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Ahmed Fayed, Ahmed Soliman, Mervat Naguib, Mahmoud Soliman, M Salaheldin
BACKGROUND: Women with chronic kidney disease commonly have menstrual irregularities and fertility abnormalities. Antimüllerian hormone (AMH) and antral follicle count (AFC) are well-recognized indicators of ovarian reserve. AIMS: To assess AMH level and total AFC in women who are on hemodialysis and after successful kidney transplantation (KTx). METHODS: Sixty women with end-stage kidney disease (ESKD) on regular hemodialysis were included in this study with 20 patients of them were going to have renal transplant...
February 8, 2019: International Urology and Nephrology
Terhi T Piltonen, Paolo Giacobini, Åsa Edvinsson, Steinar Hustad, Susanne Lager, Laure Morin-Papunen, Juha S Tapanainen, Inger Sundström-Poromaa, Riikka K Arffman
OBJECTIVE: To investigate plasma antimüllerian hormone (AMH) concentration and its relation to steroid hormone levels in pregnant women with polycystic ovary syndrome (PCOS) and controls at term. DESIGN: Case-control study. SETTING: University-affiliated hospital. PATIENT(S): A total of 74 pregnant women at term: 25 women with PCOS (aged 31.6 ± 3.9 years [mean ± standard deviation], body mass index 24.0 ± 3.9 kg/m2, mean gestational length 279 ± 9 days) and 49 controls (aged 31...
January 7, 2019: Fertility and Sterility
Vikram Sinai Talaulikar, Gerard S Conway, Antoinette Pimblett, Melanie C Davies
OBJECTIVE: To study the safety and efficacy of ovarian stimulation and oocyte cryopreservation as a method of fertility preservation in women with Turner syndrome (TS). DESIGN: Retrospective cohort study. SETTING: Reproductive medicine clinic. PATIENT(S): Seven women with TS who attended the clinic between 2011 and 2017. INTERVENTION(S): Ovarian stimulation and oocyte cryopreservation. MAIN OUTCOMES MEASURE(S): Number of oocytes cryopreserved, ovarian hyperstimulation syndrome...
December 28, 2018: Fertility and Sterility
Ricardo Azziz
No abstract text is available yet for this article.
February 2019: Fertility and Sterility
M R Nagaraja, Satya Prakash Gubbala, C R Wilma Delphine Silvia, Ramars Amanchy
We aimed to survey the monogenic causes of disorders of sex development (DSD) and thereby its prevalence in India. This study revealed mutations resulting in androgen insensitivity syndrome, 5α-reductase type 2 deficiency, and gonadal dysgenesis were commonly reported. Intriguingly, AR deficits were the most prevalent (32 mutations) and of 11/26 missense mutations were in exons 4-8 (encoding ligand binding domain). The unique features of SRD5A2 defects were p.R246Q (most prevalent) and p.G196S could be mutational hotspots, dual gene defects (p...
December 14, 2018: Systems Biology in Reproductive Medicine
Vinay Gunnala, Jessica Fields, Mohamad Irani, Debra D'Angelo, Kangpu Xu, Glenn Schattman, Zev Rosenwaks
OBJECTIVE: To investigate whether BRCA carriers with and without malignancy have decreased ovarian reserve at baseline compared with BRCA noncarriers. DESIGN: Retrospective cohort study. SETTING: Academic medical center. PATIENT(S): Seven-hundred and ninety-five oocyte cryopreservation patients, comprising BRCA carriers with and without malignancy (n = 57) and BRCA noncarriers (n = 738). INTERVENTION(S): Fertility preservation with oocyte cryopreservation...
December 5, 2018: Fertility and Sterility
Nicolás Crisosto, Amanda Ladrón de Guevara, Bárbara Echiburú, Manuel Maliqueo, Gabriel Cavada, Ethel Codner, Francisco Paez, Teresa Sir-Petermann
OBJECTIVE: To study the reproductive and metabolic differences between daughters of women with polycystic ovary syndrome (PCOSd) and control women (Cd) after menarche. DESIGN: Case-control study. SETTING: Clinical endocrinology unit. PATIENT(S): We studied 43 PCOSd and 28 Cd 1.5-6 years after menarche. INTERVENTION(S): Determination of anthropometry, pubertal development, hirsutism, oral glucose tolerance test, and GnRH analogue test...
