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https://read.qxmd.com/read/30995646/sense-of-effort-and-articulatory-contact-pressure-associated-with-talking-by-individuals-using-tracheoesophageal-speech
#1
Jeff Searl
BACKGROUND/AIMS: The aims of this study were (1) to determine locations of increased effort in the body when talking using tracheoesophageal speech (TES); (2) to compare talking effort for participants using TES and those using laryngeal speech; (3) to compare tongue-palate contact pressure during talking for TES and laryngeal speech; and (4) to assess the relationship between talking effort and articulatory contact pressure (ACP). METHODS: This cohort comparison study included 16 individuals using TES and 10 using laryngeal speech...
April 17, 2019: Folia Phoniatrica et Logopaedica
https://read.qxmd.com/read/30991149/effects-of-dietary-radix-rehmanniae-preparata-polysaccharides-on-the-growth-performance-immune-response-and-disease-resistance-of-luciobarbus-capito
#2
Chun Wu, Jinfeng Shan, Junchang Feng, Junli Wang, Chaobin Qin, Guoxing Nie, Chenlong Ding
This work explores the effects of dietary Radix Rehmanniae Preparata polysaccharide (RRPP) supplementation on the growth performance, nonspecific immune responses, immune- and growth-related gene expression and disease resistance to Aeromonas hydrophila in Luciobarbus capito. Diets containing five concentrations of 0%, 0.05%, 0.1%, 0.2% and 0.4% RRPP were fed to fish for 60 d. The results indicated that the growth performance significantly increased in the 0.1%, 0.2% and 0.4% RRPP groups compared with that in the control (P < 0...
April 13, 2019: Fish & Shellfish Immunology
https://read.qxmd.com/read/30987239/target-proteins-of-phloretin-for-its-anti-inflammatory-and-antibacterial-activities-against-propionibacterium-acnes-induced-skin-infection
#3
Dasom Cheon, Jieun Kim, Dasom Jeon, Hang-Cheol Shin, Yangmee Kim
Phloretin is a natural chalcone with antibacterial and anti-inflammatory effects. This study investigated the anti-acne activity of phloretin against Propionibacterium acnes -induced skin infection and the potential target proteins of its anti-inflammatory and antibacterial effects. Phloretin potently inhibited the growth of P. acnes and P. acnes -induced Toll-like receptor (TLR) 2-mediated inflammatory signaling in human keratinocytes. Secreted embryonic alkaline phosphatase assay confirmed that the anti-inflammatory activity of phloretin is associated with the P...
April 3, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30980357/anticancer-activities-of-natural-and-synthetic-peptides
#4
A L Hilchie, D W Hoskin, M R Power Coombs
Anticancer peptides (ACPs) are cationic amphipathic peptides that bind to and kill cancer cells either by a direct- or indirect-acting mechanism. ACPs provide a novel treatment strategy, and selected ACPs are currently in phase I clinical trials to examine their safety and overall benefit in cancer patients. Increasing the selectivity of ACPs is important so that these peptides kill cancer cells without harming normal cells. Peptide sequence modifications may help to improve ACP selectivity. ACPs also have immune-modulatory effects, including the release of danger signals from dying cancer cells, induction of chemokine genes, increasing T-cell immune responses, and inhibiting T regulatory cells...
2019: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/30979756/top-studies-relevant-to-primary-care-from-2018-from-peer
#5
REVIEW
Danielle Perry, Samantha Moe, Christina Korownyk, Adrienne J Lindblad, Michael R Kolber, Betsy Thomas, Joey Ton, Scott Garrison, G Michael Allan
OBJECTIVE: To summarize high-quality studies for 10 topics from 2018 that have strong relevance to primary care practice. QUALITY OF EVIDENCE: Study selection involved routine literature surveillance by a group of primary care health professionals. This included screening abstracts of important journals and Evidence Alerts, as well as searching ACP Journal Club . MAIN MESSAGE: Topics of the 2018 articles include whether low-dose acetylsalicylic acid improves health outcomes like cardiovascular disease (CVD); whether a low-carbohydrate diet is better than a low-fat diet for weight loss (and whether genetics matter); whether vaginal estradiol is superior to placebo for vulvovaginal symptoms of menopause; whether opioid management is better than nonopioid management for chronic back or osteoarthritis pain; whether additional water intake will decrease recurrent urinary tract infections; whether omega-3 fatty acids prevent CVD or reduce dry eyes; whether the new drug icosapent improves CVD; whether bath additives help eczema; whether acetaminophen can prevent recurrent febrile seizures; and recommendations for glycemic targets in diabetes based on reviews of evidence and other guidelines...
