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JOURNAL ARTICLE
Margherita Fabbri, Vanessa Rousseau, Jean-Christophe Corvol, Agnès Sommet, Florence Tubach, Yann De Rycke, Nathalie Bertille, Yajiththa Selvarasa, Stephanie Carvalho, Véronique Chaigneau, Christine Brefel-Courbon, Fabienne Ory-Magne, Samuel Tessier, Melissa Tir, Matthieu Bereau, Wassilios G Meissner, Claire Thiriez, Ana Marques, Philippe Remy, Vincent Schneider, Elena Moro, Luc Defebvre, Jean Luc Houeto, Stephane Prange, Alexandre Eusebio, Christian Geny, Solène Frismand, Philippe Damier, Caroline Giordana Reuther, Giovanni Castelnovo, Isabelle Benatru, Anne Doe De Maindreville, Sophie Drapier, David Maltête, Ouhaid Lagha-Boukbiza, Olivier Rascol
OBJECTIVE: To assess amantadine use and associated factors in the patients with Parkinson's disease (PD). BACKGROUND: Immediate-release amantadine is approved for the treatment of PD and is largely used in clinical practice to treat "levodopa-induced dyskinesia (LIDs). Its use varies according to countries and PD stages. The prospective NS-Park cohort collects features of PD patients followed by 26 French PD Expert Centres. METHODS: Variables used for the analyses included demographics, motor and non-motor PD symptoms and motor complications [motor fluctuations (MFs), LIDs)], antiparkinsonian pharmacological classes and levodopa equivalent daily dose (LEDD)...
April 5, 2024: Journal of Neural Transmission
#2
JOURNAL ARTICLE
Weijia Hou, Fan Wu, Yue Wang, Weihua Li, Yuanyuan Cheng, Zhizhong Zhu, Siquan Liang, Peipei Liu, Yang Yu, Jialing Wu
INTRODUCTION: Gait initiation (GI) includes automatic and voluntary movements. However, research on their impact on the first step in patients with Parkinson's disease (PD) and their relationship to freezing of gait (FOG) is lacking. We examined the effects of automatic movements (anticipatory postural adjustments [APAs]) and voluntary movements (limits of stability [LOS]) on the first step (first-step duration and first-step range of motion), along with their early recognition and prediction of slight FOG...
March 29, 2024: Parkinsonism & related Disorders
#3
JOURNAL ARTICLE
Yuhan Jiang, Mengxi Zhou, Haibin Sheng, Shuai Xu, Yajing Chen, Li Wu, Qing He, Lei Zhao, Jianren Liu, Wei Chen
BACKGROUND: Vestibular dysfunction is closely associated with the pathophysiology of Parkinson's disease (PD) accompanied by freezing of gait (FOG); however, evidence supporting this clinical association is lacking. Vestibular-evoked myogenic potentials (VEMPs) have been widely acknowledged as a crucial electrophysiological parameter in the clinical evaluation of vestibular function. OBJECTIVE: The present study investigated the possible correlation of FOG occurrence with VEMP observations in patients diagnosed with PD...
March 27, 2024: Journal of Neurology
#4
JOURNAL ARTICLE
Rohan Khatavkar, Ashutosh Tiwari, Priyanka Bhat, Achal Kumar Srivastava, S Senthil Kumaran, Deepak Joshi
Auditory and visual cues have been efficacious in laboratory-based freezing of gait (FoG) mitigation in Parkinson's disease (PD). However, real-life applications of these cues are restricted due to inconvenience to the users. Closed-loop vibrotactile cues based on temporal gait events have overcome the shortcomings of auditory and visual cueing. However, kinematic gait parameter-driven vibrotactile cueing has not been explored yet. Kinematic gait parameter-driven cueing is more effective than temporal cueing, according to FoG pathophysiology studies...
