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plasmoblastic lymphoma

Nina Yancheva, Dimitar Strashimirov, Vasil Hrischev, Tatyana Tchervenyakova, Maria Nikolova, Ivaylo Aleksiev
HIV-associated lymphoma was first classified as an AIDS-defining disease by the American Center for Disease Control and Prevention (CDC) in 1985. Non-Hodgkin's lymphomas (NHLs) are frequent malignancies in AIDS patients. The risk of NHL in the case of an underlying HIV infection is estimated to be 100 times greater than in the general population, and it increases with the progression of the retrovirus-related immunosuppression. Cases of HIV-related non-Hodgkin's lymphoma are widely documented in the literature...
June 1, 2018: Le Infezioni in Medicina
Massimo Cajozzo, Vincenzo Davide Palumbo, Salvatore Buscemi, Giuseppe Damiano, Ada Maria Florena, Daniela Cabibi, Francesco Raffaele, Antonino Alessio Anzalone, Federica Fatica, Gerlando Cocchiara, Salvatore Dioguardi, Antonio Bruno, Francesco Paolo Caronia, Attilio Ignazio Lo Monte
BACKGROUND: Plasmoblastic lymphoma is a rare and aggressive subtype of diffuse large B cell lymphoma, which occurs usually in the jaw of immunocompromised subjects. CASE PRESENTATION: We describe the occurrence of plasmoblastic lymphoma in the mediastinum and chest wall skin of an human immunodeficiency virus-negative 63-year-old Caucasian man who had had polycytemia vera 7 years before. At admission, the patient showed a superior vena cava syndrome, with persistent dyspnoea, cough, and distension of the jugular veins...
March 21, 2017: Journal of Medical Case Reports
Firoozeh Isfahani, Surabhi Amar, Harikrishna Dave, Daniel Gridley
We report the case of a 33-year-old HIV-infected man who presented with a recurrent, nonhealing perianal fistula. After multiple benign biopsies, the diagnosis of plasmablastic lymphoma (PBL) eventually was made. The patient underwent chemotherapy and radiation with a complete response. Perianal fistulas are frequent in HIV-positive patients, but PBL as a cause is extremely rare. This often delays the diagnosis and treatment of this highly aggressive disease. We review the literature and discuss the pitfalls in the diagnosis and management of the disease...
January 2015: Journal of the International Association of Providers of AIDS Care
Alejandro Avilés-Salas, José G Chanona-Vilchis, Myrna G Candelaria-Hernández, María de Lourdes Peña-Torres, Miguel Enrique Cuéllar-Mendoza
Plasmablastic lymphoma is an uncommon B-cell lymphoma representing <3% of all non-Hodgkin lymphoma associated with human immunodeficiency virus infection. It displays a distinctive affinity for extranodal presentation in the oral cavity. The case of a plasmablastic lymphoma present in the ovary, cervix and soft thigh tissues of a 27-year-old woman with human immunodeficiency infection is reported.
June 2012: Ginecología y Obstetricia de México
Jamie L Ghafari, Chandra Bhati, Eunice John, Ivo G Tzvetanov, Giuliano Testa, Hoonbae Jeon, Jose Oberholzer, Enrico Benedetti
Pediatric candidates for combined liver/bowel transplant (LBTx) experience a very high mortality on the cadaver waiting list. Our transplant center has successfully used adult living donors to treat pediatric candidates for LBTx. We report the long-term follow-up of this unique cohort of organ donors. The charts of six adult donors for LBTx performed between 2004 and 2007 were reviewed. All the pertinent clinical data were carefully reviewed and integrated with phone interviews of all donors. A total of six children (average age 13...
June 2011: Pediatric Transplantation
Esther Diana Rossi, Alberto Larghi, Elizabeth C Verna, Maurizio Martini, Domenico Galasso, Antonella Carnuccio, Luigi Maria Larocca, Guido Costamagna, Guido Fadda
OBJECTIVES: The diagnosis subtyping of lymphoma on specimens collected by endoscopic ultrasound fine-needle aspiration (EUS-FNA) can be extremely difficult. When a cytopathologist is available for the on-site evaluation, the diagnosis may be achieved by applying flow cytometric techniques. We describe our experience with immunocytochemistry (ICC) and molecular biology studies applied on EUS-FNA specimens processed with a liquid-based cytologic (LBC) preparation for the diagnosis of primary pancreatic lymphoma (PPL)...
