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Caoimhe Kirby, Jack Barrington, Lotte Sondag, James J M Loan, Floris H B M Schreuder, Barry W McColl, Catharina J M Klijn, Rustam Al-Shahi Salman, Neshika Samarasekera
BACKGROUND: Currently, there are no specific medical treatments for intracerebral haemorrhage (ICH), but the inflammatory response may provide a potential route to treatment. Given the known effects of acute brain injury on peripheral immunity, we hypothesised that inflammatory biomarkers in peripheral blood may be associated with clinical outcome following ICH, as well as perihaematomal oedema (PHO), which is an imaging marker of the neuroinflammatory response. METHODS: We searched OVID Medline and EMBASE on 07 April 2021 for studies of humans with ICH measuring an inflammatory biomarker in peripheral blood and PHO or clinical outcome...
2023: Wellcome Open Research
#2
JOURNAL ARTICLE
M L Touré, T H Baldé, M S Diallo, G Carlos Othon, N Camara, S D Barry, M M Konaté, F Sakadi, E Lamah, B Diallo, M Diakité, A Sakho, D Camara, S Condé, H Madandi, V Millimono, A K T Barry, M T Diallo, N Traoré, F D Kassa, A Koné, I S Souaré, J M Kadji, M H Diallo, A Tounkara, S A Rafkat, T M Diallo, J F Mara, F A Cissé, A Cissé
INTRODUCTION: In sub-Saharan Africa (SSA), stroke is a major public health problem and the etiological aspects are poorly studied and documented because of under-medicalization; the syphilitic etiology is rarely mentioned. PATIENTS AND METHODS: We performed a retrospective study of 472 patients hospitalized for ischemic stroke between 2016 and 2021 in the Neurology Department of the University Hospital of Conakry, confirmed by neuroradiological explorations (brain CT, MRI-Angio) and a biological workup including VDRL-TPHA serological reactions in blood and CSF...
September 2023: ENeurologicalSci
#3
JOURNAL ARTICLE
Lauren R Binnie, Mathilde M H Pauls, Philip Benjamin, Mohani-Preet K Dhillon, Shai Betteridge, Brian Clarke, Rita Ghatala, Fearghal A H Hainsworth, Franklyn A Howe, Usman Khan, Christina Kruuse, Jeremy B Madigan, Barry Moynihan, Bhavini Patel, Anthony C Pereira, Egill Rostrup, Anan B Y Shtaya, Catherine A Spilling, Sarah Trippier, Rebecca Williams, Jeremy D Isaacs, Thomas R Barrick, Atticus H Hainsworth
Cerebral small vessel disease (SVD) is common in older people and is associated with lacunar stroke, white matter hyperintensities (WMH) and vascular cognitive impairment. Cerebral blood flow (CBF) is reduced in SVD, particularly within white matter.Here we quantified test-retest reliability in CBF measurements using pseudo-continuous arterial spin labelling (pCASL) in older adults with clinical and radiological evidence of SVD (N=54, mean (SD): 66.9 (8.7) years, 15 females/39 males). We generated whole-brain CBF maps on two visits at least 7 days apart (mean (SD): 20 (19), range 7-117 days)...
August 2022: Translational Stroke Research
#4
JOURNAL ARTICLE
Fode Abass Cisse, Noémie Ligot, Kaba Conde, Djigué Souleymane Barry, Lamine Mohamed Toure, Mamadi Konate, Mohamed Fode Soumah, Karinka Diawara, Mohamed Traore, Gilles Naeije
Low- to middle-income countries (LMICs) now bear most of the stroke burden. In LMICs, stroke epidemiology and health care systems are different from HICs. Therefore, a high-income country (HIC)-based predictive model may not correspond to the LMIC stroke context. Identify the impact of modifiable variables in acute stroke management in Conakry, Guinea as potential predictors of favorable stroke outcome. Data were extracted from the Conakry stroke registry that includes 1018 patients. A logistic regression model was built to predict favorable stroke outcomes, defined as mRS 0-2...
January 21, 2022: Scientific Reports
#5
JOURNAL ARTICLE
Sally Shuxian Koh, Samantha Chia-Yi Ooi, Natalie Man-Yin Lui, Cao Qiong, Leona Ting-Yuke Ho, Irwin Kee-Mun Cheah, Barry Halliwell, Deron R Herr, Wei-Yi Ong
Ergothioneine (ET) is a naturally occurring antioxidant that is synthesized by non-yeast fungi and certain bacteria. ET is not synthesized by animals, including humans, but is avidly taken up from the diet, especially from mushrooms. In the current study, we elucidated the effect of ET on the hCMEC/D3 human brain endothelial cell line. Endothelial cells are exposed to high levels of the cholesterol oxidation product, 7-ketocholesterol (7KC), in patients with cardiovascular disease and diabetes, and this process is thought to mediate pathological inflammation...
