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Savukoski Susanna, Hannele Mäkelä, Juha Auvinen, Jari Jokelainen, Katri Puukka, Tapani Ebeling, Eila Suvanto, Maarit Niinimäki
Context: Menopausal transition is associated with increased cardiovascular risks. Available data on the effect of earlier climacterium on these risks is limited. Objective: To compare cardiovascular risk-associated parameters at the ages of 14, 31 and 46 in relation to climacteric status at the age of 46. Design, Setting and Participants: A prospective cohort study including 2685 women from the Northern Finland Birth Cohort 1966. Main Outcome Measures: Follicle-stimulating hormone (FSH), body mass index (BMI), waist circumference, waist-to-hip ratio (WHR), blood pressure (BP), body composition, cholesterol levels, testosterone levels, free androgen index (FAI), high-sensitivity C-reactive protein (hs-CRP) and liver enzymes...
February 8, 2019: Journal of Clinical Endocrinology and Metabolism
Jakub Mesinovic, Lachlan B McMillan, Catherine Shore-Lorenti, Ayse Zengin, Barbora De Courten, Peter R Ebeling, David Scott
OBJECTIVES: To determine sex-specific associations between insulin resistance and bone parameters measured by peripheral quantitative computed tomography (pQCT) in overweight and obese community-dwelling older adults. STUDY DESIGN: Cross-sectional study of 79 community-dwelling overweight and obese adults (mean±SD age 62.8±7.9 years; BMI 32.3±6.1 kg/m2 ; 58% women). MAIN OUTCOME MEASURES: pQCT assessed distal radius and tibia trabecular volumetric bone mineral density (vBMD) and proximal radius and tibia cortical vBMD, periosteal circumference, endosteal circumference and stress-strain index (SSI)...
February 6, 2019: Clinical Endocrinology
Jennifer Firn, James M McGree, Eric Harvey, Habacuc Flores-Moreno, Martin Schütz, Yvonne M Buckley, Elizabeth T Borer, Eric W Seabloom, Kimberly J La Pierre, Andrew M MacDougall, Suzanne M Prober, Carly J Stevens, Lauren L Sullivan, Erica Porter, Emma Ladouceur, Charlotte Allen, Karine H Moromizato, John W Morgan, W Stanley Harpole, Yann Hautier, Nico Eisenhauer, Justin P Wright, Peter B Adler, Carlos Alberto Arnillas, Jonathan D Bakker, Lori Biederman, Arthur A D Broadbent, Cynthia S Brown, Miguel N Bugalho, Maria C Caldeira, Elsa E Cleland, Anne Ebeling, Philip A Fay, Nicole Hagenah, Andrew R Kleinhesselink, Rachel Mitchell, Joslin L Moore, Carla Nogueira, Pablo Luis Peri, Christiane Roscher, Melinda D Smith, Peter D Wragg, Anita C Risch
Leaf traits are frequently measured in ecology to provide a 'common currency' for predicting how anthropogenic pressures impact ecosystem function. Here, we test whether leaf traits consistently respond to experimental treatments across 27 globally distributed grassland sites across 4 continents. We find that specific leaf area (leaf area per unit mass)-a commonly measured morphological trait inferring shifts between plant growth strategies-did not respond to up to four years of soil nutrient additions. Leaf nitrogen, phosphorus and potassium concentrations increased in response to the addition of each respective soil nutrient...
February 4, 2019: Nature Ecology & Evolution
Michael Hupfer, Sylvia Jordan, Christiane Herzog, Christian Ebeling, Robert Ladwig, Matthias Rothe, Jörg Lewandowski
Tube-dwelling macrozoobenthos can affect lake ecosystems in myriad ways, including changes in nutrient fluxes across the sediment-water interface. The pumping activity of chironomid larvae reinforces the transport of solutes between sediment and water. The transport of oxygen into the area surrounding the burrows generates oxidized compounds such as iron(oxy)hydroxides, which results in an additional phosphorus (P) sorption capacity similar to that of oxidized sediment surfaces. In the present study, the effect of the oxidized burrow walls of Chironomus plumosus on P binding capacity and P binding forms was tested in the laboratory using sediments with differing iron contents and varying numbers of chironomid larvae...
