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Hadi Karimzadeh, Muthamia M Kiraithe, Valerie Oberhardt, Elahe Salimi Alizei, Jan Bockmann, Julian Schulze Zur Wiesch, Bettina Budeus, Daniel Hoffmann, Heiner Wedemeyer, Markus Cornberg, Adalbert Krawczyk, Jassin Rashidi-Alavijeh, Francisco Rodríguez-Frías, Rosario Casillas, Maria Buti, Antonina Smedile, Seyed Moayed Alavian, Andreas Heinold, Florian Emmerich, Marcus Panning, Emma Gostick, David A Price, Jörg Timm, Maike Hofmann, Bijan Raziorrouh, Robert Thimme, Ulrike Protzer, Michael Roggendorf, Christoph Neumann-Haefelin
BACKGROUND & AIMS: Hepatitis D virus (HDV) super-infection in patients with hepatitis B virus (HBV) is associated with rapid progression to liver cirrhosis and hepatocellular carcinoma. Treatment options are limited, and no vaccine is available. Although HDV-specific CD8+ T cells are thought to control the virus, little is known about which HDV epitopes are targeted by virus-specific CD8+ T cells or why these cells ultimately fail to control the infection. We aimed to define how HDV escapes the CD8+ T cell-mediated response...
February 12, 2019: Gastroenterology
Cristiane Faria de Oliveira Scarponi, Raquel Duarte Nunes da Silva, Job Alves de Souza Filho, Maria Regina Lage Guerra, Marco Antônio Ferreira Pedrosa, Marcos Paulo Gomes Mol
Hepatitis delta virus (HDV) has been associated with acute or chronic hepatitis in Latin America, but there is no prevalence study covering South American countries. This meta-analysis aimed to estimate anti-HDV prevalence through a systematic review of published articles in English, Portuguese and Spanish until December 2017. Searches were conducted in Health Virtual Library, Capes, Lilacs, PubMed, and SciELO, according to defined criteria regarding participant selection and geographical setting. Study quality was assessed using the GRADE guidelines...
January 24, 2019: Revista da Sociedade Brasileira de Medicina Tropical
Edinete Melo DA Silva, Alan Kay, Cirley Lobato, Richard Muwonge, Fabien Zoulim, Carlos Brites, Raymundo Parana, Christian Trepo
The clinical outcome of hepatitis B virus (HBV) infection may be related to host and viral genetic factors, as well as to the type of infection (mono- and co-infection). To analyse the distribution/combination of HBV/HDV genotypes and the associated clinical characteristics, 409 serum samples from patients with chronic HBV (94 of them coinfected by HDV) followed at the Viral Hepatitis Referral Center of Rio Branco-Brazil were enrolled. HBV DNA and HDV RNA were amplified, respectively, by PCR and nested-PCR using specific primers in the PreC/C region and the S gene, and by RT-PCR and semi-nested-PCR using specific primers in the delta antigen region (sHD) and sequenced...
January 29, 2019: Journal of Medical Virology
Elizabeth C Townsend, Grace Y Zhang, Rabab Ali, Marian Firke, Mi Sun Moon, Ma Ai Thanda Han, Benjamin Fram, Jeffrey S Glenn, David E Kleiner, Christopher Koh, Theo Heller
BACKGROUND: Hepatitis delta virus (HDV) infection is the most rapidly progressive chronic viral hepatitis. Little is understood about the immune responses to HDV. AIM: To characterize the systemic immune environments of hepatitis B virus (HBV) and HDV patients at various disease stages. METHODS: Evaluated 129 subjects; 53 HBV, 43 HDV, 33 healthy controls. HBV and HDV subjects were categorized by aspartate aminotransferase to platelet ratio index (APRI) into mild (APRI < 0...
