
February 20, 2019: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Tania Deis, Louise Balling, Kasper Rossing, Emil Wolsk, Michael Perch, Finn Gustafsson
AIMS: Patients with heart failure (HF) are known to have a reduced pulmonary diffusion capacity for carbon monoxide (DLCO ), but little is known about how lung function relates to central haemodynamics. The aim of this study was to investigate the association between haemodynamic variables and pulmonary diffusion capacity adjusted for alveolar volume in congestive HF patients and to analyse how predicted DLCO /VA affects mortality in relation to the haemodynamic status. METHODS AND RESULTS: We retrospectively studied right heart catheterization (RHC) and lung function data on 262 HF patients (mean age 51 ± 13 years) with a left ventricular ejection fraction < 45% referred non-urgently for evaluation for heart transplantation (HTX) or left ventricular assist device (LVAD)...
February 19, 2019: ESC Heart Failure
Zeinab Ghaedrahmat, Mehdi Vosoughi, Yaser Tahmasebi Birgani, Abdolkazem Neisi, Gholamreza Goudarzi, Afshin Takdastan
In recent years, concerns over the issue of air pollution have increased as one of the significant environmental and health problems. Air pollutants can be toxic or harmful to the life of plants, animals, and humans. Contrast to primary pollutants, ozone is a secondary pollutant that is produced by the reaction between primary precursors in the atmosphere. The average of air pollutant data was compiled for the purpose of analyzing their correlation with the pulmonary function of students and the FENO biomarker from the air pollutants of the Environmental Protection Agency...
February 20, 2019: Environmental Science and Pollution Research International
Vineet Agrawal, Benjamin F Byrd, Evan L Brittain
Heart failure due to diastolic dysfunction and pulmonary hypertension are frequent comorbid conditions with significant morbidity and mortality. Identifying the presence and etiology of diastolic dysfunction in the setting of pulmonary hypertension remains challenging despite profound therapeutic and prognostic implications. Additionally, there is little guidance in identifying and parsing etiology of diastolic dysfunction in patients found to have pulmonary hypertension. This review discusses the complex interplay between left ventricular diastolic dysfunction and pulmonary hypertension...
January 2019: Pulmonary Circulation
Dominique Dos Reis, Laurie Fraticelli, Adrien Bassand, Stéphane Manzo-Silberman, Nicolas Peschanski, Sandrine Charpentier, Meyer Elbaz, Dominique Savary, Eric Bonnefoy-Cudraz, Said Laribi, Patrick Henry, Abdallah Guerraoui, Karim Tazarourte, Tahar Chouihed, Carlos El Khoury
OBJECTIVES: Cardiorenal syndrome (CRS) is the combination of acute heart failure syndrome (AHF) and renal dysfunction (creatinine clearance (CrCl) ≤60 mL/min). Real-life data were used to compare the management and outcome of AHF with and without renal dysfunction. DESIGN: Prospective, multicentre. SETTING: Twenty-six academic, community and regional hospitals in France. PARTICIPANTS: 507 patients with AHF were assessed in two groups according to renal function: group 1 (patients with CRS (CrCl ≤60 mL/min): n=335) and group 2 (patients with AHF with normal renal function (CrCl >60 mL/min): n=172)...
January 15, 2019: BMJ Open
Maciej Polak, Krystyna Szafraniec, Magdalena Kozela, Renata Wolfshaut-Wolak, Martin Bobak, Andrzej Pająk
OBJECTIVE: Previous studies have reported inverse associations between socioeconomic status (SES) and lung function, but less is known about whether pulmonary function is affected by SES changes. We aimed to describe the relationship of changes of SES between childhood and adulthood with pulmonary function. DESIGN: Cross-sectional study. PARTICIPANTS: The study sample included 4104 men and women, aged 45-69 years, residents of Krakow, participating in the Polish part of the Health, Alcohol and Psychosocial Factors in Eastern Europe Project...
January 9, 2019: BMJ Open
Valentin Mocanu, Jerry Dang, Farah Ladak, Noah Switzer, Daniel W Birch, Shahzeer Karmali
BACKGROUND: Gastrointestinal leak is one of the most severe postoperative complications after Roux-en-Y gastric bypass (RYGB), occurring in up to 2% of all patients. This has led to adoption of simpler procedures, such as sleeve gastrectomy, which have improved safety profiles but potentially less effective long-term metabolic outcomes. Yet, in contrast to sleeve gastrectomy, a paucity of modern literature exists regarding predictors of leak for RYGB. OBJECTIVES: The purpose of this study was to examine gastrointestinal leak in patients undergoing RYGB using the Metabolic and Bariatric Surgery Accreditation and Quality Improvement data registry...