March 2021: Neuromolecular Medicine
#6
REVIEW
Wei-Yi Ong, Mei-Lin Go, De-Yun Wang, Irwin Kee-Mun Cheah, Barry Halliwell
The SARS-CoV-2 virus that is the cause of coronavirus disease 2019 (COVID-19) affects not only peripheral organs such as the lungs and blood vessels, but also the central nervous system (CNS)-as seen by effects on smell, taste, seizures, stroke, neuropathological findings and possibly, loss of control of respiration resulting in silent hypoxemia. COVID-19 induces an inflammatory response and, in severe cases, a cytokine storm that can damage the CNS. Antimalarials have unique properties that distinguish them from other anti-inflammatory drugs...
January 2021: Molecular Neurobiology
#7
REVIEW
Shivani Ghoshal, Barry I Freedman
BACKGROUND: Given the increasing worldwide prevalence of chronic kidney disease (CKD), it is critical to decrease the associated risk of debilitating vascular complications, including stroke, congestive heart failure, myocardial infarction, and peripheral vascular disease. Treatment options for reducing the risk of all subtypes of stroke in patients with CKD remain limited. For patients with end-stage kidney disease (ESKD), novel applications of noninvasive imaging may help personalize the type of dialysis and dialysis prescription for patients at high-risk...
2019: American Journal of Nephrology
#8
JOURNAL ARTICLE
Kyle Steenland, Vaughn Barry, Ahti Anttila, Markku Sallmén, Damien McElvenny, A C Todd, Kurt Straif
OBJECTIVES: To investigate further whether inorganic lead is a carcinogen among adults, or associated with increased blood pressure and kidney damage, via a large mortality study. METHODS: We conducted internal analyses via Cox regression of mortality in three cohorts of lead-exposed workers with blood lead (BL) data (USA, Finland, UK), including over 88 000 workers and over 14 000 deaths. Our exposure metric was maximum BL. We also conducted external analyses using country-specific background rates...
November 2017: Occupational and Environmental Medicine
#9
RANDOMIZED CONTROLLED TRIAL
Russell E Ware, Barry R Davis, William H Schultz, R Clark Brown, Banu Aygun, Sharada Sarnaik, Isaac Odame, Beng Fuh, Alex George, William Owen, Lori Luchtman-Jones, Zora R Rogers, Lee Hilliard, Cynthia Gauger, Connie Piccone, Margaret T Lee, Janet L Kwiatkowski, Sherron Jackson, Scott T Miller, Carla Roberts, Matthew M Heeney, Theodosia A Kalfa, Stephen Nelson, Hamayun Imran, Kerri Nottage, Ofelia Alvarez, Melissa Rhodes, Alexis A Thompson, Jennifer A Rothman, Kathleen J Helton, Donna Roberts, Jamie Coleman, Melanie J Bonner, Abdullah Kutlar, Niren Patel, John Wood, Linda Piller, Peng Wei, Judy Luden, Nicole A Mortier, Susan E Stuber, Naomi L C Luban, Alan R Cohen, Sara Pressel, Robert J Adams
BACKGROUND: For children with sickle cell anaemia and high transcranial doppler (TCD) flow velocities, regular blood transfusions can effectively prevent primary stroke, but must be continued indefinitely. The efficacy of hydroxycarbamide (hydroxyurea) in this setting is unknown; we performed the TWiTCH trial to compare hydroxyurea with standard transfusions. METHODS: TWiTCH was a multicentre, phase 3, randomised, open-label, non-inferiority trial done at 26 paediatric hospitals and health centres in the USA and Canada...
February 13, 2016: Lancet
#10
RANDOMIZED CONTROLLED TRIAL
Margaret M Redfield, Kevin J Anstrom, James A Levine, Gabe A Koepp, Barry A Borlaug, Horng H Chen, Martin M LeWinter, Susan M Joseph, Sanjiv J Shah, Marc J Semigran, G Michael Felker, Robert T Cole, Gordon R Reeves, Ryan J Tedford, W H Wilson Tang, Steven E McNulty, Eric J Velazquez, Monica R Shah, Eugene Braunwald
BACKGROUND: Nitrates are commonly prescribed to enhance activity tolerance in patients with heart failure and a preserved ejection fraction. We compared the effect of isosorbide mononitrate or placebo on daily activity in such patients. METHODS: In this multicenter, double-blind, crossover study, 110 patients with heart failure and a preserved ejection fraction were randomly assigned to a 6-week dose-escalation regimen of isosorbide mononitrate (from 30 mg to 60 mg to 120 mg once daily) or placebo, with subsequent crossover to the other group for 6 weeks...
