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Retinal occlusion

Kepeng Ou, Mertsch Sonja, Sofia Theodoropoulou, Jiahui Wu, Jian Liu, David A Copland, Stefan Schrader, Lei Liu, Andrew D Dick
Regulation of vascular permeability plays a major role in the pathophysiology of visually threatening conditions such as retinal vein occlusion and diabetic retinopathy. Principally, several factors such as vascular endothelial growth factor (VEGF), are up-regulated or induced in response to hypoxia thus adversely affecting the blood-retinal barrier (BRB), resulting in retinal edema and neovascularisation. Furthermore, current evidence supports a dysregulation of the inner retinal neural-vascular integrity as a critical factor driving retinal ganglion cell (RGC) death and visual loss...
April 14, 2019: Experimental Cell Research
Caroline Ellinore Weinsjö, Gitte Buhl-Jensen, Marianne Wegener, Christoffer Tanderup Nielsen, Daniel Kondziella
This is a case report of a 29-year-old man, who presented with progressive confusion, memory problems and personality changes during 1.5 months. Later, he developed bilateral hearing impairment but had no visual symptoms. A brain MRI showed numerous small hyperintensities in both hemispheres, a retinal fluorescence angiography revealed multiple hyperfluorescent arterial occlusions, and an audiogram showed bilateral hearing impairment. The patient was treated for Susac syndrome with high-dose corticosteroids initially, followed by intravenous immunoglobulin and cyclophosphamide...
April 8, 2019: Ugeskrift for Laeger
Tomoharu Nishimura, Shigeki Machida, Atsushi Tada, Eiki Oshida, Tetsuya Muto
PURPOSE: To determine the physiology of the macula by the focal macular electroretinograms (fmERGs) in patients with branch retinal vein occlusion with macular edema (BRVOME) treated by intravitreal injections of ranibizumab (IVR). METHODS: We studied 17 eyes of 17 patients with BRVOME. The contralateral unaffected eyes served as controls. All patients were treated with an IVR at monthly intervals for 3 consecutive months. The baseline best-corrected visual acuity (BCVA), optical coherence tomographic (OCT) findings, and fmERGs were compared to the post-treatment values...
April 12, 2019: Documenta Ophthalmologica. Advances in Ophthalmology
Pritam Bawankar, Preetam Samant, Tatyarao Lahane, Ragini Parekh, Sayalee Lahane
OBJECTIVE: To study the relationship between mean platelet volume (MPV) and central retinal vein occlusion (CRVO) in hypertensive patients. DESIGN: Hospital-based, retrospective, case control design. PARTICIPANTS: The sample group consisted of 100 patients with a known history of hypertension and who are diagnosed with CRVO. The control group consisted of 100 age and sex-matched patients with the sample group and who had a sole history of hypertension without any other systemic diseases and the best corrected visual acuity of 20/20 in both the eyes...
April 2019: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Shin Kadomoto, Akihito Uji, Yuki Muraoka, Tadamichi Akagi, Manabu Miyata, Akitaka Tsujikawa
PURPOSE: To compare the retinal area measured on a panoramic en face optical coherence tomography angiography (OCTA) image with that on an ultra-widefield fluorescein angiography (UWF FA) image. METHODS: Sixteen eyes (11 with branch retinal vein occlusion, 2 with central retinal vein occlusion, 1 with branch retinal artery occlusion, and 2 with hypertensive retinopathy) were included in this study. A panoramic en face OCTA image was created from five single non-panoramic en face OCTA 12 × 12-mm images...
April 10, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Yuanyuan Zou, Xi Zhang, Jingyi Zhang, Xiangning Ji, Yuqing Liu, Shaozhen Zhao
The aim of this study was to perform an updated meta-analysis to quantitatively investigate the association between G20210A polymorphism of Prothrombin gene and the risk of retinal vein occlusion (RVO), based on the available publications with inconsistent results. We utilized the Stata software to perform the heterogeneity test, association test, Begg's and Egger's tests, and sensitivity analysis. We searched three on-line databases (PubMed, Embase, and WOS) and obtained a total of 422 articles. Based on our selection criteria, 24 case-control studies were finally enrolled in this overall meta-analysis; a subgroup analysis by the factors ethnicity, control source, and RVO type was done...
