keyword
https://read.qxmd.com/read/38203478/pathophysiology-of-pre-eclampsia-two-theories-of-the-development-of-the-disease
#21
REVIEW
Jakub Kornacki, Olga Olejniczak, Rafał Sibiak, Paweł Gutaj, Ewa Wender-Ożegowska
Pre-eclampsia (PE) continues to be a leading cause of maternal and fetal mortality and morbidity. While substantial progress has been made in understanding the pathomechanisms of PE, the pathophysiology of the disease is still not fully understood. While the "two-stage model" of the development of PE is the most widely accepted theory, stating that the placenta is the main source of the disease, there are some other pathophysiological models of PE. Among these other theories, the one considering heart dysfunction as serving as the primary cause of PE seems to be gaining increasing prominence...
December 25, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38136788/homeostatic-regulation-of-pro-angiogenic-and-anti-angiogenic-proteins-via-hedgehog-notch-grid-and-ephrin-signaling-in-tibial-dyschondroplasia
#22
REVIEW
Shah Nawaz, Muhammad Fakhar-E-Alam Kulyar, Quan Mo, Wangyuan Yao, Mudassar Iqbal, Jiakui Li
Precise coupling of two fundamental mechanisms, chondrogenesis and osteogenesis via angiogenesis, plays a crucial role during rapid proliferation of growth plates, and alteration in their balance might lead to pathogenic conditions. Tibial dyschondroplasia (TD) is characterized by an avascular, non-mineralized, jade-white "cartilaginous wedge" with impaired endochondral ossification and chondrocyte proliferation at the proximal end of a tibial bone in rapidly growing poultry birds. Developing vascular structures are dynamic with cartilage growth and are regulated through homeostatic balance among pro and anti-angiogenic proteins and cytokines...
December 5, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38134545/angiogenic-growth-factors-oxidative-stress-and-haematobiochemical-measures-as-predictors-of-preeclampsia-with-and-without-foetal-growth-restriction-a-case-control-study-in-a-ghanaian-population
#23
JOURNAL ARTICLE
Enoch Odame Anto, Wina Ivy Ofori Boadu, Charity Hughes, Emmanuel Ekow Korsah, Joseph Frimpong, Ezekiel Ansah, Augustine Tawiah, Valentine Christian Kodzo Tsatsu Tamakloe, Emmanuel Acheampong, Evans Adu Asamoah, Stephen Opoku, Elizabeth Aboagye, Etwi-Mensah Albright, Eric Adua, Ebenezer Afrifa-Yamoah, Agartha Odame Anto, Max Efui Annani-Akollor, Yaw Amo Wiafe, Christian Obirikorang
INTRODUCTION: This study compares the angiogenic growth mediators (AGMs), oxidative stress (OS) and haematobiochemical profile as well as foeto-maternal outcomes of preeclampsia (PE) with and without foetal growth restriction (FGR) and the discriminative potential of these markers for identifying these conditions. METHODS: This hospital-based case-control study recruited a total of 209 women including 109 PE women without FGR and 48 PE women with FGR as cases whereas 52 normotensive pregnant women were recruited as controls...
December 12, 2023: Placenta
https://read.qxmd.com/read/38096686/luteolin-prevents-tnf-%C3%AE-induced-nf-%C3%AE%C2%BAb-activation-and-ros-production-in-cultured-human-placental-explants-and-endothelial-cells
#24
JOURNAL ARTICLE
Adrian C Eddy, Augustine Rajakumar, Frank T Spradley, Joey P Granger, Sarosh Rana
INTRODUCTION: Preeclampsia (PE) is a serious hypertensive pregnancy disorder and a leading cause of maternal and perinatal morbidity and mortality. Despite the prevalence and complications, there are no approved therapeutics to relieve PE symptoms. Inflammation, oxidative stress, and angiogenic imbalance have been shown to contribute to the PE pathophysiology, though there is a lack of understanding in how best to target these pathways in PE. We recently demonstrated that the bioflavonoid luteolin is a potent inhibitor of the anti-angiogenic and pro-hypertensive soluble fms-like tyrosine kinase 1 (sFlt-1), and here we aimed to determine if luteolin was also capable of reducing inflammation and oxidative stress pathways...
