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https://read.qxmd.com/read/30783439/microrna-494-3p-protects-rat-cardiomyocytes-against-septic-shock-via-pten
#1
Peng Wu, Lingchen Kong, Jianzhong Li
The aim of the present study was to investigate the role of microRNA (miR)-494-3p in myocardial injury in patients with septic shock and the underlying mechanism. A total of 22 patients with sepsis and 17 patients with septic shock were included in the present study. In addition, 20 healthy subjects were recruited as the control group. Peripheral blood was collected from all subjects and a rat cardiomyocyte model of myocardial injury was constructed. Reverse transcription-quantitative polymerase chain reaction was used to measure miR-494-3p expression, while cell counting kit-8 assays were performed to assess cell proliferation...
March 2019: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/30759844/troponin-testing-for-assessing-sepsis-induced-myocardial-dysfunction-in-patients-with-septic-shock
#2
June-Sung Kim, Muyeol Kim, Youn-Jung Kim, Seung Mok Ryoo, Chang Hwan Sohn, Shin Ahn, Won Young Kim
(1) Background: Myocardial dysfunction in patients with sepsis is not an uncommon phenomenon, yet reported results are conflicting and there is no objective definition. Measurement of troponin may reflect the state of the heart and may correlate with echocardiographically derived data. This study aimed to evaluate the role of admission and peak troponin-I testing for the identification of sepsis-induced myocardial dysfunction (SIMD) by transthoracic echocardiography (TTE). (2) Methods: This was a retrospective cohort study using a prospective registry of septic shock at an Emergency Department from January 2011 and April 2017...
February 12, 2019: Journal of Clinical Medicine
https://read.qxmd.com/read/30759094/an-attention-based-deep-learning-model-of-clinical-events-in-the-intensive-care-unit
#3
Deepak A Kaji, John R Zech, Jun S Kim, Samuel K Cho, Neha S Dangayach, Anthony B Costa, Eric K Oermann
This study trained long short-term memory (LSTM) recurrent neural networks (RNNs) incorporating an attention mechanism to predict daily sepsis, myocardial infarction (MI), and vancomycin antibiotic administration over two week patient ICU courses in the MIMIC-III dataset. These models achieved next-day predictive AUC of 0.876 for sepsis, 0.823 for MI, and 0.833 for vancomycin administration. Attention maps built from these models highlighted those times when input variables most influenced predictions and could provide a degree of interpretability to clinicians...
2019: PloS One
https://read.qxmd.com/read/30756206/minocycline-promotes-cardiomyocyte-mitochondrial-autophagy-and-cardiomyocyte-autophagy-to-prevent-sepsis-induced-cardiac-dysfunction-by-akt-mtor-signaling
#4
Erfei Zhang, Xiaoying Zhao, Li Zhang, Nan Li, Jinqi Yan, Ke Tu, Ruhu Yan, Jianqiang Hu, Mingming Zhang, Dongdong Sun, Lichao Hou
Myocardial damage is responsible for the high mortality of sepsis. However, the underlying mechanism is not well understood. Cardiomyocyte autophagy alleviates the cardiac injury caused by myocardial infarction. Enhanced cardiomyocyte autophagy also has protective effects against cardiomyocyte mitochondrial injury. Minocycline enhances autophagy in many types of cells under different types of pathological stress and can be easily taken up by cardiomyocytes. The present study investigated whether minocycline prevented myocardial injury caused by sepsis and whether cardiomyocyte autophagy participated in this process...
February 12, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30737109/short-and-long-term-outcomes-of-aortic-root-repair-and-replacement-in-patients-undergoing-acute-type-a-aortic-dissection-repair-twenty-year-experience
#5
Bo Yang, Elizabeth L Norton, Reilly Hobbs, Linda Farhat, Xiaoting Wu, Whitney E Hornsby, Karen M Kim, Himanshu J Patel, G Michael Deeb
OBJECTIVE: The study objective was to evaluate the perioperative and long-term outcomes of aortic root repair and aortic root replacement and provide evidence for root management in acute type A aortic dissection. METHODS: From 1996 to 2017, 491 patients underwent aortic root repair (n = 307) or aortic root replacement (n = 184) (62% bioprosthesis) for acute type A aortic dissection. Indications for aortic root replacement were intimal tear at the aortic root, root measuring 4...