April 8, 2019: Brazilian Journal of Medical and Biological Research
Maria Eleftheriadou, Luke Nicholson, Giulia D'Alonzo, Peter K F Addison
INTRODUCTION: To report the 52-week treatment outcomes with intravitreal injections of aflibercept using a treat-and-extend regimen for treating macular edema secondary to central retinal vein occlusion (CRVO). METHODS: A retrospective analysis of patients newly diagnosed with CRVO was performed. Patients receiving aflibercept between 1 December 2016 and 31 March 2017 were included in the analysis. Data on age, gender, visual acuity measured on Early Treatment of Diabetic Retinopathy Study charts, presence of macular and peripheral ischemia, anatomical changes observed on spectral domain-optical coherence tomography examination and the number of injections needed were recorded...
April 10, 2019: Ophthalmology and Therapy
Chiara Giuffrè, Elisabetta Miserocchi, Alessandro Marchese, Maria Vittoria Cicinelli, Elena Bruschi, Giuseppe Querques, Francesco M Bandello, Giulio M Modorati
The aim is to present the changes in ultra-widefield and widefield multimodal imaging, including optical coherence tomography angiography of a 33-year-old woman diagnosed with Susac syndrome, over 1 year of follow-up. Fundus examination and multimodal imaging revealed bilateral arterial occlusion of multiple vascular branches with retinal ischemia. Over 1 year follow-up, best-corrected visual acuity improved while retinal ischemia gradually resolved. Widefield optical coherence tomography angiography showed reperfusion of macular large vessels, but not of the small capillaries...
April 10, 2019: European Journal of Ophthalmology
M I Stefanou, D Doycheva, A Ebrahimi, J-M Dörr, U Ziemann
Susac's syndrome (SuS) is a rare, probably autoimmune endotheliopathy of the central nervous system, retina and inner ear. It is characterized by a clinical triad of encephalopathy, branch retinal artery occlusions (BRAOs) and sensorineural hearing loss. To date, more than 300 cases of SuS have been reported in the literature. However, SuS remains an under- and misdiagnosed entity in the clinical setting. This report presents an exemplary case of a patient, who was initially misdiagnosed with relapsing-remitting multiple sclerosis...
April 2019: Laryngo- Rhino- Otologie
Günhal Şatırtav, Enver Mirza, Refik Oltulu, Günsu Deniz Mirza, Hürkan Kerimoğlu
PURPOSE: The purpose of this article was to evaluate monocyte count and high-density lipoprotein (HDL) cholesterol levels and their ratio (monocyte/HDL ratio [MHR]) in patients with branch retinal vein occlusion (BRVO). MATERIALS AND METHODS: A total of 50 participants were included in the study. Participants were divided into two groups: Twenty-five patients diagnosed with BRVO and 25 participants as the control group. Ocular examination findings and hematologic parameters were accessed from the file records and database, retrospectively...
April 9, 2019: Ocular Immunology and Inflammation
Jaeryung Kim, Dong Hui Lim, Kyungdo Han, Se Woong Kang, Don-Il Ham, Sang Jin Kim, Tae-Young Chung
PURPOSE: To investigate association between the development of retinal vein occlusion (RVO) and blood high-density lipoprotein cholesterol (HDL-C). DESIGN: A retrospective, nationwide, population-based cohort study. METHODS SETTING: Republic of Korea STUDY POPULATION: This study included 23,149,403 people aged 20 years or older who underwent the Korean National Health Screening Program examination between January 2009 and December 2012. Among them, the RVO group was composed of patients with an initial diagnosis of RVO made between 2009 and 2015 (n = 117,639)...
April 5, 2019: American Journal of Ophthalmology
Stephen E Langabeer
No abstract text is available yet for this article.
2019: EXCLI Journal
Hirofumi Sasajima, Kotaro Tsuboi, Kenta Murotani, Motohiro Kamei
PURPOSE: To evaluate the efficacy and safety of intravitreal drug injections using a short 34-gauge needle. STUDY DESIGN: Retrospective study. METHODS: This study included patients with age-related macular degeneration, diabetic macular edema, or macular edema associated with retinal vein occlusion. We reviewed the medical records of consecutive patients with one of those three diseases treated with antivascular endothelial growth factor (VEGF) agents using an 8-mm-long 34-gauge needle...
April 6, 2019: Japanese Journal of Ophthalmology
Adam Roche, Emma Griffin, Seamus Looby, Paul Brennan, Alan O'Hare, John Thornton, Karl Boyle, David Williams, Barry Moynihan, Sarah Power
BACKGROUND: Mechanical thrombectomy is the standard of care for acute ischemic strokes with proximal intracranial occlusion. Arterial access is commonly achieved with femoral artery puncture, although this is not always possible. In this case series, we describe 11 cases of anterior circulation stroke where direct carotid puncture was used to obtain vascular access. METHODS AND MATERIALS: A review of a prospectively maintained thrombectomy database over a 2-year period (August 2016 - August 2018) was undertaken to identify cases where direct carotid access was performed...