December 8, 2023: Placenta
https://read.qxmd.com/read/38092011/morphological-evaluation-of-the-feline-placenta-correlates-with-gene-expression-of-vascular-growth-factors-and-receptors%C3%A2
#25
JOURNAL ARTICLE
Erwin Kristobal Gudenschwager-Basso, Galit Frydman, Shaneke Weerakoon, Hariyat Andargachew, Cassandra Martin Piltaver, William R Huckle
Placental angiogenesis is critical for normal development. Angiogenic factors and their receptors are key regulators of this process. Dysregulated placental vascular development is associated with pregnancy complications. Despite their importance, vascular growth factor expression has not been thoroughly correlated with placental morphologic development across gestation in cats. We postulate that changes in placental vessel morphology can be appreciated as consequences of dynamic expression of angiogenic signaling agents...
December 13, 2023: Biology of Reproduction
https://read.qxmd.com/read/38067195/contemporaneous-perioperative-inflammatory-and-angiogenic-cytokine-profiles-of-surgical-breast-colorectal-and-prostate-cancer-patients-clinical-implications
#26
JOURNAL ARTICLE
Leili Baghaie, Fiona Haxho, Fleur Leroy, Beth Lewis, Alexander Wawer, Shamano Minhas, William W Harless, Myron R Szewczuk
Surgery-induced tumor growth acceleration and synchronous metastatic growth promotion have been observed for decades. Surgery-induced wound healing, orchestrated through growth factors, chemokines, and cytokines, can negatively impact patients harboring residual or metastatic disease. We provide detailed clinical evidence of this process in surgical breast, prostate, and colorectal cancer patients. Plasma samples were analyzed from 68 cancer patients who had not received treatment before surgery or adjuvant therapy until at least four weeks post-surgery...
December 4, 2023: Cells
https://read.qxmd.com/read/38057964/comparison-of-competing-risks-model-with-angiogenic-factors-in-midgestation-screening-for-preterm-growth-related-neonatal-morbidity
#27
JOURNAL ARTICLE
I Papastefanou, M Menenez, A Szczepkowska, B Gungil, A Syngelaki, K H Nicolaides
OBJECTIVES: First, to evaluate the predictive performance for preterm growth-related neonatal morbidity of high soluble fms-like tyrosine kinase-1 (sFLT-1) / placental growth factor (PlGF) ratio or low PlGF at mid-gestation, and second, to compare the performance of the high sFLT-1/PlGF ratio or low PlGF with that of the competing risks model for small for gestational age (SGA), utilizing a combination of maternal risk factors, sonographic estimated fetal weight (EFW) and uterine artery pulsatility index (UtA-PI)...
December 6, 2023: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/38047739/correlation-between-vitreous-level-of-angiogenic-growth-factors-and-oxygen-saturation-in-retinal-vessels-in-diabetic-retinopathy
#28
JOURNAL ARTICLE
Hana Morin, Jan Havlík, Oldrich Chrapek, Michal Hrevuš, Pavel Nemec, Leoš Rejmont, Jan Tesar, Marta Kalousova, Tomaš Zima, Martin Šín
PURPOSE: The aim of this study was to investigate whether there is any association between the levels of the angiogenic growth factors and the vascular oxygen saturation in eyes with diabetic retinopathy. METHODS: The study was designed as a prospective trial. The cohort consisted of 29 diabetic patients with scheduled vitreous procedures (intravitreal injection or pars plana vitrectomy). The control group included 30 patients scheduled for macular surgery (macular hole or epiretinal membrane)...
