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JOURNAL ARTICLE
Rita Feio-Azevedo, Markus Boesch, Silvia Radenkovic, Lukas van Melkebeke, Lena Smets, Marie Wallays, Bram Boeckx, Gino Philips, Janaíne Prata de Oliveira, Mohammad Ghorbani, Wim Laleman, Philippe Meersseman, Alexander Wilmer, David Cassiman, Hannah van Malenstein, Evangelos Triantafyllou, Cristina Sánchez, Ferran Aguilar, Frederik Nevens, Jef Verbeek, Richard Moreau, Vicente Arroyo, Alexandre Denadai Souza, Joan Clària, Diether Lambrechts, Bart Ghesquière, Hannelie Korf, Schalk van der Merwe
BACKGROUND AIMS: Acute-on-chronic liver failure (ACLF) is a complication of cirrhosis characterized by multiple organ failure and high short-term mortality. The pathophysiology of ACLF involves elevated systemic inflammation leading to organ failure, along with immune dysfunction that heightens susceptibility to bacterial infections. However, it is unclear how these aspects are associated with recovery and non-recovery in ACLF. APPROACH RESULTS: Here we mapped the single-cell transcriptome of circulating immune cells from ACLF-, acute decompensated (AD) cirrhosis patients and healthy individuals...
May 16, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#2
JOURNAL ARTICLE
Huan Wu, Yanman Zhang, Yuqian Li, Shuya Sun, Jintao Zhang, Qingsong Xie, Yue Dong, Shushu Zhou, Xuan Sha, Kuokuo Li, Jinyi Chen, Xin Zhang, Yang Gao, Qunshan Shen, Guanxiong Wang, Xiaomin Zha, Zongliu Duan, Dongdong Tang, Chuan Xu, Hao Geng, Mingrong Lv, Yuping Xu, Ping Zhou, Zhaolian Wei, Rong Hua, Yunxia Cao, Mingxi Liu, Xiaojin He
The complexities of energy transfer mechanisms in the flagella of mammalian sperm flagella have been intensively investigated and demonstrate significant diversity across species. Enzymatic shuttles, particularly adenylate kinase (AK) and creatine kinase (CK), are pivotal in the efficient transfer of intracellular ATP, showing distinct tissue- and species-specificity. Here, the expression profiles of AK and CK were investigated in mice and found to fall into four subgroups, of which Subgroup III AKs were observed to be unique to the male reproductive system and conserved across chordates...
May 16, 2024: Science China. Life Sciences
#3
JOURNAL ARTICLE
Nourhan Shebl, Mohamed Salama
No abstract text is available yet for this article.
May 18, 2024: Acta Neuropathologica
#4
JOURNAL ARTICLE
Jiaqi Wang, Qianqian Xu, Ziyang Xuan, Yuting Mao, Xi Tang, Ke Yang, Fahuan Song, Xin Zhu
OBJECTIVE: Patients with radioiodine-refractory (RAIR) differentiated thyroid carcinoma (DTC; RAIR-DTC) have a poor prognosis. The aim of this study was to provide new insights and possibilities for the diagnosis and treatment of RAIR-DTC. METHODS: The metabolomics of 24 RAIR-DTC and 18 non-radioiodine-refractory (NonRAIR) DTC patients samples were analyzed by liquid chromatograph-mass spectrometry. Cellular radioiodine uptake was detected with γ counter. Sodium iodide symporter (NIS) expression and thyroid stimulating hormone receptor (TSHR) were measured by Western blot analysis...
May 18, 2024: Oncologist
#5
JOURNAL ARTICLE
Yanping Yang, Yang Li, Wenyi Yang, Xueying Yang, Man Luo, Ling Qin, Junchao Zhu
BACKGROUND: Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the most common neurological problems occurring in the perinatal period. However, there still is not a promising approach to reduce long-term neurodevelopmental outcomes of HIE. Recently, itaconate has been found to exhibit anti-oxidative and anti-inflammatory effects. However, the therapeutic efficacy of itaconate in HIE remains inconclusive. Therefore, this study attempts to explore the pathophysiological mechanisms of oxidative stress and inflammatory responses in HIE as well as the potential therapeutic role of a derivative of itaconate, 4-octyl itaconate (4OI)...
