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(Intracranial OR cerebral) AND (athersclerosis OR stenosis OR occlusion)

Ming-Zhe Hu, An-Rong Wang, Ze-Yu Zhao, Xiang-Yan Chen, Yan-Bin Li, Bin Liu
BACKGROUND: Post-stroke depression (PSD) is one of the most prevalent emotional disorders after stroke and often results in poor outcomes. However, the underlying physiopathologic mechanism and effective treatment of PSD remain poorly elucidated. OBJECTIVE: To investigate whether paeoniflorin has antidepressant-like activity in a rat model of PSD. METHODS: Rats were randomly divided into four groups: sham-operated control (Sham), PSD, paeoniflorin (with PSD) and fluoxetine group(with PSD)...
February 13, 2019: Neurological Research
Graeme E Glass, Justine O'Hara, Natalie Canham, Deirdre Cilliers, David Dunaway, Aimee L Fenwick, Noor-Owase Jeelani, David Johnson, Tracy Lester, Helen Lord, Jenny E V Morton, Hiroshi Nishikawa, Peter Noons, Kemmy Schwiebert, Caroleen Shipster, Alison Taylor-Beadling, Stephen R F Twigg, Pradeep Vasudevan, Steven A Wall, Andrew O M Wilkie, Louise C Wilson
Mutations in the ERF gene, coding for ETS2 repressor factor, a member of the ETS family of transcription factors cause a recently recognized syndromic form of craniosynostosis (CRS4) with facial dysmorphism, Chiari-1 malformation, speech and language delay, and learning difficulties and/or behavioral problems. The overall prevalence of ERF mutations in patients with syndromic craniosynostosis is around 2%, and 0.7% in clinically nonsyndromic craniosynostosis. Here, we present findings from 16 unrelated probands with ERF-related craniosynostosis, with additional data from 20 family members sharing the mutations...
February 13, 2019: American Journal of Medical Genetics. Part A
Weizhuo Lu, Ling Xv, Jiyue Wen
OBJECTIVE: We investigated the protective effect of the extract of the Camellia japonica L. flower on cerebral ischemia-reperfusion injury in rats. METHODS: The rat ischemia-reperfusion injury was induced by middle cerebral artery occlusion for 90 minutes and reperfusion for 48 hours. The animals received an intravenous injection once a day of 20, 40, 80 mg/kg extract of C. japonica for three consecutive days before the ischemia reperfusion. The learning and memory function, the infarct volume, serum malondialdehyde (MDA) level and lactate dehydrogenase activity, and extravasation of immunoglobulin G (IgG) into cerebral parenchyma were assessed as the cell damage index...
January 2019: Arquivos de Neuro-psiquiatria
I F Ricarte, L A Dutra, O G P Barsottini, A W S de Souza, D C O de Andrade, Clp Mangueira, G S Silva
INTRODUCTION: Transcranial Doppler is a method that enables the assessment of different cerebral hemodynamic parameters. It also allows for the evaluation of the presence of right-to-left circulation shunts (RLS) and for the detection of microembolic signals (MESs), which might be associated with an increased risk of cerebrovascular events. For instance, the presence of MESs on transcranial Doppler in patients with systemic lupus erythematous (SLE) and antiphospholipid syndrome (APS) is associated with an increased risk of stroke...
February 12, 2019: Lupus
Christiaan Hendrik Bas van Niftrik, Martina Sebök, Giovanni Muscas, Marco Piccirelli, Carlo Serra, Niklaus Krayenbühl, Athina Pangalu, Oliver Bozinov, Andreas Luft, Christoph Stippich, Luca Regli, Jorn Fierstra
The clinical significance of ipsilateral thalamic diaschisis (ITD) occurring after stroke is unknown. To characterize ITD, we investigate its hemodynamic, structural, and clinical implications. A single-institution prospective cross-sectional study was conducted using 28 symptomatic cerebrovascular steno-occlusive patients undergoing both BOLD-CVR and Diamox-challenged 15 (O)-H2 O-PET. Follow-up was at least three months. In addition, 15 age-matched healthy subjects were included. ITD was diagnosed based on a BOLD-CVR thalamic asymmetry index (TAI) > +2 standard deviations from healthy subjects...