February 2019: Fertility and Sterility
Nathalie Sermondade, Charlotte Sonigo, Christophe Sifer, Sophie Valtat, Marianne Ziol, Florence Eustache, Michaël Grynberg
OBJECTIVE: To assess whether serum antimüllerian hormone (AMH) levels and antral follicle count (AFC) can predict primordial follicle density within ovarian cortex and the number of oocytes cryopreserved after in vitro maturation (IVM). DESIGN: Retrospective analysis of a case series of patients. SETTING: University hospital. PATIENT(S): Fifty-four women, 18 to 35 years of age, with breast cancer who were candidates for fertility preservation (FP) using ovarian tissue cryopreservation (OTC) associated with oocyte vitrification after unstimulated IVM between July 2013 and December 2016...
February 2019: Fertility and Sterility
Xing Yan Liu, Yun Jie Yang, Chuan Ling Tang, Kai Wang, Jun-Jiang Chen, Xiao Ming Teng, Ye Chun Ruan, Jian Zhi Yang
OBJECTIVE: To measure blood and follicular antimüllerian hormone (AMH) levels in women with polycystic ovary syndrome (PCOS) undergoing assisted reproductive technologies (ART) and to examine the direct action of insulin on AMH expression in human granulosa cells. DESIGN: Prospective clinical and experimental study. SETTING: University Hospital-based laboratory. PATIENT(S): Women with (n = 86) and without (n = 172) PCOS in ART...
November 23, 2018: Fertility and Sterility
Elena Labarta, Maria José de Los Santos, Sonia Herraiz, Maria José Escribá, Alicia Marzal, Anna Buigues, Antonio Pellicer
OBJECTIVE: To study if autologous mitochondrial transfer (AUGMENT) improves outcome in patients with previously failed in vitro fertilization (IVF). DESIGN: Randomized, controlled, triple-blind, experimental study. SETTING: Private infertility center, Valencian Institute of Infertility (IVI-RMA), Valencia, Spain. PATIENT(S): Infertile women ≤42 years of age, body mass index <30 kg/m2 , antimüllerian hormone ≥4 pmol/L, >5 million/mL motile sperm, at least one previous IVF with at least five metaphase oocytes (MIIs) collected, and low embryo quality...
November 24, 2018: Fertility and Sterility
Stine Aagaard Lunding, Susanne Elisabeth Pors, Stine Gry Kristensen, Claus Yding Andersen, Janni Vikkelsø Jeppesen, Kirsten Tryde Macklon, Anders Nyboe Andersen, Anette Tønnes Pedersen
OBJECTIVE: To describe and demonstrate a simple and secure procedure for laparoscopic autotransplantation of fragmented ovarian cortical tissue in women with diminished ovarian reserve as part of in vitro activation (IVA) of ovarian follicles. DESIGN: Step-by-step video explanation of the surgical procedure with still pictures and surgical video clips to demonstrate the detailed technique. SETTING: Fertility clinic and obstetrics and gynecology department at a university hospital...
November 2018: Fertility and Sterility
Vera Miodrag Kovačević, Luka Momir Anđelić, Ana Mitrović Jovanović
OBJECTIVE: To investigate the impact of laparoscopic endometrioma cystectomy on the ovarian reserve and to identify the most important factors that predict the ovarian reserve in patients with endometriomas. DESIGN: Prospective study. SETTINGS: Endoscopy unit of a general hospital. PATIENT(S): Fifty-four patients with unilateral (n = 37) and bilateral endometriomas (n = 17). INTERVENTIONS(S): The serum antimüllerian hormone (AMH) concentration was assessed before surgery and at 6 and 12 months after surgery...
November 2018: Fertility and Sterility
Jing Xu, Maralee S Lawson, Shoukhrat M Mitalipov, Byung S Park, Fuhua Xu
OBJECTIVE: To study whether follicular growth and oocyte maturation can be improved by antimüllerian hormone (AMH) modulation at specific stages of follicular development. DESIGN: Primary and secondary follicles were cultured in a matrix-free system and were assigned to the control group and the group with AMH supplementation during the preantral stage and neutralizing AMH antibody addition during the antral stage. SETTING: National primate research center...