December 10, 2015: New England Journal of Medicine
#11
JOURNAL ARTICLE
Ernesto Caballero-Garrido, Juan Carlos Pena-Philippides, Tamar Lordkipanidze, Denis Bragin, Yirong Yang, Erik Barry Erhardt, Tamara Roitbak
A multifunctional microRNA, miR-155, has been recently recognized as an important modulator of numerous biological processes. In our previous in vitro studies, miR-155 was identified as a potential regulator of the endothelial morphogenesis. The present study demonstrates that in vivo inhibition of miR-155 supports cerebral vasculature after experimental stroke. Intravenous injections of a specific miR-155 inhibitor were initiated at 48 h after mouse distal middle cerebral artery occlusion (dMCAO). Microvasculature in peri-infarct area, infarct size, and animal functional recovery were assessed at 1, 2, and 3 weeks after dMCAO...
September 9, 2015: Journal of Neuroscience
#12
COMPARATIVE STUDY
Samaneh Maysami, Michael J Haley, Natalia Gorenkova, Siddharth Krishnan, Barry W McColl, Catherine B Lawrence
BACKGROUND: Obesity increases the risk for ischaemic stroke and is associated with worse outcome clinically and experimentally. Most experimental studies have used genetic models of obesity. Here, a more clinically relevant model, diet-induced obesity, was used to study the impact of obesity over time on the outcome and inflammatory response after stroke. METHODS: Male C57BL/6 mice were maintained on a high-fat (60% fat) or control (12% fat) diet for 2, 3, 4 and 6 months when experimental stroke was induced by transient occlusion of the middle cerebral artery (MCAo) for either 20 (6-month diet) or 30 min (2-, 3-, 4- and 6-month diet)...
August 4, 2015: Journal of Neuroinflammation
#13
JOURNAL ARTICLE
Monique C Saleh, Barry J Connell, Desikan Rajagopal, Bobby V Khan, Alaa S Abd-El-Aziz, Inan Kucukkaya, Tarek M Saleh
The present study demonstrates the benefits of combinatorial antioxidant therapy in the treatment of ischemic stroke. Male Sprague-Dawley rats were anaesthetised and the middle cerebral artery (MCA) was occluded for 30 minutes followed by 5.5 hours of reperfusion. Pretreatment with resveratrol 30 minutes prior to MCA occlusion resulted in a significant, dose-dependent decrease in infarct volume (p<0.05) compared to vehicle-treated animals. Neuroprotection was also observed when resveratrol (2 × 10(-3) mg/kg; iv) was administered within 60 minutes following the return of blood flow (reperfusion)...
2014: PloS One
#14
JOURNAL ARTICLE
Rochus Pokan, Helmuth Ocenasek, Rainer Hochgatterer, Martin Miehl, Karin Vonbank, Serge P Von Duvillard, Barry Franklin, Sabine Würth, Ivo Volf, Manfred Wonisch, Peter Hofmann
PURPOSE: This study aimed to evaluate cardiorespiratory and hemodynamic responses during 24 h of continuous cycle ergometry in ultraendurance athletes. METHODS: Eight males (mean ± SD; age = 39 ± 8 yr, height = 179 ± 7 cm, body weight [Wt] = 77.1 ± 6.0 kg) were monitored during 24 h at a constant workload,∼25% below the first lactate turn point at 162 ± 23 W. Measurements included Wt, HR, oxygen consumption (V˙O2), cardiac output (Q), and stroke volume (SV) determined by a noninvasive rebreathing technique (Innocor; Innovision, Odense, Denmark)...