February 12, 2019: Journal of Cerebral Blood Flow and Metabolism
Enfeng Wang, Yin Wu, Jerry S Cheung, Takahiro Igarashi, Limin Wu, Xiaoan Zhang, Phillip Zhe Sun
pH-weighted amide proton transfer (APT) MRI is sensitive to tissue pH change during acute ischemia, complementing conventional perfusion and diffusion stroke imaging. However, the currently used pH-weighted magnetization transfer (MT) ratio asymmetry (MTRasym ) analysis is of limited pH specificity. To overcome this, MT and relaxation normalized APT (MRAPT) analysis has been developed that to homogenizes the background signal, thus providing highly pH conspicuous measurement. Our study aimed to calibrate MRAPT MRI toward absolute tissue pH mapping and determine regional pH changes during acute stroke...
February 9, 2019: NeuroImage
An-Rong Wang, Ming-Zhe Hu, Zhi-Lei Zhang, Ze-Yu Zhao, Yan-Bin Li, Bin Liu
Axon regeneration after cerebral ischemia in mammals is inadequate to restore function, illustrating the need to design better strategies for improving outcomes. Improvement of axon regeneration has been achieved through fastigial nucleus electrostimulation (FNS) in animal researches. However, the mechanisms underlying this neuroprotection remain poorly understood. Increasing the levels of the second messenger cyclic AMP (cAMP) enhances axon regeneration, making it an excellent candidate molecule that has therapeutic potential...
February 9, 2019: Neuroscience Letters
Hui Wang, Wei Wei, Xiaobing Lan, Ning Liu, Yuxiang Li, Hanxiang Ma, Tao Sun, Xiaodong Peng, Chunlin Zhuang, Jian Qiang Yu
Oxidative stress plays a vital role in the development of cerebral ischemic/reperfusion (I/R). Targeting oxidative stress is proposed to be an effective strategy to treat cerebral I/R injury. Gentiana macrophylla Pall is reported to have potential protective effect against stroke. Swertiamarin (Swe), an active secoiridoid glycoside compound isolated from Gentiana macrophylla Pall, has been reported to possess the antioxidative potential. This study is to explore whether Swe could prevent brain from I/R injury and the related mechanisms of oxidative stress is also elucidated using mice middle cerebral artery occlusion (MCAO) model and primary hippocampal neurons oxygen-glucose deprivation/reperfusion (OGD/R) model...
February 12, 2019: ACS Chemical Neuroscience
Sergio G Cananzi, William G Mayhan
BACKGROUND: Maternal consumption of alcohol produces abnormalities in the developing fetus and can contribute to an increased incidence of many cardiovascular-related diseases. The first goal of this study was to determine whether in utero exposure to alcohol influences reactivity of cerebral arterioles in adult (12-15-weeks old) rats. The second goal of this study was to examine whether in utero exposure to alcohol increased the susceptibility of the brain to damage following an ischemic event in adult rats...
February 12, 2019: Alcoholism, Clinical and Experimental Research
Mimi Li, Yinhui Huang, Huasong Lin, Yafang Chen
BACKGROUND: To determine whether uric acid (UA) and intracranial and extracranial atherosclerosis stenosis of elderly patients suffering from ischaemic stroke are inter-related. METHODS: Elderly patients with ischaemic stroke underwent computed tomography angiography (CTA) were enrolled between October 2015 and December 2017. We collected clinical assessment, image data, and laboratory tests, and divided patients into four groups: (1) intracranial stenosis atherosclerosis (ICAS) group, (2) combined intracranial and extracranial atherosclerosis stenosis (COAS) group, (3) extracranial carotid stenosis atherosclerosis (ECAS) group, and (4) non-cerebral stenosis atherosclerosis (NCAS) group...