January 23, 2019: Science of the Total Environment
Jakub Mesinovic, Lachlan B McMillan, Catherine Shore-Lorenti, Barbora De Courten, Peter R Ebeling, David Scott
Ageing, obesity and the metabolic syndrome (MetS) may all contribute to poor muscle health (sarcopenia). This study aimed to determine the cross-sectional associations between MetS (International Diabetes Federation classification) and sarcopenia (revised European Working Group on Sarcopenia in Older People definition) in 84 overweight and obese older adults. Components of sarcopenia included muscle strength (hand grip and leg extension), physical performance (stair climb test and short physical performance battery (SPPB), including gait speed and repeated chair stands time), muscle mass (appendicular lean mass (ALM), dual-energy X-ray absorptiometry), muscle size (peripheral quantitative computed tomography-determined calf and forearm cross-sectional area (CSA)) and muscle quality (muscle density and strength normalised to lean mass)...
January 27, 2019: Journal of Clinical Medicine
Ada S Cheung, Christopher Cunningham, Dong-Kyoon Daniel Ko, Vivian Ly, Hans Gray, Rudolf Hoermann, Boyd J G Strauss, Ebrahim Bani Hassan, Gustavo Duque, Peter Ebeling, Marcus G Pandy, Jeffrey D Zajac, Mathis Grossmann
Context: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a selective loss of leg muscle function during walking. Rodent models of ADT demonstrate that levator ani is exquisitely androgen sensitive. Objective: To determine whether the high androgen responsiveness of the levator ani muscle documented in rodents is evolutionarily conserved, and ADT is associated with a selective loss in leg muscle volumes. Design: Prospective longitudinal case-control study...
December 31, 2018: Journal of Clinical Endocrinology and Metabolism
Guy Nir, Irene Farabella, Cynthia Pérez Estrada, Carl G Ebeling, Brian J Beliveau, Hiroshi M Sasaki, Soun H Lee, Son C Nguyen, Ruth B McCole, Shyamtanu Chattoraj, Jelena Erceg, Jumana AlHaj Abed, Nuno M C Martins, Huy Q Nguyen, Mohammed A Hannan, Sheikh Russell, Neva C Durand, Suhas S P Rao, Jocelyn Y Kishi, Paula Soler-Vila, Michele Di Pierro, José N Onuchic, Steven P Callahan, John M Schreiner, Jeff A Stuckey, Peng Yin, Erez Lieberman Aiden, Marc A Marti-Renom, C-Ting Wu
Chromosome organization is crucial for genome function. Here, we present a method for visualizing chromosomal DNA at super-resolution and then integrating Hi-C data to produce three-dimensional models of chromosome organization. Using the super-resolution microscopy methods of OligoSTORM and OligoDNA-PAINT, we trace 8 megabases of human chromosome 19, visualizing structures ranging in size from a few kilobases to over a megabase. Focusing on chromosomal regions that contribute to compartments, we discover distinct structures that, in spite of considerable variability, can predict whether such regions correspond to active (A-type) or inactive (B-type) compartments...
December 26, 2018: PLoS Genetics
Daniel Ebeling, Qigang Zhong, Tobias Schlöder, Jalmar Tschakert, Pascal Henkel, Sebastian Ahles, Lifeng Chi, Doreen Mollenhauer, Hermann Andreas Wegner, Andre Schirmeisen
Selectivity is a key parameter for building customized organic nanostructures via bottom-up approaches. Therefore, strategies are needed, which allow connecting molecular entities at a specific stage of the assembly process in a chemoselective manner. Studying the mechanisms of such reactions is the key to apply these transformations for the build-up of organic nanostructures on surfaces. Especially, the knowledge about the precise adsorption geometry of intermediates at different stages during the reaction process and their interactions with surface atoms or adatoms is of fundamental importance, since often catalytic processes are involved...
December 14, 2018: ACS Nano
Evelien A W Smits, José A Soetekouw, Ebel H E Pieters, Coen J P Smits, Nicolette de Wijs-Rot, Herman Vromans
Lately, the usefulness of liposomal drug delivery systems has been debated. To better understand the underlying pharmacokinetics of the targeted drug delivery by liposomes, individual encapsulated and non-encapsulated drug concentrations in blood, tumor, liver, spleen and kidneys were quantified after i.v. administration of liposomal prednisolone phosphate in mice. Kinetic analysis shows that the tumor influx of encapsulated drug is not dominant compared to the uptake by the other tissues. Further, from a quantitative point of view, the availability of non-encapsulated drug in the tumor tissue after liposomal delivery is not pronounced as compared to the other tissues studied...
