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https://read.qxmd.com/read/30784219/dl-3-n-butylphthalide-promotes-angiogenesis-and-upregulates-sonic-hedgehog-expression-after-cerebral-ischemia-in-rats
#1
Pan-Ting Zhou, Li-Ping Wang, Mei-Jie Qu, Hui Shen, Hao-Ran Zheng, Li-Dong Deng, Yuan-Yuan Ma, Yu-Yang Wang, Yong-Ting Wang, Yao-Hui Tang, Heng-Li Tian, Zhi-Jun Zhang, Guo-Yuan Yang
INTRODUCTION: Dl-3-N-butylphthalide (NBP), a small molecule drug used clinically in the acute phase of ischemic stroke, has been shown to improve functional recovery and promote angiogenesis and collateral vessel circulation after experimental cerebral ischemia. However, the underlying molecular mechanism is unknown. AIMS: To explore the potential molecular mechanism of angiogenesis induced by NBP after cerebral ischemia. RESULTS: NBP treatment attenuated body weight loss, reduced brain infarct volume, and improved neurobehavioral outcomes during focal ischemia compared to the control rats (P < 0...
February 19, 2019: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/30777890/impact-of-single-phase-ct-angiography-collateral-status-on-functional-outcome-over-time-results-from-the-mr-clean-registry
#2
Ivo Gh Jansen, Maxim Jhl Mulder, Robert-Jan B Goldhoorn, Anna Mm Boers, Adriaan Cgm van Es, Lonneke Sf Yo, Jeannette Hofmeijer, Jasper M Martens, Marianne Aa van Walderveen, Bas Fw van der Kallen, Sjoerd Fm Jenniskens, Kilian M Treurniet, Henk A Marquering, Marieke Es Sprengers, Wouter J Schonewille, Joost Cj Bot, Geert J Lycklama A Nijeholt, Hester F Lingsma, David S Liebeskind, Jelis Boiten, Jan Albert Vos, Yvo Bwem Roos, Robert J van Oostenbrugge, Aad van der Lugt, Wim H van Zwam, Diederik Wj Dippel, Ido R van den Wijngaard, Charles Blm Majoie
BACKGROUND: Collateral status modified the effect of endovascular treatment (EVT) for stroke in several randomized trials. We assessed the association between collaterals and functional outcome in EVT treated patients and investigated if this association is time dependent. METHODS: We included consecutive patients from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in The Netherlands (MR CLEAN) Registry (March 2014-June 2016) with an anterior circulation large vessel occlusion undergoing EVT...
February 18, 2019: Journal of Neurointerventional Surgery
https://read.qxmd.com/read/30765685/a-novel-strategy-for-chronic-total-occlusion-of-the-stumpless-ostial-left-anterior-descending-artery
#3
Zhen-Yu Liao, Shen-Chang Lin
BACKGROUND Despite improvements in percutaneous coronary intervention (PCI) devices and operator expertise, coronary chronic total occlusion (CTO) poses a management dilemma for interventional cardiologists. Occasionally, in CTO lesions and in bifurcation lesions with severe curvature and stenosis, wires cannot be introduced into the main artery, although wiring into the side branch is possible. We herein report a case of stumpless ostial left anterior descending artery (LAD) CTO that was successfully treated with a novel strategy...
February 15, 2019: American Journal of Case Reports
https://read.qxmd.com/read/30765679/-portal-stent-for-gastrointestinal-bleeding-caused-by-portal-stenosis-after-hepato-biliary-pancreatic-surgery
#4
Masahiko Komagome, Yoshifumi Beck, Ryota Kogure, Tetsuya Mitsui, Rihito Nagata, Yoichi Miyata, Riki Ninomiya, Akira Maki
It is known that gastrointestinalbl eeding occurs due to portalstenosis as a complication in the hepato-biliary-pancreatic region at later postoperative stages. Our department has treated 5 portal stent cases since 2015. The pressure difference between the hepatic side and intestinalside at the portalstenosis site decreased from 9-14(median: 10)cmH2O to 0-6 (median: 2)cmH2O in all cases before and after placement of the stent, resulting in hemostasis(observation period 4-18 months, median: 12 months). In surgery of the hepato-biliary-pancreatic regions, veins flowing into the portal vein are also incised by dissection of the hepatoduodenal ligament...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/30762114/comparison-of-ct-angiography-collaterals-for-predicting-target-perfusion-profile-and-clinical-outcome-in-patients-with-acute-ischemic-stroke
#5
Shan-Shan Lu, Xuan Zhang, Xiao-Quan Xu, Yue-Zhou Cao, Lin Bo Zhao, Qiang-Hui Liu, Fei-Yun Wu, Sheng Liu, Hai-Bin Shi
OBJECTIVES: To compare collateral status on single-phase CT angiography (sCTA) and multiphase CT angiography (mCTA) and their ability to predict a target mismatch on CT perfusion (CTP) and clinical outcome in patients with acute ischemic stroke (AIS). METHODS: Seventy-three AIS patients with stroke onset between 5 and 15 h or with unclear onset time and occlusions in the M1/M2 segment of the middle cerebral artery and/or intracranial internal carotid artery underwent head non-contrast CT and CTP...