March 25, 2024: IEEE Transactions on Haptics
#5
JOURNAL ARTICLE
Nicola Tambasco, Alessandro Mechelli, Pasquale Nigro, Simone Simoni, Federico Paolini Paoletti, Paolo Eusebi, Elona Brahimi, Carlo Maremmani, Lucilla Parnetti
BACKGROUND: Olfactory dysfunction is a non-motor symptom and an important biomarker of Parkinson's disease (PD) because of its high prevalence (> 90%). Whether hyposmia correlates with motor symptoms is unclear. In the present study, we aim to investigate the relationship between olfactory impairment with both motor and non-motor features and disease variables (disease duration, stage, and severity). METHODS: One-hundred fifty-four PD patients were evaluated...
March 19, 2024: Neurological Sciences
#6
JOURNAL ARTICLE
Demi Zoetewei, Talia Herman, Pieter Ginis, Luca Palmerini, Marina Brozgol, Pablo Cornejo Thumm, Alberto Ferrari, Eva Ceulemans, Eva Decaluwé, Jeffrey M Hausdorff, Alice Nieuwboer
BACKGROUND: Cueing can alleviate freezing of gait (FOG) in people with Parkinson's disease (PD), but using the same cues continuously in daily life may compromise effectiveness. Therefore, we developed the DeFOG-system to deliver personalized auditory cues on detection of a FOG episode. OBJECTIVES: We aimed to evaluate the effects of DeFOG during a FOG-provoking protocol: (1) after 4 weeks of DeFOG-use in daily life against an active control group; (2) after immediate DeFOG-use (within-group) in different medication states...
March 14, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
#7
JOURNAL ARTICLE
Jana Seuthe, Anna Heinzel, Femke Hulzinga, Pieter Ginis, Kirsten E Zeuner, Günther Deuschl, Nicholas D'Cruz, Alice Nieuwboer, Christian Schlenstedt
INTRODUCTION: Previous studies have shown that anticipatory postural adjustments (APAs) are altered in people with Parkinson's disease but its meaning for locomotion is less understood. This study aims to investigate the association between APAs and gait initiation, gait and freezing of gait and how a dynamic postural control challenging training may induce changes in these features. METHODS: Gait initiation was quantified using wearable sensors and subsequent straight walking was assessed via marker-based motion capture...
2024: PloS One
#8
JOURNAL ARTICLE
Carl-Johan Kihlstedt, Jan Malm, Alfonso Fasano, David Bäckström
BACKGROUND: Reports of freezing of gait (FoG) in idiopathic normal pressure hydrocephalus (iNPH) are few and results are variable. This study's objective was to evaluate the frequency of FoG in a large cohort of iNPH patients, identify FoG-associated factors, and assess FoG's responsiveness to shunt surgery. METHODS: Videotaped standardized gait protocols with iNPH patients pre- and post-shunt surgery (n = 139; median age 75 (71-79) years; 48 women) were evaluated for FoG episodes by two observers (Cohens kappa = 0...
March 8, 2024: Fluids and Barriers of the CNS
#9
REVIEW
Ethan Slouha, Fadi Ibrahim, Sarah Esposito, Odelin Mursuli, Atbeen Rezazadah, Lucy A Clunes, Theofanis F Kollias
Parkinson's disease (PD) is a terminal, debilitating neurodegenerative disorder typically affecting individuals over 60. It is associated with various conditions that drastically affect the patient's quality of life (QoL). Although there is no cure for PD, its symptoms can be significantly improved and even resolved through different treatments. Mainstay treatments for PD include levodopa combined with carbidopa, dopamine agonists, and even deep brain stimulation (DBS) of the subthalamic nucleus. New treatment methods have emerged, such as botulinum toxin (BoNT), which further improve symptoms and, thus, the QoL of patients with PD...
January 2024: Curēus
#10
JOURNAL ARTICLE
Carla Silva-Batista, Jumes Lira, Daniel Boari Coelho, Andrea Cristina de Lima-Pardini, Mariana Penteado Nucci, Eugenia Casella Tavares Mattos, Fernando Henrique Magalhaes, Egberto Reis Barbosa, Luis Augusto Teixeira, Edson Amaro Junior, Carlos Ugrinowitsch, Fay B Horak
Individuals with Parkinson's disease (PD) and freezing of gait (FOG) have a loss of presynaptic inhibition (PSI) during anticipatory postural adjustments (APAs) for step initiation. The mesencephalic locomotor region (MLR) has connections to the reticulospinal tract that mediates inhibitory interneurons responsible for modulating PSI and APAs. Here, we hypothesized that MLR activity during step initiation would explain the loss of PSI during APAs for step initiation in FOG (freezers). Freezers (n = 34) were assessed in the ON-medication state...
