keyword
https://read.qxmd.com/read/38534776/the-influence-of-neurotrophins-on-the-brain-lung-axis-conception-pregnancy-and-neonatal-period
#1
REVIEW
Federica D'Amico, Cecilia Lugarà, Giovanni Luppino, Carlo Giuffrida, Ylenia Giorgianni, Eleonora Maria Patanè, Sara Manti, Antonella Gambadauro, Mariarosaria La Rocca, Tiziana Abbate
Neurotrophins (NTs) are four small proteins produced by both neuronal and non-neuronal cells; they include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). NTs can exert their action through both genomic and non-genomic mechanisms by interacting with specific receptors. Initial studies on NTs have identified them only as functional molecules of the nervous system. However, recent research have shown that some tissues and organs (such as the lungs, skin, and skeletal and smooth muscle) as well as some structural cells can secrete and respond to NTs...
March 15, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534232/advancements-in-brain-research-the-in-vivo-in-vitro-electrochemical-detection-of-neurochemicals
#2
REVIEW
Xiaoxuan Xu, Yimei Zuo, Shu Chen, Amir Hatami, Hui Gu
Neurochemicals, crucial for nervous system function, influence vital bodily processes and their fluctuations are linked to neurodegenerative diseases and mental health conditions. Monitoring these compounds is pivotal, yet the intricate nature of the central nervous system poses challenges. Researchers have devised methods, notably electrochemical sensing with micro-nanoscale electrodes, offering high-resolution monitoring despite low concentrations and rapid changes. Implantable sensors enable precise detection in brain tissues with minimal damage, while microdialysis-coupled platforms allow in vivo sampling and subsequent in vitro analysis, addressing the selectivity issues seen in other methods...
February 26, 2024: Biosensors
https://read.qxmd.com/read/38532486/cognitive-decline-a%C3%AE-pathology-and-blood-brain-barrier-function-in-aged-5xfad-mice
#3
JOURNAL ARTICLE
Geetika Nehra, Sasivimon Promsan, Ruedeemars Yubolphan, Wijitra Chumboatong, Pornpun Vivithanaporn, Bryan J Maloney, Anusorn Lungkaphin, Bjoern Bauer, Anika M S Hartz
BACKGROUND: Patients with Alzheimer's disease (AD) develop blood-brain barrier dysfunction to varying degrees. How aging impacts Aβ pathology, blood-brain barrier function, and cognitive decline in AD remains largely unknown. In this study, we used 5xFAD mice to investigate changes in Aβ levels, barrier function, and cognitive decline over time. METHODS: 5xFAD and wild-type (WT) mice were aged between 9.5 and 15.5 months and tested for spatial learning and reference memory with the Morris Water Maze (MWM)...
March 27, 2024: Fluids and Barriers of the CNS
https://read.qxmd.com/read/38532258/optimized-microburst-vns-elicits-fmri-responses-beyond-thalamic-specific-response-from-standard-vns
#4
JOURNAL ARTICLE
Jerzy P Szaflarski, Jane B Allendorfer, Jason Begnaud, Giovanni Ranuzzi, Elhum Shamshiri, Ryan Verner
OBJECTIVE: In parallel to standard vagus nerve stimulation (VNS), microburst stimulation delivery has been developed. We evaluated the fMRI-related signal changes associated with standard and optimized microburst stimulation in a proof-of-concept study (NCT03446664). METHODS: Twenty-nine drug-resistant epilepsy patients were prospectively implanted with VNS. Three 3T fMRI scans were collected 2 weeks postimplantation. The maximum tolerated VNS intensity was determined prior to each scan starting at 0...
March 26, 2024: Annals of Clinical and Translational Neurology
https://read.qxmd.com/read/38532055/tinnitus-clinical-insights-in-its-pathophysiology-a-perspective
#5
JOURNAL ARTICLE
Berthold Langguth, Dirk de Ridder, Winfried Schlee, Tobias Kleinjung
Tinnitus, the perception of sound without a corresponding external sound source, and tinnitus disorder, which is tinnitus with associated suffering, present a multifaceted clinical challenge due to its heterogeneity and its incompletely understood pathophysiology and especially due to the limited therapeutic options. In this narrative review, we give an overview on various clinical aspects of tinnitus including its heterogeneity, contributing factors, comorbidities and therapeutic pathways with a specific emphasis on the implications for its pathophysiology and future research directions...
