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Thatyanne Gradowski do Nascimento, Priscilla Santos Vieira, Sheron Campos Cogo, Marcela Ferreira Dias-Netipanyj, Nilton de França Junior, Diana Aparecida Dias Câmara, Allan Saj Porcacchia, Ronaldo Zucatelli Mendonça, Andréa Novais Moreno-Amaral, Paulo Luiz de Sá Junior, Simone Michaela Simons, Luciana Zischler, Selene Elifio-Esposito
The antitumor properties of ticks salivary gland extracts or recombinant proteins have been reported recently, but little is known about the antitumor properties of the secreted components of saliva. The goal of this study was to investigate the in vitro effect of the saliva of the hard tick Amblyomma sculptum on neuroblastoma cell lines. SK-N-SK, SH-SY5Y, Be(2)-M17, IMR-32, and CHLA-20 cells were susceptible to saliva, with 80% reduction in their viability compared to untreated controls, as demonstrated by the methylene blue assay...
February 14, 2019: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
Kiduk Han, Tae Yoon Park, Kijung Yong, Hyung Joon Cha
The surface wetting occurring in daily life causes undesired contaminations, which are critical issues in various fields. To solve these problems, the nonwetting property of a superhydrophobic (SH) surface has proven its utility by preventing contaminant infiltration, serious infections, or malfunction. However, applying SH surfaces in the biomedical field has been limited due to the weak durability and toxicity of the related components. To overcome these limitations, we developed a robust and biocompatible SH surface through combinational biomimicking of three natural organisms: lotus leaf, mussel, and sandcastle worm, for the first time...
February 20, 2019: ACS Applied Materials & Interfaces
Biao Zhang, Wang Zhang, Zhiqian Zhang, Yuanfang Zhang, Hardik Hingorani, Zhuangjian Liu, Jun Liu, Qi Ge
Four-Dimensional (4D) printing that enables 3D printed structures to change configurations over time has gained great attention due to its exciting potential in various applications. Among all the 4D printing materials, shape memory polymers (SMPs) possess higher stiffness, faster response rate, and therefore are considered as one of most promising materials for 4D printing. However, most of the SMP based 4D printing materials are (meth)acrylate thermosets which have permanently crosslinked covalent networks and cannot be repaired if any damage occurs...
February 20, 2019: ACS Applied Materials & Interfaces
S Benfeito, C Oliveira, C Fernandes, F Cagide, J Teixeira, R Amorim, J Garrido, C Martins, B Sarmento, R Silva, F Remião, E Uriarte, P J Oliveira, F Borges
Alzheimer's disease is an irreversible, complex and progressive neurodegenerative disorder associated with oxidative stress and mitochondrial dysfunction. Exogenous antioxidants can be beneficial for decreasing oxidative stress, as they are able to reward the lack of efficacy of the endogenous defense systems and raise the overall antioxidant response in a pathological condition. Along our overarching project related with the design and development of potent and safe multi-target mitochondriotropic antioxidants, based on dietary antioxidants, novel derivatives were obtained...
February 6, 2019: European Journal of Medicinal Chemistry
Piyoosh Sharma, Avanish Tripathi, Prabhash Nath Tripathi, Santosh Kumar Prajapati, Ankit Seth, Manish Kumar Tripathi, Pavan Srivastava, Vinod Tiwari, Sairam Krishnamurthy, Sushant Kumar Shrivastava
The multitarget-directed strategy offers an effective and promising paradigm to treat the complex neurodegenerative disorder, such as Alzheimer's disease (AD). Herein, a series of N-benzylpiperidine analogs (17-31 and 32-46) were designed and synthesized as multi-functional inhibitors of acetylcholinesterase (AChE) and β-secretase-1 (BACE-1) with moderate to excellent inhibitory activities. Among the tested inhibitors, 25, 26, 40, and 41 presented the most significant and balanced inhibition against both the targets...