December 1, 2023: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38039359/mitochondrial-targeted-antioxidant-attenuates-preeclampsia-like-phenotypes-induced-by-syncytiotrophoblast-specific-g%C3%AE-q-signaling
#29
JOURNAL ARTICLE
Megan A Opichka, M Christine Livergood, Kirthikaa Balapattabi, McKenzie L Ritter, Daniel T Brozoski, Kelsey K Wackman, Ko-Ting Lu, Kaleigh N Kozak, Clive Wells, Agnes B Fogo, Katherine N Gibson-Corley, Anne E Kwitek, Curt D Sigmund, Jennifer J McIntosh, Justin L Grobe
Syncytiotrophoblast stress is theorized to drive development of preeclampsia, but its molecular causes and consequences remain largely undefined. Multiple hormones implicated in preeclampsia signal via the Gαq cascade, leading to the hypothesis that excess Gαq signaling within the syncytiotrophoblast may contribute. First, we present data supporting increased Gαq signaling and antioxidant responses within villous and syncytiotrophoblast samples of human preeclamptic placenta. Second, Gαq was activated in mouse placenta using Cre-lox and DREADD methodologies...
December 2023: Science Advances
https://read.qxmd.com/read/38023379/dietary-rumen-protected-l-arginine-or-n-carbamylglutamate-enhances-placental-amino-acid-transport-and-suppresses-angiogenesis-and-steroid-anabolism-in-underfed-pregnant-ewes
#30
JOURNAL ARTICLE
Hao Zhang, Xia Zha, Bei Zhang, Yi Zheng, Xiaoyun Liu, Mabrouk Elsabagh, Yi Ma, Hongrong Wang, Guihua Shu, Mengzhi Wang
This study aimed to investigate the effects of dietary supplementation of underfed Hu ewes from d 35 to 110 of gestation with either rumen-protected L-arginine (RP-Arg) or N-carbamylglutamate (NCG) on placental amino acid (AA) transport, angiogenic gene expression, and steroid anabolism. On d 35 of gestation, 32 Hu ewes carrying twin fetuses were randomly divided into four treatment groups, each consisting of eight ewes, and were fed the following diets: A diet providing 100% of NRC's nutrient requirements for pregnant ewes (CON); A diet providing 50% of NRC's nutrient requirements for pregnant ewes (RES); RES diet plus 5 g/d NCG (RES + NCG); or RES diet plus 20 g/d RP-Arg (RES + ARG)...
December 2023: Animal Nutrition
https://read.qxmd.com/read/37982257/high-sensitivity-cardiac-troponin-i-enhances-preeclampsia-prediction-beyond-maternal-factors-and-the-sflt-1-plgf-ratio
#31
JOURNAL ARTICLE
L Bacmeister, A Goßling, A Buellesbach, A Birukov, J E Myers, S T Thomas, S Lee, M S Andersen, J S Jorgensen, A Diemert, S M Blois, P C Arck, K Hecher, F Herse, S Blankenberg, R Dechend, D Westermann, T Zeller
BACKGROUND: Preeclampsia shares numerous risk factors with cardiovascular diseases. Here, we aimed to assess the potential utility of high-sensitivity cardiac troponin I (hs-cTnI) values during pregnancy in predicting preeclampsia occurrence. METHODS: This study measured hs-cTnI levels in 3721 blood samples of 2245 pregnant women from 4 international, prospective cohorts. Three analytical approaches were used: (1) a cross-sectional analysis of all women using a single blood sample, (2) a longitudinal analysis of hs-cTnI trajectories in women with multiple samples, and (3) analyses of prediction models incorporating hs-cTnI, maternal factors, and the sFlt-1 (soluble fms-like tyrosine kinase 1)/PlGF (placental growth factor) ratio...
November 20, 2023: Circulation
https://read.qxmd.com/read/37979494/expression-of-angiogenic-factors-in-the-placenta-of-heme-oxygenase-1-deficient-mouse-embryo
#32
JOURNAL ARTICLE
Meenakshi Rana, Pooja Choubey, Gouri Nandi, Sidhant Jain, Divya Bajaj, Sonika Sharma, Sharmila Basu-Modak
Heme oxygenase 1 (Hmox1), the inducible form of heme degrading enzymes Hmoxs, is important for establishment and maintenance of pregnancy. A growing body of evidence suggests an association between Hmox1 and angiogenesis, including placental angiogenesis. In this study, we examined the expression of two angiogenic factors in the placentas of Hmox1 deficient mouse embryos, whose expression was found to be related to that of Hmox1. Relative protein levels and localization of Hmoxs and two angiogenic factors [Vegf and Prolactin along with their receptors, and Cd31/Pecam1] were compared in the placentas of Hmox1 wildtype and knockout mouse embryos using western blotting and immunohistochemistry along with histological analysis...
