keyword
https://read.qxmd.com/read/38044403/genx-uptake-by-wheat-and-rice-in-flooded-and-non-flooded-soils-a-greenhouse-experiment
#21
JOURNAL ARTICLE
Amnah Al Zbedy, Viktoria Müller, Andrew Kindness, Rainer Ebel, Gareth J Norton, Joerg Feldmann
GenX (hexafluoropropylene oxide dimer acid) belongs to the group of per- and poly-fluoroalkyl substance (PFAS) compounds introduced to replace perfluorooctanoic acid (PFOA), which has been phased out in industrial and consumer product formulations. While GenX has been investigated in lab animals, there is limited information available regarding its uptake and translocation in wheat and rice. This study reports on a greenhouse experiment in which wheat and rice grown under flooded and non-flooded conditions were exposed to two GenX concentrations in the soil (0...
December 4, 2023: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38039778/baseline-metastatic-growth-rate-is-an-independent-prognostic-marker-in-patients-with-advanced-braf-v600-mutated-melanoma-receiving-targeted-therapy
#22
JOURNAL ARTICLE
Nikolaus B Wagner, Max M Lenders, Kathrin Kühl, Lydia Reinhardt, Milena Fuchß, Natalie Ring, Ramon Stäger, Caroline Zellweger, Chiara Ebel, Susanne Kimeswenger, Angela Oellinger, Teresa Amaral, Andrea Forschner, Ulrike Leiter, Bernhard Klumpp, Wolfram Hoetzenecker, Patrick Terheyden, Joanna Mangana, Carmen Loquai, Antonio Cozzio, Claus Garbe, Friedegund Meier, Thomas K Eigentler, Lukas Flatz
BACKGROUND: Targeted therapy (TT) of BRAF V600 mutated unresectable melanoma with inhibitors of the MAPK pathway achieves response rates of up to 76%, but most patients develop secondary resistance. Albeit TT is strikingly efficacious during the first days of treatment, even in advanced cases, long-term survival is highly unlikely, especially in patients with unfavorable baseline characteristics like elevated lactate dehydrogenase (LDH). In patients treated with anti-PD-1 immune checkpoint inhibitors, elevated baseline metastatic growth rate (MGR) was the most important prognostic factor...
November 21, 2023: European Journal of Cancer
https://read.qxmd.com/read/38035755/omicron-infections-in-vaccinated-pediatric-solid-organ-transplant-recipients
#23
JOURNAL ARTICLE
John McAteer, Divya D Kalluri, Rivka R Abedon, Caroline X Qin, Scott R Auerbach, Olga Charnaya, Lara A Danziger-Isakov, Noelle H Ebel, Amy G Feldman, Evelyn K Hsu, Saeed Mohammad, Emily R Perito, Ashley M Thomas, Teresa P Y Chiang, Jacqueline M Garonzik-Wang, Dorry L Segev, William A Werbel, Douglas B Mogul
No abstract text is available yet for this article.
November 30, 2023: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/38032644/cardiometabolic-effects-of-omnivorous-vs-vegan-diets-in-identical-twins-a-randomized-clinical-trial
#24
RANDOMIZED CONTROLLED TRIAL
Matthew J Landry, Catherine P Ward, Kristen M Cunanan, Lindsay R Durand, Dalia Perelman, Jennifer L Robinson, Tayler Hennings, Linda Koh, Christopher Dant, Amanda Zeitlin, Emily R Ebel, Erica D Sonnenburg, Justin L Sonnenburg, Christopher D Gardner
IMPORTANCE: Increasing evidence suggests that, compared with an omnivorous diet, a vegan diet confers potential cardiovascular benefits from improved diet quality (ie, higher consumption of vegetables, legumes, fruits, whole grains, nuts, and seeds). OBJECTIVE: To compare the effects of a healthy vegan vs healthy omnivorous diet on cardiometabolic measures during an 8-week intervention. DESIGN, SETTING, AND PARTICIPANTS: This single-center, population-based randomized clinical trial of 22 pairs of twins (N = 44) randomized participants to a vegan or omnivorous diet (1 twin per diet)...