January 26, 2019: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Qing Guo, Zhao-Bo Shen, Xiao-Min Sun, Dan Chen, Ping Kang
OBJECTIVE: To study the association of cytoplasmic phospholipase A2 (PLA2G4) rs932476 polymorphism with the development of bronchial asthma and the response to montelukast, a leukotriene receptor antagonist, in children. METHODS: A total of 128 children with bronchial asthma were enrolled as case group, and 100 healthy children were enrolled as control group. The genotype and allele frequencies of PLA2G4 rs932476 were compared between the two groups. The children in the case group were administered with montelukast except routine treatment for 2 months, and the changes in serum levels of leukotriene B4 (LTB4), interleukin-4 (IL-4), immunoglobulin E (IgE), and interferon gamma (IFN-γ), pulmonary function and fractional exhaled nitric oxide (FeNO) after treatment were observed...
February 2019: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Tracy Z Cheng, Kevin J Choi, Adam L Honeybrook, Rasheedat T Zakare-Fagbamila, Alice L Gray, Laurie D Snyder, Scott M Palmer, Ralph Abi-Hachem, David W Jang
BACKGROUND: Patients with cystic fibrosis (CF) who have undergone lung transplantation frequently require hospitalizations and antibiotic treatments for respiratory tract infections. Although endoscopic sinus surgery (ESS) improves sinonasal quality of life in CF patients, it is unclear if ESS offers additional benefit in terms of antibiotics for pulmonary infection, hospitalization, and pulmonary function. OBJECTIVE: To determine whether ESS impacts antibiotic use or hospitalizations for pulmonary indications or pulmonary function in CF patients after lung transplantation...
February 20, 2019: American Journal of Rhinology & Allergy
Colleen G Julian, Lorna G Moore
Whether Andean populations are genetically adapted to high altitudes has long been of interest. Initial studies focused on physiological changes in the O₂ transport system that occur with acclimatization in newcomers and their comparison with those of long-resident Andeans. These as well as more recent studies indicate that Andeans have somewhat larger lung volumes, narrower alveolar to arterial O₂ gradients, slightly less hypoxic pulmonary vasoconstrictor response, greater uterine artery blood flow during pregnancy, and increased cardiac O2 utilization, which overall suggests greater efficiency of O₂ transfer and utilization...
February 15, 2019: Genes
Betty Poot, Justin Travers, Mark Weatherall, Melinda McGinty
PURPOSE OF THE STUDY: To determine the prevalence and time course of cognitive impairment in COPD patients during and after an admission to hospital with an exacerbation of COPD. STUDY DESIGN: Patients admitted to hospital with an exacerbation of COPD between October 2013 and November 2014 were administered the Montreal Cognitive Assessment (MoCA) tool, COPD assessment test (CAT), and modified BORG dyspnoea scale at three points in time: within 24 hours of admission, between 48 and 72 hours after admission and 6 weeks post discharge...
February 18, 2019: Internal Medicine Journal
A A Abd El Hakeem, S M O Mousa, M T AbdelFattah, A O AbdelAziz, S S Abd El Azeim
BACKGROUND: In β-thalassemia, there are varying degrees of ineffective haematopoiesis, intermittent haemolysis and iron overload. Excess iron is deposited in organs such as the heart, the liver, the endocrine glands and the lungs. OBJECTIVES: To evaluate the pulmonary functions in asymptomatic beta thalassemic children on regular transfusion therapy and their relation to iron overload. METHODS: The study included 50 transfusion-dependent β-thalassemic children and 50 apparently healthy children as control...
February 18, 2019: Transfusion Medicine
Hongyu Kuang, Qiang Li, Qijian Yi, Tiewei Lu
BACKGROUND: This systematic review and meta-analysis was conducted to investigate the efficacy and safety of the chronic administration of aerosolized iloprost for pulmonary arterial hypertension (PAH). METHODS: All the relevant studies were obtained from three databases, namely, PubMed, Web of Science and the Cochrane Library, from the inception of each database to June 1, 2018. In our study, chronic treatment was defined as a period lasting at least 3 months...
February 19, 2019: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
Daniel Teschner, Anna Cholaszczyńska, Frederic Ries, Hendrik Beckert, Matthias Theobald, Stephan Grabbe, Markus Radsak, Matthias Bros
ß2 integrin receptors consist of an alpha subunit (CD11a-CD11d) and CD18 as the common beta subunit, and are differentially expressed by leukocytes. ß2 integrins are required for cell-cell interaction, transendothelial migration, uptake of opsonized pathogens, and cell signaling processes. Functional loss of CD18-termed leukocyte-adhesion deficiency type 1 (LAD1)-results in an immunocompromised state characterized by frequent occurrence of severe infections. In immunosuppressed individuals Aspergillus fumigatus is a frequent cause of invasive pulmonary fungal infection, and often occurs in patients suffering from LAD1...
2019: Frontiers in Immunology
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