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placental angiogenic factors

Laura Benschop, Sarah Schalekamp-Timmermans, Zoe A Broere-Brown, Jeanine E Roeters van Lennep, Vincent W V Jaddoe, Jolien W Roos-Hesselink, M Kamran Ikram, Eric A P Steegers, James M Roberts, Robin E Gandley
BACKGROUND: Angiogenic placental growth factor (PlGF) concentrations rise during pregnancy, peaking at the end of mid-pregnancy. Low PlGF concentrations during pregnancy are associated with pregnancy complications with recognized later life cardiovascular risk. We hypothesized that low PlGF concentrations, especially in mid-pregnancy identify not only a subset of women at risk for pregnancy complications, but also women with greater cardiovascular risk factor burden after pregnancy regardless of pregnancy outcome...
February 14, 2019: Circulation
Anca Ciobanu, Alan Wright, Anca Panaitescu, Argyro Syngelaki, David Wright, Kypros H Nicolaides
BACKGROUND: In the weeks preceding the clinical onset of preeclampsia (PE) the maternal serum level of the angiogenic placental growth factor (PLGF) is decreased and that of the antiangiogenic factor soluble fms-like tyrosine kinase-1 (sFLT) is increased. Women presenting at specialist clinics with signs or symptoms of hypertensive disorders have been stratified according to concentrations of PLGF or the ratio of concentrations of sFLT and PLGF to determine clinical management for the subsequent 1-4 weeks...
February 7, 2019: American Journal of Obstetrics and Gynecology
Carsten Balser, Anne Wolf, Marc Herb, Thomas Langmann
BACKGROUND: Age-related macular degeneration (AMD) is a leading cause of visual impairment in the elderly. The neovascular (wet) form of AMD can be treated with intravitreal injections of different anti-vascular endothelial growth factor (VEGF) agents. Placental growth factor (PGF) is another member of the VEGF family of cytokines with pro-angiogenic and pro-inflammatory effects. Here, we aimed to compare single and combined inhibition of VEGF-A and PGF in the laser-induced mouse model of choroidal neovascularization (CNV) with a focus on the effects on retinal mononuclear phagocytes...
February 7, 2019: Journal of Neuroinflammation
Kelsey N Olson, Leanne M Redman, Jenny L Sones
Preeclampsia (PE) is a devastating adverse outcome of pregnancy. Characterized by maternal hypertension, when left untreated PE can result in death of both mother and baby. The cause of PE remains unknown and there is no way to predict which women will develop PE during pregnancy. The only known treatment is delivery of both the fetus and placenta, therefore an abnormal placenta is thought to play a causal role. Women with obesity before pregnancy have an increased chance of developing PE. Increased adiposity results in a heightened state of systemic inflammation which can influence placental development...
February 4, 2019: Physiological Genomics
Pascale Gerbaud, Padma Murthi, Jean Guibourdenche, Fabien Guimiot, Benoit Sarazin, Danièle Evain-Brion, Josette Badet, Guillaume Pidoux
Placental development is particularly altered in trisomy 21 (T21) affected pregnancies. We previously described in T21-affected placentae an abnormal paracrine crosstalk between villus mesenchymal core and villus trophoblasts. T21-affected are know to be characterized by their hypovascularity. However, the causes of this anomaly remain not fully elucidated. Therefore, hypothesis of an abnormal paracrine cross-talk between fetal mesenchymal core and placental endothelial cells (PLEC) was evocated. Villus mesenchymal cells from control (CMC) and T21 placentae (T21MC) were isolated and grown in culture to allow their characterization and collection of conditioned media for functional analyses (respectively CMC-CM and T21MC-CM)...
January 30, 2019: Endocrinology
Sarah J Delforce, Eugenie R Lumbers, Saije K Morosin, Yu Wang, Kirsty G Pringle
INTRODUCTION: Placental development occurs in a low oxygen environment, which stimulates angiogenesis by upregulating vascular endothelial growth factor A (VEGFA), plasminogen activator inhibitor-1 (SERPINE1) and the angiopoietin-2/-1 ratio (ANGPT2/1). At this time, Angiotensin II type 1 receptor (AT1 R) is highly expressed. We postulated that the early gestation placental oxygen milieu, by stimulating the angiotensin (Ang) II/AT1 R pathway, increases expression of proliferative/angiogenic factors...
January 2019: Placenta
Yong Cheng, Jing Feng, Xuemei Zhu, Jianhong Liang
Uveal melanoma (UM) is the major intraocular malignancy in adults, of which the molecular biology is still unknown. Therefore, this study was designed to determine the aqueous concentrations of angiogenic, inflammatory, and chemotactic cytokines in eyes with UM.Aqueous humor samples were collected from 38 patients with UM and 22 patients undergoing cataract surgery. Interleukin 6, 8 (IL-6, IL-8, respectively), interferon-inducible protein-10 (IP-10), placental growth factor1 (PIGF1), regulated on activation, normal T Cell expressed and secreted (RANTES), monocyte chemoattractant protein-1 (MCP-1), nerve growth factor-beta (NGF-β), epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and vascular endothelia growth factor A (VEGF-A) were assessed by multiplex bead assay...