February 14, 2019: European Journal of Medicinal Chemistry
Fabrizio Vallelonga, Cristina Di Stefano, Aristide Merola, Alberto Romagnolo, Gabriele Sobrero, Valeria Milazzo, Alessio Burrello, Jacopo Burrello, Maurizio Zibetti, Franco Veglio, Simona Maule
INTRODUCTION: We sought to analyze the blood pressure (BP) circadian rhythm in Parkinson's disease (PD), multiple system atrophy (MSA), and pure autonomic failure (PAF) and to evaluate the effect of vasoactive and dopaminergic medications on BP fluctuations during activities of daily living. METHODS: We analyzed data from patients with PD (n = 72), MSA (n = 18), and PAF (n = 17) evaluated with 24-h ambulatory BP monitoring (ABPM) at our Center between 1996 and 2015...
February 19, 2019: Journal of Neurology
Yelena Losev, Ashim Paul, Moran Frenkel-Pinter, Malak Abu-Hussein, Isam Khalaila, Ehud Gazit, Daniel Segal
Alzheimer's disease (AD) is the most common neurodegenerative disorder and has no disease-modifying treatment yet. The hallmarks of AD are two amyloidogenic proteins: tau and amyloid β (Aβ). Tau undergoes several posttranslational modifications, including N-glycosylation. Tau was reported to be N-glycosylated in AD brains, but not in healthy counterparts, which may affect AD etiology. Here, we aimed to examine the effect of N-glycosylation on aggregation propensity of tau. To that end, a novel SH-SY5Y cell-based model was generated in which recombinant human tau (htau) is forced to be secreted from the cells...
February 19, 2019: Scientific Reports
Jingjing Liu, Xin Xiong, Yutong Sui
OBJECTIVES: Inflammation and apoptosis play a critical role in the pathological progress of traumatic brain injury (TBI). Isoliquiritigenin is a bioactive component extracted from licorice roots, which possesses anti-inflammatory and anti-apoptotic properties. This study aims to investigate the potential effects of isoliquiritigenin on neuroinflammation in a rat model of TBI. METHODS: The SH-SY5Y cells were subjected to cell injury induced by shear stress and the effect of isoliquiritigenin on cell apoptosis was measured...
February 15, 2019: Neuroimmunomodulation
Qingmei Sun, Fufeng Liu, Jingcheng Sang, Miaoman Lin, Jiale Ma, Xiao Xiao, Sicheng Yan, C Benjamin Naman, Ning Wang, Shan He, Xiaojun Yan, Wei Cui, Hongze Liang
β-Amyloid (Aβ) is regarded as an important pathogenic target for Alzheimer's disease (AD), the most prevalent neurodegenerative disease. Aβ can assemble into oligomers and fibrils, and produce neurotoxicity. Therefore, Aβ aggregation inhibitors may have anti-AD therapeutic efficacies. It was found, here, that the marine-derived alkaloid, fascaplysin, inhibits Aβ fibrillization in vitro . Moreover, the new analogue, 9-methylfascaplysin, was designed and synthesized from 5-methyltryptamine. Interestingly, 9-methylfascaplysin is a more potent inhibitor of Aβ fibril formation than fascaplysin...
February 18, 2019: Marine Drugs
Chi-Ning Chen, Chin-Kun Hu, N Sh Izmailian, Ming-Chya Wu
There are three possible classifications of the dimer weights on the bonds of the checkerboard lattice and they are denoted as checkerboard A, B, and C lattices [Phys. Rev. E 91, 062139 (2015)PLEEE81539-375510.1103/PhysRevE.91.062139]. The dimer model on the checkerboard B and C lattices has much richer critical behavior compared to the dimer model on the checkerboard A lattice. In this paper we study in full detail the dimer model on the checkerboard B lattice. The dimer model on the checkerboard B lattice has two types of critical behavior...