February 14, 2019: European Radiology
https://read.qxmd.com/read/30762112/flair-vascular-hyperintensity-in-acute-stroke-is-associated-with-collateralization-and-functional-outcome
#6
Liang Jiang, Yu-Chen Chen, Hong Zhang, Mingyang Peng, Huiyou Chen, Wen Geng, Quan Xu, Xindao Yin, Yuehu Ma
PURPOSE: Fluid-attenuated inversion recovery vascular hyperintensity (FVH) is frequently found in stroke patients after intracranial arterial occlusion, but the prognostic value of FVH findings is unclear. We assessed whether FVH is associated with cerebral collateral status and functional outcome in patients with acute stroke patients receiving endovascular therapy. METHODS: FVH score, American Society of Interventional and Therapeutic Neuroradiology (ASITN) grade, the functional outcome at 3 months (modified Rankin Scale (mRS)), and other clinical data were collected for 37 acute stroke patients with large vessel occlusion (LVO) receiving MRI before and after endovascular therapy...
February 14, 2019: European Radiology
https://read.qxmd.com/read/30755069/signal-variance-based-collateral-index-in-dsc-perfusion-a-novel-method-to-assess-leptomeningeal-collateralization-in-acute-ischaemic-stroke
#7
Alexander Seiler, Arne Lauer, Ralf Deichmann, Ulrike Nöth, Eva Herrmann, Joachim Berkefeld, Oliver C Singer, Waltraud Pfeilschifter, Johannes C Klein, Marlies Wagner
As a determinant of the progression rate of the ischaemic process in acute large-vessel stroke, the degree of collateralization is a strong predictor of the clinical outcome after reperfusion therapy and may influence clinical decision-making. Therefore, the assessment of leptomeningeal collateralization is of major importance. The purpose of this study was to develop and evaluate a quantitative and observer-independent method for assessing leptomeningeal collateralization in acute large-vessel stroke based on signal variance characteristics in T2*-weighted dynamic susceptibility contrast (DSC) perfusion-weighted MR imaging (PWI)...
February 13, 2019: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/30738390/arterial-spin-labeling-cerebral-perfusion-changes-after-revascularization-surgery-in-pediatric-moyamoya-disease-and-syndrome
#8
Jennifer L Quon, Lily H Kim, Robert M Lober, Maryam Maleki, Gary K Steinberg, Kristen W Yeom
OBJECTIVEMoyamoya disease is a dynamic cerebrovascular condition that often requires vascular surveillance. Arterial spin labeling (ASL) is an MR perfusion method that is increasingly used for stroke and other various neurovascular pathologies. Unlike perfusion-weighted MRI, ASL uses endogenous water molecules for signal and therefore obviates gadolinium use; and provides direct, not relative, quantitative cerebral blood flow (CBF) measures. Presently, the potential role of ASL for evaluating postoperative pediatric moyamoya patients is relatively unexplored...
February 8, 2019: Journal of Neurosurgery. Pediatrics
https://read.qxmd.com/read/30738387/effect-of-choroidal-collateral-vessels-on-de-novo-hemorrhage-in-moyamoya-disease-analysis-of-nonhemorrhagic-hemispheres-in-the-japan-adult-moyamoya-trial
#9
Takeshi Funaki, Jun C Takahashi, Kiyohiro Houkin, Satoshi Kuroda, Miki Fujimura, Yasutake Tomata, Susumu Miyamoto
OBJECTIVEFollowing hemorrhagic stroke in moyamoya disease, de novo intracranial hemorrhage can occur in the previously unaffected nonhemorrhagic hemisphere. In the present analysis the authors intended to determine whether the presence in the nonhemorrhagic hemisphere of choroidal collateral vessels, which have been the focus of attention as a source of bleeding, affects the risk of de novo hemorrhage.METHODSThe subject of focus of the present cohort study was the nonhemorrhagic hemispheres of adult patients with hemorrhagic moyamoya disease enrolled in the Japan Adult Moyamoya Trial and allocated to the nonsurgical arm...
