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C. David Allis

Rachael C Barlow, David Sheng Yi Chan, Sharon Mayor, Ceri Perkins, Helen L Lawton, Arfon Gmt Powell, Wyn G Lewis
Background: Risk profile assessment and corrective interventions using optimisation of health status and prehabilitation represent an important strategy in the management of patients with a suspected cancer diagnosis. Aim: To determine the feasibility of pre-treatment optimisation and prehabilitation commenced at index primary care consultation, to improve patients' preparation for treatment by maximising the time available. Design & setting: Between January 2015 and May 2016, 195 patients presenting to 12 GP practices were deemed eligible to enter the study, of which 189 (96...
December 2018: BJGP Open
Mark van der Maas, Jing Shi, Tara Elton-Marshall, David C Hodgins, Sherald Sanchez, Daniela Ss Lobo, Sylvia Hagopian, Nigel E Turner
BACKGROUND: This study seeks to give an overview of academic research on internet-based interventions that are used to address problem gambling. The rate of treatment seeking has been demonstrated to be low across several research environments. This is in part because of the systemic barriers that treatment seekers face to accessing traditional face-to-face treatment. Making treatment resources for problem gambling available through the internet is one way to reduce the impact of those systemic barriers...
January 7, 2019: JMIR Mental Health
Silvia A Purro, Mark A Farrow, Jacqueline Linehan, Tamsin Nazari, David X Thomas, Zhicheng Chen, David Mengel, Takashi Saito, Takaomi Saido, Peter Rudge, Sebastian Brandner, Dominic M Walsh, John Collinge
We previously reported1 the presence of amyloid-β protein (Aβ) deposits in individuals with Creutzfeldt-Jakob disease (CJD) who had been treated during childhood with human cadaveric pituitary-derived growth hormone (c-hGH) contaminated with prions. The marked deposition of parenchymal and vascular Aβ in these relatively young individuals with treatment-induced (iatrogenic) CJD (iCJD), in contrast to other prion-disease patients and population controls, allied with the ability of Alzheimer's disease brain homogenates to seed Aβ deposition in laboratory animals, led us to argue that the implicated c-hGH batches might have been contaminated with Aβ seeds as well as with prions...
December 13, 2018: Nature
Xinyu Zhou, Yuqing Zhang, Toshiaki A Furukawa, Pim Cuijpers, Juncai Pu, John R Weisz, Lining Yang, Sarah E Hetrick, Cinzia Del Giovane, David Cohen, Anthony C James, Shuai Yuan, Craig Whittington, Xiaofeng Jiang, Teng Teng, Andrea Cipriani, Peng Xie
Importance: Anxiety disorders are common in children and adolescents, and uncertainty remains regarding the optimal strategy of psychotherapies in this population. Objective: To compare and rank the different types of psychotherapies and the different ways of delivering psychological treatments for anxiety disorders in children and adolescents. Data Sources: PubMed, Cochrane Central Register of Controlled Trials, EMBASE, PsycINFO, Web of Science, CINAHL (Cumulative Index to Nursing and Allied Health Literature), ProQuest Dissertations, LILACS (Literatura Latino Americana em Ciências da Saúde), international trial registers, and US Food and Drug Administration reports were searched from inception to November 30, 2017...
October 31, 2018: JAMA Psychiatry
Xin Li, Xiao-Meng Li, Yixiang Jiang, Zheng Liu, Yiwen Cui, Ka Yi Fung, Stan H E van der Beelen, Gaofei Tian, Liling Wan, Xiaobing Shi, C David Allis, Haitao Li, Yuanyuan Li, Xiang David Li
Chemical probes of epigenetic 'readers' of histone post-translational modifications (PTMs) have become powerful tools for mechanistic and functional studies of their target proteins in normal physiology and disease pathogenesis. Here we report the development of the first class of chemical probes of YEATS domains, newly identified 'readers' of histone lysine acetylation (Kac) and crotonylation (Kcr). Guided by the structural analysis of a YEATS-Kcr complex, we developed a series of peptide-based inhibitors of YEATS domains by targeting a unique π-π-π stacking interaction at the proteins' Kcr recognition site...
December 2018: Nature Chemical Biology
Chang S Chan, Saurabh V Laddha, Peter W Lewis, Matthew S Koletsky, Kenneth Robzyk, Edaise Da Silva, Paula J Torres, Brian R Untch, Janet Li, Promita Bose, Timothy A Chan, David S Klimstra, C David Allis, Laura H Tang
The commonly mutated genes in pancreatic neuroendocrine tumors (PanNETs) are ATRX, DAXX, and MEN1. We genotyped 64 PanNETs and found 58% carry ATRX, DAXX, and MEN1 mutations (A-D-M mutant PanNETs) and this correlates with a worse clinical outcome than tumors carrying the wild-type alleles of all three genes (A-D-M WT PanNETs). We performed RNA sequencing and DNA-methylation analysis to reveal two distinct subgroups with one consisting entirely of A-D-M mutant PanNETs. Two genes differentiating A-D-M mutant from A-D-M WT PanNETs were high ARX and low PDX1 gene expression with PDX1 promoter hyper-methylation in the A-D-M mutant PanNETs...