November 16, 2023: Reproductive Biology
https://read.qxmd.com/read/37973318/advances-in-preeclampsia-testing
#33
JOURNAL ARTICLE
Jessica J Miller, Victoria Higgins, Annie Ren, Samantha Logan, Paul M Yip, Lei Fu
Preeclampsia is a multisystem hypertensive disorder and one of the leading causes of maternal and fetal morbidity and mortality. The clinical hallmarks such as hypertension and proteinuria, and additional laboratory tests currently available including liver enzyme testing, are neither specific nor sufficiently sensitive. Therefore, biomarkers for timely and accurate identification of patients at risk of developing preeclampsia are extremely valuable to improve patient outcomes and safety. In this chapter, we will first discuss the clinical characteristics of preeclampsia and current evidence of the role of angiogenic factors, such as placental growth factor (PlGF) and soluble FMS like tyrosine kinase 1 (sFlt-1) in the pathogenesis of preeclampsia...
2023: Advances in Clinical Chemistry
https://read.qxmd.com/read/37963283/evaluation-of-angiogenic-factors-in-prediction-of-growth-related-neonatal-morbidity-at-term-and-comparison-with-competing-risks-model
#34
JOURNAL ARTICLE
I Papastefanou, A Nobile Recalde, Y Silva Souza, A Syngelaki, K H Nicolaides
OBJECTIVES: First, to describe the distribution of biomarkers of impaired placentation in small for gestational age (SGA) pregnancies with neonatal morbidity, second, to examine the predictive performance for growth related neonatal morbidity of high soluble fms-like tyrosine kinase-1 (sFLT-1) / placental growth factor (PlGF) ratio or low PlGF, and third, to compare the performance of the high sFLT-1/PlGF ratio or low PlGF with that of the competing risks model for SGA. METHODS: This was a prospective observational study in women attending for a routine hospital visit at 36 weeks' gestation in two maternity hospitals in England...
November 14, 2023: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/37955271/chemerin-affects-the-expression-of-angiogenesis-related-factors-in-the-porcine-endometrium-during-early-pregnancy-and-the-oestrous-cycle-an-in-vitro-study
#35
JOURNAL ARTICLE
Marta Kiezun, Kamil Dobrzyn, Jacek Kiezun, Tadeusz Kaminski, Nina Smolinska
CONTEXT: The appropriate course of angiogenesis in the endometrium is crucial for pregnancy establishment and maintenance. Very little is known about the factors linking vessel formation and immune system functioning. AIMS: We hypothesised that chemerin, an adipokine known for its involvement in the regulation of energy balance and immunological functions, may act as a potent regulator of endometrial angiogenesis during early pregnancy in pigs. METHODS: Porcine endometrial tissue explants were obtained from pregnant pigs on days 10-11, 12-13, 15-16 and 27-28, and on days 10-12 of the oestrous cycle...
November 13, 2023: Reproduction, Fertility, and Development
https://read.qxmd.com/read/37926193/alterations-in-the-von-willebrand-factor-adamts13-axis-in-preeclampsia
#36
JOURNAL ARTICLE
Lucy Neave, Mari Thomas, Rens de Groot, Andrew J Doyle, Deepak Singh, George Adams, Anna L David, Katarzyna Maksym, Marie Scully
BACKGROUND: Preeclampsia is a gestational hypertensive disorder, characterised by maternal endothelial activation, and increased ratio of soluble fms-like tyrosine kinase inhibitor-1 (sFlt-1) to placental growth factor (PlGF). The von Willebrand Factor (VWF)/ADAMTS13 axis is of interest because of the underlying endothelial activation, and clinical overlap with pregnancy-associated thrombotic thrombocytopenic purpura. OBJECTIVES: To assess VWF, ADAMTS13, and VWF/ADAMTS13 ratio in preeclampsia, and look for associations with sFlt-1/PlGF ratio, and clinical features...