March 26, 2024: Journal of the Association for Research in Otolaryngology: JARO
https://read.qxmd.com/read/38532013/haemodynamics-of-stent-mounted-neural-interfaces-in-tapered-and-deformed-blood-vessels
#6
JOURNAL ARTICLE
Weijie Qi, Andrew Ooi, David B Grayden, Nicholas L Opie, Sam E John
The endovascular neural interface provides an appealing minimally invasive alternative to invasive brain electrodes for recording and stimulation. However, stents placed in blood vessels have long been known to affect blood flow (haemodynamics) and lead to neointimal growth within the blood vessel. Both the stent elements (struts and electrodes) and blood vessel wall geometries can affect the mechanical environment on the blood vessel wall, which could lead to unfavourable vascular remodelling after stent placement...
March 27, 2024: Scientific Reports
https://read.qxmd.com/read/38531880/intracortical-recordings-reveal-vision-to-action-cortical-gradients-driving-human-exogenous-attention
#7
JOURNAL ARTICLE
Tal Seidel Malkinson, Dimitri J Bayle, Brigitte C Kaufmann, Jianghao Liu, Alexia Bourgeois, Katia Lehongre, Sara Fernandez-Vidal, Vincent Navarro, Virginie Lambrecq, Claude Adam, Daniel S Margulies, Jacobo D Sitt, Paolo Bartolomeo
Exogenous attention, the process that makes external salient stimuli pop-out of a visual scene, is essential for survival. How attention-capturing events modulate human brain processing remains unclear. Here we show how the psychological construct of exogenous attention gradually emerges over large-scale gradients in the human cortex, by analyzing activity from 1,403 intracortical contacts implanted in 28 individuals, while they performed an exogenous attention task. The timing, location and task-relevance of attentional events defined a spatiotemporal gradient of three neural clusters, which mapped onto cortical gradients and presented a hierarchy of timescales...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531502/low-frequency-stimulation-for-seizure-suppression-identification-of-optimal-targets-in-the-entorhinal-hippocampal-circuit
#8
JOURNAL ARTICLE
Piret Kleis, Enya Paschen, Ute Häussler, Carola A Haas
BACKGROUND: Mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS) is a common form of drug-resistant focal epilepsy in adults. Treatment for pharmacoresistant patients remains a challenge, with deep brain stimulation (DBS) showing promise for alleviating intractable seizures. This study explores the efficacy of low-frequency stimulation (LFS) on specific neuronal targets within the entorhinal-hippocampal circuit in a mouse model of MTLE. OBJECTIVE: /Hypothesis: Our previous research demonstrated that LFS of the medial perforant path (MPP) fibers in the sclerotic hippocampus reduced seizures in epileptic mice...
March 24, 2024: Brain Stimulation
https://read.qxmd.com/read/38530974/conductive-and-enhanced-mechanical-strength-of-mo-2-ti-2-c-3-mxene-based-hydrogel-promotes-neurogenesis-and-bone-regeneration-in-bone-defect-repair
#9
JOURNAL ARTICLE
Hongyu Wang, Yu-Ching Hsu, Chune Wang, Xiao Xiao, Zhengbin Yuan, Yong Zhu, Dazhi Yang
Bone defects are common with increasing high-energy fractures, tumor bone invasion, and implantation revision surgery. Bone is an electroactive tissue that has electromechanical interaction with collogen, osteoblasts, and osteoclasts. Hydrogel provides morphological plasticity and extracellular matrix (ECM) 3D structures for cell survival, and is widely used as a bone engineering material. However, the hydrogels have poor mechanical intensity and lack of cell adhesion, slow gelation time, and limited conductivity...
March 26, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38529870/-experimental-study-of-the-influence-of-phenozanic-acid-and-its-combination-with-valproic-acid-on-the-development-of-the-epileptic-system
#10
JOURNAL ARTICLE
A A Yakovleva, S A Litvinova, N A Gladysheva, V V Radontseva, T A Voronina
OBJECTIVE: To study the effect of phenosanic acid (PA) and its combination with valproic acid (VA) on the development of the Epi system. MATERIAL AND METHODS: A model of focal chronic epilepsy in rats was created by applying metallic cobalt to the surface of the sensorimotor area of the cortex. Long-term electrodes were implanted in the sensorimotor cortex of the left and right hemispheres, the hippocampus, and the hypothalamus. The effect of PA (80 mg/kg) and its combination with VA (200 mg/kg) on discharge activity was carried out on the 2nd day and at the stage of generalization of the Epi system - on the 6th day...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38529660/prenatal-post-implantation-development-of-collared-peccaries-pecari-tajacu-linnaeus-1758
#11
JOURNAL ARTICLE
Hélio Noberto de Araújo Júnior, Igor Renno Guimarães Lopes, Ana Caroline Freitas Caetano de Sousa, Gleidson Benevides de Oliveira, Radan Elvis Matias de Oliveira, Moisés Dantas Tertulino, Emanuel Lucas Bezerra Rocha, Paulo Ricardo Firmino, Alexsandra Fernandes Pereira, Moacir Franco de Oliveira
Given the importance of information on intrauterine development in diagnosing anomalies in the gestational development of the species for the development of assisted reproduction technologies as well as understanding the autonomy and responsiveness of the newborn, the aim of the present study was to describe the external morphology of collared peccary conceptuses. For this study, two conceptuses were used per gestational age of 25-120 days post-copulation (dpc) and neonates with 145 dpc, totalling 22 animals...