November 1, 2023: JAMA Network Open
https://read.qxmd.com/read/38018314/isolation-of-an-anionic-dicarbene-embedded-sn-2-p-2-cluster-and-reversible-co-2-uptake
#25
JOURNAL ARTICLE
Falk Ebeler, Yury V Vishnevskiy, Beate Neumann, Hans-Georg Stammler, Rajendra S Ghadwal
Decarbonylation of a cyclic bis-phosphaethynolatostannylene [(ADC)Sn(PCO)]2 based on an anionic dicarbene framework (ADC = PhC{N(Dipp)C}2 ; Dipp = 2,6-iPr2 C6 H3 ) under UV light results in the formation of a Sn2 P2 cluster compound [(ADC)SnP]2 as a green crystalline solid. The electronic structure of [(ADC)SnP]2 is analyzed by quantum-chemical calculations. At room temperature, [(ADC)SnP]2 reversibly binds with CO2 and forms [(ADC)2 {SnOC(O)P}SnP]. [(ADC)SnP]2 enables catalytic hydroboration of CO2 and reacts with elemental selenium and Fe2 (CO)9 to afford [(ADC)2 {Sn(Se)P2 }SnSe] and [(ADC)Sn{Fe(CO)4 }P]2 , respectively...
November 28, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/37942750/the-value-of-whole-body-dual-energy-x-ray-absorptiometry-in-assessing-body-composition-in-patients-with-inflammatory-bowel-disease-a-prospective-study
#26
JOURNAL ARTICLE
Anke L Nguyen, Madhuni Herath, Megan Burns, Darcy Holt, Peter R Ebeling, Frances Milat, Peter R Gibson, Gregory T Moore
OBJECTIVES: Low skeletal muscle index (SMI) is common in inflammatory bowel disease (IBD) but has an uncertain relationship with active intestinal inflammation. This study evaluated body composition by whole-body dual-energy X-ray absorptiometry (DXA) in patients with IBD and healthy controls to enable the value of formal body composition analysis to be judged. METHODS: Patients with IBD and sex/age-matched controls prospectively underwent full body composition assessment by DXA, assessment by BMI, eating questionnaires and handgrip strength...
November 7, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37913892/predicting-comorbidities-of-pregnancy-a-comparison-between-total-and-free-25-oh-d-and-their-associations-with-parathyroid-hormone
#27
RANDOMIZED CONTROLLED TRIAL
Caroline A McWhorter, Molly J Mead, Megan D Rodgers, Myla D Ebeling, Judy R Shary, Mathew J Gregoski, Danforth A Newton, John E Baatz, Bruce W Hollis, Martin Hewison, Carol L Wagner
Pregnancy is a unique time when amplified sex steroid concentrations promote an escalation in vitamin D binding protein (DBP) synthesis, associated with increased total vitamin D and metabolites, including 25-hydroxyvitamin D (25(OH)D). Free 25(OH)D concentration increases disproportionately to total 25(OH)D during pregnancy, likely an adaptation to supply the woman and fetus with readily available 25(OH)D. Highlighting the importance of the calcium metabolic stress during pregnancy, the interactional relationship between serum 25(OH)D and PTH has been evaluated...
December 2023: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/37908056/annotation-of-gc-ms-data-of-antimicrobial-constituents-in-the-antarctic-seaweed-phaeurus-antarcticus-by-molecular-networking
#28
JOURNAL ARTICLE
Gustavo Souza Dos Santos, Maria Valdeline Sousa Teixeira, Leandro da Costa Clementino, Péricles Abreu Gama-Filho, Luiz Miguel Pereira, Thaiz Rodrigues Teixeira, Niege Araçari Jacometti Cardoso Furtado, Ana Patrícia Yatsuda, Marcia Aparecida da Silva Graminha, Pio Colepicolo-Neto, RuAngelie Edrada-Ebel, Hosana Maria Debonsi
Phaeurus antarcticus is a member of the Desmarestiaceae family endemic to the Antarctic Peninsula. Reports addressing its chemical composition and biological activities are scarce. Herein, bioactive non-polar compounds of P. antarcticus against pathogenic bacteria, Leishmania amazonensis and Neospora caninum parasites were targeted through GC-MS Molecular Networking and multivariate analysis (OPLS-DA). The effects on horseradish peroxidase (HRP) were also evaluated. P. antarcticus exhibited selective bacteriostatic and bactericidal activities against Staphylococcus aureus with MIC and MBC values from 6...