February 8, 2019: Journal of Neurosurgery
https://read.qxmd.com/read/30738368/two-cases-of-debulking-surgery-for-lower-limb-diffuse-plexiform-neurofibroma-with-transcatheter-arterial-embolisation
#10
Daiki Kitano, Takeo Osaki, Mika Nakasone, Tadashi Nomura, Kazunobu Hashikawa, Hiroto Terashi
INTRODUCTION: Diffuse plexiform neurofibroma (DPN) in patients with neurofibromatosis type 1 (NF1) causes motility dysfunction in severe cases. Transcatheter arterial embolisation (TAE) is an effective haemorrhage control method in vascular tumour surgery. PRESENTATION OF CASE: We performed debulking surgery for DPN in the buttock and posterior thigh of two NF1 patients. Preoperative TAE with gelatine particles to tumour feeder vessels was conducted in both cases...
January 29, 2019: International Journal of Surgery Case Reports
https://read.qxmd.com/read/30737658/current-mechanisms-of-low-graft-flow-and-conduit-choice-for-the-right-coronary-artery-based-on-the-severity-of-native-coronary-stenosis-and-myocardial-flow-demand
#11
Hiroyuki Nakajima, Akitoshi Takazawa, Akihiro Yoshitake, Chiho Tokunaga, Masato Tochii, Jun Hayashi, Hiroaki Izumida, Daisuke Kaneyuki, Toshihisa Asakura, Atsushi Iguchi
OBJECTIVES: We investigated current mechanisms causing low graft flow (LGF) following coronary artery bypass grafting, particularly for the right coronary artery (RCA). METHODS: We retrospectively assessed 230 individual bypass grafts as the sole bypass graft for the RCA using preoperative and postoperative quantitative angiography. Overall, 155 in-situ gastroepiploic arteries (GEAs) and 75 saphenous vein grafts (SVGs) were included. The size and status of the revascularised area were examined to determine whether these factors were associated with LGF (defined as ≤ 20 mL/min with intraoperative flowmetry)...
February 8, 2019: General Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/30735466/persistent-target-mismatch-profile-24-hours-after-stroke-onset-in-defuse-3
#12
Søren Christensen, Michael Mlynash, Stephanie Kemp, Amarnath Yennu, Jeremy J Heit, Michael P Marks, Maarten G Lansberg, Gregory W Albers
Background and Purpose- Efficacy of endovascular thrombectomy has been demonstrated up to 24 hours after stroke onset in patients selected with perfusion imaging. We hypothesized that a persistent favorable perfusion profile exists in some patients beyond 24 hours from the onset and can be predicted by a lower baseline hypoperfusion intensity ratio, which indicates favorable collaterals. Methods- We identified control arm patients from the DEFUSE 3 trial (The Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke) with a diffusion weighted imaging and perfusion magnetic resonance imaging performed 24 hours following randomization and compared imaging and clinical variables between patients with persistent mismatch versus patients who no longer had a mismatch 24 hours after randomization...
February 8, 2019: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/30734042/outcomes-of-thrombectomy-in-transferred-patients-with-ischemic-stroke-in-the-late-window-a-subanalysis-from-the-defuse-3-trial
#13
Amrou Sarraj, Michael Mlynash, Sean I Savitz, Jeremy J Heit, Maarten G Lansberg, Michael P Marks, Gregory W Albers
Importance: Although thrombectomy benefit was maintained in transfer patients with ischemic stroke in early-window trials, overall functional independence rates were lower in thrombectomy and medical management-only groups. Objective: To evaluate whether the imaging-based selection criteria used in the Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3 (DEFUSE 3) trial would lead to comparable outcome rates and treatment benefits in transfer vs direct-admission patients...
February 7, 2019: JAMA Neurology
https://read.qxmd.com/read/30722692/early-scatter-laser-photocoagulation-promotes-the-formation-of-collateral-vessels-in-branch-retinal-vein-occlusion
#14
Seoung Hyun An, Woo Jin Jeong
PURPOSE: To investigate the effect of early-scatter laser photocoagulation on the formation of collateral vessels in branch retinal vein occlusion. METHODS: The medical records of 40 cases (40 patients) of branch retinal vein occlusion with macular edema were retrospectively reviewed. Of them, 23 patients were treated with intravitreal bevacizumab injection and 17 patients underwent intravitreal bevacizumab injection with additional laser treatment. Early-scatter laser photocoagulation was applied for capillary non-perfusion areas, regardless of retinal neovascularization...