May 17, 2024: Journal of Neuroinflammation
#6
JOURNAL ARTICLE
Ling-Ling Ruan, Xing-Yu Lv, Yu-Lin Hu, Ming-Xing Chen, Jing-Tang, Zhao-Hui Zhong, Mei-Hua Bao, Li-Juan Fu, Xin Luo, Shao-Min Yu, Qi Wan, Yu-Bin Ding
BACKGROUND: In the realm of assisted reproduction, a subset of infertile patients demonstrates high ovarian response following controlled ovarian stimulation (COS), with approximately 29.7% facing the risk of Ovarian Hyperstimulation Syndrome (OHSS). Management of OHSS risk often necessitates embryo transfer cancellation, leading to delayed prospects of successful pregnancy and significant psychological distress. Regrettably, these patients have received limited research attention, particularly regarding their metabolic profile...
May 17, 2024: Journal of Ovarian Research
#7
JOURNAL ARTICLE
Xiaoxiao Yang, Ke Feng, Guo Wang, Shifang Zhang, Juan Zhao, Xiangyang Yuan, Jianhong Ren
BACKGROUND: Nanoplastics, are emerging pollutants, present a potential hazard to food security and human health. Titanium dioxide nanoparticles (Nano-TiO2 ), serving as nano-fertilizer in agriculture, may be important in alleviating polystyrene nanoplastics (PSNPs) toxicity. RESULTS: Here, we performed transcriptomic, metabolomic and physiological analyzes to identify the role of Nano-TiO2 in regulating the metabolic processes in PSNPs-stressed maize seedlings (Zea mays L...
May 17, 2024: Journal of Nanobiotechnology
#8
JOURNAL ARTICLE
Ahmed Adel El-Sayed, Ahmed M Sallam, Ibrahim Abou-Soliman
BACKGROUND: In livestock, identifying the physiological and reproductive stages is valuable in guiding management decisions related to nutrition, veterinary procedures, and breeding programs. To achieve this goal, a cohort of Barki ewes in this research underwent observation across three pivotal physiological conditions: pre-pregnancy, late pregnancy, and early lactation. Blood samples were collected to investigate the changes in serum metabolic profile as well as gene expression pattern of cytokines and antioxidants markers during these stages...
May 17, 2024: BMC Veterinary Research
#9
JOURNAL ARTICLE
Shengchao Ma, Wenzhi Cao, Xiaolin Ma, Xiaofang Ye, Chongkai Qin, Bin Li, Wenna Liu, Qingwei Lu, Cuiling Wu, Xuefeng Fu
BACKGROUND: The hair follicle is a skin accessory organ that regulates hair development, and its activity varies on a regular basis. However, the significance of metabolites in the hair follicle cycle has long been unknown. RESULTS: Targeted metabolomics was used in this investigation to reveal the expression patterns of 1903 metabolites in cashmere goat skin during anagen to telogen. A statistical analysis was used to investigate the potential associations between metabolites and the hair follicle cycle...
May 17, 2024: BMC Veterinary Research
#10
JOURNAL ARTICLE
Shiqing Li, Xiaomei Li, Yueyu Ye, Man Chen, Haimin Chen, Dongfeng Yang, Meiya Li, Fusheng Jiang, Xiaobo Zhang, Chunchun Zhang
BACKGROUND: Bletilla striata (Thunb.) Reichb. f. (B. striata) is a perennial herbaceous plant in the Orchidaceae family known for its diverse pharmacological activities, such as promoting wound healing, hemostasis, anti-inflammatory effects, antioxidant properties, and immune regulation. Nevertheless, the microbe-plant-metabolite regulation patterns for B. striata remain largely undetermined, especially in the field of rhizosphere microbes. To elucidate the interrelationships between soil physics and chemistry and rhizosphere microbes and metabolites, a comprehensive approach combining metagenome analysis and targeted metabolomics was employed to investigate the rhizosphere soil and tubers from four provinces and eight production areas in China...