April 6, 2019: Journal of Neurointerventional Surgery
Mustafa Iftikhar, Tahreem A Mir, Gulnar Hafiz, Ingrid Zimmer-Galler, Adrienne W Scott, Sharon D Solomon, Akrit Sodhi, Adam S Wenick, Catherine Meyerle, Kim Jiramongkolchai, T Y Alvin Liu, J Fernando Arevalo, Mandeep Singh, Saleema Kherani, James T Handa, Peter A Campochiaro
PURPOSE: To evaluate long term visual and anatomic outcomes in patients with retinal vein occlusion (RVO) treated with anti-vascular endothelial growth factor (VEGF) agents DESIGN: Prospective, interventional case series PARTICIPANTS: Patients with central RVO (CRVO) or branch RVO (BRVO) METHODS: Number of anti-VEGF injections and improvement from baseline best-corrected visual acuity (BCVA) and central subfield thickness (CST) were prospectively recorded in 40 eyes of 39 CRVO patients and 50 eyes of 47 BRVO patients...
April 4, 2019: American Journal of Ophthalmology
Jina V Han, Dipika V Patel, David Squirrell, Charles Nj McGhee
Pseudophakic cystoid macular oedema (PCMO) remains a significant cause of compromised post-operative vision in contemporary cataract surgery. Well-established risk factors include intraoperative complications such as posterior capsule rupture and pre-operative factors including: diabetes mellitus, uveitis, retinal vein occlusion, epiretinal membrane. The role of topical glaucoma medications in PCMO continues to be debated. Current treatment strategies largely target suppression of inflammation. Topical NSAIDs remain the mainstay in prophylaxis and treatment of PCMO...
April 5, 2019: Clinical & Experimental Ophthalmology
Zhongqiang Li, Waleed Zaid, Thomas Hartzler, Alexandra Ramos, Michelle L Osborn, Yanping Li, Shaomian Yao, Jian Xu
Indocyanine green (ICG) has been widely used in medical imaging, such as in retinal angiography. Here, we describe a pilot ex vivo study of ICG-assisted near-infrared fluorescence (NIRF) dental imaging in the first (700-950 nm for ICG-NIRF-I) and second (1000-1700 nm for ICG-NIRF-II) NIR windows using human extracted teeth; our study is compared with the traditional prevalent X-ray imaging and NIR II illumination (NIRi-II, 1310 nm) without ICG enhancement. The results show that ICG fluorescence has much better imaging contrast in both windows compared with NIRi-II (by quantitatively comparing NIR intensity of the critical neighboring structures, such as enamel and dentin)...
April 5, 2019: Annals of the New York Academy of Sciences
Danny A Mammo, Collin M McClelland, John Chen, Matthew K Adams, Jose Pulido, John B Davies
INTRODUCTION: Antineutrophil cytoplasm antibody-associated vasculitides encompass a diverse spectrum of autoimmune diseases characterized by necrotizing small vessel vasculitis. Ocular manifestations may be the presenting findings of antineutrophil cytoplasm antibody-associated vasculitides. METHODS: Single, retrospective case study. RESULTS: We report the rare case of a 55-year-old woman with a cilioretinal artery occlusion as the presenting feature of perinuclear antineutrophil cytoplasm antibody-associated microscopic polyangiitis...
April 5, 2019: European Journal of Ophthalmology
Takumi Hamasaki, Yuta Itoh
We propose a varifocal occlusion technique for optical see-through head-mounted displays (OST-HMDs). Occlusion in OST-HMDs is a powerful visual cue that enables depth perception in augmented reality (AR). Without occlusion, virtual objects rendered by an OST-HMD appear semi-transparent and less realistic. A common occlusion technique is to use spatial light modulators (SLMs) to block incoming light rays at each pixel on the SLM selectively. However, most of the existing methods create an occlusion mask only at a single, fixed depth-typically at infinity...
May 2019: IEEE Transactions on Visualization and Computer Graphics
S F Cheng, M M Brown, R J Simister, T Richards
BACKGROUND: Carotid stenosis is a common cause of ischaemic stroke and transient ischaemic attack (TIA). Despite rising recognition and centralization of stroke services there has been a decline in interventions for carotid stenosis in recent years. The aim of this study was to determine the current prevalence and management of carotid stenosis in the UK. METHODS: This was a 1-year prospective observational study of consecutive patients presenting with ischaemic stroke, TIA or ischaemic retinal artery occlusion to a central London hyperacute stroke unit...
April 2, 2019: British Journal of Surgery
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