February 15, 2024: Brain Sciences
#11
JOURNAL ARTICLE
Seok Jong Chung, Su Hong Kim, Chan Wook Park, Hye Sun Lee, Mijin Yun, Yun Joong Kim, Young H Sohn, Yong Jeong, Phil Hyu Lee
INTRODUCTION: This study aimed to investigate whether regional cerebral perfusion patterns on early-phase 18 F-FP-CIT PET scans, which is typically coupled to cerebral metabolism, predict the long-term prognosis of Parkinson's disease (PD). METHODS: We enrolled 397 drug-naïve patients with early-stage PD who underwent dual-phase 18 F-FP-CIT PET scans. After quantifying the early-phase 18 F-FP-CIT PET images, cluster analysis was performed to delineate the PD subtypes according to the patterns of regional cerebral perfusion...
February 2, 2024: Parkinsonism & related Disorders
#12
Zicai Liu, Xin Wen, Xiuying Xie, Yangyou Liu, Cheng Tan, Shuanghong Kuang, Huiyu Liu
BACKGROUND: Freezing of gait (FOG) is one of the most disabling gait disturbances in Parkinson's disease (PD), affecting mobility and balance severely, thereby leading to an increased risk of falls. OBJECTIVES: The purpose of this systematic review and meta-analysis was to investigate the effects of transcranial magnetic stimulation on FOG in PD. METHODS: Based on PRISMA guidelines, we searched the databases of MEDLINE (PubMed), Cochrane Library, PEDro, Embase, and Web of Science...
2024: Frontiers in Aging Neuroscience
#13
JOURNAL ARTICLE
Po-Kai Yang, Benjamin Filtjens, Pieter Ginis, Maaike Goris, Alice Nieuwboer, Moran Gilat, Peter Slaets, Bart Vanrumste
BACKGROUND: Freezing of gait (FOG) is an episodic and highly disabling symptom of Parkinson's Disease (PD). Traditionally, FOG assessment relies on time-consuming visual inspection of camera footage. Therefore, previous studies have proposed portable and automated solutions to annotate FOG. However, automated FOG assessment is challenging due to gait variability caused by medication effects and varying FOG-provoking tasks. Moreover, whether automated approaches can differentiate FOG from typical everyday movements, such as volitional stops, remains to be determined...
February 13, 2024: Journal of Neuroengineering and Rehabilitation
#14
JOURNAL ARTICLE
Yuka Miyahara, Onanong Phokaewvarangkul, Stephen Kerr, Chanawat Anan, Haruki Toriumi, Roongroj Bhidayasiri
BACKGROUND: ON-freezing of gait (ON-FOG) in Parkinson's disease (PD), often resistant to medication, is linked to sensory deficits and proprioceptive impairment, and results in falls and reduced life quality. While visual cues from a laser cane (LC), which rapidly accesses the motor cortex, are commonly used to compensate for proprioceptive impairment, increased visual reliance may be affected by disease progression. Emerging evidence suggests that modulation of peripheral sensory processing may alleviate ON-FOG, and therapeutic Thai acupressure (TTA) may be a solution...
2024: Frontiers in Neurology
#15
JOURNAL ARTICLE
Maja L Hansen, Malene Ambjørn, Mikkel N Harndahl, Tau Benned-Jensen, Karina Fog, Kaare Bjerregaard-Andersen, Florence Sotty
Protein aggregation is a predominant feature of many neurodegenerative diseases, including synucleinopathies, which are characterized by cellular inclusions containing α-Synuclein (αSyn) phosphorylated at serine 129 (pSer129). In the present study, we characterized the development of αSyn pre-formed fibril (PFF)-induced pSer129-αSyn pathology in F28tg mice overexpressing human wild-type αSyn, as well as in ex vivo organotypic cultures and in vitro primary cultures from the same mouse model...