February 2019: Medicine (Baltimore)
Alan Leviton, Elizabeth N Allred, Raina N Fichorova, Deborah K VanderVeen, T Michael O'Shea, Karl Kuban, Olaf Dammann
OBJECTIVE:  To evaluate to what extent indicators of placenta insufficiency are associated with low concentrations of insulin-like growth factor 1 (IGF-1) and IGF-1-binding protein-1 (IGFBP-1) in neonatal blood, and to what extent the concentrations of these growth factors are associated with concentrations of proteins with inflammatory, neurotrophic, or angiogenic properties. DESIGN:  Using multiplex immunoassays, we measured the concentrations of IGF-1 and IGFBP-1, as well as 25 other proteins in blood spots collected weekly from ≥ 880 infants born before the 28th week of gestation, and sought correlates of concentrations in the top and bottom quartiles for gestational age and day the specimen was collected...
January 27, 2019: American Journal of Perinatology
Emma J Flint, Ana Sofia Cerdeira, Christopher W Redman, Manu Vatish
Preeclampsia is a pregnancy disorder causing substantial maternal and fetal morbidity and mortality. In the UK, its diagnosis currently depends upon new onset hypertension and proteinuria. There is a clinical need for enhanced screening to prevent unnecessary resource use and improve outcomes. Here, the current practice in preeclampsia diagnosis will be summarised, with assessment of the evidence that angiogenic factors could improve its management. Whilst the combination of new onset hypertension and proteinuria define and hence diagnose the disorder, separately they are poorly predictive...
January 22, 2019: Acta Obstetricia et Gynecologica Scandinavica
Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natasha Pritchard, Natalie J Hannan, Ping Cannon, Tuong Vi Nguyen, Roxanne Hastie, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino
Preeclampsia is a pregnancy complication associated with elevated placental secretion of anti-angiogenic factors, maternal endothelial dysfunction and organ injury. GATA2 is a transcription factor expressed in the endothelium which regulates vascular homeostasis by controlling transcription of genes and microRNAs, including endothelial miR126. We assessed GATA2 and miR126 in preeclampsia. Whole blood circulating GATA2 mRNA and miR126 expression were significantly decreased in women with established early-onset preeclampsia compared to gestation-matched controls (p = 0...
January 18, 2019: Scientific Reports
Yeukai Tm Mangwiro, Jessica F Briffa, Sogand Gravina, Dayana Mahizir, Kristina Anevska, Tania Romano, Karen M Moritz, James Sm Cuffe, Mary E Wlodek
Fetal growth and development are dependent on adequate placental nutrient transfer. The surface area of the placental villous network is a key determinant of nutrient exchange, which is regulated by vasculogenic and angiogenic factors. These factors are altered by intrauterine growth restriction (IUGR) and maternal obesity in both the first (F1) and second (F2) generations. We investigated the impact of endurance exercise in IUGR dams fed a High-fat diet on placental vasculogenesis and angiogenesis. Uteroplacental insufficiency (Restricted) or sham (Control) surgery was induced on embryonic day (E) 18 in Wistar-Kyoto rats...
December 15, 2018: Placenta
Nalini Govender, Jagidesa Moodley, Thajasvarie Naicker
Hypertensive disorders of pregnancy in particular the category preeclampsia (PE), remains a major cause of both maternal and fetal morbidity and mortality. Angiogenic growth factors (PlGF and VEGF) and their tyrosine kinase receptors -1 and 2 (Flt-1 and KDR) are involved in both fetal and placental development. Inadequate placentation and the consequent release of antiangiogenic soluble fms-like tyrosine kinase 1 (sFlt-1) is thus instrumental in the etiology of this disease. sFlt-1 binds to both angiogenic growth factors and neutralizes their effect thereby creating an angiogenic imbalance...
December 2018: African Journal of Reproductive Health
Cheuk-Lun Lee, Madhavi Vijayan, Xia Wang, Kevin K W Lam, Hannu Koistinen, Markku Seppala, Raymond H W Li, Ernest H Y Ng, William S B Yeung, Philip C N Chiu
STUDY QUESTION: Does glycodelin-A (GdA) induce conversion of human peripheral blood CD16-CD56bright natural killer (NK) cells to decidual NK (dNK) cells to facilitate placentation? SUMMARY ANSWER: GdA binds to blood CD16-CD56bright NK cells via its sialylated glycans and converts them to a dNK-like cells, which in turn regulate endothelial cell angiogenesis and trophoblast invasion via vascular endothelial growth factor (VEGF) and insulin-like growth factor-binding protein 1 (IGFBP-1) secretion, respectively...