April 2019: Canadian Family Physician Médecin de Famille Canadien
https://read.qxmd.com/read/30975898/mechanism-of-frataxin-bypass-in-human-iron-sulfur-cluster-biosynthesis-with-implications-for-friedreich-s-ataxia
#6
Deepika Das, Shachin Patra, Jennifer Bridwell-Rabb, David P Barondeau
In humans, mitochondrial iron-sulfur (Fe-S) cluster biosynthesis is an essential biochemical process mediated by the assembly complex consisting of cysteine desulfurase (NFS1), LYR protein (ISD11), acyl-carrier protein (ACP), and the iron-sulfur cluster assembly scaffold protein (ISCU2). The protein frataxin (FXN) is an allosteric activator that binds the assembly complex and stimulates the cysteine desulfurase and Fe-S cluster assembly activities. FXN depletion causes loss of activity of Fe-S-dependent enzymes and the development of the neurodegenerative disease Friedreich's ataxia...
April 11, 2019: Journal of Biological Chemistry
https://read.qxmd.com/read/30975712/advance-care-planning-and-place-of-death-hospitalisation-and-actual-place-of-death-in-lung-heart-and-cancer-disease-a-randomised-controlled-trial
#7
Marianne Hjorth Skorstengaard, Anders Bonde Jensen, Pernille Andreassen, Trine Brogaard, Elisabeth Brendstrup, Anders Løkke, Susanne Aagaard, Henrik Wiggers, Mette Asbjoern Neergaard
OBJECTIVES: Advance care planning (ACP) can be a way to meet patients' end-of-life preferences and enhance awareness of end-of-life care. Thereby it may affect actual place of death (APOD) and decrease the rate of hospitalisations. The aim was to investigate if ACP among terminally ill patients with lung, heart and cancer diseases effects fulfilment of preferred place of death (PPOD), amount of time spent in hospital and APOD. METHODS: The study was designed as a randomised controlled trial...
April 11, 2019: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/30974284/ginsenoside-rg3-improves-cyclophosphamide-induced-immunocompetence-in-balb-c-mice
#8
Xiao Liu, Zhaojian Zhang, Jinghua Liu, Yu Wang, Qian Zhou, Siwei Wang, Xiaoying Wang
Ginsenoside Rg3 (Rg3), which comprises Panax ginseng, is commonly used to improve the immunocompetence of cancer patients undergoing chemotherapy. This study was designed to elucidate the immunoenhancement effects of Rg3 in immunosuppressed mice induced by cyclophosphamide (CTX) treatment. Balb/c mice were administered Rg3 intragastrically once daily for 19 consecutive days and were intraperitoneally administered CTX (80 mg/kg) on days 15-19. Weight and immune organ indices were recorded. Hematological tests and cytokines were assessed using ELISA...
April 8, 2019: International Immunopharmacology
https://read.qxmd.com/read/30973625/medical-legal-partnerships-to-enhance-residency-training-in-advance-care-planning
#9
Jessie M Pettit, Anne M Ryan, Julie Armin, Barry D Weiss
BACKGROUND AND OBJECTIVES: Only about one-third of adult Americans have completed advance directives for end-of-life care, and primary care physicians report that they are not always comfortable discussing advance care planning (ACP) with patients. Current approaches to teaching clinicians about ACP have limited evidence of effectiveness. With the objective of improving residents' comfort and skill discussing ACP with patients, we developed a curriculum that involved clinicians and attorneys working together to teach first-year family medicine residents (R1) about leading ACP discussions with patients...
April 2019: Family Medicine
https://read.qxmd.com/read/30972461/novel-metagenome-derived-ornithine-lipids-identified-by-functional-screening-for-biosurfactants
#10
Wesley Williams, Lovemore Kunorozva, Iris Klaiber, Marius Henkel, Jens Pfannstiel, Leonardo J Van Zyl, Rudolf Hausmann, Anita Burger, Marla Trindade
Biosurfactants are amphiphilic molecules that interact with the surfaces of liquids leading to many useful applications. Most biosurfactants have been identified from cultured microbial sources, leaving a largely untapped resource of uncultured bacteria with potentially novel biosurfactant structures. To access the uncultured bacteria, a metagenomic library was constructed in Escherichia coli from environmental DNA within an E. coli, Pseudomonas putida and Streptomyces lividans shuttle vector. Phenotypic screening of the library in E...
