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Indrani S Bhattacharya, Joanne S Haviland, Penelope Hopwood, Charlotte E Coles, John R Yarnold, Judith M Bliss, Anna M Kirby
BACKGROUND: In an era of low local relapse rates after adjuvant breast radiotherapy, risks of late normal-tissue effects (NTE) need to be balanced against risk of relapse. NTE are assessed using patient-reported outcome measures (PROMs), clinician-reported outcomes (CRO) and photographs. This analysis investigates whether PROMs can be used as primary NTE endpoints in breast radiotherapy trials. METHODS: Analyses were conducted within IMPORT LOW (ISRCTN12852634) at 2 and 5 years...
May 2019: Radiotherapy and Oncology
Perrine Remond, Florent Aptel, Pierre Cunnac, José Labarere, Karine Palombi, Jean-Louis Pepin, Frédéric Pollet-Villard, Stephen Hogg, Ruixuan Wang, Tom MacGillivray, Emanuele Trucco, Christophe Chiquet
PURPOSE: The pathophysiology of non-arteritic AION (N-AION) is not completely understood. Studies of the retinal vasculature phenotype in patients with N-AION could help us to understand vascular abnormalities associated with the disease. DESIGN: Retrospective case series with matched controls. METHODS: Study population: 57 patients with N-AION and 57 controls matched to N-AION patients for sex, age, systemic hypertension, diabetes and obstructive sleep apnea syndrome, between September 2007 and July 2017...
April 17, 2019: American Journal of Ophthalmology
Chintan Mehta, Tasneem Mohammad, Dhwani Mehta, James Griffith, Cynthia Nicholson, Iltefat Hamzavi
BACKGROUND: Vitiligo is a disorder of dyspigmentation that can impact quality of life. While narrow band ultraviolet B (NBUVB) is an effective treatment for vitiligo, a sub-set of patients are unable to respond to phototherapy as they cannot photoadapt. However, nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to increase the minimal erythema dose. PURPOSE: To determine whether ibuprofen allows non-photoadapters to respond to therapeutic doses of NBUVB and maintain photoadaptation...
April 20, 2019: Photodermatology, Photoimmunology & Photomedicine
Keshavamurthy Vinay, Divya Kamat, Debajyoti Chatterjee, Tarun Narang, Sunil Dogra
BACKGROUND: Leprosy is a chronic granulomatous infection with varied clinical presentations. In this study, we aimed to describe the dermatoscopic features of the entire spectrum of leprosy and to correlate with clinical and histopathological findings. METHODOLOGY: This was a prospective observational study of treatment naïve leprosy patients over a period of 1 year. The study patients were categorized as per Ridley-Jopling classification based on clinical, slit skin smear and histopathological findings...
April 20, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
Jan N Weindler, Grzegorz Łabuz, Timur M Yildirim, Tamer Tandogan, Ramin Khoramnia, Gerd U Auffarth
PURPOSE: To study the effect of glistenings on the optical quality of a hydrophobic acrylic intraocular lens (IOL). SETTING: David J. Apple Laboratory, Heidelberg, Germany. DESIGN: An in vitro laboratory study. METHODS: An accelerated aging protocol was used to induce glistenings (microvacuoles) in 38 hydrophobic acrylic IOLs. The IOLs were warmed to 45°C and then cooled to 37°C. Image analysis of light-microcopy photographs determined the number and size of microvacuoles (MV)...
April 16, 2019: Journal of Cataract and Refractive Surgery
Matthias Stöck, Fatemeh Fakharzadeh, Heiner Kuhl, Beata Rozenblut-Kościsty, Sophie Leinweber, Rhiddi Patel, Mehregan Ebrahimi, Sebastian Voitel, Josef Friedrich Schmidtler, Haji Gholi Kami, Maria Ogielska, Daniel W Förster
The Hyrcanian Forests present a unique Tertiary relict ecosystem, covering the northern Elburz and Talysh Ranges (Iran, Azerbaijan), a poorly investigated, unique biodiversity hotspot with many cryptic species. Since the 1970s, two nominal species of Urodela, Hynobiidae, Batrachuperus (later: Paradactylodon ) have been described: Paradactylodon persicus from northwestern and P. gorganensis from northeastern Iran. Although P. gorganensis has been involved in studies on phylogeny and development, there is little data on the phylogeography, systematics, and development of the genus throughout the Hyrcanian Forests; genome-wide resources have been entirely missing...