December 21, 2018: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/30734878/attenuation-of-sepsis-induced-cardiomyopathy-by-regulation-of-microrna-23b-is-mediated-through-targeting-of-myd88-mediated-nf-%C3%AE%C2%BAb-activation
#6
Chao Cao, Yan Zhang, Yanfen Chai, Lijun Wang, Chengfen Yin, Songtao Shou, Heng Jin
Myocardial cell injury or cardiomyopathy is associated with excessive inflammatory response and apoptosis of cardiac myocytes during sepsis. MicroRNA-23b (miR-23b) is a multifunctional miRNA that is considered to regulate immunosuppression in sepsis. The aim of this study was to examine the effect of miR-23b on cardiomyopathy induced by sepsis and to explore the potential mechanism involved. Sprague-Dawley rats were subjected to cecal ligation and puncture (CLP), and the level of miR-23b at different time points was measured by quantitative real-time polymerase chain reaction (qPCR)...
February 8, 2019: Inflammation
https://read.qxmd.com/read/30691457/staphylococcus-pseudintermedius-septicemia-in-puppies-after-elective-cesarean-section-confirmed-transmission-via-dam-s-milk
#7
Maja Zakošek Pipan, Tanja Švara, Irena Zdovc, Bojan Papić, Jana Avberšek, Darja Kušar, Janko Mrkun
BACKGROUND: In humans, transmission of bacteria causing fatal sepsis in the neonates through mother's milk has been reported. In dogs, it is believed that bacteria from canine milk are not the primary cause of neonatal infections. Staphylococcus pseudintermedius is colonizing the skin and mucocutaneous junctions in adult dogs and can act as an opportunistic pathogen. This bacterium was previously isolated from the canine milk and, although, its transmission from the dam's milk to the newborn puppies causing a neonatal sepsis was suggested, this hypothesis has not been confirmed...
January 28, 2019: BMC Veterinary Research
https://read.qxmd.com/read/30682543/evolving-complexity-of-mif-signaling
#8
REVIEW
Stanislovas S Jankauskas, Dickson W L Wong, Richard Bucala, Sonja Djudjaj, Peter Boor
Macrophage migration inhibitory factor (MIF) is a cytokine expressed in various cell types, including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. Altered MIF expression has been associated with a multitude of diseases ranging from inflammatory disorders like sepsis, lupus and rheumatoid arthritis to organ pathologies such as heart failure, myocardial infarction, acute kidney injury, organ fibrosis and a number of malignancies. The implication of MIF in these diseases was supported by numerous animal studies...
January 23, 2019: Cellular Signalling
https://read.qxmd.com/read/30674059/-severe-tirofiban-induced-thrombocytopenia-and-thrombotic-microangiopathy-after-percutaneous-coronary-intervention
#9
Felix Sebastian Nettersheim, Christopher Hohmann, Roman Pfister, Guido Michels
HISTORY AND CLINICAL FINDING:  A 76-year-old patient suffered a non-ST-elevation myocardial infarction (NSTEMI) and was admitted to our Chest Pain Unit (CPU) for further diagnostics and therapy. EXAMINATIONS AND DIAGNOSIS:  Coronary angiography revealed an occlusion of the right coronary artery and catheter intervention with stent implantation was performed. Due to a high thrombotic burden, application of tirofiban was initiated. In the following, the patient developed hemodynamic instability, hemoptysis and a substantial decrease of the platelet count...
January 2019: Deutsche Medizinische Wochenschrift
https://read.qxmd.com/read/30644983/effect-of-nonmyeloablative-hematopoietic-stem-cell-transplantation-vs-continued-disease-modifying-therapy-on-disease-progression-in-patients-with-relapsing-remitting-multiple-sclerosis-a-randomized-clinical-trial
#10
Richard K Burt, Roumen Balabanov, Joachim Burman, Basil Sharrack, John A Snowden, Maria Carolina Oliveira, Jan Fagius, John Rose, Flavia Nelson, Amilton Antunes Barreira, Kristina Carlson, Xiaoqiang Han, Daniela Moraes, Amy Morgan, Kathleen Quigley, Kimberly Yaung, Regan Buckley, Carri Alldredge, Allison Clendenan, Michelle A Calvario, Jacquelyn Henry, Borko Jovanovic, Irene B Helenowski
Importance: Hematopoietic stem cell transplantation (HSCT) represents a potentially useful approach to slow or prevent progressive disability in relapsing-remitting multiple sclerosis (MS). Objective: To compare the effect of nonmyeloablative HSCT vs disease-modifying therapy (DMT) on disease progression. Design, Setting, and Participants: Between September 20, 2005, and July 7, 2016, a total of 110 patients with relapsing-remitting MS, at least 2 relapses while receiving DMT in the prior year, and an Expanded Disability Status Scale (EDSS; score range, 0-10 [10 = worst neurologic disability]) score of 2...