January 29, 2019: Journal of Gastroenterology and Hepatology
Mai Thanh Binh, Nghiem Xuan Hoan, Hoang Van Tong, Bui Tien Sy, Ngo Tat Trung, C-Thomas Bock, Nguyen Linh Toan, Le Huu Song, Mai Hong Bang, Christian G Meyer, Peter G Kremsner, Thirumalaisamy P Velavan
OBJECTIVES: To determine potential associations of the rs2296651 variant (c.800C > T, S267F) of NTCP with HBV and HBV plus concomitant HDV infection as well as with the progression of related liver diseases. METHODS: The S267F variant was genotyped by DNA sequencing in 620 HBV-infected patients and 214 healthy controls (HCs). Among the patients, 450 individuals were tested for HDV by a nested PCR assay. Logistic regression was applied to examine the association...
January 24, 2019: International Journal of Infectious Diseases: IJID
Kevin S H Liu, Wai-Kay Seto, Eric H Y Lau, Danny Ka-Ho Wong, Yuk-Fai Lam, Ka-Shing Cheung, Lung-Yi Mak, Kwan-Lung Ko, Wai-Pan To, Mildred W K Law, Joseph T Wu, Ching-Lung Lai, Man-Fung Yuen
Backround: Viral hepatitis epidemiological data is important for the WHO plan of eliminating viral hepatitis. We aimed to document the prevalence of viral hepatitis A to E in Hong Kong. Methods: This community-based study was open to all Hong Kong Chinese citizens aged ≥18 years. Baseline data and risk factors were collected. Hepatitis A to E serology were measured, including HBeAg/anti-HBe, anti-HDV, HBV DNA for HBsAg-positive participants and anti-HBs and anti-HBc in HBsAg-negative participants...
January 18, 2019: Journal of Infectious Diseases
Helenie Kefalakes, Christopher Koh, John Sidney, Georgios Amanakis, Alessandro Sette, Theo Heller, Barbara Rehermann
BACKGROUND & AIM: Hepatitis D virus (HDV) superinfection of patients with chronic HBV infection results in rapid progression to liver cirrhosis. Little is known about HDV-specific T cells and how they contribute to the anti-virus immune response and liver disease pathogenesis. METHODS: We isolated peripheral blood mononuclear cells from 28 patients with chronic HDV and HBV infection, identified HDV-specific CD8+ T-cell epitopes and characterized HDV-specific CD8+ T cells...
January 18, 2019: Gastroenterology
Parag Mahale, Peter Aka, Xiaohua Chen, Ruth M Pfeiffer, Ping Liu, Sarah Groover, Maimuna Mendy, Ramou Njie, James J Goedert, Gregory D Kirk, Jeffrey S Glenn, Thomas R O'Brien
Hepatocellular carcinoma (HCC) incidence is high in The Gambia and hepatitis B virus (HBV) infection is the main cause. People co-infected with HBV and hepatitis D virus (HDV) have an even greater risk of HCC and cirrhosis. Using a new HDV quantitative microarray antibody capture (Q-MAC) assay, we evaluated the association between HDV infection and HCC or cirrhosis among participants in The Gambia Liver Cancer Study. In this case-control study, cases had HCC (n=312) or cirrhosis (n=119). Controls (n=470) had no clinical evidence of liver disease and normal serum alfa-fetoprotein...
January 20, 2019: Journal of Viral Hepatitis
Gabrielle Goodrum, Martin Pelchat
Hepatitis delta virus (HDV) is unique among animal viruses. HDV is a satellite virus of the hepatitis B virus (HBV), however it shares no sequence similarity with its helper virus and replicates independently in infected cells. HDV is the smallest human pathogenic RNA virus and shares numerous characteristics with viroids. Like viroids, HDV has a circular RNA genome which adopts a rod-like secondary structure, possesses ribozyme domains, replicates in the nucleus of infected cells by redirecting host DNA-dependent RNA polymerases (RNAP), and relies heavily on host proteins for its replication due to its small size and limited protein coding capacity...