December 13, 2018: Investigational New Drugs
David Scott, Jonas Johansson, Lachlan B McMillan, Peter R Ebeling, Anna Nordstrom, Peter Nordstrom
BACKGROUND: Lower skeletal muscle density, indicating greater infiltration of adipose tissue into muscles, is associated with higher fracture risk in older adults. We aimed to determine whether mid-calf muscle density is associated with falls risk and bone health in community-dwelling older adults. METHODS: 2214 community-dwelling men and women who participated in the Healthy Ageing Initiative (Sweden) study at age 70 were included in this analysis. Mid-calf muscle density (mg/cm3 ) at the proximal tibia, and volumetric bone mineral density (vBMD) and architecture at the distal and proximal tibia and radius, were assessed by peripheral quantitative computed tomography...
December 8, 2018: Bone
E Michael Lewiecki, Rajani V Dinavahi, Marise Lazaretti-Castro, Peter R Ebeling, Jonathan D Adachi, Akimitsu Miyauchi, Evelien Gielen, Cassandra E Milmont, Cesar Libanati, Andreas Grauer
Romosozumab, a humanized monoclonal antibody that binds and inhibits sclerostin, has the dual effect of increasing bone formation and decreasing bone resorption. As previously reported in the pivotal FRActure study in postmenopausal woMen with ostEoporosis (FRAME), women with a T-score of ≤ -2.5 at the total hip or femoral neck received subcutaneous placebo or romosozumab once monthly for 12 months, followed by open-label subcutaneous denosumab every 6 months for an additional 12 months. Upon completion of the 24-month primary analysis period, eligible women entered the extension phase and received denosumab for an additional 12 months...
December 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Ilana Katz Sand, Michelle T Fabian, Russell Telford, Thomas A Kraus, Mirna Chehade, Madhan Masilamani, Thomas Moran, Colleen Farrell, Shelly Ebel, Lawrence J Cook, John Rose, Fred D Lublin
Objective: This pilot study preliminarily examined the efficacy and tolerability of cetirizine as an add-on to standard therapy for neuromyelitis optica (NMO). Methods: Eligible participants met the Wingerchuk 2006 diagnostic criteria or had a single typical episode along with positive NMO immunoglobulin G. After baseline clinical and laboratory assessments, participants began treatment with cetirizine 10 mg orally daily, in addition to their usual disease-modifying therapy for NMO, and continued for 1 year...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
Elina Peltola, Päivi Hannula, Heini Huhtala, Saara Metso, Ulla Kiviniemi, Martine Vornanen, Juhani Sand, Johanna Laukkarinen, Mirja Tiikkainen, Camilla Schalin-Jäntti, Johanna Arola, Jukka Sirén, Antti Piiroinen, Minna Soinio, Pirjo Nuutila, Mirva Söderström, Hanna Hämäläinen, Leena Moilanen, David Laaksonen, Elina Pirinen, Fia Sundelin, Tapani Ebeling, Pasi Salmela, Markus J Mäkinen, Pia Jaatinen
Objective: Insulinomas are rare pancreatic tumours. Population-based data on their incidence, clinical picture, diagnosis, and treatment are almost nonexistent. The aim of this study was to clarify these aspects in a nationwide cohort of insulinoma patients diagnosed during three decades. Design and Methods: Retrospective analysis on all adult patients diagnosed with insulinoma in Finland during 1980-2010. Results: Seventy-nine patients were diagnosed with insulinoma over the research period...
2018: International Journal of Endocrinology
Wilko Reents, Sebastian Barth, Daniel P Griese, Sebastian Winkler, Jörg Babin-Ebell, Sebastian Kerber, Anno Diegeler, Michael Zacher, Karsten Hamm
OBJECTIVES: Transapical transcatheter aortic valve implantation (TAVI) is associated with increased mortality as compared to the transfemoral (TF) access. Possible mechanisms include different patient risk profiles as well as an intrinsic injury caused by the access route itself. METHODS: All consecutive patients scheduled for TAVI between January 2009 and June 2016 at a single centre were evaluated. A comparison of 30-day mortality and morbidity rates for patients undergoing TF or transapical (TA) TAVI was performed according to the criteria of the Valve Academic Research Consortium 2...
