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ECG changes

Fanhao Ye, Wenbing Jiang, Yi Wang, Wei Lin, Hao Chen, Binglin Pan
RATIONALE: Amiodarone, a broad-spectrum antiarrhythmic drug, is widely used for the clinical treatment of tachyarrhythmias because of its safety and efficacy. PATIENT CONCERNS: A 30-year-old woman presented with known paroxysmal atrial tachycardia and severe preeclampsia. Two days before admission, she had given birth to twins. She described her symptoms as a sudden palpitation at 10:20 accompanied by chest tightness and shortness of breath. DIAGNOSIS: Cardiac arrhythmia and acute left heart failure...
February 2019: Medicine (Baltimore)
Susanne Breitner, Annette Peters, Wojciech Zareba, Regina Hampel, David Oakes, Jelani Wiltshire, Mark W Frampton, Philip K Hopke, Josef Cyrys, Mark J Utell, Cathleen Kane, Alexandra Schneider, David Q Rich
Previous studies have reported increased risks of myocardial infarction in association with elevated ambient particulate matter (PM) in the previous hour(s). However, whether PM can trigger mechanisms that act on this time scale is still unclear. We hypothesized that increases in PM are associated with rapid changes in measures of heart rate variability and repolarization. We used data from panel studies in Augsburg, Germany, and Rochester, New York, USA, and two controlled human exposure studies in Rochester...
February 13, 2019: Scientific Reports
June-Sung Kim, Muyeol Kim, Youn-Jung Kim, Seung Mok Ryoo, Chang Hwan Sohn, Shin Ahn, Won Young Kim
(1) Background: Myocardial dysfunction in patients with sepsis is not an uncommon phenomenon, yet reported results are conflicting and there is no objective definition. Measurement of troponin may reflect the state of the heart and may correlate with echocardiographically derived data. This study aimed to evaluate the role of admission and peak troponin-I testing for the identification of sepsis-induced myocardial dysfunction (SIMD) by transthoracic echocardiography (TTE). (2) Methods: This was a retrospective cohort study using a prospective registry of septic shock at an Emergency Department from January 2011 and April 2017...
February 12, 2019: Journal of Clinical Medicine
Xueting Gao, Siyun Gao, Yi Guan, Lin Huang, Jiale Huang, Li Lin, Yuan Liu, Hong Zhao, Bijun Huang, Tianyou Yuan, Yi Liu, Dandan Liang, Yangyang Zhang, Xiue Ma, Li Li, Jun Li, Daizhan Zhou, Dan Shi, Liang Xu, Yi-Han Chen
TLRs have been proven to be essential mediators for the early innate immune response. Overactivation of TLR-mediated immune signaling promotes deterioration of cardiovascular diseases; however, the role of TLRs in the heart under physiologic conditions remains neglected. Here, we show that Tlr3 deficiency induced the endoplasmic reticulum (ER) retention of Kv4.2/4.3 proteins and consequent degradation via the ubiquitin-proteasome pathway. Knockout of Tlr3 resulted in a prolonged QT interval (the space between the start of the Q wave and the end of the T wave) in mice with no significant signs of inflammation and tissue abnormality in cardiac muscles...
February 13, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Agnese Sbrollini, Marjolein C De Jongh, C Cato Ter Haar, Roderick W Treskes, Sumche Man, Laura Burattini, Cees A Swenne
BACKGROUND: Serial electrocardiography aims to contribute to electrocardiogram (ECG) diagnosis by comparing the ECG under consideration with a previously made ECG in the same individual. Here, we present a novel algorithm to construct dedicated deep-learning neural networks (NNs) that are specialized in detecting newly emerging or aggravating existing cardiac pathology in serial ECGs. METHODS: We developed a novel deep-learning method for serial ECG analysis and tested its performance in detection of heart failure in post-infarction patients, and in the detection of ischemia in patients who underwent elective percutaneous coronary intervention...
February 12, 2019: Biomedical Engineering Online
Peter J Schwartz, Massimiliano Gnecchi, Federica Dagradi, Silvia Castelletti, Gianfranco Parati, Carla Spazzolini, Luca Sala, Lia Crotti
Aims: Having shown that Lumacaftor rescued the hERG trafficking defect in the induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) of two LQT2 patients, we tested whether the commercial association Lumacaftor + Ivacaftor (LUM + IVA) could shorten the QTc in the same two patients. Methods and results: After hospital admission and 1 day of baseline recordings, half dose LUM + IVA was administered on Day 1, followed by full dose (LUM 800 mg + IVA 500 mg) for 7 days...