October 31, 2023: Chemistry & Biodiversity
https://read.qxmd.com/read/37902542/-top-5-research-studies-of-the-month-for-italian-primary-care-physicians-october-2023
#29
JOURNAL ARTICLE
Peter K Kurotschka, Alice Serafini, Mark H Ebell
This monthly article provides a selection of summaries of the most relevant studies identified as POEMs (patient-oriented evidence that matters) for Italian primary care physicians. Amoxicillin is no more likely to cause a rash than any other antibiotic in children with infectious mononucleosis. According to a good quality systematic review and network meta-analysis, only a small number of randomized controlled trials, disappointing in overall quality, suggest that for managing neuropsychiatric symptoms in adults with dementia, risperidone has the best balance of effectiveness and adverse effects...
November 2023: Recenti Progressi in Medicina
https://read.qxmd.com/read/37902335/the-2023-practitioner-s-toolkit-for-managing-menopause
#30
REVIEW
S R Davis, S Taylor, C Hemachandra, K Magraith, P R Ebeling, F Jane, R M Islam
OBJECTIVE: The Practitioner's Toolkit for Managing the Menopause, developed in 2014, provided an accessible desk-top tool for health-care practitioners caring for women at midlife. To ensure the Toolkit algorithms and supporting information reflect current best practice, the Toolkit has been revised in accordance with the published literature. METHODS: A systematic search for guidelines, position and consensus statements pertaining to the menopause and published after 2014 was undertaken, and key recommendations extracted from the Clinical Practice Guidelines determined to be the most robust by formal evaluation...
December 2023: Climacteric: the Journal of the International Menopause Society
https://read.qxmd.com/read/37896176/the-role-of-bacteriophages-in-the-gut-microbiota-implications-for-human-health
#31
REVIEW
Stephen C Emencheta, Chinasa V Olovo, Osita C Eze, Chisom F Kalu, Dinebari P Berebon, Ebele B Onuigbo, Marta M D C Vila, Victor M Balcão, Anthony A Attama
Bacteriophages (phages) are nano-sized viruses characterized by their inherent ability to live off bacteria. They utilize diverse mechanisms to absorb and gain entry into the bacterial cell wall via the release of viral genetic material, which uses the replication mechanisms of the host bacteria to produce and release daughter progeny virions that attack the surrounding host cells. They possess specific characteristics, including specificity for particular or closely related bacterial species. They have many applications, including as potential alternatives to antibiotics against multi-resistant bacterial pathogens and as control agents in bacteria-contaminated environments...
October 3, 2023: Pharmaceutics
https://read.qxmd.com/read/37894221/pseudomonassin-a-new-bioactive-ribosomally-synthesised-and-post-translationally-modified-peptide-from-pseudomonas-sp-sst3
#32
JOURNAL ARTICLE
Kevin Jace Miranda, Saif Jaber, Dana Atoum, Subha Arjunan, Rainer Ebel, Marcel Jaspars, RuAngelie Edrada-Ebel
Genome mining and metabolomics have become valuable tools in natural products research to evaluate and identify potential new chemistry from bacteria. In the search for new compounds from the deep-sea organism, Pseudomonas sp. SST3, from the South Shetland Trough, Antarctica, a co-cultivation with a second deep-sea Pseudomonas zhaodongensis SST2, was undertaken to isolate pseudomonassin, a ribosomally synthesised and post-translationally modified peptide (RiPP) that belongs to a class of RiPP called lasso peptides...