February 5, 2019: European Journal of Ophthalmology
https://read.qxmd.com/read/30720216/the-blood-pressure-paradox-in-acute-ischemic-stroke
#15
Lan Hong, Xin Cheng, Longting Lin, Andrew Bivard, Yifeng Ling, Kenneth Butcher, Qiang Dong, Mark Parsons
OBJECTIVE: To explore the association of post-stroke baseline blood pressure with cerebral collateral flow and functional outcome in acute ischemic patients with large vessel occlusion/stenosis. METHODS: Patients identified with large vessel occlusion/stenosis with baseline multimodal computed tomography, follow-up imaging, and complete clinical profiles were included. A 90-day modified Rankin Scale of 0-1 was defined as an excellent functional outcome. Cerebral collateral flow was quantified by the volume ratio of tissue within the delay time>3 seconds perfusion lesion with severely delayed contrast transit (delay time>3s/delay time>6s)...
February 5, 2019: Annals of Neurology
https://read.qxmd.com/read/30717073/carotid-vertebral-artery-bypass-with-saphenous-vein-graft-for-symptomatic-vertebrobasilar-insufficiency
#16
Hongzhou Duan, Dapeng Mo, Yang Zhang, Jiayong Zhang, Liang Li
OBJECTIVESymptomatic steno-occlusion of the proximal vertebral artery (VA) or subclavian artery (ScA) heralds a poor prognosis and high risk of stroke recurrence despite medical therapy, including antiplatelet or anticoagulant drugs. In some cases, the V2 segment of the cervical VA is patent and perfused via collateral vessels. The authors describe 7 patients who were successfully treated by external carotid artery (ECA)-saphenous vein (SV)-VA bypass.METHODSSeven cases involving symptomatic patients were retrospectively studied: 3 cases of V1 segment occlusion, 2 cases of severe in-stent restenosis in the V1 segment, and 2 cases of occlusion of the proximal ScA...
February 1, 2019: Neurosurgical Focus
https://read.qxmd.com/read/30717066/spontaneous-bilateral-internal-carotid-and-vertebral-artery-dissections-with-dominant-hemisphere-circulation-maintained-by-external-carotid-artery-ophthalmic-artery-anastomoses
#17
Danielle Golub, Lizbeth Hu, Siddhant Dogra, Jose Torres, Maksim Shapiro
Spontaneous cervical artery dissection (sCAD) is a major cause of stroke in young adults. Multiple sCAD is a rarer, more poorly understood presentation of sCAD that has been increasingly attributed to cervical trauma such as spinal manipulation or genetic polymorphisms in extracellular matrix components. The authors present the case of a 49-year-old, otherwise healthy woman, who over the course of 2 weeks developed progressive, hemodynamically significant, bilateral internal carotid artery and vertebral artery dissections...
February 1, 2019: Neurosurgical Focus
https://read.qxmd.com/read/30717056/moyamoya-syndrome-and-phace-syndrome-clinical-and-radiographic-characterization-of-the-intracranial-arteriopathy-and-response-to-surgical-revascularization
#18
Sarah Jernigan, Armide Storey, Christine Hammer, Coleman Riordan, Darren B Orbach, R Michael Scott, Edward Smith
OBJECTIVEPHACE syndrome (PHACES) has been linked to cervical and cerebral vascular anomalies, including persistent embryonic anastomoses and progressive steno-occlusive disease. However, no prior studies have documented the long-term response of PHACES patients with moyamoya disease to surgical revascularization with pial or myosynangiosis. The authors present their experience with 8 consecutive patients with PHACES and moyamoya disease.METHODSRetrospective review of patients who underwent pial synangiosis revascularization for moyamoya disease with concurrent diagnosis of PHACES...
February 1, 2019: Journal of Neurosurgery. Pediatrics
https://read.qxmd.com/read/30716491/resection-of-meningiomas-involving-major-dural-venous-sinuses-classification-technique-and-long-term-results
#19
Qazi Zeeshan, Anoop Patel, Chun-Yu Cheng, Ning-Hui Zhao, Jason Barber, Basavaraj V Ghodke, Laligam N Sekhar
OBJECTIVE: Management of meningiomas with major dural venous sinus involvement is challenging. We present our case series and perspective on reconstruction of the sinuses. METHODS: 55 patients underwent operations between 2005 and 2016 and the retrospective data were collected and analyzed. RESULTS: Cohort was younger with a mean of 51.3 years (Range 19 - 72 ) predominantly involving the superior sagittal sinus (44 patients). Sinus involvement was classified into Group 1 (<50% of sinus, n=28), Group 2 (50-99%, n=8) and Group 3 (Total occlusion, n=19)...
February 1, 2019: World Neurosurgery
https://read.qxmd.com/read/30711548/coronary-chronic-total-occlusion-with-collateral-channels-from-the-bronchial-artery
#20
Kenichiro Shimoji, Shunsuke Matsuno, Kiwamu Sudo, Etsuo Tsuchikane
No abstract text is available yet for this article.
January 25, 2019: JACC. Cardiovascular Interventions
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