January 31, 2019: Neurological Sciences
Wenwen Si, Shanyu Ye, Zhenxing Ren, Xin Liu, Zimei Wu, Yi Li, Jianhong Zhou, Saixia Zhang, Yiwei Li, Rudong Deng, Dongfeng Chen
Under harmful environmental conditions, stress granules (SGs), macromolecular aggregates that are associated with cell survival and death, are produced in the eukaryotic cytoplasm. However, whether and how microRNAs (miRNAs/miRs) modulate SG formation induced by acute ischemic stroke has not been investigated. In the present study, a rat model of middle cerebral artery occlusion (MCAO) was utilized and miRNA array profiling and reverse transcription‑quantitative polymerase chain reaction were performed. The results revealed that miR‑335 was downregulated during acute ischemic stroke, which was concomitant with reduced SG formation, enhanced apoptosis levels and increased Rho associated protein kinase 2 (ROCK2) expression...
January 22, 2019: International Journal of Molecular Medicine
Qingqing Dai, Shujuan Li, Ting Liu, Jiayin Zheng, Song Han, Aijuan Qu, Junfa Li
We previously reported that astrocytes are the main sources of interleukin (IL)-17A production that could aggravate neuronal injuries in ischemic stroke. However, the effects of IL-17A on ischemic astrocytes themselves and the underlying molecular mechanism are still unclear. In this study, we found that recombinant mouse (rm) IL-17A could significantly (P < 0.05 or <0.001) alleviate 1-hour oxygen-glucose deprivation (OGD)/reoxygenation (R) 24-hour-induced ischemic injuries in cortical astrocytes with a dose-dependent manner (n = 6 per group)...
February 11, 2019: Journal of Cellular Biochemistry
Kessarin Panichpisal, Maharaj Singh, Adil Chohan, Paul Vilar, Reji Babygirija, Mary Hook, Sharon Matyas, Nathaniel Kojis, Rehan Sajjad, Thomas Wolfe, Amin Kassam, Richard Adam Rovin
Background: The Stroke Network of Wisconsin (SNOW) scale, previously called the Pomona scale, was developed to predict large-vessel occlusions (LVOs) in patients with acute ischemic stroke (AIS). The original study showed a high accuracy of this scale. We sought to externally validate the SNOW scale in an independent cohort. Methods: We retrospectively reviewed and calculated the SNOW scale, the Vision Aphasia and Neglect Scale (VAN), the Cincinnati Prehospital Stroke Severity (CPSS), the Los Angeles Motor Scale (LAMS), and the Prehospital Acute Stroke Severity Scale (PASS) for all patients who were presented within 24 hours after onset at AHCS (14 hospitals) between January 2015 and December 2016...
November 2018: Journal of Vascular and Interventional Neurology
S G Lum, B S Gendeh, S Husain, H S Gendeh, M R Ismail, C J Toh, A Izaham, H J Tan
Iatrogenic internal carotid artery injury is a catastrophic but uncommon complication of endonasal sinus surgery. We present our experience in managing this emergency situation. A 52-year-old man underwent revision endoscopic repair of recurrent cerebrospinal fluid leak that was complicated with profuse haemorrhage during removal of the anterior wall of sphenoid sinus using a Hajek sphenoid punch forceps. Immediate packing of the sphenoid sinus controlled the haemorrhage. Urgent angiography revealed injury at the paraclival segment of the left internal carotid artery...