December 31, 2018: Viruses
Henri Gautier Ouedraogo, Seni Kouanda, Ashley Grosso, Rebecca Compaoré, Modibo Camara, Charlemagne Dabire, Rasmata Ouedraogo, Yves Traore, Stefan Baral, Nicolas Barro
BACKGROUND: Men who have sex with men (MSM) are considered to be at significant risk for sexually transmitted infections (STI) and bloodborne viruses including viral hepatitis types B, C, and D (HBV, HCV, and HDV) and human T-cell leukemia virus types 1 and 2 (HTLV 1&2). This study aimed to assess the seroprevalence and correlates of HBV, HCV, HDV, and HTLV 1&2 antibodies among MSM in Ouagadougou, Burkina Faso. METHODS: We conducted a cross-sectional survey to assess the biological and behavourial characteristics among MSM in Ouagadougou from January to April 2013...
December 29, 2018: Virology Journal
Judith N Torimiro, Aubin Nanfack, William Takang, Claude Kalla Keou, Awum Nchenda Joyce, Kevin Njefi, Kimbong Agyingi, Irenee Domkam, Desire Takou, Sylvie Moudourou, Samuel Sosso, Robinson E Mbu
BACKGROUND: HBV, HCV, HDV and HIV are blood borne and can be transmitted from mother-to-child. Reports of HBV infection rates show up to 11.9% in Cameroon while for HCV, the rate is less than 2%. More so, as pregnant women get enrolled in the HIV PMTCT Programme and stay in the care continuum, selection of HIV-1 drug resistant strains is evident. We sought to determine the seroprevalence of HBV, HCV, HDV and HIV among pregnant women, assess their knowledge, attitudes and practices on transmission and prevention of HBV infection, and determine HIV drug resistance profile of breastfeeding women...
December 22, 2018: BMC Pregnancy and Childbirth
Michelle Wille, Hans J Netter, Margaret Littlejohn, Lilly Yuen, Mang Shi, John-Sebastian Eden, Marcel Klaassen, Edward C Holmes, Aeron C Hurt
Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures that were shared with HDV, including self-complementarity and ribozyme features. The predicted viral protein shares 32% amino acid similarity to the small delta antigen of HDV and comprises a divergent phylogenetic lineage...
December 17, 2018: Viruses
Yasser Farid, Charlotte Martin, Marc Delforge, Stephane De Wit
OBJECTIVES: Human immunodeficiency virus (HIV) and hepatitis B virus (HBV) are both worldwide health concerns with similar routes of transmission and no curative treatment to date. Coinfection is associated with increased morbidity and mortality. We aim to provide epidemiological data about HIV-HBV coinfected patients and asses if management of patients following European recommendation (EACS) was achieved in a large AIDS Reference Center in Belgium. METHODS: Retrospective review of the HIV database of Saint-Pierre University Hospital in Brussels (Belgium) focusing on HIV-HBV coinfected patients in active follow-up...
December 4, 2018: Acta Clinica Belgica
Natali Abeywickrama-Samarakoon, Jean-Claude Cortay, Camille Sureau, Dulce Alfaiate, Massimo Levrero, Paul Dény
Hepatitis delta virus (HDV) is a mammalian defective virus. Its genome is a small single-stranded circular RNA of approximately 1,680 nucleotides. To spread, HDV relies on hepatitis B virus envelope proteins that are needed for viral particle assembly and egress. Severe clinical features of HBV-HDV infection include acute fulminant hepatitis and chronic liver fibrosis leading to cirrhosis and hepatocellular carcinoma. One uniqueness of HDV relies on its genome similarity to viroids, small plant infectious uncoated RNAs...
October 2018: Médecine Sciences: M/S
Xin Ye, Chise Tateno, Emily P Thi, Masakazu Kakuni, Nicholas M Snead, Yuji Ishida, Trisha R Barnard, Michael J Sofia, Takashi Shimada, Amy C H Lee
Hepatitis delta virus (HDV) infects 10-20 million individuals worldwide and causes severe fulminant hepatitis with high likelihood of cirrhosis and hepatocellular carcinoma. HDV infection cannot occur in the absence of the surface antigen (HBsAg) of the hepatitis B virus. RNA interference is an effective mechanism by which to inhibit viral transcripts, and siRNA therapeutics sharing this mechanism have begun to demonstrate clinical efficacy. Here we assessed the outcome of HBV-targeting siRNA intervention against HDV and compared it to a direct anti-HDV siRNA approach in dually infected humanized mice...