November 2010: Pancreas
Emoke Horváth, L Krenács, Eniko Bagdi, Z Pávai, I Macarie, Elod-Erno Nagy, Smaranda Demian
Plasmoblastic lymphoma (PBL) is a subtype of the diffuse large B-cell lymphoma, typically present as extranodal disease associated with human immune deficiency virus (HIV) infection. PBLs are often the initial manifestation of AIDS. Here we present a case of PBL concerning the oral cavity. A 34-year-old woman presented a tumor in the oral cavity that involved the maxilla and gingiva (confirmed by CT-scan). The gingival biopsy showed a massive infiltration by large lymphoid cells with round, vesicular nuclei, prominent nucleoli, fine chromatin and an significant amount of basophilic cytoplasm which express CD79a, CD138, cytoplasmic lambda light chain and LCA, without staining for CD20, CD38, CD3 and CTK...
2008: Romanian Journal of Morphology and Embryology
G Ott, A Rosenwald
Roughly 30-40% of diffuse large B-cell lymphomas (DLBCL) arise primarily in extranodal sites. Most frequently, they occur in the gastrointestinal tract, especially in the gastric mucosa. They also occur in the central nervous system, as testicular lymphomas, in the lungs, or in the skin. Morphologically, they show the whole spectrum of peripheral B-blasts: centroblasts, immunoblasts, or plasmoblasts. Thus, there is no actual difference in their cytomorphological presentation compared to their nodal-and frequently systemic-counterparts...
February 2007: Der Pathologe
H Merz, K Lange, R Nadrowitz, W Uckert, T Blankenstein, A C Feller
Anaplastic large cell lymphoma (ALCL) comprises approximately 25 % of all non-Hodgkin lymphomas in children and young adults. 40% of these tumours have a translocation t(2;5)(p23;q35), which fuses the nucleophosmin gene (NPM) to the anaplastic lymphoma kinase gene (ALK) resulting in a hybrid protein which contributes to the pathogenensis of ALCL. To further analyse the transforming activity in an animal model, a cDNA encoding the protein product, NPM-ALK, was incorporated into a retrovirus construct and introduced into mouse bone marrow progenitors by infection...
2003: Verhandlungen der Deutschen Gesellschaft Für Pathologie
N V Kokosadze, A M Kovrigina, N A Probatova
Stomach MALT-lymphomas have a specific feature of clinical behaviour and prognosis, this being reason to differentiate it from others gastric lymphoma's variants. 75 cases of gastric MALT-lymphomas having "classical" morphological features with polymorphic tumour infiltration. We described the only case of MALToma in our series characterised by a strong marker tendency of monoclonal plasmocytic differentiation (including plasmoblasts) with 'signet-ring' cells, Dutcher and Russel bodies using morphological, histochemical and immunohistochemical methods...
September 2004: Arkhiv Patologii
Cecelia Simonelli, Michele Spina, Roberta Cinelli, Renato Talamini, Rosamaria Tedeschi, Annunziata Gloghini, Emanuela Vaccher, Antonio Carbone, Umberto Tirelli
PURPOSE: To describe the clinical features and outcome of HIV-associated primary effusion lymphoma (PEL) and to compare them with those of the other HIV-associated non-Hodgkin's lymphomas (NHLs). PATIENTS AND METHODS: From April 1987 to June 2002, 277 patients with HIV infection and systemic NHL were diagnosed and treated in our institution. Clinical features and outcome of PEL patients were compared with the features and outcomes of 162 patients belonging to the following histologic subtypes: plasmoblastic lymphoma of oral cavity (PBLOC, n = 11), immunoblastic lymphoma (IBL, n = 76), and centroblastic B-cell lymphoma (CBCL, n = 75)...
November 1, 2003: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Cornelius Miething, Rebekka Grundler, Falco Fend, Josef Hoepfl, Claudia Mugler, Christoph von Schilling, Stephan W Morris, Christian Peschel, Justus Duyster
A t(2;5) (p23;q35) chromosomal translocation can be found in a high percentage of anaplastic large-cell lymphomas (ALCL). This genetic abnormality leads to the expression of the NPM-ALK fusion protein, which encodes a constitutively active tyrosine kinase that plays a causative role in lymphomagenesis. Employing a modified infection/transplantation protocol utilizing an MSCV-based vector, we were able to reproducibly induce two phenotypically different lymphoma-like diseases dependent on the retroviral titers used...