October 12, 2018: Nature Communications
(no author information available yet)
On September 21, the Lasker Foundation bestowed its 2018 Albert Lasker Basic Medical Research Award on Michael Grunstein, PhD, and C. David Allis, PhD, for their discoveries explaining how gene expression is regulated by chemical modifications of histones.
November 2018: Cancer Discovery
Katherine Van Loon, Michael M Mwachiro, Christian C Abnet, Larry Akoko, Mathewos Assefa, Stephen L Burgert, Steady Chasimpha, Charles Dzamalala, David E Fleischer, Satish Gopal, Prasad G Iyer, Bongani Kaimila, Violet Kayamba, Paul Kelly, Maria E Leon, Christopher G Mathew, Diana Menya, Daniel Middleton, Yohannie Mlombe, Blandina T Mmbaga, Elia Mmbaga, Gift Mulima, Gwen Murphy, Beatrice Mushi, Ally Mwanga, Amos Mwasamwaja, M Iqbal Parker, Natalie Pritchett, Joachim Schüz, Mark D Topazian, Russell E White, Valerie McCormack, Sanford M Dawsey
Esophageal cancer is the eighth most common cancer worldwide and the sixth most common cause of cancer-related death; however, worldwide incidence and mortality rates do not reflect the geographic variations in the occurrence of this disease. In recent years, increased attention has been focused on the high incidence of esophageal squamous cell carcinoma (ESCC) throughout the eastern corridor of Africa, extending from Ethiopia to South Africa. Nascent investigations are underway at a number of sites throughout the region in an effort to improve our understanding of the etiology behind the high incidence of ESCC in this region...
September 2018: Journal of Global Oncology
Akef El-Maghraby, Amin elMaghraby, Mutasim Alireza, Daniel E Etya'ale, William C Felch, Tamer Makary, Henry E Nkumbe, David E I Pyott, Serge Resnikoff, Alfred Sommer, Bruce E Spivey, Bradley R Straatsma, Hugh R Taylor
PURPOSE: To report establishment of the Magrabi ICO Cameroon Eye Institute at Yaoundé, Cameroon, as an ophthalmology subspecialty patient care and training center in Central Africa. DESIGN: Perspective METHODS: Assessment of unpublished and published material. RESULTS: To improve, preserve and restore eye health and vision in a region with world-high prevalence of functional vision impairment and blindness, the Africa Eye Foundation established the Magrabi ICO Cameroon Eye Institute as an ophthalmology subspecialty patient care center for all in need and a training center for ophthalmologists, ophthalmology subspecialists and allied personnel...
September 18, 2018: American Journal of Ophthalmology
C David Allis
No abstract text is available yet for this article.
September 20, 2018: Cell
Allie Y Chen, Pei W Thomas, Alesha C Stewart, Alexander Bergstrom, Zishuo Cheng, Callie Miller, Christopher R Bethel, Steven H Marshall, Cy V Credille, Christopher L Riley, Richard C Page, Robert A Bonomo, Michael W Crowder, David L Tierney, Walter Fast, Seth M Cohen
No abstract text is available yet for this article.
July 26, 2018: Journal of Medicinal Chemistry
Michael J Brenner, C W David Chang, Emily F Boss, Julie L Goldman, Richard M Rosenfeld, Cecelia E Schmalbach
Patient safety/quality improvement (PS/QI) is the cornerstone of 21st-century health care. Otolaryngology-Head and Neck Surgery is excited to provide a dedicated PS/QI primer. The overarching goal for this PS/QI series is to provide a comprehensive and practical resource that assists readers, authors, and peer reviewers in understanding PS/QI research, its unique methodology, and the associated reporting standards for trustworthy performance measures. The target audience includes resident and fellows, faculty from the private sector and academia, and allied health professionals...
July 2018: Otolaryngology—Head and Neck Surgery
David B Abrams, Allison M Glasser, Andrea C Villanti, Jennifer L Pearson, Shyanika Rose, Raymond S Niaura
Tobacco control has made strides in prevention and cessation, but deaths will not decline rapidly without massive behavior change. Currently, inhaled smoke from combusting tobacco is chiefly responsible for prematurely killing 7.2 million people worldwide and 530,000 in the United States annually. An array of noncombustible nicotine products (NNPs) has emerged and has disrupted the marketplace. Saving lives more speedily will require societal acceptance of locating a "sweet spot" within a three-dimensional framework where NNPs are simultaneously: 1...
June 23, 2018: Preventive Medicine
Maria A V Willrich, Bruna D Andreguetto, Meera Sridharan, Fernando C Fervenza, Linda J Tostrud, Paula M Ladwig, Ann M Rivard, MeLea D Hetrick, Ryan N Olson, Sandra C Bryant, Melissa R Snyder, David L Murray
BACKGROUND: Eculizumab (ECU) blocks complement C5 cleavage, preventing the formation of C5a and the cytolytic effects of the membrane attack complex. The presence of ECU in blood impacts routine complement tests used to monitor treatment. METHODS: Residual serum samples with normal total complement (CH50) and residual citrate plasma with normal PT/APTT were spiked with ECU at varied concentrations ranging from 25 to 600 μg/mL. In addition, seventy-one samples from patients on ECU were obtained...