November 2018: Fertility and Sterility
Chelsea Anderson, Yong-Moon Mark Park, Frank Z Stanczyk, Dale P Sandler, Hazel B Nichols
OBJECTIVE: To study the associations between dietary factors and circulating antimüllerian hormone (AMH) concentrations among late premenopausal women. DESIGN: AMH concentrations were measured in serum samples collected at enrollment from 296 women (aged 35-45 years) in the Sister Study cohort. Usual dietary intakes in the past 12 months were assessed using a validated food frequency questionnaire. Dietary exposures of interest included macronutrients, dietary fat subtypes, fiber, and glycemic index...
November 2018: Fertility and Sterility
Jose V Medrano, Teresa Vilanova-Pérez, Victoria Fornés-Ferrer, Ana Navarro-Gomezlechon, María L Martínez-Triguero, Sofía García, Javier Gómez-Chacón, Ivan Povo, Antonio Pellicer, María M Andrés, Edurne Novella-Maestre
OBJECTIVE: To study how temperature, serum, and gonadotropin supplementation affect the organotypic culture of human immature testicular tissue (ITT) in vitro. DESIGN: Experimental basic science study. SETTING: Reproductive biology laboratory. PATIENT(S): ITT from 4 boys with cancer that had testicular tissue cryopreserved as part of their fertility preservation treatment. INTERVENTION(S): In vitro organotypic culture of ITT, exposed to different temperatures (37°C vs...
November 2018: Fertility and Sterility
Ludovico Muzii, Chiara Di Tucci, Mara Di Feliciantonio, Giulia Galati, Violante Di Donato, Angela Musella, Innocenza Palaia, Pierluigi Benedetti Panici
OBJECTIVE: To evaluate if the presence of endometriomas impacts on the ovarian reserve as evaluated with antimüllerian hormone (AMH). DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Patients with unoperated endometriomas versus controls without endometriomas. INTERVENTION(S): Electronic databases searched up to June 2017 to identify articles evaluating AMH levels in patients with unoperated endometriomas versus controls without endometriomas...
October 2018: Fertility and Sterility
Lindsay Merlotti, Wendy Kuohung, John Rinehart
PURPOSE OF REVIEW: Determine if literature supports the use of anti-Müllerian hormone (AMH) as a useful biomarker of reproductive potential when cumulative live birth rates (CLBRs) per retrieval are used as the outcome variable. RECENT FINDINGS: Advances in technology used in in-vitro fertilization (IVF) permit the use of single embryo transfer to achieve expected pregnancy success rates. Many IVF cycles result in the creation of more than a single embryo suitable for transfer per oocyte retrieval...
December 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
Queenie Ho Yan Wong, Richard A Anderson
PURPOSE OF REVIEW: Iatrogenic ovarian damage can occur after chemotherapy, radiotherapy and surgery for cancer as well as for non-malignant conditions. This review describes the effects of such treatment on antimullerian hormone (AMH) and the implications of the fall in AMH in relation to ovarian function and fertility, especially in the era of improved fertility preservation strategies. RECENT FINDINGS: The risk of gonadotoxicity differs between chemotherapy regimens...
December 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
Richard A Anderson, Rachel Remedios, Amy A Kirkwood, Pip Patrick, Linsey Stevens, Laura Clifton-Hadley, Tom Roberts, Chris Hatton, Nagesh Kalakonda, Don W Milligan, Pam McKay, Clare Rowntree, Fiona M Scott, Peter W M Johnson
BACKGROUND: Adverse effects on reproductive function are a key concern in young women treated with chemotherapy for advanced Hodgkin's lymphoma. We aimed to identify risk factors for the extent of ovarian damage in women with Hodgkin's lymphoma treated with different chemotherapy regimens to inform accurate advice on options for fertility preservation. METHODS: We recruited female participants from the randomised phase 3 RATHL trial, aged 18-45 years, based on availability of participants at recruiting sites in the UK...
October 2018: Lancet Oncology
Alice J Shapiro, Sarah K Darmon, David H Barad, Norbert Gleicher, Vitaly A Kushnir
OBJECTIVE: To determine whether a relationship exists between vitamin D (25OH-D) levels and ovarian reserve parameters (antimüllerian hormone [AMH] and FSH levels) in a large cohort of infertile women with a high prevalence of diminished ovarian reserve. DESIGN: Retrospective cohort study. SETTING: Academically affiliated private fertility center. PATIENT(S): A total of 457 infertile women 21-50 years of age who had baseline hormone measurements...
September 2018: Fertility and Sterility
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