January 15, 2019: JAMA: the Journal of the American Medical Association
https://read.qxmd.com/read/30643054/-research-progress-in-amp-activated-protein-kinase-and-sepsis-induced-cardiac-dysfunction
#11
Yamin Li, Jianfeng Qiao, Wenxuan Zhang, Zhenyu Peng
Sepsis-induced cardiac dysfunction is a serious complication of sepsis with no effective treatment. AMP-activated protein kinase (AMPK) is a regulator for energy metabolism in cells and plays a key role in the energy balance. Recent studies have shown that AMPK exerted a protective effect on sepsis-induced cardiac dysfunction, which was related to the regulation of inflammation, endothelial cells injury, energy metabolism, myocardial cells apoptosis and autophagy. Therefore, AMPK is a therapeutic target for sepsis-induced cardiac dysfunction...
December 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://read.qxmd.com/read/30639495/the-modified-5-item-frailty-index-mfi-5-a-concise-and-useful-tool-for-assessing-the-impact-of-frailty-on-post-operative-morbidity-following-elective-posterior-lumbar-fusions-plf
#12
Douglas J Weaver, Azeem Tariq Malik, Nikhil Jain, Elizabeth Yu, Jeffery Kim, Safdar N Khan
BACKGROUND: The modified 5-item frailty index (mFI-5) is a concise co-morbidity based risk stratification tool that has been shown to predict the occurrence of adverse outcomes following various orthopaedic surgeries. METHODS: The 2012-2016 American College of Surgeons - National Surgical Quality Improvement Program (ACS-NSQIP) dataset was used to identify patients undergoing an elective 1-to-2 level posterior lumbar fusion for degenerative lumbar pathology. The mFI-5 score was calculated on the basis of the presence of the five co-morbidities - congestive heart failure within 30 days prior to surgery, insulin-dependent or non-insulin dependent diabetes mellitus, chronic obstructive pulmonary disease or pneumonia, partially dependent or totally dependent functional health status at time of surgery and hypertension requiring medication...
January 10, 2019: World Neurosurgery
https://read.qxmd.com/read/30635313/myocardial-calcification-secondary-to-toxic-shock-syndrome-a-comparative-review-of-17-cases
#13
Talha Ahmed, Faisal Inayat, Muhammad Haq, Taha Ahmed
Myocardial calcification is a rare and life-threatening condition. It has been associated with a myriad of causes, including ischaemic heart disease, cardiac surgery, rheumatic fever, and myocarditis. However, this entity is less well recognised in the setting of toxic shock syndrome. Published medical literature is scarce with regard to the pathogenesis and clinical implications of this potential association. We chronicle here the case of a patient with myocardial calcification secondary to toxic shock syndrome from our clinical experience...
January 10, 2019: BMJ Case Reports
https://read.qxmd.com/read/30631399/impact-of-sepsis-and-non-communicable-diseases-on-prognostic-models-to-predict-the-outcome-of-hospitalized-chronic-liver-disease-patients
#14
Fakhar Ali Qazi Arisar, Shahab Abid, Preet Ayoub Shaikh, Safia Awan
AIM: To evaluate the impact of sepsis and non-communicable diseases (NCDs) on the outcome of decompensated chronic liver disease (CLD) patients. METHODS: In this cross-sectional study, medical records of patients with CLD admitted to the Gastroenterology unit at the Aga Khan University Hospital were reviewed. Patients older than 18 years with decompensation of CLD ( i.e ., jaundice, ascites, encephalopathy, and/or upper gastrointestinal bleed) as the primary reason for admission were included, while those who were admitted for reasons other than decompensation of CLD were excluded...
December 27, 2018: World Journal of Hepatology
https://read.qxmd.com/read/30620955/-sepsis-update-evidence-based-therapy
#15
Lukas Martin, Johannes Bickenbach, Gernot Marx
Like polytrauma, acute myocardial infarction or stroke, sepsis and septic shock are medical emergencies that require adequate early detection and immediate, targeted management. The therapy of sepsis and septic shock has developed continuously in recent years. This article provides an overview of the current evidence of sepsis and septic shock therapy and its implementation into clinical practice.