September 2018: Journal of Immunological Methods
Perrine Inquimbert, Martin Moll, Alban Latremoliere, Chi-Kun Tong, John Whang, Gregory F Sheehan, Brendan M Smith, Erica Korb, Maria C P Athié, Olusegun Babaniyi, Nader Ghasemlou, Yuchio Yanagawa, C David Allis, Patrick R Hof, Joachim Scholz
Peripheral nerve lesions provoke apoptosis in the dorsal horn of the spinal cord. The cause of cell death, the involvement of neurons, and the relevance for the processing of somatosensory information are controversial. Here, we demonstrate in a mouse model of sciatic nerve injury that glutamate-induced neurodegeneration and loss of γ-aminobutyric acid (GABA)ergic interneurons in the superficial dorsal horn promote the transition from acute to chronic neuropathic pain. Conditional deletion of Grin1, the essential subunit of N-methyl-d-aspartate-type glutamate receptors (NMDARs), protects dorsal horn neurons from excitotoxicity and preserves GABAergic inhibition...
May 29, 2018: Cell Reports
John Simms, Sarah Routledge, Romez Uddin, David Poyner
The canonical CGRP receptor is a complex between calcitonin receptor-like receptor (CLR), a family B G-protein-coupled receptor (GPCR) and receptor activity-modifying protein 1 (RAMP1). A third protein, receptor component protein (RCP) is needed for coupling to Gs. CGRP can interact with other RAMP-receptor complexes, particularly the AMY1 receptor formed between the calcitonin receptor (CTR) and RAMP1. Crystal structures are available for the binding of CGRP27-37 [D31 ,P34 ,F35 ] to the extracellular domain (ECD) of CLR and RAMP1; these show that extreme C-terminal amide of CGRP interacts with W84 of RAMP1 but the rest of the analogue interacts with CLR...
May 25, 2018: Handbook of Experimental Pharmacology
Lydia W S Finley, Santosha A Vardhana, Bryce W Carey, Direna Alonso-Curbelo, Richard Koche, Yanyang Chen, Duancheng Wen, Bryan King, Megan R Radler, Shahin Rafii, Scott W Lowe, C David Allis, Craig B Thompson
A robust network of transcription factors and an open chromatin landscape are hallmarks of the naive pluripotent state. Recently, the acetyllysine reader Brd4 has been implicated in stem cell maintenance, but the relative contribution of Brd4 to pluripotency remains unclear. Here, we show that Brd4 is dispensable for self-renewal and pluripotency of embryonic stem cells (ESCs). When maintained in their ground state, ESCs retain transcription factor binding and chromatin accessibility independent of Brd4 function or expression...
May 2018: Nature Cell Biology
Michelle Mikesh, Cameron L Ghergherehchi, Sina Rahesh, Karthik Jagannath, Amir Ali, Dale R Sengelaub, Richard C Trevino, David M Jackson, Haley O Tucker, George D Bittner
Many publications report that ablations of segments of peripheral nerves produce the following unfortunate results: (1) Immediate loss of sensory signaling and motor control; (2) rapid Wallerian degeneration of severed distal axons within days; (3) muscle atrophy within weeks; (4) poor behavioral (functional) recovery after many months, if ever, by slowly-regenerating (∼1mm/d) axon outgrowths from surviving proximal nerve stumps; and (5) Nerve allografts to repair gap injuries are rejected, often even if tissue matched and immunosuppressed...
July 2018: Journal of Neuroscience Research
Diego F Morales-Briones, Aaron Liston, David C Tank
Hybridization, incomplete lineage sorting, and phylogenetic error produce similar incongruence patterns, representing a great challenge for phylogenetic reconstruction. Here, we use sequence capture data and multiple species tree and species network approaches to resolve the backbone phylogeny of the Neotropical genus Lachemilla, while distinguishing among sources of incongruence. We used 396 nuclear loci and nearly complete plastome sequences from 27 species to clarify the relationships among the major groups of Lachemilla, and explored multiple sources of conflict between gene trees and species trees inferred with a plurality of approaches...
June 2018: New Phytologist
Samuel Y S Wong, Yu Ying Sun, Aaroy T Y Chan, Maria K W Leung, David V K Chao, Carole C K Li, King K H Chan, Wai Kwong Tang, Trevor Mazzucchelli, Alma M L Au, Benjamin H K Yip
PURPOSE: We undertook a randomized controlled trial to assess the efficacy of group-based behavioral activation with mindfulness (BAM) for treating subthreshold depression in primary care in Hong Kong. METHODS: We recruited adult patients aged 18 years or older with subthreshold depression from public primary care clinics and randomly assigned them to a BAM intervention group or a usual care group. The BAM group was provided with eight 2-hour weekly BAM sessions by trained allied health care workers...
March 2018: Annals of Family Medicine
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