November 20, 2018: ACS Infectious Diseases
Özgür M Koc, Geert Robaeys, Beytullah Yildirim, Dirk Posthouwer, Niel Hens, Ger H Koek
Since the cultural diversity in Western Europe is growing, this study assessed whether foreign-born chronic hepatitis B (CHB) patients have more cirrhosis than Dutch- or Belgian-born patients, with a main focus on the Turkish population. Baseline characteristics (eg, socioeconomic status [SES]), biological characteristics, and disease outcome (eg, cirrhosis) were collected for all patients. Between December 2009 and January 2015, 269 CHB patients participated from the outpatient departments of three hospitals in the Netherlands, Belgium, and Turkey...
November 1, 2018: Journal of Medical Virology
Abdurrahman Sahin, Suzan Gurocak, Nurettin Tunc, Ulvi Demirel, Orhan Kursat Poyrazoglu, Handan Akbulut, Mehmet Yalniz, Zulal Asci Toraman, Ibrahim Halil Bahcecioglu
OBJECTIVE: This prospective study aimed to determine the prevalence of anti-HDV seropositivity among subjects who had previous hepatitis B virus (HBV) infection. METHODS: Subjects who were admitted to the gastroenterology inpatient clinic of our hospital between August 2016 and July 2017 were screened for previous HBV infection. The subjects who had HBV serology compatible with resolved HBV infection were recruited in the study, and the seroprevalance of anti-HDV was studied...
2018: Northern Clinics of Istanbul
Mohamed A Daw, Amina M Daw, Nadia E M Sifennasr, Aisha M Draha, Ahmed M Daw, Ali M Daw, Mohamed O Ahmed, Ebtisam S Mokhtar, Abdallah El-Bouzedi, Ibrahem M Daw
Background: Hepatitis D virus (HDV) infection has been considered a serious neglected pandemic, particularly in developing countries. The virus causes a more severe disease than mono infection with hepatitis B virus (HBV). The epidemiology of HDV is not well documented in North Africa, which is known to be endemic for HBV. In this study, we explored the prevalence of HDV infection and also attempted to identify factors associated with hepatitis D positive status among chronic hepatitis B patients in North Africa...
2018: TheScientificWorldJournal
Christopher Koh, Theo Heller, Jeffrey S Glenn
Hepatitis delta virus (HDV) infection of humans was first reported in 1977, and now it is now estimated that 15-20 million people are infected worldwide. Infection with HDV can be an acute or chronic process that occurs only in patients with an hepatitis B virus infection. Chronic HDV infection commonly results in the most rapidly progressive form of viral hepatitis; it is the chronic viral infection that is most likely to lead to cirrhosis, and it is associated with an increased risk of hepatocellular carcinoma...
January 2019: Gastroenterology
Giuseppina Brancaccio, Alessandra Nardi, Salvatore Madonia, Massimo Fasano, Gabriella Verucchi, Marco Massari, Sergio Maimone, Carlo Contini, Fabio Levantesi, Arianna Alfieri, Caius Gavrila, Pietro Andreone, Michele Milella, Giovanni B Gaeta
BACKGROUND: Chronic hepatitis B virus (HBV) infection remains a primary cause of morbidity and mortality worldwide. AIM: The study is aimed at updating the clinical and epidemiological profile of chronic HBV infection in Italy. METHODS: A cross-sectional multicenter prospective study enrolled consecutive HBsAg positive patients seen in 73 Italian centers in the period 2012-2015. Individual patient data were collected using an electronic platform and analyzed using standard statistical methods...
September 21, 2018: Digestive and Liver Disease
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