July 24, 2003: Oncogene
Claudia Dannenberg, Rolf Haupt, Luisa Mantovani, Axel Skuballa, Dieter Körholz
Lymphomas belong to the most treatable and curable malignant tumors of childhood. They should always be considered among differential diagnosis, even in unusual locations, and tumor material should be processed adequately to reach true diagnosis. The authors report on a 16-year-old adolescent with a tracheal lymphoma, a rare location of lymphoma in childhood. Because only formalin-fixed tumor material was obtained, pathology showed two differential diagnoses and the entity could never be fully clarified as anaplastic plasmacytoma or plasmoblastic lymphoma...
July 2003: Pediatric Hematology and Oncology
Karin Lange, Wolfgang Uckert, Thomas Blankenstein, Roger Nadrowitz, Cordula Bittner, Jean-Christophe Renauld, Jacques van Snick, Alfred C Feller, Hartmut Merz
Anaplastic large-cell lymphoma (ALCL) comprises approximately 25% of all non-Hodgkin lymphomas (NHL) in children and young adults, and up to 15% of high-grade NHL in older patients. Over 50% of these tumours carry the translocation t(2;5)(p23;q35). The result of this translocation is the fusion of the nucleophosmin (NPM) gene to the anaplastic lymphoma kinase (ALK) gene. The resulting hybrid protein contains the ALK catalytic domain that consequently confers transforming potential, which contributes to the pathogenesis of ALCL...
January 30, 2003: Oncogene
W Feiden, S Milutinovic
Diagnostically primary central nervous system lymphomas (PCNSL) have to be differentiated from glioblastoma and brain metastases. Histologically the overwhelming majority of PCNSL is represented by diffuse large B-cell lymphomas, in this series with a BCL6 expression in 80% of the cases detected by immunohistochemistry. Stereotactic biopsy is the method of choice in establishing the definite diagnosis and intraoperative smear cytology will detect the lymphoid blasts. To confirm the B-cell lineage, immunohistochemistry is needed (CD20, CD79a)...
July 2002: Der Pathologe
O Kaufmann, S Koch, J Burghardt, H Audring, M Dietel
The authors retrospectively tested the potential value of paraffin-reactive monoclonal antibodies (A103 against melan-A, T311 against tyrosinase) and antibody KBA62 as immunohistochemical markers for amelanotic metastatic melanomas. The study cases included 72 amelanotic metastases of known cutaneous melanomas, 59 poorly differentiated carcinomas, 73 sarcomas of varying histogenesis, 4 Leydig cell tumors, 10 high-grade lymphomas, and 6 plasmoblastic/anaplastic myelomas. The results were compared with immunostainings for S-100 protein and HMB-45...
August 1998: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
G Casetta, A Giammò, A Moiso, D Pacchioni
The primary perirenal localization of non-Hodgkin lymphomas is rare and normal methods of image diagnosis do not enable a reliable preoperative diagnosis. In the majority of cases renal function is not affected and this pathology is often presented as an occasional finding. The pathologies included in the differential diagnosis are renal neoplasias, abscess and inflammatory processes in a perirenal site. Echotomography shows the lesion as an hypoanechoic zone surrounding the kidney. Computed tomography show it as isodense with the renal parenchyma...
June 1997: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
C Kuhnen, H Schneele, K M Müller
Three years after heart transplantation and immunosuppressive therapy, a 66-year-old man suffered from dyspnea and showed symptoms mainly due to right heart failure. Malignant tumor cells were discovered within extensive pleural effusion. Computed tomography revealed two lesions of the liver suspicious of metastases, and recurrent blood in the stools was evident. The patient deteriorated rapidly and died 3 weeks after admission. Autopsy findings included an adenocarcinoma of the cecum (grade II) with metastases to the liver...
April 1994: Der Pathologe
J Audouin, J Diebold
The immunosecreting character of tumour cells was shown using a direct immunofluorescent technique on histological sections of fixed tissue, included in paraffin, of 43 specimens from 39 patients suffering from highly malignant ML. These ML corresponded, in the Lennert-Kiel classification, to immunoblastic (9 cases, 4 in plasmoblastic transformation) or polymorphic centroblastic ML (34 cases). In seven patients, the highly malignant ML was secondary to a low grade malignancy ML (3 CLL; 1 lymphoplasmocytic ML; 1 centroblastic centrocytic follicular ML) or to previous dysimmune state (1 Gougerot-Sjögren syndrome 1 lymphomatoid granulomatosis of Liebow)...
June 1984: Pathologie-biologie
G Hauke, J T Epplen, A Hinkkanen, N Freudenberg, G Köchling, H H Peter
No abstract text is available yet for this article.
March 31, 1988: Medizinische Klinik
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