May 17, 2024: BMC Plant Biology
#11
JOURNAL ARTICLE
Eloi Schmauch, Brian Piening, Maedeh Mohebnasab, Bo Xia, Chenchen Zhu, Jeffrey Stern, Weimin Zhang, Alexa K Dowdell, Jacqueline I Kim, David Andrijevic, Karen Khalil, Ian S Jaffe, Bao-Li Loza, Loren Gragert, Brendan R Camellato, Michelli F Oliveira, Darragh P O'Brien, Han M Chen, Elaina Weldon, Hui Gao, Divya Gandla, Andrew Chang, Riyana Bhatt, Sarah Gao, Xiangping Lin, Kriyana P Reddy, Larisa Kagermazova, Alawi H Habara, Sophie Widawsky, Feng-Xia Liang, Joseph Sall, Alexandre Loupy, Adriana Heguy, Sarah E B Taylor, Yinan Zhu, Basil Michael, Lihua Jiang, Ruiqi Jian, Anita S Chong, Robert L Fairchild, Suvi Linna-Kuosmanen, Minna U Kaikkonen, Vasishta Tatapudi, Marc Lorber, David Ayares, Massimo Mangiola, Navneet Narula, Nader Moazami, Harvey Pass, Ramin S Herati, Adam Griesemer, Manolis Kellis, Michael P Snyder, Robert A Montgomery, Jef D Boeke, Brendan J Keating
In a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human decedents did not show evidence of acute-onset cellular- or antibody-mediated rejection. Here, to better understand the detailed molecular landscape following xenotransplantation, we carried out bulk and single-cell transcriptomics, lipidomics, proteomics and metabolomics on blood samples obtained from the transplanted decedents every 6 h, as well as histological and transcriptomic tissue profiling. We observed substantial early immune responses in peripheral blood mononuclear cells and xenograft tissue obtained from decedent 1 (male), associated with downstream T cell and natural killer cell activity...
May 17, 2024: Nature Medicine
#12
JOURNAL ARTICLE
Hui Wang, Qianfan Hu, Yuzhong Chen, Xing Huang, Yipeng Feng, Yuanjian Shi, Rutao Li, Xuewen Yin, Xuming Song, Yingkuan Liang, Te Zhang, Lin Xu, Gaochao Dong, Feng Jiang
Osimertinib (Osi) is a widely used epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). However, the emergence of resistance is inevitable, partly due to the gradual evolution of adaptive resistant cells during initial treatment. Here, we find that Osi treatment rapidly triggers adaptive resistance in tumor cells. Metabolomics analysis reveals a significant enhancement of oxidative phosphorylation (OXPHOS) in Osi adaptive-resistant cells. Mechanically, Osi treatment induces an elevation of NCOA4, a key protein of ferritinophagy, which maintains the synthesis of iron-sulfur cluster (ISC) proteins of electron transport chain and OXPHOS...
May 17, 2024: Nature Communications
#13
REVIEW
Xinyu Chu, Wangsheng Zhu, Xue Li, Erzheng Su, Jiahong Wang
Bitterness is one of the five basic tastes generally considered undesirable. The widespread presence of bitter compounds can negatively affect the palatability of foods. The classification and sensory evaluation of bitter compounds have been the focus in recent research. However, the rigorous identification of bitter tastes and further studies to effectively mask or remove them have not been thoroughly evaluated. The present paper focuses on identification of bitter compounds in foods, structural-based activation of bitter receptors, and strategies to reduce bitter compounds in foods...
May 2024: Food Research International
#14
JOURNAL ARTICLE
Xue Chen, Yanwei Mao, Rongrong Liang, Lixian Zhu, Xiaoyin Yang, David L Hopkins, Yimin Zhang
To explore the underlying mechanisms by which superchilling (SC, -3 °C within 5 h of slaughter) improves beef tenderness, an untargeted metabolomics strategy was employed. M. Longissimus lumborum (LL) muscles from twelve beef carcasses were assigned to either SC or very fast chilling (VFC, 0 °C within 5 h of slaughter) treatments, with conventional chilling (CC, 0 ∼ 4 °C until 24 h post-mortem) serving as the control (6 per group). Biochemical properties and metabolites were investigated during the early post-mortem period...