January 29, 2024: Cells
#16
JOURNAL ARTICLE
Wenjing Song, Zixuan Zhang, Bingchen Lv, Jinyu Li, Hao Chen, Shenyang Zhang, Jie Zu, Liguo Dong, Chuanying Xu, Manli Zhou, Tao Zhang, Ran Xu, Jienan Zhu, Tong Shen, Su Zhou, Chenchen Cui, Shuming Huang, Xi Wang, Yujing Nie, Kainat Aftab, Qihua Xiao, Xueling Zhang, Guiyun Cui, Wei Zhang
BACKGROUND: Freezing of gait (FOG) is a common and disabling phenomenon in patients with Parkinson's disease (PD), but effective treatment approach remains inconclusive. Dysfunctional emotional factors play a key role in FOG. Since primary motor cortex (M1) connects with prefrontal areas via the frontal longitudinal system, where are responsible for emotional regulation, we hypothesized M1 may be a potential neuromodulation target for FOG therapy. The purpose of this study is to explore whether high-frequency rTMS over bilateral M1 could relieve FOG and emotional dysregulation in patients with PD...
2024: Frontiers in Aging Neuroscience
#17
REVIEW
Khalid A Hanafy, Tudor G Jovin
IMPORTANCE: While the understanding of inflammation in the pathogenesis of many neurological diseases is now accepted, this special commentary addresses the need to study chronic inflammation in the propagation of cognitive Fog, Asthenia, and Depression Related to Inflammation which we name Brain FADE syndrome. Patients with Brain FADE syndrome fall in the void between neurology and psychiatry because the depression, fatigue, and fog seen in these patients are not idiopathic, but instead due to organic, inflammation involved in neurological disease initiation...
2024: Frontiers in Immunology
#18
JOURNAL ARTICLE
Caroline S Aitken, Olivia Samotus, Anish S Naidu, Mandar Jog, Rajni V Patel
Parkinson's Disease (PD) has been found to cause force control deficits in upper and lower limbs. About 50% of patients with advanced PD develop a debilitating symptom called freezing of gait (FOG), which has been linked to force control problems in the lower limbs, and some may only have a limited response to the gold standard pharmaceutical therapy, levodopa, resulting in partially levodopa-responsive FOG (PLR-FOG). There has been limited research on investigating upper-limb force control in people with PD with PLR-FOG, and without FOG...
January 18, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
#19
JOURNAL ARTICLE
Abdullah Al Jaja, Téa Sue, Margaret Prenger, Ken N Seergobin, Jessica A Grahn, Penny A MacDonald
BACKGROUND: Freezing of gait (FOG) is an intractable motor symptom in Parkinson's disease (PD) that increases fall risk and impairs the quality of life. FOG has been associated with anxiety, with experimental support for the notion that anxiety itself provokes FOG. We investigated the effect of acute anxiety reduction via alprazolam on FOG in PD. METHODS: In ten patients with PD, FOG, and normal cognition, we administered 0.25 mg alprazolam in one session and placebo in another, in counterbalanced order...
2024: Parkinson's Disease
#20
JOURNAL ARTICLE
Justyna Okarmus, Jette Bach Agergaard, Tina C Stummann, Henriette Haukedal, Malene Ambjørn, Kristine K Freude, Karina Fog, Morten Meyer
Ubiquitination of mitochondrial proteins plays an important role in the cellular regulation of mitophagy. The E3 ubiquitin ligase parkin (encoded by PARK2) and the ubiquitin-specific protease 30 (USP30) have both been reported to regulate the ubiquitination of outer mitochondrial proteins and thereby mitophagy. Loss of E3 ligase activity is thought to be pathogenic in both sporadic and inherited Parkinson's disease (PD), with loss-of-function mutations in PARK2 being the most frequent cause of autosomal recessive PD...
January 15, 2024: Cell Death & Disease
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