November 9, 2018: European Journal of Cardio-thoracic Surgery
Andrea Giustina, Robert A Adler, Neil Binkley, Roger Bouillon, Peter R Ebeling, Marise Lazaretti-Castro, Claudio Marcocci, Rene Rizzoli, Christopher T Sempos, John P Bilezikian
Context: Vitamin D is classically recognized as a regulator of calcium and phosphorus metabolism. Recent advances in the measurement of vitamin D metabolites, diagnosis of vitamin D deficiency, and clinical observations have led to an appreciation that along with its role in skeletal metabolism, vitamin D may well have an important role in non-classical settings. Measurement of the circulating form of vitamin D that best describes total body stores, namely 25-hydroxyvitamin D, can be unreliable despite many sophisticated methodologies that have been proposed and implemented...
October 31, 2018: Journal of Clinical Endocrinology and Metabolism
U Reinhold, H Petering, T Dirschka, A Rozsondai, J Gille, H Kurzen, R Ostendorf, A Ebeling, M Stocker, P Radny
BACKGROUND: It is important to collect data about the risk of transformation of an actinic keratosis (AK) lesion into squamous cell carcinoma (SCC) after a single photodynamic therapy (PDT) with 5-ALA patch for a longer follow-up period under daily routine. QUESTIONS ADDRESSED: The purpose of this non-interventional study (NIS) was to collect data on the frequency of occurrence of SCCs in the treated area during an interval of two years after a single 5-ALA patch-PDT...
October 16, 2018: Experimental Dermatology
Hanh H Nguyen, Denise M van de Laarschot, Annemieke Jmh Verkerk, Frances Milat, M Carola Zillikens, Peter R Ebeling
Atypical femoral fractures (AFFs) are uncommon and have been associated particularly with long-term antiresorptive therapy, including bisphosphonates. Although the pathogenesis of AFFs is unknown, their identification in bisphosphonate-naïve individuals and in monogenetic bone disorders has led to the hypothesis that genetic factors predispose to AFF. Our aim was to review and summarize the evidence for genetic factors in individuals with AFF. We conducted structured literature searches and hand-searching of conference abstracts/reference lists for key words relating to AFF and identified 2566 citations...
January 2018: JBMR Plus
D Alex Quistberg, Leah L Thompson, James Curtin, Frederick P Rivara, Beth E Ebel
OBJECTIVE: Measure the impact of automated photo speed enforcement in school zones on motorist speed and speeding violation rates during school travel. METHODS: Automated enforcement cameras, active during school commuting hours, were installed around four elementary schools in Seattle, Washington, USA in 2012. We examined the effect of automated enforcement on motorist speeds and speed violation rates during the citation period (10 December 2012 to 15 January 2015) compared with the 'warning' period (1 November to 9 December 2012)...
October 2, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
Bastian Ebeling, Khaled Belal, François Stoffelbach, Patrice Woisel, Muriel Lansalot, Franck D'Agosto
A robust and straightforward synthesis of waterborne polymer nanospheres bearing the supramolecular association unit dialkoxynapthalene at their surface is presented using polymerization-induced self-assembly (PISA). A RAFT agent bearing this unit is first employed to produce poly(acrylic acid) chains, which are then chain-extended with styrene (S) to spontaneously form the nano-objects via RAFT aqueous emulsion polymerization. The particular challenge posed by the dialkoxynapthalene hydrophobicity can be overcome by the use of PISA and the deprotonation of the poly(acrylic acid)...
September 10, 2018: Macromolecular Rapid Communications
A Trinh, P Wong, M C Fahey, P R Ebeling, P J Fuller, F Milat
CONTEXT: Bone fragility in cerebral palsy (CP) is secondary to a complex interplay of functional, hormonal, and nutritional factors that affect bone remodelling. A greater understanding of bone microarchitectural changes seen in CP should assist therapeutic decision making. OBJECTIVE: To examine the relationship between trabecular bone score (TBS), BMD and fractures in adults with CP; the influence of clinical factors and body composition on bone microarchitecture were explored...
December 2018: Bone
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