February 6, 2019: European Heart Journal
Kendra J Homan, Leslie A Sim, Susan L Crowley, Jocelyn R Lebow, Lisa N Kransdorf
OBJECTIVE: To examine the medical assessment and triage of pediatric patients with anorexia nervosa (AN) initially seen in primary care. METHODS: A retrospective cohort study was conducted for all pediatric patients with AN who had eating/weight concerns and initially identified symptoms in primary care in a single health care system between January 1, 2010, and December 31, 2016. Information on presenting concern, medical assessment/laboratory tests, clinical diagnoses, treatment recommendations, and referrals were abstracted from the medical record...
February 2019: Journal of Developmental and Behavioral Pediatrics: JDBP
Hai-Di Wu, Hong-Yan Cao, Zi-Kai Song, Shuo Yang, Ming-Long Tang, Yang Liu, Ling Qin
BACKGROUND: Rivaroxaban is a non-vitamin K antagonist oral anticoagulant that does not require coagulation monitoring based on current recommendations. Our goal is to explore whether routine coagulation monitoring should not be required for all patients receiving oral rivaroxaban, what relationship between routine coagulation abnormalities and bleeding, and how to deal with the above clinical situations through our case and review of the literature. CASE SUMMARY: We report a 67-year-old woman with a history of atrial fibrillation who presented to the hospital with worsening dyspnea and cough...
February 6, 2019: World Journal of Clinical Cases
Angel Moreno, Kendal Endicott, Matthew Skancke, Mary Kate Dwyer, Jaclyn Brennan, Igor R Efimov, Gregory Trachiotis, David Mendelowitz, Matthew W Kay
The balance of sympathetic and parasympathetic tone provides exquisite control of heart rate and contractility and has also been shown to modulate coronary flow and inflammation. Understanding how autonomic balance is altered by cardiac disease is an active area of research, and developing new ways to control this balance provides insights into disease therapies. However, achieving acute neuron-specific stimulation of autonomic neurons can be difficult in experiments that measure the acute effects of nerve stimulation on the heart...
2019: Frontiers in Physiology
Takehito Sasaki, Kohki Nakamura, Shigeto Naito
A 28-year-old female presented with fulminant lymphocytic myocarditis. She developed cardiogenic shock, frequent sustained ventricular tachycardia, and fibrillation (VT and VF). The left ventricular ejection fraction improved from 5% to 40% after medical therapy, but the right ventricular systolic dysfunction and enlargement persisted. In addition, sustained VTs, requiring direct current cardioversion, occurred during oral administration of amiodarone following intravenous amiodarone, even after percutaneous stellate ganglion block...
February 8, 2019: International Heart Journal
H Honoré, K Eggertsen, S Sondergaard
BACKGROUND: Patients suffering brain injury may experience paroxystic sympathetic hyperactivity, presenting diagnostic and therapeutic challenges in neurointensive rehabilitation. The syndrome has been modelled as peripheral and central excitatory:inhibitory ratios of autonomous nervous activity. Another model represents the symptoms as oscillations of the two components of the autonomous nervous system. In therapeutic framework, the syndrome is perceived as the patient misconstruing sensory input relating body positioning...
February 4, 2019: NeuroRehabilitation
Hua He, XiaoDong Li, BingBing Ke, Zhuo Chen, FuSheng Han, YuJie Zeng
PURPOSE: To determine whether the midrange ejection fraction (mrEF) is associated with increased risk of deterioration of cardiac function (DCF) after dual chamber permanent pacemaker (PPM) implantation. METHODS: We performed a prospective cohort study of relevance in patients with EF ≥ 40% and indications for PPMs. Patient characteristics were recorded at baseline and 1 day, 1 month, 3 months, and 6 months after PPM implantation with leads placed in the right ventricular apex...
February 9, 2019: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Abhijit Mondal, John Lackey, Mossab Saeed, Fei-Yi Wu, Jordan Johnson, Chao Huang, Frank Sachse, Robert Hitchcock, Aditya Kaza
OBJECTIVES: We performed preclinical validation of intraoperative fiber-optic confocal microscopy (FCM) and assessed its safety and efficacy in an ovine model of the pediatric heart. METHODS: Intraoperative imaging was performed using an FCM system (Cellvizio, Mauna Kea Technology, Paris, France) with specialized imaging miniprobe (GastroFlex UHD, Mauna Kea Technologies). Before imaging, we applied an extracellular fluorophore, sodium fluorescein, to fluorescently label extracellular space...
February 6, 2019: Seminars in Thoracic and Cardiovascular Surgery
Federico Formenti, Cameron Dockerill, Lasitha Kankanange, Luyu Zhang, Tetsuo Takaishi, Koji Ishida
The aim of this study was to assess the changes determined by increased cadence on skeletal muscle oxygenation during cycling at an exercise intensity equal to the ventilatory threshold (Tvent ).Nine healthy, active individuals with different levels of cycling experience exercised at a power output equal to Tvent , pedaling at cadences of 40, 50, 60, 70, 80 and 90 rpm, each for 4 min. Cadences were tested in a randomized counterbalanced sequence. Cardiopulmonary and metabolic responses were studied using an ECG for heart rate, and gas calorimetry for pulmonary oxygen uptake and carbon dioxide production...