January 2019: Physical Review. E
Jéssica Andréia Pereira Barbosa, Marllon Alex Nascimento Santana, Tonny Cley Campos Leite, Tatiane Bezerra de Oliveira, Fernanda Virginia Barreto Mota, Isla Vanessa Gomes Alves Bastos, Allan Jonathan Chernichiarro Corrêa, Elba Lúcia Cavalcanti de Amorim, Jeymesson Raphael Cardoso Vieira, Tania Maria Sarmento Silva, Andréa Lopes Bandeira Delmiro Santana, Márcia Silva do Nascimento, Teresinha Gonçalves da Silva
OBJECTIVE: Avicennia schaueriana Stapf is an endemic mangrove species widely used by traditional Brazilian communities as a folk remedy for the treatment of rheumatism, ulcers, and skin wounds. The aim of the present study was to evaluate the gastroprotective potential of the ethyl acetate extract from the leaves of A. schaueriana (As-AcOEt). METHODS: Ultra-performance liquid chromatography coupled with diode-array detection and quadrupole time-of-flight mass spectrometry (UPLC-DAD-QTOF-MS/MS) was performed to identify chemical constituents of the ethyl acetate extract from the leaves ofA...
February 16, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Douglas L Feinstein, Kamil Gierzal, Asif Iqbal, Sergey Kalinin, Richard Ripper, Matthew Lindeblad, Alexander Zahkarov, Alexander Lyubimov, Richard van Breemen, Guy Weinberg, Israel Rubinstein
Brodifacoum (BDF) is a potent, long-acting anticoagulant rodenticide that can cause fatal poisoning in humans. The chemical structure of BDF includes 2 chiral carbons, resulting in 2 pairs of diastereomers, BDF-cis (R/S and S/R) and BDF-trans (R/R and S/S). However, the relative potency of these molecules is not known. The purpose of this study was to compare the in vitro and in vivo toxic effects of the 2 BDF diastereomer pairs. In adult Sprague-Dawley rats BDF-cis was significantly more toxic than BDF-trans (LD50 values of 219 versus 316 µg/kg, respectively) while racemic BDF had intermediate potency (266 µg/kg)...
February 16, 2019: Toxicology Letters
Anurag Kumar, Nutan Chauhan, Shailza Singh
Leishmania parasites possess an exceptional oxidant and chemical defense mechanism, involving a very unique small molecular weight thiol, trypanothione (T[SH]2 ), that helps the parasite to manage its survival inside the host macrophage. The reduced state of T[SH]2 is maintained by NADPH-dependent trypanothione reductase (TryR) by recycling trypanothione disulfide (TS2 ). Along with its most important role as central reductant, T[SH]2 have also been assumed to regulate the activation of iron-sulfur cluster proteins (Fe/S)...
2019: Frontiers in Cellular and Infection Microbiology
Huaqian Dong, Xiang Ye, Li Zhong, Jinhong Xu, Jinhua Qiu, Jun Wang, Yiming Shao, Huiqin Xing
There are numerous types of pathological changes in human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND), including apoptosis of neurons. HIV-1 transactivator of transcription (Tat) protein, which is encoded by HIV-1, may promote apoptosis in HAND. Forkhead box O3 (FOXO3) is a multispecific transcription factor that has roles in many biological processes, including cellular apoptosis. The aim of this study was to determine whether FOXO3 is activated by HIV-1 Tat and to investigate its role in neuronal apoptosis in HAND...
2019: Frontiers in Neuroscience
T A Prokhorova, I S Boksha, O K Savushkina, E B Tereshkina, G Sh Burbaeva
The review aims to attract attention of psychiatrists and neurologists to a role of α-Klotho protein in biochemical mechanisms that counteract pathogenic processes of neurodegenerative and psychiatric diseases and to possible therapeutic potential of the protein. Basing on the analysis of contemporary literature, the authors summarized the results of model experiments and a few clinical trials (in psychiatry and neurology) indicating the role of α-Klotho protein in the brain processes of neurogenesis, dendrite growth, myelination (oligodendroglia differentiation and activity), regulation of antioxidant system, and synthesis of glutamate neurotransmitter system components, regulation of the activity and synthesis of ion channel protein components and membrane transporters, synaptic plasticity...