May 2024: Anatomia, Histologia, Embryologia
https://read.qxmd.com/read/38527238/bergaptol-inhibits-glioma-cell-proliferation-and-induces-apoptosis-via-stat3-bcl-2-pathway
#12
JOURNAL ARTICLE
Hao Huang, Junrong Zhang, Jianbing Wu, Chunfu Du, Bo Zheng, Zhangchao Guo, Ligang Chen, Deming Zhang, Luotong Liu
Glioblastoma (GBM) is the most common primary malignant brain tumour and lacks therapeutic options with significant effects. The aberrant activation of STAT3 is a critical factor in glioma progression via activating multiple signalling pathways that promote glioma. Among them, the antiapoptotic gene Bcl-2 could be upregulated by p-STAT3, which is an important reason for the continuous proliferation of glioma. We previously reported that bergaptol, a natural furanocoumarin widely found in citrus products, exerts antineuroinflammatory effects by inhibiting the overactivation of STAT3...
March 22, 2024: Anti-cancer Drugs
https://read.qxmd.com/read/38519537/prediction-of-pacemaker-induced-cardiomyopathy-using-a-convolutional-neural-network-based-on-clinical-findings-prior-to-pacemaker-implantation
#13
JOURNAL ARTICLE
Mitsunori Oida, Takuya Mizutani, Eriko Hasumi, Katsuhito Fujiu, Kosaku Goto, Kunihiro Kani, Tsukasa Oshima, Takumi J Matsubara, Yu Shimizu, Gaku Oguri, Toshiya Kojima, Issei Komuro
Risk factors for pacemaker-induced cardiomyopathy (PICM) have been previously reported, including a high burden of right ventricular pacing, lower left ventricular ejection fraction, a wide QRS duration, and left bundle branch block before pacemaker implantation (PMI). However, predicting the development of PICM remains challenging. This study aimed to use a convolutional neural network (CNN) model, based on clinical findings before PMI, to predict the development of PICM. Out of a total of 561 patients with dual-chamber PMI, 165 (mean age 71...
March 22, 2024: Scientific Reports
https://read.qxmd.com/read/38518365/electrode-sharpness-and-insertion-speed-reduce-tissue-damage-near-high-density-penetrating-arrays
#14
JOURNAL ARTICLE
Ingrid N McNamara, Steven M Wellman, Lehong Li, James Regis Eles, Sajishnu Savya, Harbaljit S Sohal, Matthew R Angle, Takashi D Yoshida Kozai
OBJECTIVE: Over the past decade, neural electrodes have played a crucial role in bridging biological tissues with electronic and robotic devices. This study focuses on evaluating the optimal tip profile and insertion speed for effectively implanting Paradromics' high-density Fine Microwire Arrays (FμA) prototypes into the primary visual cortex (V1) of mice and rats, addressing the challenges associated with the "bed-of-nails" effect and tissue dimpling. APPROACH: Tissue response was assessed by investigating the impact of electrodes on the blood-brain barrier (BBB) and cellular damage, with a specific emphasis on tailored insertion strategies to minimize tissue disruption during electrode implantation...
March 22, 2024: Journal of Neural Engineering
https://read.qxmd.com/read/38518284/comprehensive-characterization-of-intracranial-hemorrhage-in-deep-brain-stimulation-a-systematic-review-of-literature-from-1987-to-2023
#15
JOURNAL ARTICLE
Cletus Cheyuo, Artur Vetkas, Can Sarica, Suneil K Kalia, Mojgan Hodaie, Andres M Lozano
OBJECTIVE: Deep brain stimulation (DBS) is an effective treatment for medically refractory movement disorders and other neurological conditions. To comprehensively characterize the prevalence, locations, timing of detection, clinical effects, and risk factors of DBS-related intracranial hemorrhage (ICH), the authors performed a systematic review of the published literature. METHODS: PubMed, EMBASE, and Web of Science were searched using 2 concepts: cerebral hemorrhage and brain stimulation, with filters for English, human studies, and publication dates 1980-2023...