October 15, 2023: Microorganisms
https://read.qxmd.com/read/37847034/surgical-outcome-of-patients-with-supratentorial-meningiomas-aged-80-years-or-older-retrospective-international-multicenter-study
#33
MULTICENTER STUDY
Christoph Schwartz, Ilari Rautalin, Jürgen Grauvogel, Marco Bissolo, Waseem Masalha, Christine Steiert, Oliver Schnell, Jürgen Beck, Florian Ebel, David Bervini, Andreas Raabe, Thomas Eibl, Hans-Herbert Steiner, Nathan A Shlobin, Khizar R Nandoliya, Mark W Youngblood, James P Chandler, Stephen T Magill, Alexander Romagna, Jens Lehmberg, Manuel Fuetsch, Julian Spears, Arwin Rezai, Barbara Ladisich, Matthias Demetz, Christoph J Griessenauer, Mika Niemelä, Miikka Korja
BACKGROUND AND OBJECTIVES: Demographic changes will lead to an increase in old patients, a population with significant risk of postoperative morbidity and mortality, requiring neurosurgery for meningiomas. This multicenter study aims to report neurofunctional status after resection of patients with supratentorial meningioma aged 80 years or older, to identify factors associated with outcome, and to validate a previously proposed decision support tool. METHODS: Neurofunctional status was assessed by the Karnofsky Performance Scale (KPS)...
February 1, 2024: Neurosurgery
https://read.qxmd.com/read/37836534/vitamin-d-and-child-neurodevelopment-a-post-hoc-analysis
#34
JOURNAL ARTICLE
Megan D Rodgers, Molly J Mead, Caroline A McWhorter, Myla D Ebeling, Judy R Shary, Danforth A Newton, John E Baatz, Mathew J Gregoski, Bruce W Hollis, Carol L Wagner
INTRODUCTION: Vitamin D (VitD) has been shown to impact neurodevelopment. Studies have shown that higher 25-hydroxy-vitamin D (25(OH)D) concentrations (the indicator of vitD status) may be associated with better neurodevelopmental outcomes, although current data are conflicting. This study examined the relationship between total circulating 25(OH)D concentrations and neurodevelopmental outcomes in 3-5-year-old (3-5 yo) children. METHODS: In this study, pregnant women were randomized to receive 400 (standard dose), 2000, or 4000 IU vitD3 /day...
October 3, 2023: Nutrients
https://read.qxmd.com/read/37822780/novel-in-training-evaluation-report-in-an-internal-medicine-residency-program-improving-the-quality-of-the-narrative-assessment
#35
JOURNAL ARTICLE
Marc Gutierrez, Kelsey Wilson, Brant Bickford, Joseph Yuhas, Ronald Markert, Kathryn M Burtson
OBJECTIVE: To determine whether incorporating our novel in-training evaluation report (ITER), which prompts each resident to list at least three self-identified learning goals, improved the quality of narrative assessments as measured by the Narrative Evaluation Quality Instrument (NEQI). METHODS: A total of 1468 narrative assessments from a single institution from 2017 to 2021 were deidentified, compiled, and sorted into the pre-intervention form arm and post-intervention form arm...
2023: Journal of Medical Education and Curricular Development
https://read.qxmd.com/read/37821444/multidimensional-responses-of-grassland-stability-to-eutrophication
#36
JOURNAL ARTICLE
Qingqing Chen, Shaopeng Wang, Elizabeth T Borer, Jonathan D Bakker, Eric W Seabloom, W Stanley Harpole, Nico Eisenhauer, Ylva Lekberg, Yvonne M Buckley, Jane A Catford, Christiane Roscher, Ian Donohue, Sally A Power, Pedro Daleo, Anne Ebeling, Johannes M H Knops, Jason P Martina, Anu Eskelinen, John W Morgan, Anita C Risch, Maria C Caldeira, Miguel N Bugalho, Risto Virtanen, Isabel C Barrio, Yujie Niu, Anke Jentsch, Carly J Stevens, Daniel S Gruner, Andrew S MacDougall, Juan Alberti, Yann Hautier
Eutrophication usually impacts grassland biodiversity, community composition, and biomass production, but its impact on the stability of these community aspects is unclear. One challenge is that stability has many facets that can be tightly correlated (low dimensionality) or highly disparate (high dimensionality). Using standardized experiments in 55 grassland sites from a globally distributed experiment (NutNet), we quantify the effects of nutrient addition on five facets of stability (temporal invariability, resistance during dry and wet growing seasons, recovery after dry and wet growing seasons), measured on three community aspects (aboveground biomass, community composition, and species richness)...