January 31, 2019: Acta Otorhinolaryngologica Italica
S Vidale, E Agostoni, G Grampa, A Consoli, D Consoli
Intracranial stenosis is a well-established stroke risk factor with an increase of stroke recurrence or TIA up to 12.6% at 1 year. Treatments are different: medical and endovascular. We performed a multiple treatment comparison analysis to detect the best treatment in reducing the risk of stroke recurrence. We searched in Medline, Embase, Cochrane Central Register of Controlled Trials databases between 1979 and October 2017. Inclusion criteria were prospective randomized trials that evaluated patients with TIA or stroke due to intracranial stenosis and treated with different medical therapies and/or endovascular procedures...
February 8, 2019: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Martin Krueger, Bianca Mages, Constance Hobusch, Dominik Michalski
In the setting of stroke, ischemia-related blood-brain barrier (BBB) dysfunction aggravates the cerebral edema, which critically impacts on the clinical outcome. Further, an impaired vascular integrity is associated with the risk of intracranial bleeding, especially after therapeutic recanalization. Therefore, the present study was aimed to investigate early vascular alterations from 30 min to 4 h after experimental middle cerebral artery occlusion (MCAO) in mice. Here, an extravasation of the permeability marker FITC-albumin was detectable in animals 2 and 4 h after MCAO...
February 11, 2019: Acta Neuropathologica Communications
Junji Takasugi, Kaori Miwa, Yoshiyuki Watanabe, Shuhei Okazaki, Kenichi Todo, Tsutomu Sasaki, Manabu Sakaguchi, Hideki Mochizuki
Background and Purpose- Carotid artery stenosis is common in the elderly and contributes to cognitive impairment and dementia. Cortical cerebral microinfarcts (CMIs) play an important role in vascular cognitive impairment and dementia. We aimed to investigate the association between CMIs on 3T magnetic resonance imaging and clinical and radiological features, including plaque morphology, and cognitive function in patients with carotid stenosis. Methods- Eighty-nine patients with >30% carotid stenosis on ultrasound were prospectively enrolled, and underwent brain and carotid artery magnetic resonance imaging...
February 12, 2019: Stroke; a Journal of Cerebral Circulation
Slaven Pikija, Jozef Magdic, Laszlo K Sztriha, Monika Killer-Oberpfalzer, Nele Bubel, Anita Lukic, Johann Sellner
Ischemic stroke related to tandem internal carotid and middle cerebral artery (TIM) occlusion is a challenging condition where endovascular treatment (EVT) is an emerging revascularization option. The identification of factors influencing clinical outcomes can assist in creating appropriate therapeutic algorithms for such patients. This study aimed to evaluate prognostic factors in the context of EVT for TIM occlusion. We performed a retrospective study of consecutive patients with TIM occlusion admitted within 6 h from symptom onset to two tertiary stroke centers...
February 10, 2019: Journal of Clinical Medicine
Claudio Baracchini, Filippo Farina, Alessio Pieroni, Anna Palmieri, Caterina Kulyk, Federica Viaro, Joseph-Domenico Gabrieli, Giacomo Cester, Francesco Causin, Renzo Manara
BACKGROUND: Intracranial hemorrhage (ICH) is the most feared complication of endovascular treatment (EVT) for acute ischemic stroke due to anterior circulation large vessel occlusion (LVO). The purpose of this study was to identify cerebral hemodynamic predictors of ICH and poor outcome in patients with successful recanalization. MATERIALS AND METHODS: Serial transcranial color-coded sonography (TCCS) examinations assessed vessel status and cerebral hemodynamics of 226 [mean-age 69...
February 8, 2019: World Neurosurgery
Peng Hu, Hong-Qi Zhang, Xiao-Yu Li, Xian-Zeng Tong
BACKGROUND: The STA connected to proximal MCA has been reported before. However, the flow supply capacity of the double-barrel STA to proximal MCA bypass in treating complex intracranial aneurysms has not been well documented. METHODS: Consecutive cases using this technique to treat complex intracranial aneurysms during the past five years have been collected. SEP and MEP monitoring were applied for each patient to determine any ischaemic events during the surgery...
February 8, 2019: World Neurosurgery
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