March 22, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38518011/splice-implantation-of-multiple-drug-eluting-stents-for-tandem-severe-stenosis-of-the-internal-carotid-artery-a-case-report
#16
JOURNAL ARTICLE
Qinghai Dai, Lingfeng Shu, Pengcheng Zhu, Hongtu Tan, Tao Wu
RATIONALE: Severe stenosis of the internal carotid artery tandem affects the blood supply to the brain and threatens human life, which can be solved by interventional procedures. PATIENT CONCERNS: A 64-year-old male patient presented with a sudden onset of dizziness, palpitation, numbness, and weakness of the limbs. Imaging studies suggested multiple tandem severe stenoses from the left internal carotid artery contrast C2 to C4. DIAGNOSIS: Severe stenosis of the left internal carotid tandem...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38517764/a-long-acting-lyotropic-liquid-crystalline-implant-promotes-the-drainage-of-macromolecules-by-brain-related-lymphatic-system-in-treating-aged-alzheimer-s-disease
#17
JOURNAL ARTICLE
Xinyu Shan, Yichao Lu, Zhenyu Luo, Xiaoqi Zhao, Mei Pang, Hang Yin, Xuemeng Guo, Huanli Zhou, Junlei Zhang, Jiaxin Huang, Yingying Shi, Jinfang Lou, Lihua Luo, Jian You
Numerous evidence has demonstrated that the brain is not an immune-privileged organ but possesses a whole set of lymphatic transport system, which facilitates the drainage of harmful waste from brains to maintain cerebral homeostasis. However, as individuals age, the shrinkage and dysfunction of meningeal and deep cervical lymphatic networks lead to reduced waste outflow and elevated neurotoxic molecules deposition, further inducing aging-associated cognitive decline, which act as one of the pathological mechanisms of Alzheimer's disease...
March 22, 2024: ACS Nano
https://read.qxmd.com/read/38517356/circadian-changes-in-aperiodic-activity-are-correlated-with-seizure-reduction-in-patients-with-mesial-temporal-lobe-epilepsy-treated-with-responsive-neurostimulation
#18
JOURNAL ARTICLE
Chantel M Charlebois, Daria Nesterovich Anderson, Elliot H Smith, Tyler S Davis, Blake J Newman, Angela Y Peters, Amir M Arain, Alan D Dorval, John D Rolston, Christopher R Butson
OBJECTIVES: Responsive neurostimulation (RNS) is an established therapy for drug-resistant epilepsy that delivers direct electrical brain stimulation in response to detected epileptiform activity. However, despite an overall reduction in seizure frequency, clinical outcomes are variable, and few patients become seizure-free. The aim of this retrospective study was to evaluate aperiodic electrophysiological activity, associated with excitation/inhibition balance, as a novel electrographic biomarker of seizure reduction to aid early prognostication of the clinical response to RNS...
March 22, 2024: Epilepsia
https://read.qxmd.com/read/38513334/improving-the-quality-of-computed-tomography-brain-images-in-the-presence-of-cochlear-implant-induced-metal-artefacts-through-the-additional-use-of-tissue-mimicking-materials-alongside-metal-artefact-reduction-software
#19
JOURNAL ARTICLE
F M Lenham, G R Iball
INTRODUCTION: Metal artefact reduction software (MAR) can be used to improve Computed Tomography (CT) image quality in the presence of implanted metalwork; however, this software is not effective for superficial metallic structures such as cochlear implants (CI). This study aimed to investigate whether the effectiveness of MAR software could be improved for brain scans with CI present through the use of tissue mimicking materials (TMM) placed exteriorly to the implant. METHODS: In this two-part study, a CI was positioned on the surface of water and anthropomorphic phantoms and imaged using a helical CT brain protocol...
March 20, 2024: Radiography
https://read.qxmd.com/read/38512234/human-whole-eye-donation-for-research-optimizing-clinical-trial-informed-consent
#20
JOURNAL ARTICLE
Katrina A Bramstedt
IMPORTANCE: Posthumous whole-eye (globe) donations for research lack a mechanism that reinvolves the existing ophthalmic research team of the donor unless there is a preplanned donor directive. Disconnection between the deceased and their research team equates to lost opportunities for the research team to have a longitudinal view of the eyes that have been involved in their research. OBJECTIVES: To use the clinical trial informed consent process to create a posthumous research donation opportunity that directs the donation to the currently affiliated research team of the donors (preserving the longitudinal research experience)...
March 21, 2024: JAMA Ophthalmology
keyword
keyword
108385
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.