L Bacmeister, A Goßling, A Buellesbach, A Birukov, J E Myers, S T Thomas, S Lee, M S Andersen, J S Jorgensen, A Diemert, S M Blois, P C Arck, K Hecher, F Herse, S Blankenberg, R Dechend, D Westermann, T Zeller
BACKGROUND: Preeclampsia shares numerous risk factors with cardiovascular diseases. Here, we aimed to assess the potential utility of high-sensitivity cardiac troponin I (hs-cTnI) values during pregnancy in predicting preeclampsia occurrence. METHODS: This study measured hs-cTnI levels in 3721 blood samples of 2245 pregnant women from 4 international, prospective cohorts. Three analytical approaches were used: (1) a cross-sectional analysis of all women using a single blood sample, (2) a longitudinal analysis of hs-cTnI trajectories in women with multiple samples, and (3) analyses of prediction models incorporating hs-cTnI, maternal factors, and the sFlt-1 (soluble fms-like tyrosine kinase 1)/PlGF (placental growth factor) ratio...
November 20, 2023: Circulation