April 18, 2019: Genes
Adel Elnashar, Smruti K Patel, Almaz Kurbanov, Kseniya Zvereva, Jeffrey T Keller, Andrew W Grande
OBJECTIVEPercutaneous stereotactic radiofrequency rhizotomy (PSR) is often used to treat trigeminal neuralgia, a serious condition that results in lancinating, episodic facial pain. Thorough understanding of the microsurgical anatomy of the foramen ovale (FO) and its surrounding structures is required for efficient, effective, and safe use of this technique. This morphometric study compares anatomical and surgical orientations to identify the variations of the FO and assess cannulation difficulty.METHODSBilateral foramina from 174 adult human dry skulls (348 foramina) were analyzed using anatomical and surgical orientations in photographs from standardized projections...
April 19, 2019: Journal of Neurosurgery
César Capinha
Spatiotemporal predictions of ecological phenomena are highly useful and significant in scientific and socio-economic applications. However, the inadequate availability of ecological time-series data often impedes the development of statistical predictions. On the other hand, considerable amounts of temporally discrete biological records (commonly known as 'species occurrence records') are being stored in public databases, and often include the location and date of the observation. In this paper, we describe an approach to develop spatiotemporal predictions based on the dates and locations found in species occurrence records...
April 18, 2019: International Journal of Biometeorology
Sharon Armarnik, Michael Mimouni, Dafna Goldenberg, Fani Segev, Amit Meshi, Ori Segal, Noa Geffen
PURPOSE: The purpose of the study was to describe findings demonstrated by anterior segment spectral domain optical coherence tomography (AS-OCT) in various types of deeply embedded corneal foreign bodies. METHODS: In this experimental study, an ex vivo model of calf eyes was used and seven different foreign bodies were deeply embedded in the cornea, consisting of five different materials: glass, plastic, metal, wood, and pencil graphite. The eyes were photographed and then scanned by AS-OCT...
April 18, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
M Bengtsson, A Al-Ateyah, G Wall, J P Becktor, L Rasmusson
The outcome of treatment in orthognathic surgery is dependent on preoperative surgical planning. The main purpose of the present study was to evaluate from photographs the improvement in facial appearance after orthognathic surgery. In addition, the outcomes of two different planning techniques, 2-dimensional and 3-dimensional, were compared and the correlation between the outcome and health-related quality of life (HRQoL) assessed. The study was a randomised controlled trial with the intervention being either 2-dimensional or 3-dimensional treatment planning...
April 15, 2019: British Journal of Oral & Maxillofacial Surgery
Marcus Hedblom, Bengt Gunnarsson, Martin Schaefer, Igor Knez, Pontus Thorsson, Johan N Lundström
: Noise from city traffic is one of the most significant environmental stressors. Natural soundscapes, such as bird songs, have been suggested to potentially mitigate or mask noise. All previous studies on masking noise use self-evaluation data rather than physiological data. In this study, while respondents ( n = 117) watched a 360° virtual reality (VR) photograph of a park, they were exposed to different soundscapes and mild electrical shocks. The soundscapes-"bird song", "bird song and traffic noise", and "traffic noise"-were played during a 10 min recovery period while their skin conductance levels were assessed as a measure of arousal/stress...
April 17, 2019: International Journal of Environmental Research and Public Health
Heinrich Gerding, Gabor Mark Somfai, Marco Langenegger
BACKGROUND: It was the aim of this study to analyse the refractive outcome of toric intraocular lens (t-IOL) implantation guided by a newly developed method of photographic alignment. MATERIAL AND METHODS: Fourteen eyes of 10 patients (6 females, 4 males, age 63.4 ± 6.7 (40.6 - 68.0) years [mean ± 1 SD (range)]) were included in this retrospective study. All eyes received an Oculentis Tplus LS-313 (Oculentis, Berlin, Germany) t-IOL after standard phacoemusification (n = 4) or femtocataract laser-assisted surgery (n = 10)...
April 2019: Klinische Monatsblätter Für Augenheilkunde
Itsara Lertjirachai, Maxwell S Stem, Stavros N Moysidis, Nicole Koulisis, Antonio Capone, Kimberly A Drenser, Michael T Trese
BACKGROUND AND OBJECTIVE: To quantify vessel tortuosity among infants with retinopathy of prematurity (ROP). PATIENTS AND METHODS: This was a retrospective study including 61 RetCam images from 33 infants. The laser treatment (LT) group included 17 infants who underwent laser for ROP. The no-treatment (NT) group included 16 infants. The modified ROPtool was used to calculate mean vessel tortuosity (MVT) and highest vessel tortuosity (HVT) for the participants and for the standard plus disease photograph from the Early Treatment for Retinopathy of Prematurity (ETROP) study...