December 28, 2018: Human Reproduction
Kei Tanaka, Momoe Watanabe, Shinji Tanigaki, Mitsutoshi Iwashita, Yoichi Kobayashi
OBJECTIVES: Tumor necrosis factor-alpha (TNF- α) promotes tumor growth by enhancing tumor angiogenesis; however, the effects on choriocarcinoma remain unknown. We investigated the effects of TNF-α on the production of placental growth factor (PlGF) and vascular endothelial growth factor-A (VEGF-A) in BeWo cells and also examined its significance on the interactions with the endothelial cells by using human umbilical vein endothelial cells (HUVECs). MATERIALS & METHODS: After incubation with TNF-α (10-105  pg/mL), the expression of PlGF and VEGF-A in BeWo cells were assessed by ELISA and RT-PCR...
December 24, 2018: Placenta
Dagmar Pfeiffer, Karin Wankhammer, Christina Stefanitsch, Kerstin Hingerl, Berthold Huppertz, Gottfried Dohr, Gernot Desoye, Ingrid Lang
PURPOSE: Blood vessel reconstruction is an increasing need of patients suffering from cardiovascular diseases. For the development of microvascular prostheses, efficient endothelialization is mandatory to prevent graft occlusion. Here, we assessed the impact of amnion-derived mesenchymal stem/stromal cells (hAMSC), known for their important angiogenic potential, on the integrity and stability of endothelial cells exposed to shear stress in vascular grafts. METHODS: Human placental endothelial cells (hPEC) were cultured at the inner surface of an expanded polytetrafluoroethylene (ePTFE) graft positioned within a bioreactor and exposed to a minimal shear stress of 0...
December 26, 2018: International Journal of Artificial Organs
Elise M Philips, Leonardo Trasande, Linda G Kahn, Romy Gaillard, Eric A P Steegers, Vincent W V Jaddoe
STUDY QUESTION: Are early-pregnancy urinary bisphenol and phthalate metabolite concentrations associated with placental function markers, blood pressure (BP) trajectories during pregnancy and risk of gestational hypertensive disorders? SUMMARY ANSWER: Early-pregnancy bisphenols and phthalate metabolites were not consistently associated with maternal BP changes or gestational hypertensive disorders, but subclinical, statistically significant associations with placental angiogenic markers and placental hemodynamics were identified...
December 20, 2018: Human Reproduction
Asli Ozmen, Dijle Kipmen-Korgun, Emin Türkay Korgun
OBJECTIVE: The mammalian target of rapamycin (mTOR) signaling pathway has newly been recommended to be a nutrient sensor in the placenta. It is speculated that mTORC1 may be activated in diabetes, associated with increased placental nutrient availability. Thus, we aimed to investigate the mTOR signaling pathway both in diabetic and non-diabetic placenta and searched for the alterations of angiogenic factors VEGF, VEGFR1 and VEGFR2. METHODS: Streptozotocin (STZ) was administered by intravenous injection in doses of 60 mg/kg body weight and STZ injected rats were exposed to Everolimus (Rapamycin analog) and sacrificed at gestational days 14 and 20...
December 12, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Berthold Huppertz
Although massive efforts have been undertaken to elucidate the etiology of the pregnancy syndrome preeclampsia, its developmental origin remains a mystery. Most efforts of the last decade have focused on biomarkers to predict and/or diagnose preeclampsia, including the anti-angiogenic factor sFlt-1 (soluble fms-like tyrosin kinase-1), the angiogenic factor PGF (placental growth factor) and PP13 (placental protein 13). The origins of these marker proteins are still under debate, and so far their actions have only been describe separate from each other...
December 12, 2018: Biochimica et biophysica acta. Molecular basis of disease
Nobuhiro Terao, Hideki Koizumi, Kentaro Kojima, Tetsuya Yamagishi, Kenji Nagata, Koji Kitazawa, Yuji Yamamoto, Kengo Yoshii, Asako Hiraga, Munetoyo Toda, Shigeru Kinoshita, Chie Sotozono, Junji Hamuro
Purpose: To clarify the distinct molecular pathogenesis of central serous chorioretinopathy (CSC) and pachychoroid neovasculopathy (PNV). Methods: Aqueous humor (AH) was collected from 18 acute CSC, 20 chronic CSC, and 20 PNV patients. Concentrations of 30 cytokines in the AH were analyzed using a multiplex bead immunoassay, and the cytokine profiles were compared among these three groups of patients. The areas of choroidal vascular hyperpermeability (CVH) and choroidal thickness (CT), including measurement of the vascular layers, were investigated to analyze the features of choroidal abnormality in acute CSC, chronic CSC, and PNV...
December 3, 2018: Investigative Ophthalmology & Visual Science
Clare L Whitehead, Tu'uhevaha J Kaitu'u-Lino, Natalie K Binder, Sally Beard, Natasha De Alwis, Fiona Brownfoot, Stephen Tong, Natalie J Hannan
INTRODUCTION: Preeclampsia is a severe complication of pregnancy, and likely arises from abnormal placental development in early pregnancy. Persistent placental hypoxia is thought to trigger the release of anti-angiogenic factors into the maternal circulation leading to widespread endothelial dysfunction. Epidermal growth factor-like domain 7 (EGFL7) is a secreted angiogenic factor that may play a key role in the disrupted angiogenesis seen in response to placental hypoxia that characterizes preeclampsia...
October 2018: Pregnancy Hypertension
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