2019: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Rui Guo, Tian-Ming Lv, Feng-Ying Han, Bin Lin, Guo-Dong Yao, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang Song
Three pairs of enantiomeric dihydrobenzofuran neolignans (1a/1b-3a/3b) including four new compounds (1a/1b and 2a/2b) were isolated from the fruit of Crataegus pinnatifida. Their structures including the absolute configurations were elucidated by extensive spectroscopic analyses and comparison between the experimental measurements of electronic circular dichroism (ECD) and the calculated ECD spectra. Additionally, all the enantiomeric neolignans were investigated for their neuroprotective activities against H2 O2 -induced cell injury in human neuroblastoma SH-SY5Y cells...
February 8, 2019: Bioorganic Chemistry
Nanuli Sh Nadaraia, Lela Sh Amiranashvili, Maia Merlani, Meri L Kakhabrishvili, Nana N Barbakadze, Athina Geronikaki, Anthi Petrou, Vladimir Poroikov, Ana Ciric, Jarmila Glamoclija, Marina Sokovic
Fourteen steroid compounds were in silico evaluated using computer program PASS as antimicrobial agents. The experimental studies evaluation revealed that all compounds have good antibacterial activity with MIC at range of 0.003-0.96 mg/mL and MBC 0.06-1.92 mg/mL. Almost all compounds except of compound 4 (3β-acetoxy-1/ -p-chlorophenyl-3/ -methyl-5α-androstano[17,16-d]pyrazoline) were more potent than Ampicillin, and they were equipotent or more potent than Streptomycine. All compounds exhibited good antifungal activity with MIC at 0...
February 15, 2019: Steroids
Lin Danyu, Liang Yanran, Jing Xiuna, Chen Ying, Peng Sudan, Zhou Tianen, Zeng Zhifen, Zheng Dezhi, Huang Kaixun, Xie Yingyu, Tao Enxiang
The transfer of misfolded α-Synuclein (α-Syn) from cell to cell as a prion protein is important in α-Synucleinopathies. Extraneous α-Syn induces apoptosis of dopaminergic neurons by causing mitochondrial dysfunction. However, the mechanism by which α-Syn disrupts the mitochondrial function is still unclear. In the present study, we used a gene microarray and western blotting analysis to show that the expression of mitochondrially encoded cytochrome c oxidase subunit 2 (MT-CO2, COXII) increased significantly in SY-SH5Y cells stimulated by α-Syn for 24h...
February 15, 2019: Experimental Cell Research
Xiyuan Mao, Ruoyu Cheng, Hongbo Zhang, Jinhong Bae, Liying Cheng, Lu Zhang, Lianfu Deng, Wenguo Cui, Yuguang Zhang, Hélder A Santos, Xiaoming Sun
The fabrication of highly biocompatible hydrogels with multiple unique healing abilities for the whole healing process, for example, multifunctional hydrogels with injectable, degradation, antibacterial, antihypoxic, and wound healing-promoting properties that match the dynamic healing process of skin flap regeneration, is currently a research challenge. Here, a multifunctional and dynamic coordinative polyethylene glycol (PEG) hydrogel with mangiferin liposomes (MF-Lip@PEG) is developed for clinical applications through Ag-S coordination of four-arm-PEG-SH and Ag+ ...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Songwei He, Fuhui Wang, Yixin Zhang, Jinlong Chen, Lining Liang, Yuan Li, Mengdan Zhang, Xiao Yang, Hongshen Pang, Yingying Li, Xiaofen Huang, Dajiang Qin, Duanqing Pei, Hao Sun, Hui Zheng
The relationship between active DNA demethylation induced by overexpressing Tet1 and passive DNA demethylation induced by suppressing Dnmt1 remains unclear. Here, we found that DNMT1 preferentially methylated, but TET1 preferentially demethylated, hemi-methylated CpG sites. These phenomena resulted in a significant overlap in the targets of these two types of DNA demethylation and the counteractions of Dnmt1 and Tet1 during somatic cell reprogramming. Since the hemi-methylated CpG sites generated during cell proliferation were enriched at core pluripotency loci, DNA demethylation induced by Tet1 or sh-RNA against Dnmt1 ( sh-Dnmt1 ) was enriched in these loci, which, in combination with Yamanaka factors, led to the up-regulation of these genes and promoted somatic cell reprogramming...
2019: Cell Discovery
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