April 1, 2019: Ophthalmic Surgery, Lasers & Imaging Retina
Kazuya Morino, Tomoaki Murakami, Yoko Dodo, Shota Yasukura, Tatsuya Yoshitake, Masahiro Fujimoto, Akitaka Tsujikawa
Purpose: To compare the characteristics of macular and extramacular white spots on wide-field swept-source optical coherence tomography angiography (SS-OCTA) and optical coherence tomography (OCT) images in diabetic retinopathy (DR). Methods: We retrospectively reviewed 107 eyes of 64 patients with DR, of whom nominal 12 × 12 mm SS-OCTA images centered on the optic disc and ultrawide field photographs were acquired. White spots on fundus photographs corresponded to hyperreflective lesions in the superficial en-face OCT images, and the characteristics of these white spots were investigated...
April 1, 2019: Investigative Ophthalmology & Visual Science
Christine Moffatt, Aimee Aubeeluck, Elodie Stasi, Sandrine Mestre, Sara Rowan, Susie Murray, Isabelle Quere
Background: The aims of this study were to explore, using visual art methodology, how children and adolescents perceive their lymphedema and conceptualize the barriers and enablers in self-management and to explore the role of an educational camp in promoting self-efficacy. Methods: Participants (speaking English, French, and Italian) were recruited during an educational camp for children with lymphedema. Children and adolescents used different methodologies to depict living and self-managing their condition...
April 2019: Lymphatic Research and Biology
Gokce Yildiran, Mustafa Sutcu, Osman Akdag, Cemil Isik, Zekeriya Tosun
INTRODUCTION: Hand photography is effective and advantageous for assessing functional deficits and improvements related to surgery. In this study, it is aimed to investigate whether the correct active range of motion (ROM) is masked by the passive ROM in a wrist joint. METHOD: Eleven patients who were treated for unilateral wrist fractures were included in the study. Photography was performed in all patients by the same surgeon according to the conventional hand surgery photography approach and the active ROM photography approach...
April 15, 2019: Annals of Plastic Surgery
Isabelle Bardet, Patrick Goudot, Jean-Baptiste Kerbrat, Olivier Mauchamp
INTRODUCTION: The purpose of this study was to compare two structural cephalometric analysis (Delaire and Sassouni) as surgical decision tools. These two analyses do not include dental compensation for skeletal discrepancies and have been proven reliable especially for the Sendai surgery first protocol developed by Sugawara. MATERIAL AND METHOD: The two analysis were performed on 20 surgical cases and the proposed skeletal modifications were compared in order to measure the differences and see if those differences varied according to the facial type...
March 2019: L' Orthodontie Française
Grazielle Fialho de Souza, Renato Minelli Figueira, Maria Beatriz Alkmim, Lidiane Aparecida Pereira de Sousa, Leonardo Bonisson, Antonio Luiz Pinho Ribeiro, Daniel Vitor Vasconcelos-Santos
Introduction: Early diagnosis and prompt therapy of diabetic retinopathy (DR) are essential to prevent visual loss, but access of the diabetic population to regular fundus examination by an ophthalmologist remains a challenge. Methods: This prospective comparative study, including two referral health centers in the state of Minas Gerais, Southeastern Brazil, assesses applicability and economic viability of fundus photography-based teleophthalmology screening for DR. Results: A total of 2,662 eyes of 1,331 patients were examined at both health centers...
April 17, 2019: Telemedicine Journal and E-health
Fernando Mateo, Juan J Carrasco, Marta Aguilar-Rodríguez, Emilio Soria-Olivas, Santiago Bonanad, Felipe Querol, Sofía Pérez-Alenda
INTRODUCTION: The joint range of motion (ROM) is an important clinical parameter used to assess the loss of functionality resulting from joint bleedings in people with haemophilia. These episodes require a close follow-up and, to decrease patients' hospital dependence, telemedicine tools are needed. Therefore, this study is aimed to analyse the validity of the Microsoft Kinect V2 sensor with corrected angle measurement to be used in the monitoring of elbow ROM in people with haemophilia...
April 17, 2019: Haemophilia: the Official Journal of the World Federation of Hemophilia
Anish Jindal, Irene Ctori, Bruno Fidalgo, Priya Dabasia, Konstantinos Balaskas, John G Lawrenson
PURPOSE: In recent years, there has been widespread investment in imaging technologies by community optometrists in the UK, most notably optical coherence tomography (OCT). The aim of the current study was to determine the value of OCT in the diagnosis of posterior segment diseases in a representative sample of community optometrists using a clinical vignette methodology. METHODS: A group of community optometrists (n = 50) initially completed a standardised training package on OCT interpretation followed by a computer-based assessment featuring 52 clinical vignettes, containing images of healthy (n = 8) or glaucomatous (n = 18) discs or healthy (n = 8) or diseased (n = 18) fundi...
May 2019: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
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