February 8, 2019: International Journal of Sports Medicine
Seo-Won Choi, Na Ra Yun, Dong-Hyun Choi, Young-Jae Ki, Seok Won Kim, Choon-Mee Kim, Dong-Min Kim
This study compared the frequency of abnormal electrocardiogram (ECG) types between scrub typhus patient group and age- and gender-matched health checkup group and their associations with disease severity in scrub typhus patient. Demographic characteristics and ECG and laboratory findings of patients with scrub typhus admitted to Chosun University Hospital, and normal subjects visiting the hospital for health checkup from January 2008 to December 2012 were retrospectively studied. Electrocardiogram abnormalities at admission were observed in 72 of 165 (43...
February 2019: American Journal of Tropical Medicine and Hygiene
Noor Aimie-Salleh, M B Malarvili, Anna C Whittaker
Adverse childhood experiences have been suggested to cause changes in physiological processes and can determine the magnitude of the stress response which might have a significant impact on health later in life. To detect the stress response, biomarkers that represent both the Autonomic Nervous System (ANS) and Hypothalamic-Pituitary-Adrenal (HPA) axis are proposed. Among the available biomarkers, Heart Rate Variability (HRV) has been proven as a powerful biomarker that represents ANS. Meanwhile, salivary cortisol has been suggested as a biomarker that reflects the HPA axis...
February 7, 2019: Medical & Biological Engineering & Computing
Nermin T El-Said, Eman A Mohamed, Ragia A Taha
Doxorubicin (DOX) so far continues to be one of the most potent and effective anticancer drugs. Therefore, it is still needed to search for a safe and effective therapy that can opposite DOX-induced cardiotoxicity. Irbesartan (IRB), an angiotensin II receptor blocker, has a wide-ranging variety of biological activities. The present study was designed to explore the possible protective effects of IRB against DOX-induced cardiotoxicity and the underlying mechanisms. Rats were divided into four groups: control, IRB (40 mg/kg, orally/daily) for 3 weeks, DOX (2...
February 7, 2019: Naunyn-Schmiedeberg's Archives of Pharmacology
Amit Frenkel, Yair Binyamin, Vladimir Zeldetz, Leonid Koyfman, Moti Klein, Evgeni Brotfain
Pneumomediastinum (PNMD) entails the presence of air or other gas in the mediastinum and is also known as mediastinal emphysema. PNMD may cause a wide variety of signs and symptoms, as well as ECG abnormality, including ST segment changes. We present a 56-year-old man admitted to our hospital after a facial trauma. After undergoing tracheostomy, he complained of chest discomfort. A chest X-ray in the posteroanterior view showed PNMD, and an ECG was suggestive of inferior-lateral wall myocardial infarction. An urgent cardiac catheterisation identified a critical obstruction at the origin of the right coronary artery...
February 6, 2019: BMJ Case Reports
Christopher L H Chen, Purabi Reang Sharma, Boon Yeow Tan, Casuarine Low, Narayanaswamy Venketasubramanian
Background: Dementia is a large and growing health care burden globally, and its major cause is Alzheimer's disease (AD). MLC901 (Neuroaid II) is a simplified form of MLC601 (Neuroaid), a Traditional Chinese Medicine with neuroprotective and neuroproliferative properties in cellular and animal models of brain injury. MLC601 has been shown to modulate amyloid precursor protein (APP) processing in human neuroblastoma cell cultures and increase the levels of soluble APPα. In addition, MLC901 has been shown to reduce tau phosphorylation in vitro...
2019: Alzheimer's & Dementia: Translational Research & Clinical Interventions
Yu Ueda, Taylor L Slabaugh, Ashley L Walker, Eric S Ontiveros, Paul-Michael Sosa, Rachel Reader, Jeffrey A Roberts, Joshua A Stern
Hypertrophic cardiomyopathy (HCM) is frequently associated with sudden cardiac death, presumably due to the development of malignant arrhythmias. The risk of sudden cardiac death due to HCM has been reported to be predicted by assessing electrocardiographic (ECG) changes including frequencies and complexities of arrhythmias as well as heart rate variability (HRV) as an assessment of autonomic balance. Sudden cardiac death in association with naturally-occurring left ventricular hypertrophy (LVH) has been reported in a colony of rhesus macaques and is under investigation as a potential non-human primate model of human HCM...
2019: Frontiers in Veterinary Science
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