April 10, 2019: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/30964831/takingaim-a-precision-health-framework-for-promoting-person-centered-advance-care-planning
#11
Suzanne S Sullivan
Advance care plans (ACP) align care with individual values and goals for the end of life, yet their rates are low. Communication barriers are a primary reason for these low rates. Precision health approaches that target individuals based on personal needs, behaviors, or choices may improve communication and positively influence rates of advance care plans. A framework to guide these efforts is needed. The purpose of this study is to develop a framework that guides clinicians in identifying individuals who will benefit from targeted advance care planning conversations...
April 5, 2019: Journal of Hospice and Palliative Nursing: JHPN
https://read.qxmd.com/read/30964385/integrating-advance-care-planning-videos-into-surgical-oncologic-care-a-randomized-clinical-trial
#12
Rebecca A Aslakson, Sarina R Isenberg, Norah L Crossnohere, Alison M Conca-Cheng, Madeleine Moore, Akshay Bhamidipati, Silvia Mora, Judith Miller, Sarabdeep Singh, Sandra M Swoboda, Timothy M Pawlik, Matthew Weiss, Angelo Volandes, Thomas J Smith, John F P Bridges, Debra L Roter
BACKGROUND: Preoperative advance care planning (ACP) may benefit patients undergoing major surgery. OBJECTIVE: To evaluate feasibility, safety, and early effectiveness of video-based ACP in a surgical population. DESIGN: Randomized controlled trial with two study arms. SETTING: Single, academic, inner-city tertiary care hospital. SUBJECTS: Patients undergoing major cancer surgery were recruited from nine surgical clinics...
April 9, 2019: Journal of Palliative Medicine
https://read.qxmd.com/read/30964375/advance-care-planning-for-patients-with-cirrhosis-in-a-structured-inpatient-outpatient-hepatology-program
#13
Nilofar Najafian, Jordan S Sack, Angela M DeLisle, Simona Jakab
BACKGROUND: Patients with end-stage liver disease (ESLD) have high mortality, but low utilization of palliative care. A transitional care liver clinic (TCLC), bridging inpatient hepatology care to outpatient clinics, should offer the ideal setting for advance care planning (ACP). OBJECTIVE: To examine ACP and related outcomes for TCLC patients who died within one year of the initial TCLC visit. DESIGN: Retrospective chart review. SETTING: Nontransplant eligible ESLD patients, seen in TCLC postdischarge from an inpatient liver unit...
April 9, 2019: Journal of Palliative Medicine
https://read.qxmd.com/read/30963279/fluorometric-label-free-aptasensor-for-detection-of-the-pesticide-acetamiprid-by-using-cationic-carbon-dots-prepared-with-cetrimonium-bromide
#14
Zeinab Saberi, Behzad Rezaei, Ali Ashghar Ensafi
A fluorometric aptamer-based method is described for sensitive detection of the pesticide acetamiprid. Cationic carbon dots (cCDs) with blue fluorescence were synthesized from cetrimonium bromide (CTAB) by a hydrothermal method. In the presence of the acetamiprid aptamers with a negative charge, the aptamers bind to the surface of the cCDs due to electrostatic attraction. As a result, the fluorescence of the cCDs is quenched partially (the best measurement was done at excitation/emission wavelengths of 360/445 nm)...
April 8, 2019: Mikrochimica Acta
https://read.qxmd.com/read/30962640/a-qualitative-approach-to-improving-advanced-pharmacy-practice-experiences-in-an-acpe-international-certified-program
#15
Ibrahim Sales, Mansour Adam Mahmoud, Hisham Aljadhey, Nouf Ibrahim Almeshal
Objective. To explore the opinions and recommendations of university and health care professional experts regarding the Advanced Pharmacy Practice Experiences (APPE) curriculum at the King Saud University College of Pharmacy. Methods. Forty-eight health care professionals of different backgrounds participated in a roundtable discussion during a 1-day meeting. The discussion revolved around three predefined themes: the doctor of pharmacy (PharmD) program learning outcomes, regulations and responsibilities and APPE activities and syllabi, non-clinical rotations, and assessment...