May 2024: Food Research International
#15
REVIEW
Eugen-Dan Radu, Vlad Mureșan, Teodora Emilia Coldea, Elena Mudura
Beer is the third most consumed beverage in the world, trailing only water and tea but ranking first among alcoholic beverages. In recent years, producers and researchers have shown a growing interest in brewing diversification and innovation, due to of the widespread consumption of beer. In order to create beers and beer-like products with unique and consumer-pleasing characteristics, the use of unconventional raw materials has become a subject of intensive research. The purpose of this paper is to identify, evaluate and summarize the findings of all relevant unconventional raw materials used in relevant scientific studies, as well as the effect on the metabolomics of beer and beer-like beverages...
May 2024: Food Research International
#16
JOURNAL ARTICLE
Hongbin Lin, Shiqi Liao, Zesu Zhou, Ziting Yan, Jianhua Zhao, Yue Xiang, Min Xu, Jie Zhao, Ping Liu, Wengwu Ding, Yu Rao, Jie Tang
Pixian broad bean paste is a renowned fermented seasoning. The fermentation of broad bean is the most important process of Pixian broad bean paste. To enhance the flavor of tank-fermented broad bean paste, salt-tolerant Bacillus amyloliquefaciens strain was inoculated, resulting in an increase in total amount of volatile compounds, potentially leading to different flavor characteristics. To investigate the fermentation mechanism, monoculture simulated fermentation systems were designed. Metabolomics and transcriptomics were used to explore Bacillus amyloliquefaciens' transcriptional response to salt stress and potential aroma production mechanisms...
May 2024: Food Research International
#17
JOURNAL ARTICLE
Ling Ni, Chaojun Jiang, Quanyou Guo, Hai Chi, Chengqi Fan, Jiangao Shi, Na Lin, Zhidong Liu, Shengjun Chen
This study aimed to determine the effect of different frozen temperatures during storage on the quality of Antarctic krill (Euphausia superba) and assess the change at the metabolite level via a combination of physicochemical property analysis, liquid chromatography-tandem mass spectrometry (LC-MS) based non-targeted metabolomics profiling. Regarding samples stored at -20 °C, the expressions of 7055 metabolites were elevated, while 2313 were downregulated. Lipids and lipid molecules had the highest proportion of differential metabolites...
May 2024: Food Research International
#18
REVIEW
Sanchita Rauth, Mokenge Malafa, Moorthy P Ponnusamy, Surinder K Batra
Gastrointestinal (GI) cancers are the leading cause of new cancer cases and cancer-related deaths worldwide. The treatment strategies for patients with GI tumors have focused on oncogenic molecular profiles associated with tumor cells. Recent evidence demonstrated that tumor cell functions are modulated by its microenvironment, compromising fibroblasts, ECMs, microbiome, immune cells, and the enteric nervous system. Along with the TME components, alterations in key metabolic pathways have emerged as a hallmark of tumor cells...
May 15, 2024: Gastroenterology
#19
REVIEW
Young Seok Cho, Kai Han, Jin Xu, James J Moon
Recent advancements in genomics, transcriptomics, and metabolomics have significantly advanced our understanding of the human gut microbiome and its impact on the efficacy and toxicity of anti-cancer therapeutics, including chemotherapy, immunotherapy, and radiotherapy. In particular, prebiotics, probiotics, and postbiotics are recognized for their unique properties in modulating the gut microbiota, maintaining the intestinal barrier, and regulating immune cells, thus emerging as new cancer treatment modalities...
May 15, 2024: Advanced Drug Delivery Reviews
#20
JOURNAL ARTICLE
Pascual García-Pérez, Merve Tomas, Araceli Rivera-Pérez, Vania Patrone, Gianluca Giuberti, Esra Capanoglu, Luigi Lucini
Microgreens constitute natural-based foods with health-promoting properties mediated by the accumulation of glucosinolates (GLs) and phenolic compounds (PCs), although their bioaccessibility may limit their nutritional potential. This work subjected eight Brassicaceae microgreens to in vitro gastrointestinal digestion and large intestine fermentation before the metabolomics profiling of PCs and GLs. The application of multivariate statistics effectively discriminated among species and their interaction with in vitro digestion phases...
May 6, 2024: Food Chemistry
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