October 11, 2023: Nature Communications
https://read.qxmd.com/read/37784262/consolidative-radio-therapy-in-place-of-autologous-stem-cell-transplant-in-patients-with-low-risk-relapsed-refractory-r-r-classic-hodgkin-lymphoma-chl-treated-with-nivolumab-plus-brentuximab-vedotin-checkmate-744
#37
JOURNAL ARTICLE
B S Hoppe, S Daw, P Cole, D Hodgson, A Beishuizen, N Garnier, S Buffardi, M Mascarin, T Ebeling, A Akyol, R Crowe, Y Xu, R Drachtman, K M Kelly, T Leblanc, P D Harker-Murray
PURPOSE/OBJECTIVE(S): Standard of care treatment for patients with relapsed and refractory classic Hodgkin lymphoma (RRHL) involves second line therapy followed by high dose therapy and autologous stem cell transplant (HDT/ASCT) and carries with it significant costs and toxicities to the patient. Some patients with RRHL may not require such intensive therapy, especially in the era of targeted chemotherapy and checkpoint inhibitors. CheckMate 744 (NCT02927769) evaluated a novel second-line therapy that omits HDT/ASCT by combining brentuximab vedotin (BV) and a nivolumab (N) followed by consolidative ISRT for low risk RRHL...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37778052/perioperative-continuation-or-ultra-early-resumption-of-antithrombotics-in-elective-neurosurgical-cranial-procedures
#38
JOURNAL ARTICLE
Jonathan Rychen, Valentin F Weiger, Florian S Halbeisen, Florian Ebel, Muriel Ullmann, Luigi Mariani, Raphael Guzman, Jehuda Soleman
OBJECTIVE: Discontinuation of antithrombotics (AT) prior to elective cranial procedures is common practice, despite the higher risk of thromboembolic complications in these patients. The aim of this study was to investigate the risks and benefits of a new perioperative management protocol of continuation or ultra-early AT resumption in elective cranial procedures. METHODS: This study was an analysis of a prospectively collected cohort of patients undergoing elective cranial surgery with (AT group) and without (control group) AT...
October 2023: Neurosurgical Focus
https://read.qxmd.com/read/37776976/association-of-state-medicaid-expansion-policies-with-pediatric-liver-transplant-outcomes
#39
JOURNAL ARTICLE
Holly Payton Shifman, Chiung-Yu Huang, Andrew F Beck, John Bucuvalas, Emily R Perito, Evelyn K Hsu, Noelle H Ebel, Jennifer C Lai, Sharad I Wadhwani
Children from minoritized/socioeconomically deprived backgrounds suffer disproportionately high rates of uninsurance and graft failure/death after liver transplant. Medicaid expansion was developed to expand access to public insurance. Our objective was to characterize the impact of Medicaid expansion policies on long-term graft/patient survival after pediatric liver transplantation. All pediatric patients (<19 years) who received a liver transplant between January 1, 2005, and December 31, 2020 in the US were identified in the Scientific Registry of Transplant Recipients (N = 8489)...
September 28, 2023: American Journal of Transplantation
https://read.qxmd.com/read/37773818/effect-of-a-religious-coping-intervention-of-rational-emotive-behavior-therapy-on-mental-health-of-adult-learners-with-type-ii-diabetes
#40
RANDOMIZED CONTROLLED TRIAL
Nkechi Mercy Okeke, Beatrice N Onah, Nwakaego Ebele Ekwealor, Stella Chinweudo Ekwueme, Joy Onyinyechukwu Ezugwu, Esther Nwarube Edeh, Polycarp M D Okeke, Roland Ndille, Charles C Onwuadi, Amos N Amedu, John Chidubem Nwaogaidu, Rebecca Ginikanwa Nnamani, Charles Nkem Okolie, Kingsley Okoro, Kingsley Christopher Solomon, Ola Elizabeth Owonibi
BACKGROUND: Some previous studies have highlighted the high rate of mental health problems associated with type II diabetes (T2DM). The primary purpose of this study was to investigate the effect of a religious coping intervention of rational emotive behavior therapy (REBT) on the mental health of adult learners with T2DM. METHODS: This study utilized a randomized controlled trial to select 146 adult learners with T2DM and mental health-related problems. The treatment group was made up of 73 adult learners, while the control group was also made up of 73 adult learners...
September 29, 2023: Medicine (Baltimore)
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