March 2019: American Journal of Pharmaceutical Education
https://read.qxmd.com/read/30962634/health-informatics-competencies-for-pharmacists-in-training
#16
Linda Gore Martin, Terri L Warholak, Ana L Hincapie, Tyler Gallo, Andrea L Kjos, Aacp Joint Task Force On Informatics
Objective. To gather feedback from focus groups regarding health informatics competencies that should be taught in a Doctor of Pharmacy (PharmD) curricula and to revise the competencies based on this feedback. Methods. The pharmacy informatics task force of the American Association of Colleges of Pharmacy (AACP) used 11 sources to create a list of pharmacy informatics competencies. Subsequently, faculty feedback about the competency list was obtained via two synchronous online focus groups in August 2015. The list was then revised based on the feedback...
March 2019: American Journal of Pharmaceutical Education
https://read.qxmd.com/read/30959470/advance-care-planning-improves-psychological-symptoms-but-not-quality-of-life-and-preferred-end-of-life-care-of-patients-with-cancer
#17
Siew Tzuh Tang, Jen-Shi Chen, Fur-Hsing Wen, Wen-Chi Chou, John Wen-Cheng Chang, Chia-Hsun Hsieh, Chen Hsiu Chen
BACKGROUND: This study was conducted to examine whether a longitudinal advance care planning (ACP) intervention facilitates concordance between the preferred and received life-sustaining treatments (LSTs) of terminally ill patients with cancer and improves quality of life (QoL), anxiety symptoms, and depressive symptoms during the dying process. PATIENTS AND METHODS: Of 795 terminally ill patients with cancer from a medical center in Taiwan, 460 were recruited and randomly assigned 1:1 to the experimental and control arms...
April 1, 2019: Journal of the National Comprehensive Cancer Network: JNCCN
https://read.qxmd.com/read/30954599/the-heart-rhythm-society-american-college-of-physicians-atrial-fibrillation-screening-and-education-initiative
#18
Lynda E Rosenfeld, Alpesh Navin Amin, Jonathan C Hsu, Asa Oxner, Mellanie True Hills, David S Frankel
BACKGROUND: The prevalence of both atrial fibrillation (AF) and stroke is increasing. Stroke is common in AF and can have devastating consequences, especially when AF is unrecognized, and anticoagulation is not initiated. OBJECTIVES: To demonstrate the feasibility and yield, both in identifying previously undiagnosed AF and educating patients and caregivers about AF, of systematic screening events in Internal Medicine practices using a mobile electrocardiogram (ECG) device (Kardia/AliveCor iECG)...
April 4, 2019: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/30953170/de-novo-design-of-anticancer-peptides-by-ensemble-artificial-neural-networks
#19
Francesca Grisoni, Claudia S Neuhaus, Miyabi Hishinuma, Gisela Gabernet, Jan A Hiss, Masaaki Kotera, Gisbert Schneider
Membranolytic anticancer peptides (ACPs) are drawing increasing attention as potential future therapeutics against cancer, due to their ability to hinder the development of cellular resistance and their potential to overcome common hurdles of chemotherapy, e.g., side effects and cytotoxicity. In this work, we present an ensemble machine learning model to design potent ACPs. Four counter-propagation artificial neural-networks were trained to identify peptides that kill breast and/or lung cancer cells. For prospective application of the ensemble model, we selected 14 peptides from a total of 1000 de novo designs, for synthesis and testing in vitro on breast cancer (MCF7) and lung cancer (A549) cell lines...
April 5, 2019: Journal of Molecular Modeling
https://read.qxmd.com/read/30951852/exposure-to-acute-ammonia-stress-influences-survival-immune-response-and-antioxidant-status-of-pacific-white-shrimp-litopenaeus-vannamei-pretreated-with-diverse-levels-of-inositol
#20
Shijun Chen, Yingying Yu, Yujie Gao, Peng Yin, Lixia Tian, Jin Niu, Yongjian Liu
The effect of acute ammonia challenge on survival, immune response and antioxidant status of Litopenaeus vannamei pretreated with diets containing different inositol levels was investigated. Shrimp (initial mean weight 0.40 ± 0.00 g) were randomly allocated in 18 tanks (30 shrimp per tank) and triplicate tanks were fed with a control diet without myo-inositol (MI) supplementation (242.6 mg inositol kg-1 diet) or diets containing diverse levels of inositol (368.8, 459.7, 673.1, 993.8 and 1674.4  mg kg-1 diet) as treatment groups for 8-week...
April 2, 2019: Fish & Shellfish Immunology
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