February 2014: Medicine and Science in Sports and Exercise
#15
RANDOMIZED CONTROLLED TRIAL
Margaret M Redfield, Horng H Chen, Barry A Borlaug, Marc J Semigran, Kerry L Lee, Gregory Lewis, Martin M LeWinter, Jean L Rouleau, David A Bull, Douglas L Mann, Anita Deswal, Lynne W Stevenson, Michael M Givertz, Elizabeth O Ofili, Christopher M O'Connor, G Michael Felker, Steven R Goldsmith, Bradley A Bart, Steven E McNulty, Jenny C Ibarra, Grace Lin, Jae K Oh, Manesh R Patel, Raymond J Kim, Russell P Tracy, Eric J Velazquez, Kevin J Anstrom, Adrian F Hernandez, Alice M Mascette, Eugene Braunwald
IMPORTANCE: Studies in experimental and human heart failure suggest that phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise capacity in heart failure with preserved ejection fraction (HFPEF). OBJECTIVE: To determine the effect of the phosphodiesterase-5 inhibitor sildenafil compared with placebo on exercise capacity and clinical status in HFPEF. DESIGN: Multicenter, double-blind, placebo-controlled, parallel-group, randomized clinical trial of 216 stable outpatients with HF, ejection fraction ≥50%, elevated N-terminal brain-type natriuretic peptide or elevated invasively measured filling pressures, and reduced exercise capacity...
March 27, 2013: JAMA
#16
JOURNAL ARTICLE
Smriti Agarwal, Daniel J Scoffings, P Simon Jones, S Tulasi Marrapu, Patrick J Barry, Eoin W O'Brien, Jean-Claude Baron, Elizabeth A Warburton
BACKGROUND: Increasing age is the single largest non-modifiable risk factor for ischaemic stroke. Animal models have substantiated the view that age related neuron vulnerability to ischaemia plays a role in stroke and other age related neurological diseases. Given the key role of the ischaemic penumbra in stroke pathophysiology, we hypothesised that age has an impact on penumbral tissue and its acute determinants. METHODS: We studied a prospective cohort of patients (n=39) at a mean time of 154...
March 2013: Journal of Neurology, Neurosurgery, and Psychiatry
#17
RANDOMIZED CONTROLLED TRIAL
Kalkidan Bishu, Anita Deswal, Horng H Chen, Martin M LeWinter, Gregory D Lewis, Marc J Semigran, Barry A Borlaug, Steven McNulty, Adrian F Hernandez, Eugene Braunwald, Margaret M Redfield
BACKGROUND: Acute decompensated heart failure (ADHF) occurs with preserved (heart failure with preserved ejection fraction [HFpEF] ≥50%) or reduced (heart failure with reduced ejection fraction [HFrEF] <50%) ejection fraction. Natriuretic peptide (NP) levels are lower in HFpEF than HFrEF. We hypothesized that lower NP levels in HFpEF may be associated with other differences in biomarkers, specifically, renin-angiotensin-aldosterone system (RAAS) activation, oxidative stress, and a biomarker that reflects collagen synthesis...
November 2012: American Heart Journal
#18
REVIEW
Philip B Gorelick, David Nyenhuis, Barry J Materson, David A Calhoun, William J Elliott, Robert A Phillips, Sandra J Taler, Raymond R Townsend
No abstract text is available yet for this article.
September 2012: Journal of the American Society of Hypertension: JASH
#19
JOURNAL ARTICLE
Jesus M Pradillo, Adam Denes, Andrew D Greenhalgh, Herve Boutin, Caroline Drake, Barry W McColl, Eleanor Barton, Spencer D Proctor, James C Russell, Nancy J Rothwell, Stuart M Allan
Many neuroprotective agents have been effective in experimental stroke, yet few have translated into clinical application. One reason for this may be failure to consider clinical comorbidities/risk factors in experimental models. We have shown that a naturally occurring interleukin-1 receptor antagonist (IL-1Ra) is protective against ischemic brain damage in healthy animals. However, protective effects of IL-1Ra have not been determined in comorbid animals. Thus, we tested whether IL-1Ra protects against brain injury induced by experimental ischemia in aged JCR-LA (corpulent) rats, which have clinically relevant risk factors...
September 2012: Journal of Cerebral Blood Flow and Metabolism
#20
JOURNAL ARTICLE
S Agarwal, P S Jones, J A Alawneh, N M Antoun, P J Barry, E Carrera, P E Cotter, E W O'Brien, I Salih, D J Scoffings, J-C Baron, E A Warburton
BACKGROUND: Despite use in clinical practice and major positive trials of thrombolysis, non-contrast computed tomography (NCCT) is not sensitive for identifying penumbral tissue in acute stroke. This study evaluated how physiological imaging using CT perfusion (CTP) could add to the diagnostic utility of an NCCT and inform clinical decisions regarding thrombolysis. METHODS: Forty imaging datasets containing NCCT and CTP were retrospectively identified from a cohort of consecutive acute stroke patients...
2011: Cerebrovascular Diseases
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