November 3, 2023: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/37925874/prediction-of-adverse-outcome-by-ophthalmic-artery-doppler-and-angiogenic-markers-in-pregnancies-with-new-onset-hypertension
#37
JOURNAL ARTICLE
Katherine G Y Lau, Emmanouil Kountouris, Laura Salazar-Rios, Kypros H Nicolaides, Nikos A Kametas
OBJECTIVES: To compare the ophthalmic artery Doppler peak systolic velocity ratio (OA PSV-ratio) and soluble fms-like tyrosine kinase-1/placental growth factor ratio (sFlt-1/PlGF ratio) in predicting adverse maternal and perinatal outcomes in women presenting with new onset hypertension. STUDY DESIGN: Prospective cohort study in a specialist hypertension clinic, within a tertiary referral centre. MAIN OUTCOME MEASURES: Comparison between the OA PSV-ratio and sFlt-1/PlGF ratio in predicting delivery within one week from presentation and adverse maternal and perinatal outcomes e...
December 2023: Pregnancy Hypertension
https://read.qxmd.com/read/37902727/ophthalmic-artery-doppler-and-biomarkers-of-impaired-placentation-at-36%C3%A2-weeks-gestation-in-pregnancies-with-small-fetuses
#38
JOURNAL ARTICLE
A Arechvo, A Wright, A Nobile Recalde, R Liandro, M Charakida, K H Nicolaides
OBJECTIVES: First, to compare the ophthalmic artery peak systolic velocity (PSV) ratio and biomarkers of impaired placentation at 36 weeks' gestation in women who delivered small for gestational age (SGA) or fetal growth restricted (FGR) neonates in the absence of hypertensive disorders with those who developed preeclampsia (PE) or gestational hypertension (GH) and those unaffected by SGA, FGR, PE or GH. Second, to examine the associations between PSV ratio, uterine artery pulsatility index (UtA-PI), placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFLT-1) with birthweight z-score or percentile...
October 30, 2023: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/37887854/the-importance-of-inflammatory-and-angiogenic-markers-in-the-evaluation-of-early-cardiovascular-disease-risk-in-women-with-hypertensive-disorders-of-pregnancy
#39
REVIEW
Tatjana Maselienė, Emilija Struckutė, Rūta Breivienė, Diana Ramašauskaitė, Vilma Dženkevičiūtė
BACKGROUND: Women with hypertensive disorders of pregnancy (HDP) have a significantly higher risk of developing cardiovascular diseases later in life. The stratification of this risk using biomarkers during pregnancy can help to identify these women and apply early prevention. OBJECTIVE: We aimed to determine proinflammatory cytokines and angiogenic markers, echocardiographic parameter changes after delivery and predict early cardiovascular disease risk in women with arterial hypertension and its complications during pregnancy...
September 22, 2023: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/37871914/effects-of-1-year-tofacitinib-therapy-on-angiogenic-biomarkers-in-rheumatoid-arthritis
#40
JOURNAL ARTICLE
György Kerekes, Monika Czókolyová, Attila Hamar, Anita Pusztai, Gábor Tajti, Mónika Katkó, Edit Végh, Zsófia Pethő, Nóra Bodnár, Ágnes Horváth, Boglárka Soós, Szilvia Szamosi, Zsolt Hascsi, Mariann Harangi, Katalin Hodosi, György Panyi, Tamás Seres, Gabriella Szűcs, Zoltán Szekanecz
OBJECTIVES: Cardiovascular (CV) morbidity and mortality, and perpetuated synovial angiogenesis have been associated with RA. In our study we evaluated angiogenic factors in relation to vascular inflammation and function, and clinical markers in RA patients undergoing 1-year tofacitinib therapy. METHODS: Thirty RA patients treated with either 5 mg or 10 mg twice daily tofacitinib were included in a 12-month follow-up study. Eventually, 26 patients completed the study and were included in data analysis...
October 23, 2023: Rheumatology
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