January 2019: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://read.qxmd.com/read/30611795/chemically-synthesized-secoisolariciresinol-diglucoside-lgm2605-improves-mitochondrial-function-in-cardiac-myocytes-and-alleviates-septic-cardiomyopathy
#16
Dimitra Kokkinaki, Matthew Hoffman, Charikleia Kalliora, Ioannis D Kyriazis, Jennifer Maning, Anna Maria Lucchese, Santhanam Shanmughapriya, Dhanendra Tomar, Joon Young Park, Hong Wang, Xiao-Feng Yang, Muniswamy Madesh, Anastasios Lymperopoulos, Walter J Koch, Melpo Christofidou-Solomidou, Konstantinos Drosatos
Sepsis is the overwhelming systemic immune response to infection, which can result in multiple organ dysfunction and septic shock. Myocardial dysfunction during sepsis is associated with advanced disease and significantly increased in-hospital mortality. Our group has shown that energetic failure and excess reactive oxygen species (ROS) generation constitute major components of myocardial dysfunction in sepsis. Because ROS production is central to cellular metabolic health, we tested if the synthetic anti-oxidant lignan secoisolariciresinol diglucoside (SDG; LGM2605) would alleviate septic cardiac dysfunction and investigated the underlying mechanism...
January 3, 2019: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/30604255/sepsis-related-myocardial-injury-is-associated-with-mst1-upregulation-mitochondrial-dysfunction-and-the-drp1-f-actin-signaling-pathway
#17
Xiuling Shang, Jun Li, Rongguo Yu, Pengli Zhu, Yingrui Zhang, Jingqing Xu, Kaihua Chen, Min Li
LPS-induced septic cardiomyopathy has been found to be connected with mitochondrial stress through unknown mechanisms. Mitochondrial fission is an early event in mitochondrial dysfunction. The aim of our study was to determine the role and regulatory mechanism of mitochondrial fission in the progression of LPS-induced septic cardiomyopathy, with a particular focus on Mst1 and F-actin. Our data demonstrated that Mst1 expression was rapidly upregulated in LPS-treated hearts and that increased Mst1 promoted cardiomyocyte death by inducing mitochondrial stress...
January 2, 2019: Journal of Molecular Histology
https://read.qxmd.com/read/30603642/unstable-angina-trends-and-characteristics-associated-with-length-of-hospitalization-in-the-face-of-diminishing-frequency-an-evidence-of-a-paradigm-shift
#18
Aaqib H Malik, Nauman Siddiqui, Wilbert S Aronow
Background: Unstable angina (UA) has been one of the most common presentations of acute coronary syndrome. The numbers of admitted UA patients have been diminishing in the recent past. However, we are seeing higher costs and higher length of inpatient stay. We attempt to identify the trends and characteristics of length of hospitalization in patients admitted with UA using a nationally representative dataset. Methods: We used the nationwide inpatient sample (NIS) from 2002-2014 to assess the factors associated with length of stay in patients admitted with unstable angina using ICD-9-CM primary diagnosis codes (411...
December 2018: Annals of Translational Medicine
https://read.qxmd.com/read/30558090/sepsis-induced-takotsubo-syndrome-in-young-premenopausal-women-two-case-reports
#19
Fan Wang, Wei Wen
RATIONALE: Takotsubo syndrome (TTS) most commonly occurs in postmenopausal women who have been exposed to a triggering event such as acute physical or emotional distress. Sepsis-induced TTS in young premenopausal women were rarely reported. In particular, the relationship between sepsis-induced TTS and sepsis-induced cardiomyopathy (SIC) remains to be illuminated. PATIENT CONCERNS: Two young premenopausal women were admitted to the hospital with sepsis and myocardial involvement...
December 2018: Medicine (Baltimore)
https://read.qxmd.com/read/30555342/enzymatic-activity-is-not-required-for-phospholipase-d-mediated-tnf-%C3%AE-regulation-and-myocardial-healing
#20
Meike Klier, Simone Gorressen, Marc-Andre Urbahn, David Barbosa, Margriet Ouwens, Jens W Fischer, Margitta Elvers
Phospholipase D1 is a regulator of tumor necrosis factor-α expression and release upon LPS-induced sepsis and following myocardial infarction (MI). Lack of PLD1 leads to a reduced TNF-α mediated inflammatory response and to enhanced infarct size with declined cardiac function 21 days after ischemia reperfusion (I/R) injury. Deficiency of both PLD isoforms PLD1 and PLD2 as well as pharmacological inhibition of the enzymatic activity of PLD with the PLD inhibitor FIPI protected mice from arterial thrombosis and ischemic brain infarction...
2018: Frontiers in Physiology
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